Abstract: A heart valve assembly has a frame comprising an inflow section, an outflow section, and a connecting section that is located between the inflow section and the outflow section. The inflow section has a plurality of legs that extend radially outwardly, and the connecting section has a greater flexibility than the inner section. The assembly also includes a plurality of leaflets coupled to the connecting section, a valve skirt extending from the leaflets towards the inflow section of the frame, and a cuff section, with the legs and the cuff section together defining a cuff for engagement with a native annulus.

Abstract: A heart valve assembly has a leaflet support structure and a leaflet assembly. The leaflet support structure has a wire frame that supports the leaflet assembly. The leaflet assembly has first and second separate leaflets, each of which is comprised of a skirt section and a sinus leaflet section. Each skirt section has a flange portion and a body portion that has a smaller diameter than the flange portion, with the body portion having opposing side edges, and a curved opening defined by a first stitching edge at about the central portion of the body portion. Each sinus leaflet section has an outflow edge, and a curved second stitching edge, with the sinus leaflet section stitched to the skirt section along the first and second stitching edges. The opposing side edges of the body portion of the first leaflet are stitched to the corresponding side edges of the body portion of the second leaflet.

Abstract: A beam shaping assembly for neutron capture therapy includes a beam inlet, a target having nuclear reaction with an incident proton beam from the beam inlet to produce neutrons forming a neutron beam defining a main axis, a moderator adjoining to the target, a reflector surrounding the moderator, a thermal neutron absorber adjoining to the moderator, a radiation shield arranged inside the beam shaping assembly and a beam outlet. The neutrons are moderated to epithermal neutron energies. The reflector leads the neutrons deviated from the main axis back, and a gap channel is arranged between the moderator and the reflector. The thermal neutron absorber is used for absorbing thermal neutrons so as to avoid overdosing in superficial normal tissue during therapy. The radiation shield is used for shielding leaking neutrons and photons so as to reduce dose of the normal tissue not exposed to irradiation.

Abstract: An implant delivery system is disclosed which includes an inner tube assembly, an outer tube assembly and a functional handle. The functional handle includes a threaded rod, a push-pull control member, a casing tube, a displacement tube, an inner tube fixing member, an outer tube fixing member and a stability tube fixing member. The threaded rod extends through a bore of the displacement tube. A fastener of the push-pull control member is able to engage a thread provided on a leading portion of the threaded rod. A trailing portion of the threaded rod is provided with a knob. The push-pull control member includes a fastener, springs and a button. The fastener is able to extend through a slot to engage a thread of the threaded rod in the displacement tube. The springs are configured to cause an automatic locking of the fastener and the threaded rod. The button is provided on the fastener.

Abstract: The present invention relates to a heart valve assembly (1000), comprising a frame (1) and a heart valve (100), wherein the frame (1) supports the heart valve (100) or is interconnected thereto, preferably by sewing or sewing alone, the frame (1) comprising at least a first guiding structure (2a) for guiding at least one tension thread (5) for folding and/or unfolding the frame (1) around or along the frame (1), preferably at an outside or an outer circumference of the guiding structure (2a), wherein the heart valve (100), comprises at least two leaflets (101, 101?, 101?); an interconnecting tissue (301) interconnecting the leaflets (101, 101?, 101?) with the frame; wherein the interconnecting tissue (301) or parts thereof, respectively, is interconnected to at least one of the guiding structures (2a, 2b) such that it covers the guiding structure (2a, 2b) or parts thereof at an inner circumference of the guiding structure (2a, 2b) and such that it also covers at least both an upper part (2c) and a lower part

Abstract: A heart valve assembly has a heart valve assembly that has a wire frame comprising an anchor section, a generally cylindrical valve support section, and a neck section that transitions between the anchor section and the valve support section. The wire frame includes a plurality of supports extending radially outwardly in an annular manner about an upper end of the valve support section, and the anchor section has an annular flange that extends radially therefrom, so that an annular space is defined between the annular flange and the annular supports for receiving or capturing the native annulus when the heart valve is deployed. The heart valve assembly also includes a leaflet assembly having a plurality of leaflets that are stitched to the valve support section and which are positioned on an inflow side of the neck section.

