Patents Assigned to Merck Patent Gesellschaft Mit
  • Patent number: 4824852
    Abstract: New indole derivatives of the general formula I ##STR1## in which Ind is a 3-indolyl radical which can be substituted by a hydroxymethyl, methylenedioxy, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, CN or COW group and/or can be substituted once or twice by alkyl, O-alkyl, OH, F, Cl or Br,is H, OH, O-alkyl, NH.sub.2, NH-alkyl or N(alkyl).sub.2,is --(CH.sub.2).sub.n --, --CH.sub.2 --S--CH.sub.2 CH.sub.2 --, --CH.sub.2 --SO--CH.sub.2 CH.sub.2 --or --CH.sub.2 --SO.sub.2 --CH.sub.2 CH.sub.2 --,Z is --(CH.sub.2).sub.m --, --CH.dbd.CH--, --CHOH--, --CO--, S, SO, SO.sub.2 or O,is 2, 3, 4 or 5 andis 1, 2 or 3, in which the alkyl groups each have 1-4 C atoms, and their salts,have effects on the central nervous system.
    Type: Grant
    Filed: February 8, 1988
    Date of Patent: April 25, 1989
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Henning Bottcher, Hans-Heinrich Hausberg, Christoph Seyfried, Klaus-Otto Minck
  • Patent number: 4822682
    Abstract: Articles having a substrate coated with a oriented polymer having polar monomer units wherein the monomer units and main polymer chains originate from cyclic monomers polymerized by ring opening polymerization through impinging light on the coated surface.
    Type: Grant
    Filed: July 23, 1987
    Date of Patent: April 18, 1989
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Dieter Dorsch, Rudolf Eidenschink, Claus P. Herz
  • Patent number: 4820839
    Abstract: Nitrogen-containing heterocyclic esters of the formula I,R.sup.1 -A.sup.1 -Z.sup.1 -A.sup.2 -[Z.sup.2 -A.sup.3 ].sub.m -R.sup.2 Iin which R.sup.1, R.sup.2, A.sup.1, A.sup.2, A.sup.3, Z.sup.1, Z.sup.2 and m have the meaning specified in patent claim 1, are suitable as components of smectic liquid-crystalline phases.
    Type: Grant
    Filed: January 23, 1987
    Date of Patent: April 11, 1989
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Joachim Krause, Andreas Wachtler, Volker Reiffenrath, Bernhard Scheuble, Reinhard Hittich
  • Patent number: 4818428
    Abstract: The invention relates to liquid crystal phases (LC phases) having a particularly low threshold voltage, a particularly low ratio K.sub.3 /K.sub.1 of the elastic constants for bending (K.sub.3) and spreading (K.sub.1) and broad nematic phase ranges, these phases containing at the same time at least one highly polar component of reduced degree of association and, to reduce the quotient K.sub.3 /K.sub.1 of the elastic constants for bending (K.sub.3) and spreading (K.sub.1) of the phases to a value.ltoreq.1.1, at least one apolar liquid crystal component.
    Type: Grant
    Filed: September 12, 1986
    Date of Patent: April 4, 1989
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Bernhard Scheuble, Georg Weber, Joachim Krause
  • Patent number: 4818431
    Abstract: New tetrahydropyran derivatives of the formula I ##STR1## in which G is H.sub.2 or .dbd.O, R.sup.1 and R.sup.2 are each an alkyl group having 1-10 C atoms, it also being possible for one or two CH.sub.2 groups to be replaced by O atoms, or are F, Cl, Br or CN, R.sup.2 is also H, A.sup.1 and A.sup.2 are each 1,4-phenylene, 1,4-cyclohexylene, 1,3-dioxane-2,5-diyl, piperidine-1,4-diyl, 1,4-bicyclo[2.2.2]octylene or pyrimidine-2,5-diyl groups which are unsubstituted or substituted by 1-4 F atoms, Z.sup.1 and Z.sup.2 are each --CO--O--, --O--CO--, --CH.sub.2 CH.sub.2 --, --OCH.sub.2 --, --CH.sub.2 O--, or a single bond, m and n are each 0, 1, 2 or 3, but (m+n) is at least 1 and at most 3, it being possible, when m is 2 or 3, for the group A.sup.1 and, when n is 2 or 3, for the groups A.sup.2 each to be identical or different from one another, and the acid addition salts of those among these compounds which are basic, are suitable for use as components in liquid-crystal dielectrics.
