Patents Assigned to Meiji Seika Pharma Co., Ltd.
  • Publication number: 20190322686
    Abstract: A compound represented by the general formula (1) below or a pharmacologically acceptable salt thereof: [In the formula (1), R1 and R2 may be the same or different and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a carboxy group, a cyano group, an optionally substituted C1-6 alkyl group et al.; R3 represents a hydrogen atom; R4 represents an optionally substituted 4- to 10-membered monocyclic heterocyclic group containing 1 to 4 heteroatoms selected from an oxygen atom, a nitrogen atom, and a sulfur atom; X represents a group represented by the following formula: —CH2—, —CH2—CH2—, —CH2—CH2—CH2—, or —CH2—O—CH2—; and Z represents a hydrogen atom or a hydroxyl group.
    Type: Application
    Filed: December 26, 2017
    Publication date: October 24, 2019
    Applicant: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Keiji TAMURA, Takeru YAMAKAWA, Satoshi ISSHIKI, Yoshinari WAKIYAMA, Shohei OUCHI, Takashi MATSUHIRA, Natsuki ISHIDA, Yuji TABATA
  • Publication number: 20190270709
    Abstract: The present invention provides a method for producing a compound represented by the following formula (I) with a compound represented by the following formula (A) as a starting substance via production of an intermediate represented by the following formula (B) by use of a trifluoroacetic acid ester and a metal base.
    Type: Application
    Filed: September 15, 2017
    Publication date: September 5, 2019
    Applicant: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Shigeki KITSUDA, Nozomu NAKANISHI, Shinjiro SUMI
  • Patent number: 10349655
    Abstract: Provided is a pest control composition containing a novel iminopyridine derivative and other pest control agents. Provided is a pest control composition containing an iminopyridine derivative represented by the following Formula (I) and at least one of other pest control agents: [in the formula (I), Ar represents a 5- to 6-membered heterocycle which may be substituted, A represents a heterocycle having a 5- to 10-membered unsaturated bond including one or more nitrogen atoms, and has an imino group substituted with an R group at a position adjacent to the nitrogen atom present on the cycle, Y represents hydrogen, halogen and the like, and R represents any one of groups represented by the following Formulae (a) to (e), (y) or (z)].
    Type: Grant
    Filed: February 24, 2016
    Date of Patent: July 16, 2019
    Assignee: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Ryo Horikoshi, Yasumichi Onozaki, Satoshi Nakamura, Masahiro Nomura, Makoto Matsumura, Masaaki Mitomi
  • Publication number: 20190202831
    Abstract: A process for producing crystals of a compound represented by the following formula (I): by crystallizing the compound from an aqueous solution containing the compound and an inorganic salt, such as sodium chloride. Such crystals can be subjected to lyophilization to provide a lyophilized composition having a desirable storage stability.
    Type: Application
    Filed: March 8, 2019
    Publication date: July 4, 2019
    Applicant: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Takaya OGAWA, Takuya YOKOYAMA, Shusuke FURUYAMA, Masato ICHIKI, Kenichi FUSHIHARA
  • Publication number: 20190200610
    Abstract: Provided is a pest control composition containing a novel iminopyridine derivative and other pest control agents. Provided is a pest control composition containing an iminopyridine derivative represented by the following Formula (I) and at least one of other pest control agents: [in the formula (I), Ar represents a 5- to 6-membered heterocycle which may be substituted, A represents a heterocycle having a 5- to 10-membered unsaturated bond including one or more nitrogen atoms, and has an imino group substituted with an R group at a position adjacent to the nitrogen atom present on the cycle, Y represents hydrogen, halogen and the like, and R represents any one of groups represented by the following Formulae (a) to (e), (y) or (z)].
    Type: Application
    Filed: March 7, 2019
    Publication date: July 4, 2019
    Applicant: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Ryo HORIKOSHI, Yasumichi Onozaki, Satoshi Nakamura, Masahiro Nomura, Makoto Matsumura, Masaaki Mitomi
  • Patent number: 10301343
    Abstract: According to the present invention, it is possible to efficiently remove 13-dihydroepi-daunorubicin and 4?-epi-feudomycin, which are typical impurities possibly contained in 4?-epi-daunorubicin as a starting material, by using an organic acid salt of 4?-epi-daunorubicin or a hydrate or solvate thereof as a novel production intermediate, thus making it possible to produce high-purity epirubicin.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: May 28, 2019
    Assignee: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Kenichiro Mori, Takuto Umezu, Takahisa Maruyama, Sojiro Shiokawa
  • Patent number: 10294224
    Abstract: A process for producing crystals of a compound represented by the following formula (I): by crystallizing the compound from an aqueous solution containing the compound and an inorganic salt, such as sodium chloride. Such crystals can be subjected to lyophilization to provide a lyophilized composition having a desirable storage stability.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: May 21, 2019
    Assignee: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Takaya Ogawa, Takuya Yokoyama, Shusuke Furuyama, Masato Ichiki, Kenichi Fushihara
  • Publication number: 20190047966
    Abstract: A compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof: [in the formula (I), A1 represents a methylene group or the like; A2 represents a methylene group or an oxygen atom; A3 represents an azetidinyl group, a pyrrolidinyl group, a piperidinyl group, a piperazinyl group, or a homopiperazinyl group which is optionally substituted with —N(R1)R2, —N(R1)R3, and/or —R3; A4 represents —O—, —S—, —S(O)—, —S(O)2—, or —N(R1)—; A5 represents an optionally substituted C3-10 cycloalkylalkyl group or the like; R4 represents a halogen atom or the like; and n represents an integer of 0 or 1].
