Patents Assigned to Meiji Seika Kabushiki Kaisha
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Patent number: 7138263Abstract: There is provided an endoglucanase enzyme, which is useful for reducing fuzz of regenerated cellulose-containing fabrics, improving the touch and appearance, color clarification, localized variation in color, reducing stiffness and using it as components of a detergent, as well as deinking waste paper and improving freeness of paper pulp. A cDNA coding for the endoglucanase enzyme NCE5 was cloned and its DNA sequence and amino acid sequence derived from it were determined.Type: GrantFiled: May 22, 2001Date of Patent: November 21, 2006Assignee: Meiji Seika Kabushiki KaishaInventors: Koichiro Murashima, Naomi Sumida, Akitaka Nakane, Koji Yanai, Tomoko Nishimura, Jinichiro Koga, Takeshi Murakami, Toshiaki Kono
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Patent number: 6419972Abstract: There are provided a stick type expanded starch confectionery with a wave-like configuration on its surface and a process for easily manufacturing the same, which uses an extruder method. According to the process, the stick type expanded starch confectionery is obtained by adjusting amounts of water and calcium salt to an amount of starch raw material to prepare a dough, whereby fluidity of thermally treated dough extruded from a double-staged die which belongs to an extruder is controlled.Type: GrantFiled: September 29, 2000Date of Patent: July 16, 2002Assignee: Meiji Seika Kabushiki KaishaInventors: Shuji Akimoto, Hajime Hamada, Iwao Hachiya
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Patent number: 5990101Abstract: Novel carbapenem derivatives, represented by the following formula (I), having a substituted or unsubstituted imidazo[5,1-b]thiazolium-6-ylmethyl group at the 2-position are disclosed. The compounds represented by the formula (I) have potent antibacterial activity against a wide spectrum of bacteria from Gram-positive bacteria to Gram-negative bacteria including Pseudomonas aeruginosa and, in addition, have potent antibacterial activity against various .beta.-lactamase-producing bacteria and MRSA and are very stable against DHP-1.Type: GrantFiled: March 12, 1997Date of Patent: November 23, 1999Assignee: Meiji Seika Kabushiki KaishaInventors: Kazuhiro Aihara, Yuko Kano, Sohjiro Shiokawa, Toshiro Sasaki, Fumihito Setsu, Yumiko Toyooka, Miyuki Ishii, Kunio Atsumi, Katsuyoshi Iwamatsu, Atsushi Tamura
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Patent number: 5958981Abstract: A .gamma.-diketone compound represented by the following formula (I) and a pharmaceutically acceptable salt and solvate thereof having platelet aggregation inhibitory activity is disclosed: ##STR1## wherein B is --Z--(CH.sub.2).sub.q COOR.sup.Type: GrantFiled: March 27, 1998Date of Patent: September 28, 1999Assignee: Meiji Seika Kabushiki KaishaInventors: Tomoaki Miura, Eiki Shitara, Shokichi Ohuchi, Kiyoaki Katano
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Patent number: 5883089Abstract: Compounds, represented by the following formula (I), having a .beta.