Abstract: A heart valve assembly has a frame having an anchoring section defined by a plurality of rows of cells, with each cell defined by a plurality of struts that encircle each cell, and a pair of legs extending from the anchoring section. The assembly also includes a leaflet assembly that has a plurality of leaflets that are stitched to the legs. The heart valve assembly is delivered to the location of a native mitral annulus, and the anchoring section is deployed inside the left atrium such that the anchoring section is completely retained in the left atrium, and the legs and leaflets extend through the native mitral annulus.

Abstract: A tissue resecting device includes an elongated shaft having a central axis, a distal end, and a proximal end. A ceramic or other housing is mounted at the distal end of the shaft and has a tissue-receiving window. A movable electrode is configured to be rotationally oscillated or otherwise moved across the window. In one instance, the rotatable moveable electrode may have a dogleg configuration with a free end constrained within an arcuate slot formed near the window. In another instance, the movable electrode may have a U-shaped configuration with a distal end coupled to a pivot in the housing which is aligned with a rotational drive member.

Abstract: The present invention relates to an apparatus (100) for folding or unfolding at least one medical implant (300) by using at least one tension thread (11, 11?), wherein the apparatus (100) includes a shaft (1) including a reception area for receiving the implant (300), a tensioning device for altering a shape of the foldable and/or unfoldable implant (300) by the tension thread (11, 11?), and a clamping mechanism for clamping at least one section of at least one of the tension threads (11, 11?). The present invention further relates to a set and a method.

Abstract: A heart valve assembly has a heart valve assembly that has an anchor section, a generally cylindrical valve support section, and a neck section that transitions between the anchor section and the valve support section. A plurality of supports extend radially outwardly in an annular manner about an upper end of the valve support section, and the anchor section has an annular flange that extends radially therefrom, so that an annular space is defined between the annular flange and the annular supports for receiving or capturing the native annulus when the heart valve is deployed. The heart valve assembly also includes a leaflet assembly having a plurality of leaflets that are stitched to the valve support section and which are positioned on an inflow side of the neck section.

Abstract: A collapsible-expandable tubular stent (29) constructed of shape-memory material which is implantable into a human heart, which comprises proximal and distal rings (71, 73) and at least two spaced apart posts (69) that extend axially between said rings (71, 73), said distal ring (73) comprising a plurality of distal arms (77) which are connected to the distal ring (73) at only one end and which have a free opposite end; said proximal ring (71) comprising a plurality of, which are connected at only one end to the proximal ring (71) and which have a free opposite end, which proximal arms (75) are constructed to swing radially outward at their free ends.

Abstract: The method for the automated and assisted acquisition of anatomical surfaces includes a first acquisition of the surfaces undertaken in order to create a first numerical model and a perioperative second acquisition undertaken by scanning the surfaces in order to create a second numerical model for identifying the coordinates of the surfaces. The surfaces are supported by a robotic arm; and then the models are brought into correspondence by resetting. The scanning in the second acquisition includes making a preliminary identification of the coordinates of noteworthy points on the surfaces manually, assisted by the robotic arm, and the identifying parts a the points, in order to construct a reference frame and to determine a scanning region; creating an intermediate model from the reference frame and at least one of the points; preliminary resetting the first model with the second model; and automatically scanning the determined zone.

Abstract: Provided herein is a pharmaceutical composition comprising vitamin C and chromium-free vitamin K, and optionally one or more pharmaceutically acceptable excipient(s). Also provided herein is a chromium-free pharmaceutical composition comprising vitamin C and vitamin K, and optionally one or more pharmaceutically acceptable excipient(s). Further provided herein is a method of treating, preventing, or managing an NF?B-mediated condition, disorder, or disease, comprising administering to the subject a therapeutically effective amount of vitamin C and chromium-free vitamin K. Provided herein are methods for treating, preventing, or ameliorating one or more symptoms of a polycystic disease in a subject, comprising administering to the subject a therapeutically effective amount of vitamins C and K.

