Patents Assigned to Merck Patent Gesellschaft Mit
  • Patent number: 5059531
    Abstract: Pilocarpine is isolated from Pilocarpus from suspension cultures of from in vitro cultures of differentiated plants, where, to establish the in vitro cultures, specific culture media are used which differ in their hormone composition and which are used in a particular sequence.
    Type: Grant
    Filed: March 22, 1991
    Date of Patent: October 22, 1991
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventor: Gerhard R. Reuther
  • Patent number: 5055224
    Abstract: A liquid crystal phase consisting of at least three components A, B and C, each of which contains one or more compounds, wherein component A has a viscosity of at most about 25 mPa.s at 20.degree., a clearing point of at most 130.degree. and a dielectric anisotropy between about -2 and about +2, component B has a dielectric anisotropy above about +8, component C has a clearing point of more than 130.degree. and a dielectric anisotropy between about -2 and about +2, characterized in that component A contains at least one compound of the formula III ##STR1## in which R.sup.1 is alkyl of 1 to 12 C atoms, in which in addition one or two non-adjacent CH.sub.2 groups can be replaced by O atoms, --CO--, --O--CO--, --CO--O-- and/or --CH.dbd.CH-- groups,R.sup.2 has one of the meanings of R.sup.1, ##STR2## Z.sup.1 is --CO--O--, --O--CO-- or --CH.sub.2 CH.sub.2 --, o is 1 or, if A.sup.
    Type: Grant
    Filed: January 27, 1989
    Date of Patent: October 8, 1991
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Ian C. Sage, Michael K. Chambers
  • Patent number: 5055223
    Abstract: Aryl-sulfur pentafluorides of the formula I ##STR1## wherein R, A, Z, n, m and X.degree. have the meaning indicated in claim 1 are suitable for use as components of liquid-crystal phases for field-effect and/or bi-stability effect displays.
    Type: Grant
    Filed: December 27, 1989
    Date of Patent: October 8, 1991
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Volker Reiffenrath, Rudolf Eidenschink, Georg Weber
  • Patent number: 5055221
    Abstract: Compounds of the formula I,R.sup.1 --A.sup.1 --Z.sup.1 --A.sup.2 --[Z.sup.2 --A.sup.3 ].sub.m --R.sup.2 Iin which R.sup.1, R.sup.2, A.sup.1, A.sup.2, A.sup.3, Z.sup.1, Z.sup.2 and m have the meaning specified in patent claim 1, are suitable as components of smectic liquid-crystalline phases.
    Type: Grant
    Filed: June 5, 1989
    Date of Patent: October 8, 1991
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Bernhard Scheuble, Klaus Bofinger, Reinhard Hopf, Axel Pausch, Rudolf Eidenschink, Joachim Krause, Andreas Wachtler
  • Patent number: 5047556
    Abstract: The invention relates to photoinitiators having a combined structure ##STR1## and their use as photoinitiators in the photopolymerization of ethylenically unsaturated compounds or binder systems containing them.
    Type: Grant
    Filed: August 8, 1989
    Date of Patent: September 10, 1991
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Manfred Kohler, Jorg Ohngemach
  • Patent number: 5045573
    Abstract: Compounds of the general formula I ##STR1## wherein Z is CR.sup.1 R.sup.2 (OR.sup.3) or phenyl,R.sup.1 being H, C.sub.1-6 -alkyl or phenyl,R.sup.2 being H, C.sub.1-6 -alkyl or C.sub.1-6 -alkoxy andR.sup.3 being H, C.sub.1-6 -alkyl or C.sub.1-6 -alkanoyl andZ' is Y-[(CH.sub.2).sub.m -X].sub.n -,X being CH.sub.2 or 0,Y being OH; COOH or SO.sub.3 H including the alkali metal, alkaline earth metal or ammonium salts thereof and also the salts thereof with organic nitrogen bases; or NRR' in which R and R' are in each case H, C.sub.1-20 -alkyl or C.sub.1-4 -hydroxyalkyl, if appropriate quaternized or in the form of the acid addition salts, andn and m each being the numbers 1-4, are excellently suitable as photoinitiators for the photopolymerization of ethylenically unsaturated compounds, in particular in aqueous systems.
    Type: Grant
    Filed: April 13, 1989
    Date of Patent: September 3, 1991
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Manfred Kohler, Jorg Ohngemach, Gregor Wehner, Jurgen Gehlhaus
  • Patent number: 5045229
    Abstract: Difluoromethylene compounds of the formula IR.sup.1 --(A.sup.1 --Z.sup.1).sub.m --A.sup.2 --Q--CF.sub.2 --(A.sup.3 --Z.sup.2).sub.n --A.sup.4 --R.sup.2 Iin which R.sup.1, R.sup.2, A.sup.1, A.sup.2, A.sup.3, A.sup.4, Z.sup.1, Z.sup.2, m and n are as defined herein and Q is --CO--, --O-- or --S--, can be used as components of liquid-crystalline media for liquid-crystal and electrooptical display elements.
