Patents Assigned to Medipost Co., Ltd
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Patent number: 11332715Abstract: Disclosed is a method for culturing mesenchymal stem cells, comprising culturing mesenchymal stem cells in a medium containing calcium in a concentration of from 2.1 to 3.8 mM and magnesium in a concentration of from 1.0 to 3.0 mM under a hypoxic condition of 2 to 5% oxygen. The culturing method can increase the population of mesenchymal stem cells even with a small number of passages by improving mesenchymal stem cells in proliferative capacity and viability. In addition, the mesenchymal stem cells prepared by the culturing method are effectively used to treat or improve a pulmonary disease.Type: GrantFiled: March 29, 2019Date of Patent: May 17, 2022Assignee: MEDIPOST CO., LTDInventors: Yoon-Sun Yang, Won Il Oh, Sun Jae Kwon, Mi Yeon Lee, Hong Bae Jeon
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Publication number: 20210228637Abstract: A pharmaceutical composition containing hyaluronic acid and mesenchymal stem cells and its use in treating cartilage damage-associated diseases are disclosed. Compared to when hyaluronic acid and mesenchymal stem cells are administered as a mixture, administering mesenchymal stem cells after first administering hyaluronic acid may exhibit superior effects in alleviating disease symptoms in joint tissues affected by arthritis and also decrease the load on knees due to body weight. Accordingly, the pharmaceutical composition may be beneficially used in the treatment of cartilage damage-associated diseases.Type: ApplicationFiled: June 5, 2019Publication date: July 29, 2021Applicant: MEDIPOST CO., LTDInventors: Yun Sun YANG, Wonil OH, Soo Jin CHOI, Miyoung LEE, Jueun HA, Minju LEE
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Publication number: 20210228636Abstract: A pharmaceutical composition comprising HLA-A2-expressing mesenchymal stem cells as an effective ingredient and its use in prevention or treatment of inflammatory disease are disclosed. The mesenchymal stem cells expressing HLA-A2 on the surface thereof inhibit the secretion of the inflammatory cytokine TNF-a and increase the expression of the anti-inflammatory markers CD163 and Arg-1, so that the pharmaceutical composition comprising the mesenchymal stem cells as an effective ingredient can be advantageously used for suppressing inflammation or treating inflammatory diseases.Type: ApplicationFiled: June 5, 2019Publication date: July 29, 2021Applicant: MEDIPOST CO., LTD.Inventors: Yun Sun YANG, Wonil OH, Soo Jin CHOI, Jihye KWAK, Dong Hyon KIM, Hoon LIM
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Publication number: 20210220256Abstract: Provided is a composition for preventing hair-loss and promoting hair growth, which contains, as an active ingredient, a conditioned media of stem cells stimulated by particular hair catagen inducers including TGF-?, a method of manufacturing the same, and methods of treatment thereof. In particular, disclosed is a use of the function of very effective hair growth by secreting Wnt3a, Bcl-2, CyclinD-1 and the like, which are known as signal transduction proteins.Type: ApplicationFiled: April 5, 2021Publication date: July 22, 2021Applicant: MEDIPOST Co., Ltd.Inventors: Yoon Sun YANG, Wonil OH, Jang Young LEE, Soo Jin CHOI, Hong Bae JEON, Ju-Yeon KIM, Hoon LIM, Seung-Hyun SHIN, Won-Seok PARK
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Publication number: 20190218517Abstract: Disclosed is a method for culturing mesenchymal stem cells, comprising culturing mesenchymal stem cells in a medium containing calcium in a concentration of from 2.1 to 3.8 mM and magnesium in a concentration of from 1.0 to 3.0 mM under a hypoxic condition of 2 to 5% oxygen. The culturing method can increase the population of mesenchymal stem cells even with a small number of passages by improving mesenchymal stem cells in proliferative capacity and viability. In addition, the mesenchymal stem cells prepared by the culturing method are effectively used to treat or improve a pulmonary disease.Type: ApplicationFiled: March 29, 2019Publication date: July 18, 2019Applicant: MEDIPOST CO., LTD.Inventors: Yoon-Sun Yang, Won II Oh, Sun Jae Kwon, Mi Yeon Lee, Hong Bae Jeon
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Patent number: 10307442Abstract: A pharmaceutical composition for the prevention or treatment of a pulmonary disorder is provided. The composition contains mesenchymal stem cells showing improved proliferation and differentiation capacity which are characterized by the expression or non-expression of one or more particular cell markers. Also, provided is a method for obtaining mesenchymal stem cells showing improved proliferation and differentiation capacity based on the expression or non-expression of such cell markers. The mesenchymal stem cells having improved proliferation and differentiation capacity can be easily obtained from mesenchymal stem cells of various origins based on the expression or non-expression of CD26, CD49f, CD146 and EGFR. The mesenchymal stem cells thus obtained can be effectively used for the prevention or treatment of a pulmonary disorder such as, for example, pulmonary emphysema.Type: GrantFiled: March 4, 2016Date of Patent: June 4, 2019Assignee: MEDIPOST CO., LTD.Inventors: Yoon Sun Yang, Wonil Oh, Hye Jin Jin, Hong Bae Jeon, Miyeon Kim
