Patents Assigned to Meiji Seika Kabushiki Kaisha
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Patent number: 5141946Abstract: Compounds of the general formula (I): ##STR1## and pharmaceutically acceptable salts thereof, in whichA, B, C and D each represent --CH.dbd. or --N.dbd., with the proviso that at least one of them is --N.dbd.;X represents --NH--, --O-- or --S--;Y represents --(CH.sub.2).sub.p -- wherein p is an integer from 0 to 4, --C(CH.sub.3).sub.2 --, --CH.sub.2 CH.dbd.CH--, --CH.sub.2 CO--, --CF.sub.2 -- or --CH.sub.2 COCH.sub.2 --;R.sup.1 represents a hydrogen atom, a C.sub.1-4 alkyl group, a halogen atom or a C.sub.1-4 alkoxy group;R.sup.2 represnts a hydrogen atom, a hydroxyl group, a saturated or unsaturated C.sub.1-6 alkyl group, a C.sub.1-6 alkoxy group, a carboxyl group, a saturated or unsaturated C.sub.Type: GrantFiled: June 14, 1991Date of Patent: August 25, 1992Assignee: Meiji Seika Kabushiki KaishaInventors: Kiyoaki Katano, Tamako Tomomoto, Hiroko Ogino, Naoki Yamazaki, Fumiya Hirano, Yasukatsu Yuda, Fukio Konno, Motohiro Nishio, Tomoya Machinami, Seiji Shibahara, Takashi Tsuruoka, Shigeharu Inouye
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Patent number: 5118784Abstract: Disclosed is a poly-.gamma.-glutamic acid ester comprising recurring units represented by the following formula (A): ##STR1## wherein R represents an ester-forming group, and recurring units represented by the following formula (B): ##STR2## wherein the former units (A) occupy at least 40% and the polymerization degree, that is, the total number of both the units (A) and (B), is at least 1000.Type: GrantFiled: February 8, 1991Date of Patent: June 2, 1992Assignee: Meiji Seika Kabushiki KaishaInventors: Hidetoshi Kubota, Yoshimasa Fukuda, Hidehi Takebe, Takeshi Endo
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Patent number: 5079255Abstract: Compounds of the general formula (I): ##STR1## and pharmaceutically acceptable salts thereof, in which A, B, C and D each represent --CH.dbd. or --N.dbd., with the proviso that at least one of them is --N.dbd.;X represents --NH--, --O-- or --S--;Y represents --(CH.sub.2).sub.p -- wherein p is an integer from 0 to 4, --C(CH.sub.3).sub.2 --, --CH.sub.2 CH.dbd.CH--, --CH.sub.2 CO--, --CF.sub.2 -- or --CH.sub.2 COCH.sub.2 --;R.sup.1 represents a hydrogen atom, a C.sub.1-4 alkyl group, a halogen atom or a C.sub.1-4 alkoxy group;R.sup.2 represents a hydrogen atom, a hydroxyl group, a saturated or unsaturated C.sub.1-6 alkyl group, a C.sub.1-6 alkoxy group, a carboxyl group, a saturated or unsaturated C.sub.Type: GrantFiled: June 27, 1990Date of Patent: January 7, 1992Assignee: Meiji Seika Kabushiki KaishaInventors: Kiyoaki Katano, Tamako Tomomoto, Hiroko Ogino, Yamazaki Naoki, Fumiya Hirano, Yasukatsu Yuda, Fukio Konno, Motohiro Nishio, Tomoya Machinami, Seiji Shibahara, Takashi Tsuruoka, Shigeharu Inouye
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Patent number: 5061702Abstract: A novel cephem compound which has antimicrobial activity is disclosed. The cephem compound is represented by the formula: ##STR1## wherein R.sup.1 represents a hydrogen atom or a carboxyl group; R.sup.2 and R.sup.3, which may be the same or different, each represent a hydrogen atom or a lower alkyl group of 1-3 carbon atoms; and R.sup.4 and R.sup.5, which may be the same or different, each represent a hydrogen atom or an acyl group; and pharmaceutically acceptable salts thereof.Type: GrantFiled: September 5, 1989Date of Patent: October 29, 1991Assignee: Meiji Seika Kabushiki KaishaInventors: Kunio Atsumi, Katsuyoshi Iwamatsu, Kenji Sakagami, Takashi Yoshida, Haruo Yamamoto, Seiji Shibahara, Shigeharu Inouye
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Patent number: 4988686Abstract: Disclosed is a novel cephem compound which is either one of a cis- or trans-isomer or a mixture of the cis-and trans-isomers, represented by the following general formula (I) and a pharmacologically acceptable salt thereof: ##STR1## wherein all of the substituents are as defined hereinbefore. Also disclosed are a process for producing the above compound and its use as an anti-bacterial agent comprising the same.Type: GrantFiled: June 28, 1989Date of Patent: January 29, 1991Assignee: Meiji Seika Kabushiki KaishaInventors: Kunio Atsumi, Katsuyoshi Iwamatsu, Kenji Sakagami, Hiroko Ogino, Takashi Yoshida
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Patent number: 4950660Abstract: The present invention relates to a cephem compound of formula (III) shown in the description. The compound is useful as an intermediate for the synthesis of .beta.-lactam antibiotics of new class and also to a process for producing the same. The cephem compound (III) is produced by reacting a cephem compound of formula (I) with a nitrogen-containing compound of formula (II) under acid-capturing conditions. The process can be performed easily under mild conditions.Type: GrantFiled: September 6, 1988Date of Patent: August 21, 1990Assignee: Meiji Seika Kabushiki KaishaInventors: Kunio Atsumi, Yuichi Yamamoto, Kenji Sakagami, Ken Nishihata, Shinichi Kondo