    Type: Grant
    Filed: March 16, 1990
    Date of Patent: September 3, 1991
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Ekkehard Bartmann, Reinhard Hittich, Hans-Adolf Kurmeier, Eike Poetsch, Herbert Plach
  • Patent number: 5043093
    Abstract: Pyrimidines of the formula I ##STR1## in which R is an alkyl gorup of 1-15 C atoms in which in addition one or two nonadjacent Ch.sub.2 groups can be replaced by --0--, --CO--, --O--CO--, --CO--O--, --CHY-- and/or --CH.dbd.CH--, or is H, F, Cl or CN,X is --O--CH.sub.2 --R.sup.1, --S--R.sup.2, --NCS or --COO--A--R.sup.3,Y is halogen, CN or OH,R.sup.1 is an alkyl group of 1-15 C atoms, in which one or more nonadjacent CH.sub.2 groups are replaced by --O--, --CO--, --0--CO--, --CO--O--, --CHY-- and/or by --CH.dbd.CH--,R.sup.2 is an alkyl group of 1-15 C atoms, in which in addition one or two nonadjacent CH.sub.2 groups can be replaced by --O--, --CO--, --O--CO--, --CO--O--, --CHY-- and/or --CH.dbd.CH--,A is a trans-1,4-cyclohexylene group which is unsubstituted or monosubstituted or disubstituted by F and/or Cl atoms and/or CH.sub.3 groups and/or CN groups, or is a single bond, andR.sup.3 is an alkyl group of 1-15 C atoms, in which in addition ne or two nonadjacent and, if A is a single bond, nonterminal CH.sub.
    Type: Grant
    Filed: September 12, 1986
    Date of Patent: August 27, 1991
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Joachim Krause, Rudolf Eidenschink, Reinhard Hittich, Bernhard Scheuble
  • Patent number: 5035839
    Abstract: Composition which form hydrogen bridges are suitable for the preparation of materials of non-linear optical properties.
    Type: Grant
    Filed: October 17, 1988
    Date of Patent: July 30, 1991
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Dieter Dorsch, Rudolf Eidenschink, Bernhard Rieger, Gerd Marowsky
  • Patent number: 5036068
    Abstract: Novel benzoxazine derivatives of the formula I ##STR1## wherein R.sup.1 to R.sup.5 have the meanings defined herein, and salts thereof, exhibit effects on the cardiovascular system.
    Type: Grant
    Filed: November 22, 1989
    Date of Patent: July 30, 1991
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Manfred Baumgarth, Rolf Gericke, Rolf Bergmann, Jacques De Peyer, Ingeborg Lues
  • Patent number: 5030383
    Abstract: The invention relates to a liquid crystal display element with a particularly low temperature-dependence of the threshold voltage.
    Type: Grant
    Filed: October 30, 1987
    Date of Patent: July 9, 1991
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Bernhard Scheuble, Reinhard Hittich, Rudolf Eidenschink
  • Patent number: 5030741
    Abstract: The invention relates to cyclic organometallic compounds which are intramolecularly stabilized and also to their use to produce thin films and epitaxial layers by gas-phase deposition.
    Type: Grant
    Filed: May 18, 1989
    Date of Patent: July 9, 1991
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Dietrich Erdmann, Ludwig Pohl, Martin Hostalek, Matthias Lokai
  • Patent number: 5026642
    Abstract: In a process for the reduction of ketones, the keto compounds are enantioselectively reduced to give secondary alcohols by means of microorganisms. Keto compounds of the formulaR.sup.3 NH--CHR.sup.1 --CO--CH.sub.2 --COOR.sup.2in which R.sup.1, R.sup.2 and R.sup.3 have the meanings defined herein are used as starting compounds.
    Type: Grant
    Filed: July 22, 1988
    Date of Patent: June 25, 1991
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Hans-Eckart Radunz, Harry Schwartz, Martin Heinrich
  • Patent number: 5026705
    Abstract: New benzimidazolylpyridazinones of the formula I ##STR1## in which R.sup.1 is a styryl or mononculear of binuclear heteroaryl radical which contains 1-4 heteroatoms, each of which is unsubstituted or singly or multiply substituted by alkyl, alkoxy, alkylthio, halogen, OH, SH, amino, alkylamino, dialkylamino, acylamino having 1-8 C atoms, nitro, COOH, COOalkyl and/or CN,R.sup.2 R.sup.3, R.sup.4 and R.sup.5 are each H or alkyl andR.sup.6 and R.sup.7 are each H, or together are a C--C bond, and in which the alkyl and alkoxy groups each contain 1-4 C atoms,and their salts, show positive inotropic, vasodilating and antithrombotic actions.