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Patent number: 10294456Abstract: Disclosed is a method for culturing mesenchymal stem cells, comprising culturing mesenchymal stem cells in a medium containing calcium in a concentration of from 2.1 to 3.8 mM and magnesium in a concentration of from 1.0 to 3.0 mM under a hypoxic condition of 2 to 5% oxygen. The culturing method can increase the population of mesenchymal stem cells even with a small number of passages by improving mesenchymal stem cells in proliferative capacity and viability. In addition, the mesenchymal stem cells prepared by the culturing method are effectively used not only as a safe cell therapeutic agent due to their lacking immunogenicity, but also as a cartilage regenerating medicine owing to their excellent secretion of cytokines.Type: GrantFiled: January 11, 2017Date of Patent: May 21, 2019Assignee: MEDIPOST CO., LTDInventors: Yoon-Sun Yang, Won Il Oh, Sun Jae Kwon, Mi Yeon Lee, Hong Bae Jeon
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Patent number: 10238692Abstract: Provided are a pharmaceutical composition for prevention and treatment of a neural disease including at least one selected from the group consisting of mesenchymal stem cells (MSCs), a culture solution of the MSCs, activin A, PF4, decorin, galectin 3, GDF15, glypican 3, MFRP, ICAM5, IGFBP7, PDGF-AA, SPARCL1, thrombospondin-1, WISP1, progranulin, IL-4, a factor inducing expression thereof, and any combination thereof, and a method therefor.Type: GrantFiled: November 16, 2009Date of Patent: March 26, 2019Assignee: MEDIPOST CO., LTDInventors: Yoon-Sun Yang, Won II Oh, Jong Wook Chang, Ju Yeon Kim
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Patent number: 10150950Abstract: A method for culturing mesenchymal stem cells. The method includes isolating mesenchymal stem cells having a size of 8 ?m or less and culturing the mesenchymal stem cells in a medium containing calcium and magnesium and under a low oxygen condition. The method can significantly improve the proliferative capacity and differentiation potential of the mesenchymal stem cells.Type: GrantFiled: August 29, 2014Date of Patent: December 11, 2018Assignee: MEDIPOST CO., LTDInventors: Yoon-Sun Yang, Won Il Oh, Hye Jin Jin, Soon-Jae Kwon, Miyeon Kim
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Publication number: 20180008531Abstract: Provided are a composition for preventing hair loss and stimulating hair growth, which includes small-sized stem cells, particularly, small-sized stem cells having a diameter of 8 ?m or less, or a culture thereof as an active ingredient, a method of preparing the same, and a use of the same. Provided is a use of the composition utilizing a hair growth stimulating function of the small-sized stem cells having a diameter of 8 ?m or less to considerably increase activity of hair follicle stem cells in a telogen phase.Type: ApplicationFiled: September 22, 2017Publication date: January 11, 2018Applicant: MEDIPOST CO., LTD.Inventors: Yoon Sun YANG, Wonil OH, Jang Young LEE, Soo Jin CHOI, Hong Bae JEON, Ju-Yeon KIM, Hoon LIM
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Publication number: 20170360839Abstract: A pharmaceutical composition for the prevention or treatment of a pulmonary disorder is provided. The composition contains mesenchymal stem cells showing improved proliferation and differentiation capacity which are characterized by the expression or non-expression of one or more particular cell markers. Also, provided is a method for obtaining mesenchymal stem cells showing improved proliferation and differentiation capacity based on the expression or non-expression of such cell markers. The mesenchymal stem cells having improved proliferation and differentiation capacity can be easily obtained from mesenchymal stem cells of various origins based on the expression or non-expression of CD26, CD49f, CD146 and EGFR. The mesenchymal stem cells thus obtained can be effectively used for the prevention or treatment of a pulmonary disorder such as, for example, pulmonary emphysema.Type: ApplicationFiled: March 4, 2016Publication date: December 21, 2017Applicant: MEDIPOST CO., LTD.Inventors: Yoon Sun YANG, Wonil OH, Hye Jin JIN, Hong Bae JEON, Miyeon KIM
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Publication number: 20170191036Abstract: Disclosed is a method for culturing mesenchymal stem cells, comprising culturing mesenchymal stem cells in a medium containing calcium in a concentration of from 2.1 to 3.8 mM and magnesium in a concentration of from 1.0 to 3.0 mM under a hypoxic condition of 2 to 5% oxygen. The culturing method can increase the population of mesenchymal stem cells even with a small number of passages by improving mesenchymal stem cells in proliferative capacity and viability. In addition, the mesenchymal stem cells prepared by the culturing method are effectively used not only as a safe cell therapeutic agent due to their lacking immunogenicity, but also as a cartilage regenerating medicine owing to their excellent secretion of cytokines.Type: ApplicationFiled: January 11, 2017Publication date: July 6, 2017Applicant: MEDIPOST CO., LTD.Inventors: Yoon-Sun YANG, Won Il OH, Sun Jae KWON, Mi Yeon LEE, Hong Bae JEON
