Patents Assigned to Medicure International, Inc.
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Patent number: 7115625Abstract: Methods for treating cardiovascular and related diseases such congestive heart failure are described. The methods are directed to concurrently administering a compound such as pyridoxal-5?-phosphate, pyridoxamine, pyridoxal, or a 3-acylated pyridoxal analogue with a therapeutic cardiovascular compound.Type: GrantFiled: August 12, 2003Date of Patent: October 3, 2006Assignee: Medicure International Inc.Inventors: Rajat Sethi, Wasimul Haque
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Patent number: 7105673Abstract: The present invention provides for pyridoxine phosphonate analogues such as, for example, ((2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridyl)alkylphosphonates, and (2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridyl)azaalkylphosphonates) and to pyridoxine malonate analogues, such as, for example, ((2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridylmethyl)malonates), pharmaceutical compositions, and methods for treatment of cardiovascular and related diseases, and diabetes mellitus and related diseases.Type: GrantFiled: October 28, 2002Date of Patent: September 12, 2006Assignee: Medicure International Inc.Inventor: Wasimul Haque
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Patent number: 6897228Abstract: The invention provides pyridoxal and pyridoxine analogues, pharmaceutical compositions containing pyridoxine and pyridoxal analogues, and methods of administering pharmaceutical compositions containing a therapeutically effective amount of at least one of these analogues. In accordance with the present invention, the pyridoxal and pyridoxine analogues can be used in the treatment or prevention of of heparin induced thrombocytopenia (HIT, stroke, and ischemia, and in the treatment of symptoms thereof. The the pyridoxal and pyridoxine analogues can be used in neuroprotection.Type: GrantFiled: April 10, 2003Date of Patent: May 24, 2005Assignee: Medicure International Inc.Inventor: Wasimul Haque
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Publication number: 20050107443Abstract: The invention provides pyridoxal and pyridoxine analogues, pharmaceutical compositions containing pyridoxine and pyridoxal analogues, and methods of administering pharmaceutical compositions containing a therapeutically effective amount of at least one of these analogues. In accordance with the present invention, the pyridoxal and pyridoxine analogues can be used in the treatment or prevention of of heparin induced thrombocytopenia (HIT), stroke, and ischemia, and in the treatment of symptoms thereof. The the pyridoxal and pyridoxine analogues can be used in neuroprotection.Type: ApplicationFiled: December 21, 2004Publication date: May 19, 2005Applicant: Medicure International Inc.Inventor: Wasimul Haque
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Patent number: 6867215Abstract: The present invention provides for pyridoxine phosphonate analogues such as, for example, ((2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridyl)alkylphosphonates, and (2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridyl)azaalkylphosphonates) and to pyridoxine malonate analogues, such as, for example, ((2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridylmethyl)malonates), pharmaceutical compositions, and methods for treatment of cardiovascular and related diseases, and diabetes mellitus and related diseases.Type: GrantFiled: February 28, 2003Date of Patent: March 15, 2005Assignee: Medicure International Inc.Inventor: Wasimul Haque
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Patent number: 6861439Abstract: A method of treating a cerebrovascular disease, particularly stroke, is described. A method of treating a cerebrovascular disease includes administering pyridoxal-5?-phosphate, pyridoxal, pyridoxine, pyridoxamine, 3-acylated analogues of pyridoxal, 3-acylated analogues of pyridoxal-4,5-aminal, pyridoxine phosphonate analogues, or pharmaceutical compositions thereof.Type: GrantFiled: September 24, 2002Date of Patent: March 1, 2005Assignee: Medicure International, Inc.Inventors: Wasimul Haque, Rajat Sethi
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Publication number: 20040186077Abstract: The invention teaches compound of general formula: 1Type: ApplicationFiled: March 17, 2003Publication date: September 23, 2004Applicant: Medicure International Inc.Inventors: James Diakur, Wasimul Haque, Wenlian Zhang, Junzhi Yao, Vinh Pham
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Patent number: 6780997Abstract: Pharmaceutical compositions including an effective amount of the compound of formula IV in which R1 is hydrogen or alkyl; R2 is —CHO, —CH2OH, —CH3 or —CO2R5 in which R5 is hydrogen, alkyl, or aryl; or R2 is —CH2O-alkyl- in which alkyl is covalently bonded to the oxygen at the 3-position instead of R1; R3 and R3′ are independently hydrogen or halo; or R3 and R3′ taken together constitute a second covalent bond between the carbons to which they are substituent; and R4 is hydrogen; or a pharmaceutically acceptable acid addition salt thereof, are taught. Also taught are methods of using the compositions, including for the treatment of myocardial infarctions, ischemia, congestive heart failure, arrhythmia, blood clots, hypertrophy, diabetes, insulin resistance, diabetes related damage, and obesity.Type: GrantFiled: October 28, 2002Date of Patent: August 24, 2004Assignee: Medicure International Inc.Inventor: Wasimul Haque
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Publication number: 20040121988Abstract: A method of treating a cerebrovascular disease, particularly stroke, is described. A method of treating a cerebrovascular disease includes administering pyridoxal-5′-phosphate, pyridoxal, pyridoxine, pyridoxamine, 3-acylated analogues of pyridoxal, 3-acylated analogues of pyriodoxal-4,5-animal, pyridoxine phosphonate analogues, or pharmaceutical compositions thereof.Type: ApplicationFiled: December 3, 2003Publication date: June 24, 2004Applicant: Medicure International Inc.Inventors: Wasimul Haque, Rajat Sethi
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Publication number: 20040038945Abstract: Methods for treating cardiovascular and related diseases such as hypertrophy are described. The methods are directed to concurrently administering a compound such as pyridoxal-5′-phosphate, pyridoxamine, pyridoxal, or a 3-acylated pyridoxal analogue with a therapeutic cardiovascular compound.Type: ApplicationFiled: August 12, 2003Publication date: February 26, 2004Applicant: Medicure International Inc.Inventors: Rajat Sethi, Wasimul Haque