    Type: Application
    Filed: January 27, 2017
    Publication date: February 14, 2019
    Applicant: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Mami ARAI, Takeru YAMAKAWA, Rie NAKAJIMA, Kota MURASAKI, Yoshinari WAKIYAMA, Yuta FUJIWARA, Makoto ISHIKAWA, Tomohisa NINOMIYA
  • Publication number: 20190031659
    Abstract: A process for producing a compound of the following Formula (VII-CR): The process involving providing a compound represented by the following Formula (VI): in a case where the R3ONHC(?O) side chain in the compound of the Formula (VI) has a protecting group, removing the protecting group from the compound of the Formula (VI) with an acid, and adding an ester-based poor solvent to the resultant reaction solution to precipitate the compound of Formula (VII-CR), wherein in the compounds of the Formulas (VII-CR) and (VI), R3 is a C1-6 alkyl or a heterocycle.
    Type: Application
    Filed: October 1, 2018
    Publication date: January 31, 2019
    Applicant: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Takao ABE, Takeshi FURUUCHI, Yoshiaki SAKAMAKI, Nakako MITSUHASHI, Yumiko SAITO
  • Patent number: 10131665
    Abstract: A crystalline form of a diazabicyclooctane derivative represented by the following Formula (VII), and processes for producing the same:
    Type: Grant
    Filed: October 8, 2014
    Date of Patent: November 20, 2018
    Assignee: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Takao Abe, Takeshi Furuuchi, Yoshiaki Sakamaki, Nakako Mitsuhashi, Yumiko Saito
  • Publication number: 20180327729
    Abstract: An object is to identify endoglucanase and ?-glucosidase genes by isolating genomic DNA containing cellulase genes, which are classified into endoglucanases or ?-glucosidases, from Acremonium cellulolyticus, and sequencing the nucleotide sequences thereof. The inventors intensively compared the amino acid sequences of known endoglucanases and ?-glucosidases with each other to find conserved region of amino acid sequences in Acremonium cellulolyticus, and various primers were designed based on the information. PCR was carried out using the various primers thus designed and genomic DNA or cDNA as a template. As a result, gene fragments of endoglucanases and ?-glucosidases were obtained. Primers were designed based on the gene fragments, and PCR was carried out to amplify nine genes of endoglucanases and ?-glucosidases. The nucleotide sequences thereof were sequenced, and the present invention was completed.
    Type: Application
    Filed: July 18, 2018
    Publication date: November 15, 2018
    Applicant: MEIJI SEIKA PHARMA CO., LTD.
    Inventor: Fumikazu Yokoyama
  • Patent number: 10125355
    Abstract: By combination of hydrophobic chromatography and strongly basic anion-exchange chromatography, a novel, highly hydrophobic ?-glucosidase was successfully identified from Acremonium cellulolyticus. Further, a gene corresponding to the identified ?-glucosidase was isolated. When multiple modifications were introduced into the base sequence of the gene, the gene was successfully expressed in Trichoderma viride at a high level, and the expression product successfully exhibited a high ?-glucosidase activity.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: November 13, 2018
    Assignee: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Fumikazu Yokoyama, Kengo Yokoyama, Nobuko Mazuka
  • Patent number: 10123978
    Abstract: A patch for a nail for treating dermatophytosis which includes a pressure-sensitive adhesive layer containing an acrylic-based pressure-sensitive adhesive and 2-(3, 5-dimethyl-1H-pyrazol-1-yl)-5-methylphenol or a salt thereof, wherein the acrylic-based pressure sensitive adhesive contains a copolymer of 2-ethylhexyl acrylate and N-vinylpyrrolidone, and wherein a mass ratio of the 2-ethylhexyl acrylate and the N-vinylpyrrolidone is 70:30 to 90:10.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: November 13, 2018
    Assignees: MEIJI SEIKA PHARMA CO., LTD., NICHIBAN COMPANY LIMITED
    Inventors: Koji Kawahara, Noriko Kan, Shihoko Watanabe, Kyohei Matsuo
  • Patent number: 10085449
    Abstract: A compound of formula (Ie?): wherein Ar?, R1, R4e and Y are as defined herein and a method of controlling pests using the compound.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: October 2, 2018
    Assignee: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Shinzo Kagabu, Masaaki Mitomi, Shigeki Kitsuda, Ryo Horikoshi, Masahiro Nomura, Yasumichi Onozaki
  • Publication number: 20180258089
    Abstract: A process for preparing a diazabicyclooctane compound represented by the following formula (I): wherein A represents RcO—; B represents NH or NC1-6 alkyl; C represents a benzyl group; Rc represents a C1-6 alkyl group; A is substituted with one substituent Fn1, wherein Fn1 represents an azetidine group; the process including: (a) silylating the compound represented by the following formula (IV-c): wherein in the formula (IV-c), OBn represents benzyloxy, and (b) carrying out an intramolecular urea formation reaction.
