Abstract: An electronic switching device, in particular tunnel junctions, containing an organic molecular layer for use in memory, sensors, field-effect transistors or Josephson junctions. More particularly, related to the field of random access non-volatile memristive memories (RRAM). Another aspect is a compound of formula I for use in a molecular layer. Also, the use of the molecular layer and processes for the production and operation of an electronic switching element and components based thereon.

Abstract: The present invention relates to a liquid crystal (LC) medium comprising a compound of formula I and one or more compounds of formula II as defined in claim 1, and to the use thereof for optical, electro-optical and electronic purposes, in particular in LC displays, especially in IPS, FFS, VA or PS-VA displays.

Abstract: Novel crystalline forms of 4-1(7-chloro-2-methoxybenzo[bll 1,5]naphthyridin-10-yl)aminol-2,6-bis(pyrrolidin-l-%Ilmethyl)phenol and salts thereof are useful, in particular for pharmaceutical formulations. Processes can be used for manufacturing the crystalline forms, and the crystalline forms can be used in methods of treatment.

Abstract: The present invention relates to a liquid crystal (LC) medium comprising a compound of formula I and one or more compounds selected from the group of compounds of the formulae IIA, IIB, IIC and IID, as defined in claim 1, and to the use thereof for optical, electro-optical and electronic purposes, in particular in LC displays, especially in IPS, FFS, VA or PS-VA displays.

Abstract: A steerable antenna having a plurality of radiating elements and a plurality of modifier elements configured for shifting phase and/or adjusting amplitude of a signal to be emitted by the radiating elements is disclosed. Each of the radiating elements is coupled to one of the modifier elements, wherein the modifier elements each comprise a liquid crystalline medium and wherein the modifier elements are configured such that the adjustment of the phase and/or amplitude is dependent on a state of the liquid crystalline medium. The steerable antenna further comprises a signal generator connected to the modifier elements and configured for generating a signal suited for dielectric heating of the liquid crystalline media of the modifier elements. Further aspects relate to a method for heating and/or controlling the temperature of the liquid crystalline medium of such a steerable antenna.

Abstract: The present invention relates to new coating compositions for the preparation of functional surface coatings on various base material substrates. The coating compositions are polysilazane polybutadiene hybrid coating compositions which are based on a silazane polymer and a specific functionalized butadiene polymer. The coating compositions are particularly suitable for the preparation of functional surface coatings on various base material substrates to provide improved physical and/or chemical surface properties.

Abstract: The present application relates to a rack (1) for holding a plurality of petri-dishes (P), comprising a main body (2) with a plurality of adjacent and spaced apart holding portions (3) each configured to receive and support, in a substantially parallel orientation that is substantially perpendicular to a longitudinal direction (X) of the rack (1), a petri-dish (P), wherein each holding portion (3) includes positioning features (4) for positioning the petri-dish (P) in the holding portion (3) and allowing insertion of the petri-dish (P) from a lateral side in a direction substantially perpendicular to the longitudinal direction (X). The holding portions (3) and positioning features (4) respectively comprise a pair of separation elements (11) spaced apart from each other to define therebetween a slot (12) configured to receive the petri-dish (P).

Abstract: B7-H6-based compounds disclosed herein have favorable characteristics. Pharmaceutical compositions containing such a compound, the use of such compounds, and treatment with such pharmaceutical compositions are also disclosed. Methods for preparing a compound with an increased affinity for NKp30 are provided.

Abstract: The tricyclic heterocycles disclosed herein are useful as TEAD binders and/or inhibitors of YAP-TEAD and TAZ-TEAD protein-protein interaction or binding and for the prevention and/or treatment of several medical conditions including hyperproliferative disorders and diseases, in particular cancer.

Abstract: The present invention relates to liquid compositions and formulations comprising a protein having a reduced viscosity and/or increased stability. Furthermore, the invention relates to methods for reducing the viscosity and/or increasing the stability of a protein solution.

Abstract: Substituted amide derivatives are useful for the prevention and/or treatment of several medical conditions including hyperproliferative disorders and diseases.

Abstract: The present invention relates to liquid-crystal (LC) media having negative dielectric anisotropy comprising one or more compounds of formula I and one, two, three or more compounds of formula III as defined in claim 1, and to the use of the LC media for optical, electro-optical and electronic purposes, in particular useful to enable energy-saving LC displays of the VA, IPS or FFS type.

Abstract: The invention relates to a polymerisable LC material comprising at least one di- or multireactive mesogenic compound and at least one compound of formula I, in which the parameter R1, A1, Z1, Z2, n, Sp, P, p1, p2, L1, L2, r1, r2, m and R2 have one of the meanings as given in claim 1. Furthermore, the present invention relates also to a method for the preparation of a polymerisable LC material, a polymer film obtainable from the corresponding polymerisable LC material, to a method of preparation of such polymer film, and to the use of such polymer film and said polymerisable LC material for optical, electro-optical, decorative or security devices.

Abstract: The present invention relates to a radar-compatible coating comprising metal-effect pigments on a substrate, to a process for the production of such a coating, and to the use of a substrate coated in this manner, in particular in vehicle construction.

Abstract: The present invention relates to biomarkers associated with the clinical response to an FGF-18 compound before or during treatment of a cartilage disorder. It relates more particularly to specific proteins present in the blood, serum, synovial fluid or in the urine, which can be used as biomarkers for the diagnosis, pre-treatment of patients and during therapy of cartilage disorders. The invention can be used in predicting the response to an FGF-18 compound treatment, before starting the treatment or during the treatment. It could be used for selecting/identifying subjects to be treated according to specific doses and/or dosing regimens by intra-articular administration of an FGF-18 compound. The use of these biomarkers in diagnostics could result in increased benefit and reduced risk-benefit ratio in subjects.

Abstract: The present invention relates to biomarkers associated with the clinical response to an FGF-18 compound before or during treatment of a cartilage disorder. The present invention more particularly relates to specific proteins present in the blood, serum, synovial fluid or in the urine, which can be used for the diagnosis and treatment of cartilage disorders. The invention further discloses specific proteins that are related to cartilage response to an FGF-18 compound treatment as well as diagnostic tools and kits based on their expression profile. Thus, the invention can be used in predicting the response to an FGF-18 compound treatment, before starting the treatment with FGF-18 or during the treatment. It could be used for selecting/identifying subjects to be treated by intra-articular administration of an FGF-18 compound. The use of these biomarkers in diagnostics could result in increased benefit and reduced risk in subjects.

Abstract: Combinations of (S)-3-Hydroxy-1-(1H-indol-5-yl)-2-oxo-pyrrolidine-3-carboxylic acid 3,5-difluoro-benzylamide and a VEGFR/VEGF inhibitor, or their physiologically acceptable salts are disclosed. Such combination are useful for the prophylaxis or treatment of cancer.

Abstract: The present invention relates to a liquid-crystal (LC) medium comprising polymerizable compounds, to its use for optical, electro-optical and electronic purposes, in particular in LC displays, especially in LC displays of the PSA (polymer sustained alignment) or SA (self-aligning) mode, to an LC display of the PSA or SA mode comprising the LC medium, and to a process of manufacturing the LC display using the LC medium, especially an energy-saving LC display and energy-saving LC display production process.

Abstract: An ATM inhibitor can be used in the treatment of coronavirus infections, including COVID-19, alone or in combination with one or more additional therapeutic agents.

Abstract: The present invention encompasses ATR inhibitor for use in the treatment of virus infections, including SARS-CoV infections such as COVID-19, alone or in combination with one or more additional therapeutic agents.