Patents Assigned to Merck Patent GmbH
  • Patent number: 6143319
    Abstract: An active-substance-containing transdermal therapeutic system for the controlled release of estradiol or its pharmaceutically acceptable derivatives alone or combined with gestagens consisting of a backing layer, an active-substance-containing reservoir which is bonded thereto and produced by using pressure sensitive adhesives, and a removable protective layer is characterized by the fact that the pressure sensitive adhesive comprises esters of colophony.
    Type: Grant
    Filed: October 30, 1997
    Date of Patent: November 7, 2000
    Assignees: LTS Lohmann Therapie-Systeme GmbH, Merck Patent GmbH
    Inventors: Reinhold Meconi, Frank Seibertz, Michael Horstmann, Rainer Lichtenberger
  • Patent number: 6139926
    Abstract: The present invention relates to polyimide photo alignment films for liquid crystal display devices comprising an aromatic tetracarboxylic dianhydride component containing 3,3',4,4'-benzophenone tetracarboxylic dianhydride and an aromatic diamine component containing at least one diamine of the group of formulae AI to AIII as given in the text. Further display devices and methods of their fabrication employing a photo alignment process are disclosed.
    Type: Grant
    Filed: May 21, 1998
    Date of Patent: October 31, 2000
    Assignees: E. I. du Pont de Nemours and Company, Merck Patent GmbH
    Inventors: Brian Carl Auman, Melvin P. Zussman, Bernd Fiebranz, Edgar Bohm
  • Patent number: 6136035
    Abstract: A modular hip joint prosthesis is assembled from a head section having a connection for the ball of the joint and from a shaft section. The shaft section is joined by a insert connection to the head section, and provision is made for fixing the insert connection. The insert connection is situated in the region of Shenton's arc. The respective contours, in longitudinal section, of the head and shaft sections in the region of the connection merge smoothly, without any substantial change in direction, irrespective of the relative mutual alignments of the sections at any given time, with the exception of a gap in the immediate vicinity of the connection.
    Type: Grant
    Filed: July 25, 1997
    Date of Patent: October 24, 2000
    Assignee: Merck Patent GmbH
    Inventors: Gunter Lob, Hans-Joachim Fischer, Gerd Steur, Curt Kranz
  • Patent number: 6060071
    Abstract: Cosmetic preparations for the care of aged, dry or irritated skin are prepared using a compound of the formula Ia or Ib ##STR1##
    Type: Grant
    Filed: October 20, 1997
    Date of Patent: May 9, 2000
    Assignee: Merck Patent GmbH
    Inventors: Lothar Motitschke, Hansjurgen Driller, Erwin Galinski
  • Patent number: 6056894
    Abstract: TN liquid-crystal displays and supertwist liquid-crystal displays (SLCDs) having very short response times and good steepnesses and angle dependencies are obtained by using nematic liquid-crystal mixtures which comprise at least one compound of formula IA ##STR1## and at least one compound of the formula IB ##STR2## in which R.sup.a, R.sup.b, R.sup.c, L and r are as defined herein.
    Type: Grant
    Filed: February 26, 1998
    Date of Patent: May 2, 2000
    Assignee: Merck Patent GmbH
    Inventors: Harald Hirschmann, Clarissa Weller, Volker Reiffenrath
  • Patent number: 6057472
    Abstract: A process for the preparation of a highly pure alkyl 2-cyanoacrylate, wherein alkyl has 1-10 C atoms, characterized in thata) formaldehyde is reacted with an alkyl cyanoacetate ester by means of a catalyst in a solvent mixture selected from the group comprising ethylacetate, diglyme, dichloroethane and benzene, yielding an oligo-(alkyl 2-cyanoacrylate);b) the product of (a) is separated in the form of a solid;c) the product of (b) is depolymerized under sulfur dioxide atmosphere free from other polymerization inhibitors to yield an alkyl 2-cyanoacrylate with a purity of 98-100%
    Type: Grant
    Filed: August 6, 1998
    Date of Patent: May 2, 2000
    Assignee: Merck Patent GmbH
    Inventors: Valerie Sailhan, Rosy Eloy, Louis Giral, Fran.cedilla.ois Schue
  • Patent number: 6042745
    Abstract: The invention relates to an electroptical system which, between 2 electrode layers, contains a PDLC film comprising a liquid crystal mixture forming micro-droplets in an optically isotropic, transparent polymer matrix. The liquid crystal mixture comprises one or more compounds of the formula I ##STR1## wherein Z.sup.1, Z.sup.2, ##STR2## X.sup.1, X.sup.2, Q, Y, n and R are as defined herein. The liquid crystal mixture additionally contains one or more reactive liquid crystalline compounds in order to obtain improved switching times especially at low temperatures.
