Patents Assigned to Meiji Seika Pharma Co., Ltd.
  • PDE4 Inhibitor
    Publication number: 20160159783
    Abstract: Provided is a compound represented by formula (1a) or a pharmacologically acceptable salt thereof. However, R1 to R6 in the formula each independently represent an alkyl group or the like.
    Type: Application
    Filed: July 10, 2014
    Publication date: June 9, 2016
    Applicant: Meiji Seika Pharma Co., Ltd.
    Inventors: Chika Kikuchi, Yuji Tabata, Takeru Yamakawa, Takashi Matsuhira, Naoko Watanabe, Natsuki Kubota, Kaori Kaneda
  • Method for producing pest control agent
    Patent number: 9357776
    Abstract: To supply a derivative having a 2-acyliminopyridine structure and being represented by the following formula (I) in an amount required as a pest control agent stably and at a low cost, provided is a method comprising the steps of: acylating an amino group at position 2 of a compound represented by formula (A) by use of an acylating agent, to thereby produce a compound represented by formula (B); and further alkylating a nitrogen atom at position 1 of the compound represented by formula (B): [where Ar represents a phenyl group or a 5-to 6-membered heterocycle, R1 represents a C1-6 alkyl group, and Y represents a hydrogen atom; a halogen atom; a hydroxyl group; a C1-6 alkyl group which may be substituted with a halogen atom; a C1-6 alkyloxy group which may be substituted with a halogen atom; a cyano group; a formyl group; or a nitro group].
    Type: Grant
    Filed: August 24, 2012
    Date of Patent: June 7, 2016
    Assignee: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Nozomu Nakanishi, Yoshimasa Fukuda, Shigeki Kitsuda, Ikuya Ohno
  • Probe for analyzing biological tissue and method for utilizing same
    Patent number: 9354240
    Abstract: The present invention relates to a method for obtaining cells or cell populations having a high biological activity from a biological tissue by enzymatic isolation, and probes for use in the method; more specifically to a method for analyzing a biological tissue, comprising applying two or more probes respectively containing biological-component binding domains through which two or more proteins bind to a predetermined biological component, to an isolated biological tissue, and analyzing binding amounts of the probes to the biological tissue.
    Type: Grant
    Filed: March 15, 2012
    Date of Patent: May 31, 2016
    Assignees: TOHOKU UNIVERSITY, MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Youhei Yamagata, Masafumi Goto, Kimiko Watanabe
  • COMPOUNDS USEFUL FOR PRODUCING AN OPTICALLY ACTIVE DIAZABICYCLOOCTANE COMPOUND
    Publication number: 20160137645
    Abstract: An optically active (2S,5R)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylic acid compound defined by the following formula (F): wherein R1 represents CO2R, CO2M, or CONH2, wherein R represents an allyl group or a benzyl group, and M represents a hydrogen atom, an inorganic cation, or an organic cation; and R2 represents a benzyl group or an allyl group.
    Type: Application
    Filed: January 27, 2016
    Publication date: May 19, 2016
    Applicant: Meiji Seika Pharma Co., Ltd.
    Inventors: Takao ABE, Masayuki OKUE, Yoshiaki SAKAMAKI
  • PHARMACEUTICAL FOR IMPROVING DYSPHAGIA
    Publication number: 20160128978
    Abstract: A dysphagia improving composition characterized in that a substance having an inhibitory action on an angiotensin converting enzyme, which is a degrading enzyme of substance P, is administered locally in a dosage not influencing blood pressure, and a pharmaceutical for improving dysphagia containing the composition.