    Type: Application
    Filed: May 8, 2018
    Publication date: September 13, 2018
    Applicant: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Takao ABE, Takeshi FURUUCHI, Yoshiaki SAKAMAKI, Seiichi INAMURA, Akihiro MORINAKA
  • Patent number: 10053679
    Abstract: An object is to identify endoglucanase and ?-glucosidase genes by isolating genomic DNA containing cellulase genes, which are classified into endoglucanases or ?-glucosidases, from Acremonium cellulolyticus, and sequencing the nucleotide sequences thereof. The inventors intensively compared the amino acid sequences of known endoglucanases and ?-glucosidases with each other to find conserved region of amino acid sequences in Acremonium cellulolyticus, and various primers were designed based on the information. PCR was carried out using the various primers thus designed and genomic DNA or cDNA as a template. As a result, gene fragments of endoglucanases and ?-glucosidases were obtained. Primers were designed based on the gene fragments, and PCR was carried out to amplify nine genes of endoglucanases and ?-glucosidases. The nucleotide sequences thereof were sequenced, and the present invention was completed.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: August 21, 2018
    Assignee: MEIJI SEIKA PHARMA CO., LTD.
    Inventor: Fumikazu Yokoyama
  • Patent number: 10052281
    Abstract: A dysphagia improving composition characterized in that a substance having an inhibitory action on an angiotensin converting enzyme, which is a degrading enzyme of substance P, is administered locally in a dosage not influencing blood pressure, and a pharmaceutical for improving dysphagia containing the composition.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: August 21, 2018
    Assignee: Meiji Seika Pharma Co., Ltd.
    Inventors: Koichi Kitamura, Maho Kondo, Kiyoshi Shimoyama, Toru Kurosawa
  • Publication number: 20180214470
    Abstract: A compound represented by the following general formula (I) or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutical composition thereof, and the use thereof to prevent or treat infectious diseases and a method to prevent or treat infectious diseases using those regimen are disclosed. The compound represented by formula (I) has an antibacterial activity against both gram-positive and gram-negative bacteria, and is useful in the prevention or treatment of infectious diseases caused by these bacteria.
    Type: Application
    Filed: July 29, 2016
    Publication date: August 2, 2018
    Applicants: MICROBIAL CHEMISTRY RESEARCH FOUNDATION, MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Yoshiaki TAKAHASHI, Eijiro UMEMURA, Takashi IDA, Masayuki IGARASHI
  • Publication number: 20180200199
    Abstract: A patch for a nail for treating dermatophytosis which includes a pressure-sensitive adhesive layer containing an acrylic-based pressure-sensitive adhesive and 2-(3, 5-dimethyl-1H-pyrazol-1-yl)-5-methylphenol or a salt thereof, wherein the acrylic-based pressure sensitive adhesive contains a copolymer of 2-ethylhexyl acrylate and N-vinylpyrrolidone, and wherein a mass ratio of the 2-ethylhexyl acrylate and the N-vinylpyrrolidone is 70:30 to 90:10.
    Type: Application
    Filed: January 9, 2018
    Publication date: July 19, 2018
    Applicants: MEIJI SEIKA PHARMA CO., LTD., NICHIBAN COMPANY LIMITED
    Inventors: Koji KAWAHARA, Noriko KAN, Shihoko WATANABE, Kyohei MATSUO
  • Patent number: 10023573
    Abstract: A process for preparing a diazabicyclooctane compound represented by the following formula (I): wherein A represents RcO—; B represents NH or NC1-6 alkyl; C represents a benzyl group; Rc represents a C1-6 alkyl group; A is substituted with one substituent Fn1, wherein Fn1 represents an azetidine group; the process including: (a) silylating the compound represented by the following formula (IV-c): wherein in the formula (IV-c), OBn represents benzyloxy, and (b) carrying out an intramolecular urea formation reaction.
    Type: Grant
    Filed: May 1, 2017
    Date of Patent: July 17, 2018
    Assignee: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Takao Abe, Takeshi Furuuchi, Yoshiaki Sakamaki, Seiichi Inamura, Akihiro Morinaka