    Type: Grant
    Filed: January 16, 1998
    Date of Patent: March 28, 2000
    Assignee: Merck Patent GmbH
    Inventors: David Coates, Owain Llyr Parri, Simon Greenfield, Martin David Tillin, Mark John Goulding, Patrick Nolan
  • Patent number: 6037349
    Abstract: Imidazopyridine derivatives ad pharmacologically acceptable salts having antagonistic properties towards angiotensin II can be used for the treatment of hypertension, aldosteronism and cardiac insufficiency.
    Type: Grant
    Filed: January 4, 1999
    Date of Patent: March 14, 2000
    Assignee: Merck Patent GmbH
    Inventors: Werner Mederski, Johannes Sombroek, Pierre Schelling, Norbert Beier, Ingeborg Lues, Klaus-Otto Minck
  • Patent number: 5972098
    Abstract: Single-layer or multilayer titanate-containing pearlescent pigments comprising iron titanate and, if appropriate, titanium oxide and/or iron oxide, which is obtainable by solidification of an aqueous solution of a thermally hydrolysable titanium compound on a continuous belt, detachment of the layer formed, coating of the resulting titanium dioxide platelets, after or without intermediate drying, with iron oxide in a wet process, and drying and calcining of the resulting material in an oxidizing or reducing gas atmosphere at not less than 500.degree. C., the layer thicknesses of the titanium dioxide layer and iron dioxide layer being adjusted such that either the stoichiometric ratio between iron oxide and titanium dioxide necessary for the formation of pseudo-brookite or ilmenite is obtained or an excess of iron oxide or titanium dioxide is present.
    Type: Grant
    Filed: January 9, 1998
    Date of Patent: October 26, 1999
    Assignee: Merck Patent GmbH
    Inventors: Stefanie Andes, Sabine Hock, Gunter Brenner, Dieter Bruckner, Andrea Heyland, Matthias Kuntz, Karl Osterried, Gerhard Pfaff, Michael Schmelz
  • Patent number: 5888206
    Abstract: A joint prosthesis includes a shaft part insertable into a tubular bone and a head part joining the shaft part and including a joint connection element. The head part includes a sleeve region having a through bore adapted to a cross section of a shaft of the joint connection element. The longitudinal axis of the shaft part and the joint connection element form an obtuse angle when the joint connection element is introduced into the through bore of the head part.
    Type: Grant
    Filed: August 6, 1997
    Date of Patent: March 30, 1999
    Assignee: Merck Patent GmbH
    Inventors: Gunter Lob, Hans-Joachim Fischer, Gerd Steur, Curt Kranz
  • Patent number: 5856432
    Abstract: A polyimide alignment film based on pyromellitic dianhydride and a bis(4-aminophenoxy) aromatic compound, such as 1,3-bis(4-aminophenoxy)benzene or 1,4-bis(4-aminophenoxy)benzene, providing low tilt angles of from 1 to 2 degrees when used in liquid crystal displays.
    Type: Grant
    Filed: November 20, 1997
    Date of Patent: January 5, 1999
    Assignees: E. I. duPont de Nemours and Company, Merck Patent GmbH
    Inventors: Brian Carl Auman, Edgar Bohm
  • Patent number: 5840308
    Abstract: Antiviral and antifungal compositions comprising a mixture of a ferrous salt and a plant extract of pomegranate rind, Viburnum plicatum leaves or flowers, tea leaves, or maple leaves in an aqueous solution are disclosed. The compositions are mainly used to prevent the growth of, or kill, viruses or fungi on surfaces. The compositions do not substantially affect bacterial viability as measured by colony forming ability.