-(substituted or unsubstituted imidazo?5,1-b!thiazolyl)vinyl group at the 3-position of the cephem ring and a salt and an ester thereof are disclosed. The compounds have antibacterial activity against a very wide spectrum of bacteria and potent antibacterial activity against Gram-positive bacteria, Gram-negative bacteria, and resistant bacteria. ##STR1## wherein X represents CH or N, R.sup.1 represents a hydrogen atom or an amino protective group, R.sup.2 represents a hydrogen atom, a C.sub.1-6 alkyl group, a C.sub.3-7 cycloalkyl group, or a hydroxy protective group, R.sup.3 is absent or represents a hydrogen atom, a salt forming cation, or a carboxyl protective group, R.sup.4, R.sup.5, and R.sup.6, which may be the same or different, each independently represent a hydrogen atom or a C.sub.1-6 alkyl group, R.sup.7+ is absent or a cation of a C.sub.1-6 alkyl, and n is an integer of 0 to 1.Type: GrantFiled: March 12, 1997Date of Patent: March 16, 1999Assignee: Meiji Seika Kabushiki KaishaInventors: Eijiro Umemura, Kunio Atsumi, Katsuyoshi Iwamatsu, Atsushi Tamura
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Patent number: 5840895Abstract: Compounds of formulae (II), (III), (IV) and (V) or salts thereof are intermediates for pharmacologically active tricyclic benzazepine and benzothiazepine derivatives, ##STR1## wherein R represents hydrogen, alkyl, phenylalkyl, or a protective group of a triazole ring, R.sup.1 -R.sup.5 represent hydrogen, alkyl, alkenyl, alkoxy, amino, oxim or hydroxyl, and R.sup.41 represents hydrogen, C.sub.1-6 alkyl which may be optionally substituted, or a protective group for a carboxyl group.Type: GrantFiled: June 26, 1997Date of Patent: November 24, 1998Assignee: Meiji Seika Kabushiki KaishaInventors: Yasuo Ohtsuka, Takashi Shishikura, Hiroko Ogino, Kenichi Fushihara, Mami Kawaguchi, Seiji Tsutsumi, Megumi Imai, Keiko Shito, Koji Tsuchiya, Junko Tanaka, Takako Iwasaki, Shigeru Hoshiko, Takashi Tsuruoka
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Patent number: 5814636Abstract: A compound represented by the general formula (I) and a pharmaceutically acceptable salt and solvate thereof having an effect for inhibiting the aggregation of platelets is disclosed: ##STR1## wherein A, B and C represent independently CH.sub.2 or C.dbd.O;X and Y are different from each other, and each of them is CH or N;D is --(CH.sub.2).sub.k -- or --(CH.sub.2).sub.m --CO-- where k is an integer of 1 to 4; and m is an integer of 0 to 3;E is the following group (II) or (III): ##STR2## wherein n is an integer of 1 to 3; and Z is --W--(CH.sub.2).sub.p --COOR.sup.3 (wherein W is --O-- or a bond; p is an integer of 1 to 4; and R.sup.3 is hydrogen, lower alkyl or an ester residue which can be removed under physiological conditions); R.sup.1 is hydrogen or lower alkyl; and R.sup.2 is hydrogen atom or lower alkyl.Type: GrantFiled: July 10, 1996Date of Patent: September 29, 1998Assignee: Meiji Seika Kabushiki KaishaInventors: Kiyoaki Katano, Shokichi Ohuchi, Tomoaki Miura, Eiki Shitara, Masaro Shimizu, Kazue Yaegashi, Naoto Ohkura, Yasuko Isomura, Hiroyuki Iida, Midori Ishikawa, Kenji Asai, Emiko Hatsushiba
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Patent number: 5786387Abstract: A compound represented by the formula (I) is disclosed. The compound of the formula (I) is useful as a fine particle drug carrier. When used as the fine particle drug carrier, the compound efficiently avoids a reticuloendothelial system and has a long circulation time in blood.Type: GrantFiled: January 25, 1996Date of Patent: July 28, 1998Assignee: Meiji Seika Kabushiki KaishaInventors: Hiroshi Watanabe, Kumi Taniguchi, Chikako Udagawa, Takashi Ando, Satoru Nakabayashi
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Patent number: 5760053Abstract: A .gamma.-diketone compound represented by the following formula (I) and a pharmaceutically acceptable salt and solvate thereof having platelet aggregation inhibitory activity is disclosed: ##STR1## wherein B is --Z--(CH.sub.2).sub.q COOR.sup.Type: GrantFiled: September 5, 1996Date of Patent: June 2, 1998Assignee: Meiji Seika Kabushiki KaishaInventors: Tomoaki Miura, Eiki Shitara, Shokichi Ohuchi, Kiyoaki Katano