Abstract: The present invention provides an anti-fracture sheath. The anti-fracture sheath comprises a tube body and an expansion section for accommodating an implantable device, wherein one side of the distal end of the tube body is joined with the expansion section, at least two reinforcing ribs are axially arranged on the tube wall of the expansion section in an internally extending manner, and the proximal ends of the reinforcing ribs extend from the expansion section and are fixedly connected with the tube wall of the tube body; and the materials of the reinforcing ribs are Kevlar fibers, the diameter of each reinforcing rib is from 0.03 mm to 0.12 mm, and the number of the reinforcing ribs is from two to four. The anti-fracture sheath provided by the present invention has the advantage that the strength of the expansion section is improved when the whole compliance of the sheath is maintained, thereby avoiding fracture of the sheath in an implantable device releasing process.

Abstract: A walking movement device is provided for producing a walking movement of a human being with two controlled foot guiding units, each having a foot plate for placing a foot thereon. The foot plates are alternately movable forward and backwards in opposite directions to stimulate the walking movement. The foot plates are coupled with at least one drive unit, via which drive unit the walking movement of the foot plates can be produced, and have a suspension unit for easing the weight on the human being. The foot plates each have a front and a rear partial area with the at least one drive unit being configured to move the rear partial area out of the common plane with respect to the front partial area and back again during the walking movement of the foot plates, in order to enable bending of the midfoot toe joint during the movement process.

Abstract: An apparatus for providing treatment to at least one tissue includes a distal balloon, a proximal balloon, and at least one intermediate balloon positioned between the distal balloon and the proximal balloon and inflatable independently from the distal and proximal balloons. A source lumen is positioned within at least the intermediate balloon receives a radiation source to treat target tissue adjacent the intermediate balloon.

Abstract: A surgical instrument for thermally-mediated therapies in targeted tissue volumes and for causing thermal effects in polymer tissue-contacting members. In one embodiment, the instrument has a working end with an interior chamber that is supplied with a biocompatible liquid. An energy source causes a liquid-to-vapor phase change within the interior of the instrument. The vapor phase media then is ejected from the working surface of the instrument, and a controlled vapor-to-liquid phase change in an interface with tissue applies thermal energy substantially equal to the heat of vaporization to ablate tissue. The vapor-to-liquid phase transitions, or internal energy releases, can be provided about thin-film flexible structures for engaging body lumens and cavities. An exemplary embodiment can be used for shrinking, sealing, welding or creating lesions in tissue—while causing limited collateral thermal damage and while totally eliminating electrical current flow in the engaged tissue.

Abstract: A catheter for detachably receiving an expandable and/or decollapsible or unfoldable, respectively, implant, in particular a stent may include at least one assembly for controlling the expansion and/or the unfolding or decollapsing, respectively, of the implant from a first diameter to a second diameter and/or its return back from the second diameter to the first diameter. Furthermore, an implant, in particular a stent, and a set including a catheter and an implant are proposed.

Abstract: Provided herein is a method of treating, preventing, or managing osteolysis in a subject, comprising administering to the subject a therapeutically effective amount of vitamin C, or a pharmaceutically acceptable salt, solvate, or hydrate thereof, in combination with vitamin K, or a single enantiomer, a mixture of enantiomers, or a mixture of diastereomers thereof, or a pharmaceutically acceptable salt, solvate, or hydrate thereof.

Abstract: A flavored, fiber-enriched liquid beverage concentrate of an acidulant, a flavor, a high-intensity sweetener, a dietary fiber, and water, the dietary fiber comprising about 20 to 60 percent by weight of the concentrate volume with a pH in a range of about 1.4 to about 4.0. A method of delivering dietary fiber from a liquid beverage concentrate is disclosed.