    Type: Application
    Filed: June 13, 2013
    Publication date: May 12, 2016
    Applicant: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Koichi KITAMURA, Maho KONDO, Kiyoshi SHIMOYAMA, Toru KUROSAWA
  • N-[1-((6-chloropyridin-3-yl) methyl)pyridin-2(1H)-ylidene]-2,2,2-trifluoroacetamide for control of animal parasitic pests and agricultural/horticultural pests
    Patent number: 9328068
    Abstract: A compound of formula (Ie?): wherein Ar?, R1, R4e and Y are as defined herein and a method of controlling pests using the compound.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: May 3, 2016
    Assignee: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Shinzo Kagabu, Masaaki Mitomi, Shigeki Kitsuda, Ryo Horikoshi, Masahiro Nomura, Yasumichi Onozaki
  • Pyripyropene a biosynthetic gene
    Patent number: 9315785
    Abstract: An isolated novel polynucleotide comprising a nucleotide sequence encoding at least one polypeptide involved in biosynthesis of pyripyropene A, a recombinant vector comprising the polynucleotide and a transformant comprising the polynucleotide are disclosed. By the present invention, a pyripyropene A biosynthetic gene useful for production of a novel pyripyropene analog, improvement of productivity of a pyripyropene A-producing bacterium, production of an insecticidal agent for microorganisms, creation of a plant resistant to insect pests or the like are provided.
    Type: Grant
    Filed: September 10, 2013
    Date of Patent: April 19, 2016
    Assignee: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Hiroyuki Anzai, Kentaro Yamamoto, Mariko Tsuchida, Kazuhiko Oyama, Masaaki Mitomi
  • ARBEKACIN DERIVATIVE, AND PRODUCTION AND USE THEREOF
    Publication number: 20160096859
    Abstract: It has been found that adding carbon dioxide or the like to a solution containing arbekacin free base makes it possible to produce arbekacin derivatives including arbekacin carbonate and carbamic acid of arbekacin. Moreover, it has been found that the arbekacin derivatives have a high stability, and that the use thereof enables efficient productions of highly-pure arbekacin free base and pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: May 29, 2014
    Publication date: April 7, 2016
    Applicant: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Hiroyasu MIWA, Hisashi KISHI, Toshiro SASAKI, Takashi MURATA, Makoto OYAMA, Nao SANO, Ayako ODAGIRI
  • Compounds useful for producing an optically active diazabicyclooctane compound
    Patent number: 9284273
    Abstract: A compound of the following compound (B): wherein tBu represents a tert-butyl group. A compound of the following compound (C): wherein tBu represents a tert-butyl group, and TFA represents a trifluoroacetyl group.
    Type: Grant
    Filed: April 1, 2015
    Date of Patent: March 15, 2016
    Assignee: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Takao Abe, Masayuki Okue, Yoshiaki Sakamaki
  • Aminoglycoside antibiotics
    Patent number: 9260465
    Abstract: This invention relates to novel aminoglycoside antibiotics, which have potent antimicrobial activity against bacteria, which induce infectious diseases, particularly MRSA, and has no significant nephrotoxicity, and process for producing them. More particularly, the present invention relates to compounds represented by formula (Ia) or their pharmacologically acceptable salts or solvates, or their diastereomer mixtures, antimicrobial agents comprising them, and a process for producing them.
    Type: Grant
    Filed: August 20, 2013
    Date of Patent: February 16, 2016
    Assignees: MEIJI SEIKA PHARMA CO., LTD., MICROBIAL CHEMISTRY RESEARCH FOUNDATION
    Inventors: Yoshihiko Kobayashi, Yoshihisa Akiyama, Takeshi Murakami, Nobuto Minowa, Masaki Tsushima, Yukiko Hiraiwa, Shoichi Murakami, Mitsuhiro Abe, Kazushige Sasaki, Shigeru Hoshiko, Toshiaki Miyake, Yoshiaki Takahashi, Daishiro Ikeda
  • Method for producing glufosinate P free acid
    Patent number: 9255115
    Abstract: The present invention provides a method for producing crystalline glufosinate P free acid with high purity from glufosinate P hydrochloride salt. In addition, the present invention also provides a method comprises a process of: dissolving glufosinate P hydrochloride salt in a solvent which is a mixed solvent of water and an alcohol(s) selected from the group of methanol, ethanol, propyl alcohol and isopropyl alcohol, and a ratio of water to the alcohol(s) is from 1:3 to 1:100 by volume; crystallizing glufosinate P free acid after neutralizing by addition of a base.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: February 9, 2016
    Assignee: MEIJI SEIKA PHARMA CO. LTD.