    Type: Grant
    Filed: May 30, 1990
    Date of Patent: June 25, 1991
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Helmut Prucher, Rochus Jonas, Jaime Piulats, Michael Klockow
  • Patent number: 5022923
    Abstract: Pearl luster pigments based on mica flakes coated with metal oxides are provided with a top coating of tin dioxide and/or cerium dioxide to improve their stability in glazes and enamels.
    Type: Grant
    Filed: October 8, 1986
    Date of Patent: June 11, 1991
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Axel Rau, Klaus Ambrosius, Klaus D. Franz
  • Patent number: 5023379
    Abstract: A process for the production of hydroxyamines of the formula IR.sup.1 --CH(OH)--CH(NHR.sup.3)--R.sup.2 (I)whereinR.sup.1 and R.sup.2 independently of one another are H or CH.sub.2 OH andR.sup.3 is H, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -hydroxyalkyl comprising reacting an oxo compound with an amine and reducing the resultant ketimine with a reducing agent.
    Type: Grant
    Filed: March 12, 1990
    Date of Patent: June 11, 1991
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Ernst Felder, Michael Romer, Hans Bardonner, Hartmut Hartner, Wolfgang Fruhstorfer
  • Patent number: 5015747
    Abstract: The invention relates to organometallic compounds which are stabilized intramolecularly and have a cyclic or bicyclic structure and to the use thereof for the preparation of thin films and epitaxial layers by gas phase deposition.
    Type: Grant
    Filed: April 7, 1989
    Date of Patent: May 14, 1991
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Martin Hostalek, Ludwig Pohl, Dietrich Erdmann, Herbert Schumann, Uwe Hartmann, Meino Heyen, Holger Jurgensen
  • Patent number: 5013853
    Abstract: A compound of the formula: ##STR1## where in x-y is --CO--CH.sub.2 --, --COCR.sup.10-, --CHOHCHR.sup.8-, --CH.dbd.CR.sup.8 -- or ##STR2## and R.sup.9 is various, R.sup.1 and R.sup.8 are alkyl, R.sub.2 is H or alkyl and R.sup.1 and R.sup.2 are alkylene, are disclosed as useful as intermediates for cardiovascular agents.
    Type: Grant
    Filed: May 5, 1989
    Date of Patent: May 7, 1991
    Assignee: Merck Patent Gesellschaft MIT Beschrankter Haftung
    Inventors: Rolf Gericke, Manfred Baumgarth, Ingeborg Lues, Rolf Bergmann, Jacques De Peyer
  • Patent number: 5009711
    Abstract: The application relates to a preferably golden color luster pigment based on lamellar substrates, in particular mica, which have been coated with metal oxides, the metal oxide layer containing both titanium and iron and the pigment containing mainly a pseudobrookite layer formed by simultaneous precipitation of the metal oxides. This golden color luster pigment is suitable for cosmetic articles because of its physiological acceptability and is particularly suitable for silicate melts because of its resistance to heat and chemicals.
    Type: Grant
    Filed: September 12, 1988
    Date of Patent: April 23, 1991
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Ralf Emmert, Manfred Weigand
  • Patent number: 5002694
    Abstract: Nitrogen-containing heterocyclic compounds of the formula II ##STR1## wherein R.sup.1 and R.sup.2 in each case denote an alkyl group having 1 to 15 C atoms, wherein one or more CH.sub.2 groups may also be replaced by a grouping selected from the group comprising --O--, --S--, --CO--, --O--CO--, --O--COO--, --CO--O--, --CH.dbd.CH--, --CH--halogen and --CHCN--, or else by a combination of two suitable groupings, two heteroatoms not being directly linked to each other,m denotes 0 or 1,Ar denotes 1,4-phenylene, 4,4'-biphenylyl or 2,6-naphthylene, wherein one or more CH groups are in each case replaced by N,Z denotes --C--O--, --O--CO--, --CH.sub.2 O--, --OCH.sub.2 --, --CH.sub.2 CH.sub.2 --, --CH.sub.2 CHCN--, --CHCNCH.sub.2 --, --CH.dbd.CH or a single bond, andA denotes unsubstituted 1,4-cyclonexylene or 11,4-cyclohexylene substituted in position 1 or position 4 by CN,with the proviso that if A=unsubstituted 1,4-cyclonexylene, Z denotes --CHCNCH.sub.2 -- or --CH.sub.2 CHCN-- and/or at least one CH.sub.
    Type: Grant
    Filed: May 13, 1987
    Date of Patent: March 26, 1991
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Andreas Wachtler, Rudolf Eidenschink, Joachim Krause, Bernhard Scheuble