Abstract: The present invention relates to a pharmaceutical composition for the prevention or treatment of neurological disorders, comprising an ICAM-1 (intercellular adhesion molecule-1) protein, or a fragment or a variant thereof as an active ingredient, which can increase the expression of neprilysin to remove amyloid-beta (A?), a cause of dementia, and is thus useful in preventing or treating a neurological disease including Alzheimer's disease.
Type:
Grant
Filed:
February 2, 2012
Date of Patent:
December 24, 2013
Assignee:
Medipost Co., Ltd.
Inventors:
Yoon-Sun Yang, Won Il Oh, Jong Wook Chang, Ji Hyun Kim
Abstract: A use of a composition comprising umbilical cord blood-derived mesenchymal stem cells for inducing differentiation and proliferation of neural precursor cells or neural stem cells to neural cells is provided, the composition being effective for the treatment of nerve injury diseases.
Type:
Application
Filed:
August 19, 2013
Publication date:
December 12, 2013
Applicant:
Medipost Co., Ltd.
Inventors:
Wonil OH, Yoon-Sun YANG, Jong Wook CHANG, Soo Jin CHOI, Ju-Yeon KIM
Abstract: Provided is a gene therapy composition for transferring one of a therapeutic gene, a maker gene, or a mixture thereof to a cell that expresses interleukin-8 (IL-8) or GRO-? and induces tropism of mesenchymal stem cells isolated from umbilical cord blood and/or the mesenchymal stem cells expanded from said mesenchymal stem cells (UCB-MSCs), wherein the cell-treating composition includes UCB-MSCs. Provided is a composition for treating disease related to a cell expressing IL-8 or GRO-?, that is, a brain tumor in gene therapy, by using UCB-MSCs. Provided is a composition or kit for diagnosing brain tumors, preventing brain tumors, treating brain tumors, or monitoring brain tumor treatment progression by using UCB-MSCs.
Type:
Grant
Filed:
December 8, 2009
Date of Patent:
August 13, 2013
Assignee:
Medipost Co., Ltd.
Inventors:
Jong Wook Chang, Dal Soo Kim, Yoon-Sun Yang, Won Il Oh
Abstract: Provided is a gene therapy composition for transferring one of a therapeutical gene, a maker gene, or a mixture thereof to a cell that expresses interleukin-8(IL-8) or GRO-? and induces tropism of mesenchymal stem cells isolated from umbilical cord blood and/or the mesenchymal stem cells expanded from said mesenchymal stem cells (UCB-MSCs), wherein the cell-treating composition includes UCB-MSCs. Provided is a composition for treating disease related to a cell expressing IL-8 or GRO-?, that is, a brain tumor in gene therapy, by using UCB-MSCs. Provided is a composition or kit for diagnosing brain tumors, preventing brain tumors, treating brain tumors, or monitoring brain tumor treatment progression by using UCB-MSCs.
Abstract: The present invention relates to a pharmaceutical composition for the prevention or treatment of neurological disorders, comprising an ICAM-1 (intercellular adhesion molecule-1) protein, or a fragment or a variant thereof as an active ingredient, which can increase the expression of neprilysin to remove amyloid-beta (A?), a cause of dementia, and is thus useful in preventing or treating a neurological disease including Alzheimer's disease.
Type:
Application
Filed:
February 2, 2012
Publication date:
August 2, 2012
Applicant:
MEDIPOST CO., LTD.
Inventors:
Yoon-Sun YANG, Won Il OH, Jong Wook CHANG, Ji Hyun KIM
Abstract: Provided are a pharmaceutical composition for prevention and treatment of a neural disease including at least one selected from the group consisting of mesenchymal stem cells (MSCs), a culture solution of the MSCs, activin A, PF4, decorin, galectin 3, GDF15, glypican 3, MFRP, ICAM5, IGFBP7, PDGF-AA, SPARCL1, thrombospondin-1, WISP1, progranulin, IL-4, a factor inducing expression thereof, and any combination thereof, and a method therefor.
Type:
Application
Filed:
November 16, 2009
Publication date:
October 27, 2011
Applicant:
MEDIPOST CO., LTD.
Inventors:
Yoon-Sun Yang, Won ll Oh, Jong Wook Chang, Ju Yeon Kim
Abstract: There is provided a method for the isolation and cultivation of mesenchymal stem/progenitor cells from umbilical cord blood, and also to a method for the differentiation of the umbilical cord blood-derived mesenchymal stem/progenitor cells into various mesenchymal tissues. The method include overlaying umbilical cord blood onto Ficoll-Hypaque solution; centrifuging the umbilical cord blood on the Ficoll-Hypaque solution to obtain a mononuclear cell layer; reacting cells obtained by monolayer culture of the mononuclear cells with antibodies to mesenchymal stem/progenitor cell-specific antigens for a predetermined period of incubation time; isolating only cells bound to their corresponding antibodies using a cell sorter; and cultivating the isolated cells, thereby obtaining mesenchymal stem/progenitor cells with high purity and excellent viability.
Type:
Application
Filed:
October 14, 2009
Publication date:
July 22, 2010
Applicant:
Medipost Co., Ltd.