    Inventors: Nozomu Nakanishi, Takashi Ando, Nobuto Minowa, Masaaki Mitomi
  • BETA-LACTAMASE INHIBITOR AND PROCESS FOR PREPARING THE SAME
    Publication number: 20160024090
    Abstract: A diazabicyclooctane compound, which is a beta-lactame inhibitor, represented by the following formula (I): wherein A represents Ra(Rb)N— or RcO—; B represents NH or NC1-6 alkyl; C represents benzyl, H or SO3M, wherein M represents H, an inorganic or an organic cation; Ra and Rb represent H, C1-6 alkyl or acyl; Rc represents C1-6 alkyl or a heterocyclyl; A is unsubstituted or substituted with 0 to 4 substituents Fn1, wherein Fn1 represents C1-6 alkyl, O?, or Rg-(CH2)0-3—, wherein Rg represents a heterocyclyl, phenyl, heteroaryl, acyl, RdO2S—, Re(Rf)N—, Re(Rf)NCO—, ReO—, ReOCO— or a protective group, wherein Rd represents C1-6 alkyl or MO—; Re and Rf represent H or C1-6 alkyl, and a heterocycle having at least one nitrogen atom may be formed between Ra and Rb, between Rc and B, or between Re and Rf.
    Type: Application
    Filed: October 1, 2015
    Publication date: January 28, 2016
    Applicant: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Takao ABE, Takeshi FURUUCHI, Yoshiaki SAKAMAKI, Seiichi INAMURA, Akihiro MORINAKA
  • Beta-lactamase inhibitor and process for preparing the same
    Patent number: 9181250
    Abstract: A diazabicyclooctane compound, which is a beta-lactame inhibitor, represented by the following formula (I): wherein A represents Ra(Rb)N— or RcO—; B represents NH or NC1-6 alkyl; C represents benzyl, H or SO3M, wherein M represents H, an inorganic or an organic cation; Ra and Rb represent H, C1-6 alkyl or acyl; Rc represents C1-6 alkyl or a heterocyclyl; A is unsubstituted or substituted with 0 to 4 substituents Fn1, wherein Fn1 represents C1-6 alkyl, O?, or Rg-(CH2)0-3—, wherein Rg represents a heterocyclyl, phenyl, heteroaryl, acyl, RdO2S—, Re(Rf)N—, Re(Rf)NCO—, ReO—, ReOCO— or a protective group, wherein Rd represents C1-6 alkyl or MO—; Re and Rf represent H or C1-6 alkyl, and a heterocycle having at least one nitrogen atom may be formed between Ra and Rb, between Rc and B, or between Re and Rf.
    Type: Grant
    Filed: May 30, 2013
    Date of Patent: November 10, 2015
    Assignee: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Takao Abe, Takeshi Furuuchi, Yoshiaki Sakamaki
  • Cellulase preparation comprising endoglucanases derived from two different types of microorganisms
    Patent number: 9181537
    Abstract: By having a cellulase preparation comprising at least a certain amount of endoglucanases derived from two different types of microorganisms, the cellulase preparation can be provided with a higher activity and a wider pH property than those of cellulase preparations each containing one of the endoglucanases alone. Moreover, by introducing and expressing simultaneously two different types of cellulase genes in a single host cell, a cellulase preparation having a high activity and a wide pH property can be produced easily.
    Type: Grant
    Filed: July 1, 2010
    Date of Patent: November 10, 2015
    Assignee: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Kaoru Okakura, Koichiro Murashima
  • Method for producing pyripyropene
    Patent number: 9169504
    Abstract: There is provided a method for culturing a microorganism in which a particular polynucleotide or a recombinant vector comprising it/them is introduced with an intermediate compound necessary for biosynthesis of pyripyropene A. The method of the present invention allows for the production of pyripyropene.
