Patents Assigned to Mercer University
  • Patent number: 8081005
    Abstract: Symmetrical differential capacitive sensors are disclosed. Methods of making and using symmetrical differential capacitive sensors are also disclosed.
    Type: Grant
    Filed: March 17, 2009
    Date of Patent: December 20, 2011
    Assignee: The Corporation of Mercer University
    Inventors: Scheng Chiang Lee, Randall Douglas Peters
  • Publication number: 20100111984
    Abstract: A method for forming microspheres containing bioactive material, comprising dissolving a polymer matrix, such as albumin or beta-cyclodextrin, in an aqueous medium in a first vessel; contacting the dissolved polymer matrix with a crosslinking agent, such as glutaraldehyde, to crosslink the polymer matrix and the crosslinking agent; neutralizing with sodium bisulfate any excess crosslinking agent remaining after crosslinking is substantially complete; solubilizing in a second vessel a bioactive material in an aqueous solution; mixing the solubilized bioactive material together with the neutralized crosslinked polymer matrix in solution to form a mixture; and, spray drying the mixture to produce nanospheres, whereby substantial bioactivity of the biomaterial is retained upon cellular uptake.
    Type: Application
    Filed: September 29, 2009
    Publication date: May 6, 2010
    Applicant: THE CORPORATION OF MERCER UNIVERSITY
    Inventor: Martin J. D'Souza
  • Publication number: 20090081306
    Abstract: A method of forming microspheres of a bioactive material, such as a protein polymer or drug by nebulizing a solubilized form of a material to be encapsulated and an encapsulating material, such as albumin, in a stirred chilled solvent system comprising a vegetable oil, mineral oil and/or a lower alcohol such that the formed microspheres demonstrate intracellular bioactivity when taken up by macrophages.
    Type: Application
    Filed: September 8, 2008
    Publication date: March 26, 2009
    Applicant: THE CORPORATION OF MERCER UNIVERSITY
    Inventor: Martin J. D'Souza
  • Patent number: 7425543
    Abstract: A method of forming microspheres of a bioactive material, such as a protein polymer or drug by nebulizing a solubilized form of a material to be encapsulated and an encapsulating material, such as albumin, in a stirred chilled solvent system comprising a vegetable oil, mineral oil and/or a lower alcohol such that the formed microspheres demonstrate intracellular bioactivity when taken up by macrophages.
    Type: Grant
    Filed: August 29, 2002
    Date of Patent: September 16, 2008
    Assignee: The Corporation of Mercer University
    Inventor: Martin J. D'Souza
  • Patent number: 7105158
    Abstract: Compositions useful in treating immune modulated disease comprising an anticytokine antibody or immune active drug capable of modifying cytokine activity or modulating the immune system microencapsulated with a biodegradable nonantigenic material, such as albumin or PLGA. When the composition is introduced into a subject, it is phagocytosed by the target organ, the target organ digests the microsphere, releasing the drug or an active form or fragment thereof intracellularly. The drug then modifies the target organ function, thereby modulating it's activity. A method is disclosed for preparation of the microencapsulated composition.
    Type: Grant
    Filed: November 1, 1996
    Date of Patent: September 12, 2006
    Assignee: The Corporation of Mercer University
    Inventors: Martin J. D'Souza, William Carl Oettinger, James Cameron Oliver
  • Patent number: 6962899
    Abstract: Pharmaceutically acceptable compounds for administering to a subject, comprising the general structure II: wherein R1 is an L-amino acid or salt or ester thereof, or an L-amino acid containing peptide or salt or ester thereof; and wherein the stereochemistry about the carbon-carbon double bond is trans. The invention further relates to pharmaceutical compositions comprising the aforementioned compounds.
    Type: Grant
    Filed: December 4, 2002
    Date of Patent: November 8, 2005
    Assignees: Georgia Tech Research Corporation, Mercer University
    Inventors: Sheldon W. May, Stanley H. Pollock
  • Patent number: 6727851
    Abstract: A system for locating electromagnetic signal sources via the rotational Doppler effect whereby a radar station generating electromagnetic signals, such as radar frequency signals, initially scans the sky for aircraft. An aircraft having the system operationally installed thereon and utilizing apparatus or navigational systems already present on the aircraft receives radar signals. The system is programmed to capture radar signal parameters and extract the rotational Doppler frequencies induced by the motion of the aircraft. The angular velocity of the host platform is often the dominant source of this frequency; however, lateral velocity is not detrimental to the process. The measurement of the rotational Doppler frequency is accomplished through antennas presently installed on large numbers of military aircraft with no requirement for phase calibration of the electrical paths between antennas and receiver.
    Type: Grant
    Filed: September 20, 2001
    Date of Patent: April 27, 2004
    Assignee: The Corporation of Mercer University
    Inventors: Charles David Bass, Jerome S. Finnigan, Peter Joseph Bryant
  • Patent number: 6555110
    Abstract: Compositions useful in treating immune modulated disease comprising an anticytokine antibody or immune active drug capable of modifying cytokine activity or modulating the immune system microencapsulated with a biodegradable nonantigenic material, such as albumin or PLGA. When the composition is introduced into a subject, it is phagocytosed by the target organ, the target organ digests the microsphere, releasing the drug or an active form or fragment thereof intracellularly. The drug then modifies the target organ function, thereby modulating it's activity. A method is disclosed for preparation of the microencapsulated composition.
    Type: Grant
    Filed: May 4, 1995
    Date of Patent: April 29, 2003
    Assignee: The Corporation of Mercer University
    Inventor: Martin J. D'Souza
  • Patent number: 6495514
    Abstract: The invention relates to a method for reducing inflammation in a subject by administering to the subject an effective amount of the compound having the structure I or II: wherein, R1 is C1-C10 branched or straight chain alkyl, aryl, an amino acid, or a peptide; and R2 is hydrogen or lower C1-C5 branched or straight alkyl, or the salt or ester thereof, wherein the stereochemistry about the carbon-carbon double bond is trans. The invention further relates to a method of inducing an analgesic effect by administering to a subject an effective amount of the compound having the structure I or II. The invention further relates to a compound having the structure II, wherein, R1 is an N-acyl amino acid or peptide, or the salt or ester thereof.
    Type: Grant
    Filed: January 21, 1998
    Date of Patent: December 17, 2002
    Assignee: Mercer University
    Inventors: Sheldon W. May, Stanley H. Pollock
  • Patent number: 5445553
    Abstract: A system and method for cleaning or removing coatings, such as paint, from a surface with a stream of particles. A carbon dioxide (CO.sub.2) pelletizer forms carbon dioxide pellets, which are delivered by a delivery system against a surface to be cleaned. The delivery system includes a hopper for containing the pellets and a high pressure air supply. A feeder introduces the pellets from the hopper into the high pressure air. The combined high pressure air and pellets are directed along a delivery hose to a nozzle, which directs the air and pellets against a surface to be cleaned. Temperature sensors are provided to monitor the temperature of the pressurized air at various points in the delivery system. Signals from the temperature sensor are provided in a feedback control manner to a control valve. The control valve controls the introduction of liquid nitrogen (N.sub.2) into the air stream at a mixing chamber in the delivery system.
    Type: Grant
    Filed: January 22, 1993
    Date of Patent: August 29, 1995
    Assignee: The Corporation of Mercer University
    Inventors: Michael A. Cryer, William D. Danielson, Robert A. Babb