Abstract: An apparatus for determining the air-kerma rate of an x-ray device comprises a data obtaining component for obtaining data of the x-ray device, a calculation component for calculating the air-kerma rate from the obtained data, and an outputting component for outputting the calculated air-kerma rate, where the calculation component uses an algebraic formula for the calculation of the air-kerma rate.

Abstract: Methods, systems, and related computer program products for are described for non-invasive detection of intracranial pressure (ICP) variations in an intracranial compartment of a patient. Optical radiation is propagated transcranially into the intracranial compartment, and optical radiation that has migrated through at least a portion of the intracranial compartment and back out of the cranium is detected. At least one signal representative of the detected optical radiation is processed to extract therefrom at least one component signal that varies in time according to at least one of an intrinsic physiological oscillation and an externally driven oscillation in the patient. Examples of suitable intrinsic physiological oscillations include intrinsic respiratory and cardiac oscillations. Examples of suitable externally driven oscillations include ventilated respiratory oscillations and externally mechanically induced oscillations.

Abstract: A filter cassette and a method for allowing a leak to be detected are disclosed, in which the filter cassette comprises a main body defining a first chamber. The main body includes an inlet and an outlet, a filter separating the first chamber into first and second sub-chambers, the inlet being in fluid communication with the first sub-chamber and the second sub-chamber being in fluid communication with the outlet. The main body also includes a second chamber is defined by the main body and the filter, wherein in absence of a leak the second chamber is substantially not in fluid communication with the first chamber. The main body further includes a port in fluid communication with the second chamber, whereby measuring a fluid characteristic in the second chamber by means of the port allows a detection of a leak, i.e. an external leak or a bypass leakage.

Abstract: An instrument and method for tissue thermotherapy including an inductive heating means to generate a vapor phase media that is used for interstitial, intraluminal, intracavity or topical tissue treatment. In one method, the vapor phase media is propagated from a probe outlet to provide a controlled vapor-to-liquid phase change in an interface with tissue to thereby apply ablative thermal energy delivery.

Abstract: The present invention relates to a non-invasive optical system equipped with optical tomographic scanning method and algorithm for quantifying scattering and absorption properties and chromophore concentrations of highly scattering medium such as biological tissues, for 3D mapping and imaging reconstruction of the spatial and temporal variations in such properties. The invention further relates to a method and an apparatus for simultaneous measurement of concentrations of biochemical substances and blood oxygen saturation inside a biological tissue and arterial blood.

Abstract: This invention relates to the working end of a medical instrument that applies energy to tissue. In one embodiment, the instrument has a microfluidic tissue-engaging surface fabricated by soft lithography means together with optional superlattice cooling means that allows for very precise control of energy application, for example in neurosurgery applications. The tissue-engaging surface can eject a high-heat content vapor into the engaged tissue for treating tissue, while the superlattice cooling structure can prevent collateral thermal damage. Also, the superlattice cooling structure can be used to localize heat at a selected depth in tissue and prevent surface ablation. Also, the superlattice cooling structure can be used to prevent tissue sticking to a thermal energy delivery surface. In another embodiment, the tissue-engaging surface can be used in a jaw structure for sealing tissue together with hydrojet means for transecting the tissue.

Abstract: An instrument and method for applying thermal energy to targeted tissue. An instrument and method for tissue thermotherapy. In one embodiment, a method includes providing a vapor source comprising a pump configured for providing a flow of liquid media from a liquid media source into a vaporization chamber having a heating mechanism, actuating the pump to provide the liquid into the vaporization chamber, applying energy from the heating mechanism to convert a substantially water liquid media into a minimum water vapor level for causing an intended effect in tissue. For examples such levels can comprise at least 60% water vapor, at least 70% water vapor, at least 80% water vapor or at least 90% water vapor for causing an intended effect in tissue.

Abstract: An apparatus for determining the air-kerma rate of an x-ray device comprises a data obtaining component for obtaining data of the x-ray device, a calculation component for calculating the air-kerma rate from the obtained data, and an outputting component for outputting the calculated air-kerma rate, where the calculation component uses an algebraic formula for the calculation of the air-kerma rate.

Abstract: The invention relates to an optical fibre with a connector piece that has a recess, such as a bore hole, for instance, for accommodating the optical fibre, wherein a fluid channel (18, 14) is provided that begins at the end of the recess and through which a fluid can pass. The invention furthermore relates to an optical fibre with a plug with a gripping piece that has two end openings, wherein the fibre enters into the gripping piece in one end opening and the light of the fibre or the fibre can exit from the gripping piece through the other end opening, wherein the end openings (15, 16) of the gripping piece (2) are interconnected in a way allowing throughflow.