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Patent number: 5698692Abstract: A compound represented by the general formula (I) and a pharmaceutically acceptable salt and solvate thereof having an effect for inhibiting the agglutination of platelets is disclosed: ##STR1## wherein R.sup.1 represents a group --W--(CH.sub.2).sub.i --COOR.sup.3,R.sup.2 represents a hydrogen atom or a group --W--(CH.sub.2).sub.i --COOR.sup.3 or --OR.sup.4,X represents --CH.dbd. or --N.dbd.,Y represents(i) a group --(CO).sub.k --N(R.sup.5)--Z--, wherein Z represents a bond or a group --(CH.sub.2).sub.m --CO-- or a group --(CH.sub.2).sub.m --CHR.sup.6 --,(ii) a group --(CH.sub.2).sub.m --N(R.sup.5)--(CO).sub.k --, or(iii) a group --(CO).sub.k --Het, wherein Het represents a five- or six-membered heterocyclic ring comprising a nitrogen atom,A represents(i) the following groups (II), (III) or (IV) ##STR2## B represents a bond, C.sub.1-6 alkylene or C.sub.2-6 alkenylen.Type: GrantFiled: October 18, 1996Date of Patent: December 16, 1997Assignee: Meiji Seika Kabushiki KaishaInventors: Kiyoaki Katano, Shokichi Ohuchi, Eiki Shitara, Masaro Shimizu, Kazue Yaegashi, Tomoaki Miura, Yasuko Isomura, Hiroyuki Iida, Midori Ishikawa, Kenji Asai, Emiko Hatsushiba, Mami Kawaguchi, Takashi Tsuruoka
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Patent number: 5686442Abstract: The tricyclic benzazepine and benzothiazepine derivatives represented by the formula (I) and pharmacologically acceptable salts thereof are disclosed. ##STR1## wherein Z represents CO, --CR.sup.6 R.sup.7 -- or --S(O).sub.n, R represents hydrogen, alkyl, phenylalkyl, or a protective group of a triazole ring, R.sup.1 -R.sup.5 represent hydrogen, alkyl, alkenyl, alkoxy, amino, oxim or hydroxyl. These compounds have anti-allergic effect and are useful for the treatment and prophylaxis of allergic diseases.Type: GrantFiled: October 26, 1995Date of Patent: November 11, 1997Assignee: Meiji Seika Kabushiki KaishaInventors: Yasuo Ohtsuka, Takashi Shishikura, Hiroko Ogino, Kenichi Fushihara, Mami Kawaguchi, Seiji Tsutsumi, Megumi Imai, Keiko Shito, Koji Tsuchiya, Junko Tanaka, Takako Iwasaki, Shigeru Hoshiko, Takashi Tsuruoka
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Patent number: 5663162Abstract: Compounds represented by the following formula (I), that is, cephem derivatives having substituted or unsubstituted imidazo[5,1-b]thiazolium-6-yl as a substituent at the 3-position of the cephem ring: ##STR1## wherein X represents CH or N, R.sup.1 represents H, alkyl, alkenyl or the like, and R.sup.2, R.sup.3, R.sup.4 and R.sup.5 represent H, alkyl, carbamoyl, amino or the like. The above compounds have excellent antibacterial activity, and useful as medicines for the treatment of various infectious diseases caused by bacteria.Type: GrantFiled: July 25, 1995Date of Patent: September 2, 1997Assignee: Meiji Seika Kabushiki KaishaInventors: Kunio Atsumi, Eijiro Umemura, Yuko Kano, Sohjiro Shiokawa, Toshiaki Kudo, Masaki Tsushima, Katsuyoshi Iwamatsu, Atsushi Tamura, Seiji Shibahara
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Patent number: 5661144Abstract: Compounds represented by the following formula (I), that is, cephem derivatives having substituted or unsubstituted 3-(imidazo[5,1-b]thiazolium-6-yl)-1-propenyl as a substituent at the 3-position of the cephem ring: ##STR1##Type: GrantFiled: June 28, 1996Date of Patent: August 26, 1997Assignee: Meiji Seika Kabushiki KaishaInventors: Masaki Tsushima, Kunio Atsumi, Katsuyoshi Iwamatsu, Atsushi Tamura