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Patent number: 4839378Abstract: Fluorophthalimide compounds represented by the following general formula (I): ##STR1## wherein R each stands for an ethyl group or an isopropyl group, are effective for controlling diseases of agricultural plants, especially diseases caused by microorganisms belonging to the genus Rhizoctonia, represented by sheath blight of rice plants, and diseases caused by Basidomycetes.Type: GrantFiled: April 28, 1987Date of Patent: June 13, 1989Assignee: Meiji Seika Kabushiki KaishaInventors: Masao Koyama, Michiaki Iwata, Kunihiko Kurihara, Masaji Sezaki
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Patent number: 4783415Abstract: A DNA segment of a gene coding for a signal peptide is disclosed the segment is to be used in a host-vector system employing a bacterium belonging to the genus Streptomyces as a host by incorporation in the vector DNA. The segment comprises a DNA having a base sequence coding for the peptide having the amino acid sequence from X to Y in the annexed FIG. 1.A vector plasmid to be used for transformation of bacteria belonging to the genus Streptomyces is also disclosed. The plasmid comprises a DNA segment with a base sequence coding for an extra-cellular .alpha.-amylase derived from Streptomyces hygroscopicus SF-1084 strain or a mutant thereof the DNA segment incorporated into a vector plasmid is to be used in a host-vector system employing a bacterium belonging to the genus Streptomyces as a host and also having a DNA segment necessary for expression of the gene information of the DNA segment.Type: GrantFiled: March 27, 1985Date of Patent: November 8, 1988Assignee: Meiji Seika Kabushiki KaishaInventors: Shigeru Hoshiko, Osamu Makabe, Shunzo Fukatsu, Kozo Nagaoka
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Patent number: 4657142Abstract: A carton is formed by rolling a sectorial piece of sheet material, preferably a lamination of at least paper and a plastic that is impervious to fluid, into the shape of a flattened cone. The lapping side edges and apex end of the cone are both sealed, whereas its base end is to be closed and sealed after placing a desired food product into the carton therethrough. The overlapping edge of the sealed side seam has a tab protruding therefrom, which tab is to be pulled for opening the carton by tearing same along a loop of tear-off strip around the cone. The cone is flattened along a pair of opposite indented lines preformed in the sheet material so as to extend between the apex end and base end of the cone. Each indented line is bifurcated at a midportion thereof into a pair of spaced apart branch lines to impart thickness to the carton.Type: GrantFiled: July 18, 1985Date of Patent: April 14, 1987Assignees: Meiji Seika Kabushiki Kaisha, Dai Nippon Insatsu Kabushiki KaishaInventors: Yoshihiko Mizoguchi, Keiichi Sekine, Yasutoyo Komiya, Yoshio Nishida
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Patent number: 4418070Abstract: A 5-phenylthiazole derivative represented by the formula: ##STR1## wherein R represents a hydrogen atom, a lower alkyl group, a hydroxyl group, an amino group or a mercapto group, or a pharmaceutically acceptable salt thereof shows a cardiac effect and a low toxicity to a human or animal with little influence on atrium rhythms.Type: GrantFiled: February 4, 1982Date of Patent: November 29, 1983Assignee: Meiji Seika Kabushiki KaishaInventors: Tsuneo Okonogi, Shunzo Fukatsu, Mitsugu Hachisu, Hiroko Kawashima, Keiko Shitoh, Yasuharu Sekizawa
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Patent number: 4159771Abstract: A container comprises a plurality of interconnected compartments having rim flanges therearound and being individually sealed by a lid sheet attached to the rim flanges after portions of a product have been placed in respective compartments, the lid sheet being provided with edge slits and the rim flanges being provided with cutout notches which facilitate the prying and lifting of a corner portion of lid sheet and tearing off of a part thereof to unseal and open only a selected one of the compartments without disturbing the other compartments. This container in a preferred embodiment of the invention is housed in an outer box which can be easily opened to expose only parts of the container for selective unsealing of the compartments as stated above, and which can be easily reclosed for further storing of any remaining portions of the product.Type: GrantFiled: November 22, 1977Date of Patent: July 3, 1979Assignees: Meiji Seika Kabushiki Kaisha, Dai Nippon Insatsu Kabushiki KaishaInventors: Kenji Komatsu, Teruyoshi Wakamatsu
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Patent number: 4040716Abstract: A kaleidoscopic peep-show viewing device comprises an outer box of tubular shape with open opposite ends and with inscriptions printed on the inner surface thereof, an inner box adapted to slide telescopically within the outer box, and an optically reflecting member of peaked solid shape having a base, vertex, and mirror surface therebetween and joined at its base to one end of the inner box to slide thus unitarily therewith, the printed inscriptions, when viewed through one open end of the outer box as reflected images on the mirror surface, being optically collected thereby into single coherent pictures successively appearing and disappearing as the inner box is thus slid.Type: GrantFiled: March 8, 1976Date of Patent: August 9, 1977Assignees: Dai Nippon Insatsu Kabushiki Kaisha, Meiji Seika Kabushiki KaishaInventor: Izuru Matsubara