    Type: Grant
    Filed: November 24, 1986
    Date of Patent: April 4, 1989
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Rudolf Eidenschink, Joachim Krause, Peter Fuss
  • Patent number: 4818076
    Abstract: The circular polarizer comprises a liquid crystal cell, the liquid crystal layer (8) of which is present as a so-called "blue phase" and can be exposed to a variable electric field. The blue phase is an optically isotropic chiral phase which, like the cholesteric phase, reflects circularly polarized light within a narrow frequency band and accordingly, in this spectral region, transmits only light which is circularly polarized (in the opposite sense). Under the influence of the field, the reflection band changes its position and can be shifted almost continuously from blue to red by means of relatively small voltage changes.The circular polarizer can, by means of simple additional measures, for instance by including a color-neutral circular polarizer, be developed into a color modulator and, in particular, it also makes a multi-colored display of information possible.
    Type: Grant
    Filed: June 12, 1987
    Date of Patent: April 4, 1989
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Gerd Heppke, Feodor Oestreicher
  • Patent number: 4814020
    Abstract: The invention relates to pigment preparations, in which a platelet-shaped nacreous pigment is coated with a polymer resin and, if appropriate, plasticizers, solvents and surfactants.
    Type: Grant
    Filed: August 11, 1987
    Date of Patent: March 21, 1989
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Manfred Kieser, Otto Stahlecker
  • Patent number: 4812555
    Abstract: New peptides of the formula IX--Z--NR.sup.2 --CHR.sup.3 --CHOH--(CHR.sup.4).sub.n --CO--Ewherein X, Z, R.sup.2, R.sup.3, R.sup.4, E and n are as defined herein and their salts inhibit the activity of human plasma renin.
    Type: Grant
    Filed: March 22, 1988
    Date of Patent: March 14, 1989
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Peter Raddatz, Gunter Holzemann, Alfred Jonczyk, Claus J. Schmitges, Klaus O. Minck
  • Patent number: 4812258
    Abstract: Liquid crystalline fluorine-containing pyrimidine compounds have the formula I ##STR1## wherein R.sup.1 and R.sup.2 are H, R, OR or OCOR, and one of them can also be CN or F, or, if A is a covalent bond, also one or both of R.sup.1 and R.sup.2 can be 4-R.sup.4 -phenyl or 4-R-cyclohexyl, wherein R.sup.4 is R, OR, cyano, f or OCOR; wherein R is an alkyl group of 1 to 12 C atoms; R.sup.3 is F or, if one of the radicals R.sup.1 or R.sup.2 is F or 4-fluorophenyl, also H; Z is 1,3-pyrimidin-2,5-diyl; and A is 1,4-phenylene, 1,4-cyclohexylene or a covalent bond.Fluorine-containing pyrimidine compounds are useful components of liquid crystal dielectrics for electro-optical display devices.
    Type: Grant
    Filed: April 8, 1987
    Date of Patent: March 14, 1989
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Joachim Krause, Michael Romer, Ludwig Pohl, Bernhard Scheuble, Georg Weber
  • Patent number: 4806238
    Abstract: The invention relates to a chromatography column consisting of a metal tube which is filled with a sorbent and is provided with distribution elements and sealing elements at both ends. A screw connection for connecting capillaries which consists of at least one support nut attached to the column tube and a union nut are provided. The support nut is supported against two removable collar half-shells and can thus be removed from the column tube when the union nut is unscrewed.
    Type: Grant
    Filed: November 19, 1987
    Date of Patent: February 21, 1989
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Gunther Sattler, Gunter Hauke
  • Patent number: 4806128
    Abstract: A process for preparing pigment dyes comprising reducing a colloidal dispersion of an impure dye to form a solution of the leucobase, introducing into this solution a finely divided substrate and, by adding an oxidizing agent, oxidizing the leucobase to form the vat dye, which thereby precipitates and deposits on the substrate.
    Type: Grant
    Filed: October 10, 1986
    Date of Patent: February 21, 1989
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventor: Juan M. Figueras
  • Patent number: 4805675
    Abstract: A sliding valve for withdrawing liquid or gaseous chemical products from a container has a cylindrical valve spool which slides axially in a bore through a valve housing. A first annular groove of the valve spool connects, in the open position of the valve, a product supply line to a product withdrawal line. On one side of this first annular groove there is a second annular groove which, in the open position, connects a gas supply line to a gas withdrawal line. An annular groove on the other side is connected to the second annular groove. By this arrangement, protective gas is admitted to the valve spaces on either side of the first annular groove, which handles the product, with the result that escape of the product to the outside, or penetration of impurities, are positively prevented.