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Publication number: 20040033992Abstract: Methods for treating cardiovascular and related diseases such congestive heart failure are described. The methods are directed to concurrently administering a compound such as pyridoxal-5′-phosphate, pyridoxamine, pyridoxal, or a 3-acylated pyridoxal analogue with a therapeutic cardiovascular compound.Type: ApplicationFiled: August 12, 2003Publication date: February 19, 2004Applicant: Medicure International Inc.Inventors: Rajat Sethi, Wasimul Haque
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Publication number: 20040033990Abstract: Methods for treating cardiovascular and related diseases such as myocardial infarction are described. The methods are directed to concurrently administering a compound such as pyridoxal-5′-phosphate, pyridoxamine, pyridoxal, or a 3-acylated pyridoxal analogue with a therapeutic cardiovascular compound.Type: ApplicationFiled: August 12, 2003Publication date: February 19, 2004Applicant: Medicure International Inc.Inventors: Rajat Sethi, Wasimul Haque
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Publication number: 20040033993Abstract: Methods for treating cardiovascular and related diseases such as ischemia, ischemia reperfusion injuries, and myocardial ischemia, are described. The methods are directed to concurrently administering a compound such as pyridoxal-5′-phosphate, pyridoxamine, pyridoxal, or a 3-acylated pyridoxal analogue with a therapeutic cardiovascular compound.Type: ApplicationFiled: August 12, 2003Publication date: February 19, 2004Applicant: Medicure International Inc.Inventors: Rajat Sethi, Wasimul Haque
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Publication number: 20040033989Abstract: Methods for treating cardiovascular and related diseases such as arrhythmia are described. The methods are directed to concurrently administering a compound such as pyridoxal-5′-phosphate, pyridoxamine, pyridoxal, or a 3-acylated pyridoxal analogue with a therapeutic cardiovascular compound.Type: ApplicationFiled: August 12, 2003Publication date: February 19, 2004Applicant: Medicure International Inc.Inventors: Rajat Sethi, Wasimul Haque
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Publication number: 20040033991Abstract: Methods for treating cardiovascular and related diseases such as blood clots are described. The methods are directed to concurrently administering a compound such as pyridoxal-5′-phosphate, pyridoxamine, pyridoxal, or a 3-acylated pyridoxal analogue with a therapeutic cardiovascular compound.Type: ApplicationFiled: August 12, 2003Publication date: February 19, 2004Applicant: Medicure International Inc.Inventors: Rajat Sethi, Wasimul Haque
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Patent number: 6677356Abstract: Methods for treating cardiovascular and related diseases such as hypertrophy, hypertension, congestive heart failure, ischemia, ischemia reperfusion injuries in various organs, arrhythmia, and myocardial infarction, are described. The methods are directed to concurrently administering a compound such as pyridoxal-5′-phosphate, pyridoxamine, pyridoxal, or a 3-acylated pyridoxal analogue with a therapeutic cardiovascular compound.Type: GrantFiled: August 24, 2000Date of Patent: January 13, 2004Assignee: Medicure International Inc.Inventors: Rajat Sethi, Wasimul Haque
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Patent number: 6667315Abstract: The present invention provides for pyridoxine phosphonate analogues such as, for example, ((2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridyl)alkylphosphonates, and (2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridyl)azaalkylphosphonates) and to pyridoxine malonate analogues, such as, for example, ((2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridylmethyl)malonates), pharmaceutical compositions, and methods for treatment of cardiovascular and related diseases, and diabetes mellitus and related diseases.Type: GrantFiled: October 28, 2002Date of Patent: December 23, 2003Assignee: Medicure International Inc.Inventor: Wasimul Haque
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Publication number: 20030181422Abstract: The present invention provides for pyridoxine phosphonate analogues such as, for example, ((2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridyl)alkylphosphonates, and (2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridyl)azaalkylphosphonates) and to pyridoxine malonate analogues, such as, for example, ((2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridylmethyl)malonates), pharmaceutical compositions, and methods for treatment of cardiovascular and related diseases, and diabetes mellitus and related diseases.Type: ApplicationFiled: February 28, 2003Publication date: September 25, 2003Applicant: Medicure International Inc.Inventor: Wasimul Haque
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Patent number: 6605612Abstract: The present invention provides for pyridoxine phosphonate analogues such as, for example, ((2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridyl)alkylphosphonates, and and (2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridyl)azaalkylphosphonates) and to pyridoxine malonate analogues, such as, for example, ((2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridylmethyl)malonates), pharmaceutical compositions, and methods for treatment of cardiovascular and related diseases, and diabetes mellitus and related diseases.Type: GrantFiled: February 28, 2001Date of Patent: August 12, 2003Assignee: Medicure International Inc.Inventor: Wasimul Haque
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Patent number: 6586414Abstract: A method of treating a cerebrovascular disease, particularly stroke, is described. A method of treating a cerebrovascular disease includes administering pyridoxal-5′-phosphate, pyridoxal, pyridoxine, pyridoxamine, 3-acylated analogues of pyridoxal, 3-acylated analogues of pyriodoxal-4,5-animal, pyridoxine phosphonate analogues, or pharmaceutical compositions thereof.Type: GrantFiled: March 28, 2001Date of Patent: July 1, 2003Assignee: Medicure International Inc.Inventors: Wasimul Haque, Rajat Sethi