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Patent number: 5599815Abstract: Compounds represented by the formula (I) and pharmacologically acceptable salts thereof: ##STR1## These compounds have little extrapyramidal effect and thus are effective as an anti-psychotic agent having few side effects.Type: GrantFiled: December 20, 1994Date of Patent: February 4, 1997Assignee: Meiji Seika Kabushiki KaishaInventors: Yoshimasa Fukuda, Toshiro Sasaki, Yuuko Nakatani, Yasuyuki Ichimaru, Taiichiro Imanishi
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Patent number: 5594004Abstract: A compound represented by the general formula (I) and a pharmaceutically acceptable salt and solvate thereof having an effect for inhibiting the agglutination of platelets is disclosed: ##STR1## wherein R.sup.1 represents a group --W--(CH.sub.2).sub.i --COOR.sup.3,R.sup.2 represents a hydrogen atom or a group --W--(CH.sub.2).sub.i --COOR.sup.3 or --OR.sup.4,X represents --CH.dbd. or --N.dbd.,Y represents(i) a group --(CO).sub.k --N(R.sup.5)--Z--, wherein Z represents a bond or a group --(CH.sub.2).sub.m --CO-- or a group --(CH.sub.2).sub.m --CHR.sup.6 --,(ii) a group --(CH.sub.2).sub.m --N(R.sup.5)--(CO).sub.k --, or(iii) a group --(CO).sub.k -Het, wherein Het represents a five- or six-membered heterocyclic ring comprising a nitrogen atom,A represents(i) the following groups (III) or (IV) ##STR2## B represents a bond, C.sub.1-6 alkylene or C.sub.2-6 alkenylen.Type: GrantFiled: January 30, 1995Date of Patent: January 14, 1997Assignee: Meiji Seika Kabushiki KaishaInventors: Kiyoaki Katano, Shokichi Ohuchi, Eiki Shitara, Masaro Shimizu, Kazue Yaegashi, Tomoaki Miura, Yasuko Isomura, Hiroyuki Iida, Midori Ishikawa, Kenji Asai, Emiko Hatsushiba, Mami Kawaguchi, Takashi Tsuruoka
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Patent number: 5449694Abstract: (-)-Ritodrine, that is (-)-erythro-1-(p-hydroxyphenyl)-2-[2-(p-hydroxyphenyl)ethylamino]-1-propan ol or a salt thereof substantially free from the (+)-isomer is disclosed. The compound has a strong suppressive effect on uterine contraction in comparison with (.+-.)-ritodrine and (+)-ritodrine and has the same level of toxicity as these compounds, so that it can be used as a therapeutic agent of threatened premature birth and threatened abortion as well as a therapeutic agent of dysmenorrhea having a high safety.Type: GrantFiled: March 1, 1994Date of Patent: September 12, 1995Assignee: Meiji Seika Kabushiki KaishaInventors: Naoki Yamazaki, Yoshimasa Fukuda, Yoshiaki Shibazaki, Tetsutarou Niizato, Isao Kosugi, Shin Yoshioka
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Patent number: 5418171Abstract: The present invention relates to an apparatus for determining the presence or absence of a target analyte in a liquid sample, comprising:(i) a container capable of accommodating the liquid sample and having a transparent portion; and(ii) an insertion member which is capable of being inserted into the container comprising;a porous member which has a main surface and a reverse surface and which has on the main surface a substance capable of specifically binding to the target analyte; andan absorbent bonded to the reverse surface of the porous member;the porous member being supported in the insertion member whereby, when the insertion member is inserted into the container, the main surface can be observed from the outside of the container through the transparent portion of the vessel and the liquid sample is absorbed into the absorbent through the porous member.According to the analyzer of the present invention, the presence or absence of a target analyte in a sample can be easily determined.Type: GrantFiled: November 30, 1992Date of Patent: May 23, 1995Assignee: Meiji Seika Kabushiki KaishaInventors: Fumio Kimura, Naohisa Koizumi, Koichi Matsuo, Minoru Aoyagi, Kiyomi Harakawa