    Type: Grant
    Filed: June 11, 1986
    Date of Patent: February 21, 1989
    Assignee: Merck Patent Gesellschaft MIT Beschrankter Haftung
    Inventors: Frank Joseph, Helmuth Krauss, Peter Muller, Klaus Kreher
  • Patent number: 4800161
    Abstract: The invention relates to a process for the microbiological preparation of aldose-1-epimerase by cultivating microorganisms in a nutrient medium and release of the enzyme from the cells, which process is characterized in that microorganisms of the genus Acinetobacter are used.
    Type: Grant
    Filed: September 5, 1985
    Date of Patent: January 24, 1989
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Wolfgang Ebeling, Harald Metz, Wolfgang Brummer, Gunter Schmid, Ulrich Behrendt
  • Patent number: 4799774
    Abstract: By suitable choice of the liquid crystal parameters K.sub.3 /K.sub.1 and K.sub.3 /K.sub.2, it becomes possible to achieve a steep electrooptical characteristic line and a maximum contrast with minimum dependence on the viewing angle in electrooptical display elements with a twist angle with a value between 150.degree. and 250.degree..
    Type: Grant
    Filed: November 17, 1987
    Date of Patent: January 24, 1989
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Guter Baur, Bernhard Scheuble, Waltraud Fehrenbach
  • Patent number: 4798627
    Abstract: Dampening agents or dampening agent concentrates for offset printing are disclosed which contain copper ions as corrosion inhibitors. Such dampening agents exhibit virtually no corrosive action on the offset printing machine parts with which they come into contact, in particular the printing cylinders made of nickel metal.
    Type: Grant
    Filed: October 14, 1986
    Date of Patent: January 17, 1989
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Dieter Schmitt, Manfred Urban
  • Patent number: 4797282
    Abstract: A drug depot, which can be implanted in the body, for the controlled, delayed release of cytostatics, comprises a synthetic material based on polyacrylates and/or polymethacrylates containing a cytostatic and at least one amino acid. The depot can be used in a particularly advantageous manner for the local control of tumors.
    Type: Grant
    Filed: April 18, 1986
    Date of Patent: January 10, 1989
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Helmut Wahlig, Elvira Dingeldein
  • Patent number: 4793921
    Abstract: New separation materials for thin layer chromatography are based on carrier materials coated with an adsorbent silica gel layer which has been surface-modified by a silanizing agent after the coating step. The degree of covering of the modifying reagent can be adjusted in a defined an controllable manner, e.g., from 0.15 to 0.8 .mu.mol/m.sup.2 in the case of reversed phase materials and 1.2 to 2.5 .mu.mol/m.sup.2 in the case of hydrophilic materials. A process for the preparation of these separation materials is also provided.
    Type: Grant
    Filed: December 9, 1987
    Date of Patent: December 27, 1988
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Heinz E. Hauck, Willi Jost
  • Patent number: 4788299
    Abstract: New ketolactones of the formula I ##STR1## wherein R.sup.1 is H, alkyl having 1-6 C atoms or aryl having 6-14 C atoms andR.sup.2 and R.sup.3 together are an O atom or together are a bond,and salts thereof,can be used as intermediate products in the preparation of prostaglandin derivatives.
    Type: Grant
    Filed: June 17, 1987
    Date of Patent: November 29, 1988
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventor: Bernhard Riefling
  • Patent number: 4788215
    Abstract: Halogenohydroxyflavones ##STR1## in which R is alkyl having 1-3 C atoms,X is F, Cl, Br or I, andm, n and p are each 1, 2 or 3,and their esters with sulfuric acid and phosphoric acid, and the salts of these compounds, are suitable for the treatment of hyperthyroidism.
    Type: Grant
    Filed: September 18, 1987
    Date of Patent: November 29, 1988
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Josef Kramer, Klaus Irmscher, Helmut Prucher, Rolf-Dieter Hesch
  • Patent number: D299275
    Type: Grant
    Filed: November 26, 1986
    Date of Patent: January 3, 1989
    Assignee: Merck Patent Gesellschaft mit beschraenkter Haftung
    Inventor: Wilhelm Ott