    Type: Grant
    Filed: January 19, 2011
    Date of Patent: October 27, 2015
    Assignee: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Hiroyuki Anzai, Kentaro Yamamoto, Kazuhiko Oyama, Mariko Tsuchida, Kimihiko Goto, Masaaki Mitomi
  • LOCAL ADMINISTRATION-TYPE PHARMACEUTICAL FOR IMPROVING DYSPHAGIA
    Publication number: 20150297512
    Abstract: A dysphagia improving composition characterized in that a substance having an inhibitory action on an angiotensin converting enzyme, which is a degrading enzyme of substance P, is administered locally in a dosage not influencing blood pressure, and a pharmaceutical for improving dysphagia containing the composition.
    Type: Application
    Filed: December 20, 2012
    Publication date: October 22, 2015
    Applicant: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Koichi Kitamura, Maho Kondo, Kiyoshi Shimoyama, Toru Kurosawa
  • C-4? position substituted macrolide derivative
    Patent number: 9139609
    Abstract: A macrolide compound represented by the formula (I) effective against erythromycin resistant bacteria (for example, resistant pneumococci, streptococci and mycoplasmas).
    Type: Grant
    Filed: February 20, 2012
    Date of Patent: September 22, 2015
    Assignees: TAISHO PHARMACEUTICAL CO., LTD., MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Tomohiro Sugimoto, Naoki Sasamoto, Jun Kurosaka, Masato Hayashi, Kanako Yamamoto, Masato Kashimura, Yasunobu Ushiki, Haruhisa Ogita, Tomoaki Miura, Kenichi Kanemoto, Kou Kumura, Satoshi Yoshida, Keiji Tamura, Eiki Shitara
  • Process for producing 4-carbonyloxyquinoline derivatives
    Patent number: 9126934
    Abstract: An objective of the present invention is to provide a process for producing 4-carbonyl oxyquinoline derivatives useful as agricultural and horticultural pesticides and fungicides. The objective can be attained by a process for producing 4-carbonyl oxyquinoline derivatives represented by general formula (1), the process including reacting a quinolone derivative with a halogenated compound or an acid anhydride in the presence of a phase transfer catalyst and a base.
    Type: Grant
    Filed: November 16, 2011
    Date of Patent: September 8, 2015
    Assignees: NIPPON KAYAKU CO., LTD., MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Shizuo Shimano, Akinori Morikawa, Kenichi Yamamoto, Hiroki Hotta, Kazumi Yamamoto, Nozomu Nakanishi, Nobuto Minowa
  • COMPOUNDS USEFUL FOR PRODUCING AN OPTICALLY ACTIVE DIAZABICYCLOOCTANE COMPOUND
    Publication number: 20150239840
    Abstract: A compound of the following compound (B): , wherein tBu represents a tert-butyl group. A compound of the following compound (C): , wherein tBu represents a tert-butyl group, and TFA represents a trifluoroacetyl group.
    Type: Application
    Filed: April 1, 2015
    Publication date: August 27, 2015
    Applicant: Meiji Seika Pharma Co., Ltd.
    Inventors: Takao ABE, Masayuki OKUE, Yoshiaki SAKAMAKI
  • NDM inhibitor
    Patent number: 9115079
    Abstract: An objective of the present invention is to provide a novel NDM (New Delhi metallo-?-lactamase) inhibitor that functions as a drug for restoring the antibacterial activity of ?-lactam antibiotics that have been inactivated as a result of decomposition by NDM.
    Type: Grant
    Filed: July 26, 2012
    Date of Patent: August 25, 2015
    Assignee: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Akihiro Morinaka, Kazunori Maebashi, Takashi Ida, Muneo Hikida, Mototsugu Yamada, Takao Abe