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Patent number: 5399566Abstract: The invention provides compounds represented by the following formula (I) ##STR1## or a pharmaceutically acceptable salts thereof wherein A represents ##STR2## B represents a carboxy or tetrazolyl group; and X represents --O--, --NH-- or --S(O).sub.t --.The compounds possess angiotensin II antagonism, and may be used as an antihypertensive agent, a therapeutic agent to congestive heart failure, an antianxiety agent and a cognitive enhancing agent.Type: GrantFiled: September 10, 1991Date of Patent: March 21, 1995Assignee: Meiji Seika Kabushiki KaishaInventors: Kiyoaki Katano, Hiroko Ogino, Eiki Shitara, Hiromi Watanabe, Jun Nagura, Naomi Osada, Yasuyuki Ichimaru, Fukio Konno, Tomoya Machinami, Takashi Tsuruoka
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Patent number: 5190952Abstract: A 4-acyloxyquinoline derivative represented by the general formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom, a C.sub.1 -C.sub.18 alkyl, C.sub.2 -C.sub.18 alkenyl, C.sub.3 -C.sub.10 cycloalkyl which may be optionally substituted, phenylloweralkyl, phenoxyloweralkyl, aryl group, a group OR.sup.4, where R.sup.4 represents a lower alkyl or aryl group, or a group ##STR2## where X represents an oxygen or a sulphur atom; R.sup.2 represents a hydrogen atom, a lower alkyl alkyl group or a group --COOR.sup.5 where R.sup.5 represents a hydrogen atom or a lower alkyl group; R.sup.3 represents a hydrogen atom, a C.sub.1 -C.sub.10 alkyl or C.sub.2 -C.sub.10 alkenyl group, provided that R.sup.1 does not represent OR.sup.4 when R.sup.2 is a hydrogen atom and R.sup.3 is methyl; R.sup.2 and R.sup.3 together represent a group (CH.sub.2).sub.Type: GrantFiled: July 5, 1990Date of Patent: March 2, 1993Assignee: Meiji Seika Kabushiki KaishaInventors: Nobuto Minowa, Tomoya Machinami, Seiji Shibahara, Keiichi Imamura, Michiaki Iwata, Masaru Shimura, Shigeharu Inouye
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Patent number: 5171746Abstract: A thiazole or imidazole derivative having the general formula (I): ##STR1## wherein: R.sup.1 and R.sup.2, which may be the same or different, each independently represent a hydrogen atom, or a phenyl or heteroaryl group, or R.sup.1 and R.sup.2 may together form a benzene ring which may be optionally substituted by a halogen atom or a lower alkyl optionally substituted by a halogen atom, lower alkoxy or nitro group;A represents a sulfur atom or --NH--;B represents a lower alkoxy group optionally substituted by a halogen atom; a five- or six-membered saturated heterocyclic ring containing one nitrogen or oxygen atom which ring may be optionally substituted; a six-membered saturated heterocyclic ring containing one oxygen atom plus one nitrogen atom; a group --XR.sup.3 where X represents a group --NR.sup.4 wherein R.sup.3 and R.sup.4, which may be the same or different, each independently represent a lower alkyl group; or a group --NHC(.dbd.Y)R.sup.5 where Y represents an oxygen or sulfur atom or a group .dbd.Type: GrantFiled: April 9, 1991Date of Patent: December 15, 1992Assignee: Meiji Seika Kabushiki KaishaInventors: Tomoya Machinami, Kazue Yasufuku, Seiji Shibahara, Yasukatsu Yuda, Fumiya Hirano