Abstract: A hygienic dispensing package includes a container having a top panel with a dispensing aperture selectively covered by a slide closure. The closure rides within a flat channel of the top panel and is in tongue and groove engagement with parallel side walls of the channel. One of a pair of spaced sockets in the channel is engaged by a detent formed on the underside of the closure when the aperture is covered; the detent seats in the other socket when the aperture is uncovered. The detent is formed as a protrusion on an integral cantilever leaf of the closure to assure intimate sliding contact between the faces of the channel and the closure and effective sealing of the aperture.

Abstract: Improving cell therapy and tissue regeneration in a patient suffering from a cardiovascular or a neurological disease by treating a tissue of the patient with shock waves and/or applying to the patient a therapeutically effective amount of stem cells and/or progenitor cells. Such treatment increases expression of chemoattractants, pro-angiogenic factors, and pro-survival factors. The chemoattractants can be, for example, vascular endothelial growth factor (VEGF) or stromal cell derived factor 1 (SDF-1). For example, the treated tissue can be located in the patient's heart or in a skeletal muscle of the patient, and the shock waves can be extracorporeal shock waves (ESW) or intracorporeal shock waves. The cardiovascular disease can have an ischemic or non-ischemic etiology. For example, the cardiovascular disease can be a myocardial infarction, ischemic cardiomyopathy, or a dilatative cardiomyopathy. For example, the neurological disease can be a peripheral neuropathy or neuropathic pain.

Abstract: A combined androgen deprivation and thermotherapy cancer treatment. For example, the combination can be used to treat prostate cancer. Chemical compounds, including a non-steroidal anti-androgen and/or an LH-RH agonist, such as androgen deprivation therapy (“ADT”), can be used in combination with application of non-ionizing radiation to treat cancer. The chemical compounds can be administered before, simultaneously with, and/or after the application of the non-ionizing radiation. When the ADT is applied before the application of the radiation, a reduction in cancer volume can be expected. In patients treated in such a manner, evidence of recurring cancer was not observed.

Abstract: Methods, systems, and related computer program products for non-invasive monitoring of a biological volume, such as a human brain, are described. In one preferred embodiment, each of a plurality of optical sources emits optical radiation into the biological volume each of a plurality of optical detectors detects optical radiation impinging thereupon from the biological volume. The optical measurements are processed to compute a requisite property value associated with each source-detector pair. For each source-detector pair, a volumetric basis region corresponding thereto is weighted by the requisite property value, the volumetric basis region being predetermined and representative of an estimated subvolume of the biological volume encountered by optical radiation emitted from that source and propagating to that detector. The weighted volumetric basis regions are accumulated into a volumetric cumulative array, and a display output is generated based at least in part on the volumetric cumulative array.

Abstract: The invention relates to a light guide with at least one photorefractive area, wherein a volume hologram is formed in the photorefractive area in such a way that light coupled into the light guide can be decoupled by the volume hologram at a predetermined angle and/or with a predetermined focus.

Abstract: An information technology system for a health care environment is disclosed. Health care instruments transfer medical data to wireless access points. Mobile user interfaces transfer user instructions to the wireless access points. Identity tags transfer identity information to the wireless access points. The wireless access points transfer the data, instructions, and information to a server system. The server system processes the medical data to generate display data and processes the user instructions to generate control data. The server system transfers the display data and the control data to the wireless access points. The wireless access points transfer the display data to the mobile user interfaces and transfer the control data to the instruments. The user interfaces control their displays responsive to the display data. The instruments operate responsive to the control data.

Abstract: Interventional immobilization devices used to immobilize a body part and then, during a medical procedure, orient a medical device to treat located tissue within the body part are provided. The devices are designed to immobilize body tissue while preserving, or substantially preserving, the three-dimensional or volumetric integrity of the immobilized tissue. The device enables real time (RT) imaging-guided interventional (IGI) capabilities when the devices are coupled with medical imaging systems, such as magnetic resonance imaging (MRI) systems.

Abstract: A method and a apparatus for transferring medically effective substances in the form of molecules, such as DNA, oligos, certain chemicals, etc., into the living cells of humans, animals and/or plants using acoustic energy or through cavitation which is produced by acoustic energy in vitro, ex vivo and in vivo. Via suitable sensors, the lifetime of the cavitation bubbles is determined or specified, which then for its part acts as the criterion or the function for controlling the acoustic intensity and thus also the cavitation intensity.