Inventors:
Chul-Won HA, Yoon-Sun Yang, Sung-Eun Yang
Abstract: Provided is a gene therapy composition for transferring one of a therapeutical gene, a maker gene, or a mixture thereof to a cell that expresses interleukin-8(IL-8) or GRO-? and induces tropism of mesenchymal stem cells isolated from umbilical cord blood and/or the mesenchymal stem cells expanded from said mesenchymal stem cells (UCB-MSCs), wherein the cell-treating composition includes UCB-MSCs. Provided is a composition for treating disease related to a cell expressing IL-8 or GRO-?, that is, a brain tumor in gene therapy, by using UCB-MSCs. Provided is a composition or kit for diagnosing brain tumors, preventing brain tumors, treating brain tumors, or monitoring brain tumor treatment progression by using UCB-MSCs.
Type:
Application
Filed:
December 8, 2009
Publication date:
June 10, 2010
Applicant:
MEDIPOST CO., LTD.
Inventors:
Jong Wook CHANG, Dal Soo KIM, Yoon-Sun YANG, Won Il OH
Abstract: A use of a composition comprising umbilical cord blood-derived mesenchymal stem cells for inducing differentiation and proliferation of neural precursor cells or neural stem cells to neural cells is provided, the composition being effective for the treatment of nerve injury diseases.
Type:
Application
Filed:
November 29, 2007
Publication date:
March 25, 2010
Applicant:
Medipost Co., Ltd.
Inventors:
Wonil Oh, Yoon-Sun Yang, Jong Wook Chang, Soo Jin Choi, Ju-Yeon Kim
Abstract: Disclosed is a composition for the treatment of cartilage or bone damage or loss or defect. The composition comprises mesenchymal stem cells separated from umbilical cord blood and/or mesenchymal stem cells proliferated and/or differentiated. The composition also comprise chondrocytes and/or chondroblasts, or osteocytes and/or osteoblasts, differentiated from the mesenchymal stem cells separated from the umbilical cord blood.
Type:
Application
Filed:
September 24, 2008
Publication date:
March 5, 2009
Applicant:
Medipost Co., Ltd.
Inventors:
Chul-Won Ha, Yoon-Sun Yang, Sung-Eun Yang
Abstract: Disclosed is a composition for the treatment of cartilage or bone damage or loss or defect. The composition comprises mesenchymal stem cells separated from umbilical cord blood and/or mesenchymal stem cells proliferated and/or differentiated. The composition also comprise chondrocytes and/or chondroblasts, or osteocytes and/or osteoblasts, differentiated from the mesenchymal stem cells separated from the umbilical cord blood.
Type:
Application
Filed:
September 24, 2008
Publication date:
February 19, 2009
Applicant:
Medipost Co., Ltd.
Inventors:
Chul-Won HA, Yoon-sun Yang, Sung-Eun Yang
Abstract: Disclosed is a composition for the treatment of cartilage or bone damage or loss or defect. The composition comprises mesenchymal stem cells separated from umbilical cord blood and/or mesenchymal stem cells proliferated and/or differentiated. The composition also comprise chondrocytes and/or chondroblasts, or osteocytes and/or osteoblasts, differentiated from the mesenchymal stem cells separated from the umbilical cord blood.
Type:
Application
Filed:
September 24, 2008
Publication date:
January 22, 2009
Applicant:
Medipost Co., Ltd.
Inventors:
Chul-Won Ha, Yoon-Sun Yang, Sung-Eun Yang
Abstract: There is provided a method of treating lung diseases including administering cells separated or proliferated from umbilical cord blood to a patient suffering from such diseases.
Type:
Application
Filed:
August 1, 2008
Publication date:
December 18, 2008
Applicants:
SAMSUNGN LIFE PUBLIC WELFARE FOUNDATION, MEDIPOST CO., LTD
Inventors:
Yun Sil CHANG, Won Soon Park, Yoon-Sun Yang
Abstract: Disclosed herein is a composition for the treatment of articular cartilage damage or loss or defect. The composition for the treatment of articular cartilage injury of the present invention includes (i) cellular components separated, proliferated, and/or differentiated from the umbilical cord blood, (ii) a culture medium; and (iii) a biocompatible polymer. The composition has very superior ability of proliferation and differentiation and easier to be collected and acquired.
Type:
Grant
Filed:
August 14, 2002
Date of Patent:
December 2, 2008
Assignees:
Medipost Co., Ltd
Inventors:
Chul-Won Ha, Yoon-Sun Yang, Sung-Eun Yang
Abstract: The present invention relates to a composition comprising separated or proliferated cells from umbilical cord blood for treating developmental and/or chronic lung disease, more precisely a composition containing separated or proliferated cells from umbilical cord blood for intratracheal administration for treating developmental and/or chronic lung disease. The cells of the composition of the present invention have excellent activities of proliferation and differentiation, so that the extraction, separation and selection of a tissue donor are all very easy. Besides, the composition of the invention can be very effectively used for the treatment of developmental and/or chronic diseases by intratracheal administration.
Type:
Application
Filed:
June 22, 2006
Publication date:
August 2, 2007
Applicants:
Samsung Life Public Welfare Foundation, Medipost Co., Ltd.
Inventors:
Yun Sil Chang, Won Soon Park, Yoon-Sun Yang
Abstract: The present application discloses a method for expanding a population of mammalian cells comprising contacting the cells with angiopoietin 1.