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Patent number: 9580687Abstract: Disclosed is a method for culturing mesenchymal stem cells, comprising culturing mesenchymal stem cells in a medium containing calcium in a concentration of from 2.1 to 3.8 mM and magnesium in a concentration of from 1.0 to 3.0 mM under a hypoxic condition of 2 to 5% oxygen. The culturing method can increase the population of mesenchymal stem cells even with a small number of passages by improving mesenchymal stem cells in proliferative capacity and viability. In addition, the mesenchymal stem cells prepared by the culturing method are effectively used not only as a safe cell therapeutic agent due to their lacking immunogenicity, but also as a cartilage regenerating medicine owing to their excellent secretion of cytokines.Type: GrantFiled: September 2, 2013Date of Patent: February 28, 2017Assignee: Medipost Co., Ltd.Inventors: Yoon-Sun Yang, Won Il Oh, Sun Jae Kwon, Mi Yeon Lee, Hong Bae Jeon
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Patent number: 9498497Abstract: There is provided a method of treating lung diseases including administering cells separated or proliferated from umbilical cord blood to a patient suffering from such diseases.Type: GrantFiled: August 1, 2008Date of Patent: November 22, 2016Assignees: MEDIPOST Co., Ltd., Samsung Life Public Welfare FoundationInventors: Yun Sil Chang, Won Soon Park, Yoon-Sun Yang
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Patent number: 9439931Abstract: A use of a composition comprising umbilical cord blood-derived mesenchymal stem cells for inducing differentiation and proliferation of neural precursor cells or neural stem cells to neural cells is provided, the composition being effective for the treatment of nerve injury diseases.Type: GrantFiled: August 19, 2013Date of Patent: September 13, 2016Assignee: MEDIPOST CO., LTDInventors: Wonil Oh, Yoon-Sun Yang, Jong Wook Chang, Soo Jin Choi, Ju-Yeon Kim
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Patent number: 9408892Abstract: Thrombospondin 1 (TSP-1), TSP-2, interleukin 17B receptor (IL-17BR) and heparin-binding epidermal growth factor-like growth factor (HB-EGF) associated with stem cell activity and use thereof.Type: GrantFiled: June 19, 2013Date of Patent: August 9, 2016Assignee: MEDIPOST CO., LTDInventors: Yoon-Sun Yang, Won Il Oh, Hong Bae Jeon, Mee Hyun Jung, Sang Young Jeong
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Publication number: 20160222353Abstract: A method for culturing mesenchymal stem cells. The method includes isolating mesenchymal stem cells having a size of 8 ?m or less and culturing the mesenchymal stem cells in a medium containing calcium and magnesium and under a low oxygen condition. The method can significantly improve the proliferative capacity and differentiation potential of the mesenchymal stem cells.Type: ApplicationFiled: August 29, 2014Publication date: August 4, 2016Applicant: MEDIPOST CO., LTD.Inventors: Yoon-Sun YANG, Won II OH, Hye Jin JIN, Soon-Jae KWON, Miyeon KIM
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Patent number: 9387226Abstract: A use of a composition comprising umbilical cord blood-derived mesenchymal stem cells for inducing differentiation and proliferation of neural precursor cells or neural stem cells to neural cells is provided, the composition being effective for the treatment of nerve injury diseases.Type: GrantFiled: November 29, 2007Date of Patent: July 12, 2016Assignee: MEDIPOST CO., LTDInventors: Wonil Oh, Yoon-Sun Yang, Jong Wook Chang, Soo Jin Choi, Ju-Yeon Kim
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Publication number: 20160000698Abstract: Provided are a composition for preventing hair loss and stimulating hair growth, which includes small-sized stem cells, particularly, small-sized stem cells having a diameter of 8 ?m or less, or a culture thereof as an active ingredient, a method of preparing the same, and a use of the same. Provided is a use of the composition utilizing a hair growth stimulating function of the small-sized stem cells having a diameter of 8 ?m or less to considerably increase activity of hair follicle stem cells in a telogen phase.Type: ApplicationFiled: March 2, 2015Publication date: January 7, 2016Applicant: MEDIPOST CO., LTD.Inventors: Yoon Sun YANG, Wonil OH, Jang Young LEE, Soo Jin CHOI, Hong Bae JEON, Ju-Yeon KIM, Hoon LIM
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Publication number: 20160000699Abstract: Provided is an a composition for preventing hair-loss and promoting hair growth containing as an active ingredient conditioned media of stem cells stimulated by particular hair catagen inducers including TGF-?, a method of manufacturing the same, and a use thereof. In particular, the present invention relates to a use of the function of very effective hair growth by secreting Wnt3a, Bcl-2, CyclinD-1 and the like, which are known as signal transduction proteins.Type: ApplicationFiled: July 6, 2015Publication date: January 7, 2016Applicant: MEDIPOST Co., Ltd.Inventors: Yoon Sun YANG, Wonil OH, Jang Young LEE, Soo Jin CHOI, Hong Bae JEON, Ju-Yeon KIM, Hoon LIM, Seung-Hyun SHIN, Won-Seok PARK