    Type: Grant
    Filed: September 17, 1996
    Date of Patent: November 24, 1998
    Assignee: Merck Patent GmbH
    Inventors: Sabah Abdel Amir Jassim, Stephen Paul Denyer, Gordon Sydney Anderson Birnie Stewart
  • Patent number: 5827678
    Abstract: The invention is directed to an assay reagent comprising bacteria cells which have been killed but which retain a functional metabolic activity. The assay reagent is useful in a method for assaying an analyte when the functional metabolic activity of the killed cells is signal-generating. A kit for assaying an analyte using the assay reagent of the invention is also provided.
    Type: Grant
    Filed: July 9, 1996
    Date of Patent: October 27, 1998
    Assignee: Merck Patent GmbH
    Inventors: Ian Philip Hesslewood, Gordon Sydney Anderson Birnie Stewart
  • Patent number: 5776926
    Abstract: The invention relates to compositions in the form of cefixime-containing non-aqueous suspensions which have syrup-like characteristics, characterized in that they are free of thickening ancillary substances and contain a microfine powder of bulking agent with a particle size distribution with at least 80% by weight having a maximum diameter of 32 .mu.m and a maximum of 5% by weight having a diameter larger than 50 .mu.m, are very easily redispersible and are chemically stable.
    Type: Grant
    Filed: March 3, 1997
    Date of Patent: July 7, 1998
    Assignee: Merck Patent GmbH
    Inventors: Joachim Bolz, Gertraud Wagner, Eckhard Oelrich, Dirk Radtke
  • Patent number: 5759442
    Abstract: A polyimide alignment film based on 2,2-bis(3,4-dicarboxyphenyl)hexafluoropropane dianhydride and ortho-substituted aromatic diamines, such as 2,3,5,6-tetramethyl-p-phenylene diamine, 2,4,6-trimethyl-m-phenylene diamine and 1,5-diaminonaphthalene, providing high voltage holding ratio and high tilt angle when used in active matrix liquid crystal displays.
    Type: Grant
    Filed: March 7, 1997
    Date of Patent: June 2, 1998
    Assignees: E. I. du Pont de Nemours and Company, Merck Patent GmbH
    Inventors: Brian Carl Auman, Edgar Bohm, Bernd Fiebranz
  • Patent number: 5731404
    Abstract: A polyimide alignment film based on pyromellitic dianhydride and a bis(4-aminophenoxy) aromatic compound, such as 1,3-bis(4-aminophenoxy)benzene or 1,4-bis(4-aminophenoxy)benzene, providing low tilt angles of from to 2 degrees when used in liquid crystal displays.
    Type: Grant
    Filed: November 1, 1995
    Date of Patent: March 24, 1998
    Assignees: E. I. du Pont de Nemours and Company, Merck Patent GmbH
    Inventors: Brian Carl Auman, Edgar Bohm
  • Patent number: 5723330
    Abstract: A method for testing for target bacteria involves adding bacteriophage to a sample to infect the bacteria in the sample; killing extracellular bacteriophage without killing phage-infected bacteria; amplifying bacteriophage remaining in the sample; and causing the bacteriophage to infect reporter bacteria and thereby produce an observable signal. The reporter bacteria are genetically engineered to have an indicator gene which on expression gives rise to a detectable signal, wherein expression of the indicator gene is initiated on bacteriophage infection of the bacteria.
    Type: Grant
    Filed: December 19, 1995
    Date of Patent: March 3, 1998
    Assignee: Merck Patent GmbH
    Inventors: Catherine Elizabeth Dunn Rees, Katalin Rostas-Mulligan, Simon Fearon Park, Stephen Paul Denyer, Gordon Sydney Anderson Birnie Stewart, Sabah Abdel Amir Jassim
  • Patent number: 5587360
    Abstract: The inhibitor is protein derived leech tissue or leech secretions (for example, from Hirudo medicinalis), which is capable of binding to native collagen, in such a way that substantially no cleavage breakdown products of coilagen molecules occur on SDS-PAGE. The protein substantially inhibits collagen-induced platelet aggregation or adhesion, has a molecular weight of 60-70 kilodaltons in reduced form and has optimum activity at pH 8.0.
    Type: Grant
    Filed: April 9, 1993
    Date of Patent: December 24, 1996
    Assignee: Merck Patent GmbH
    Inventor: Roy T. Sawyer
  • Patent number: 5558986
    Abstract: A method of preparing an extract of an intracellular component, wherein cells are contacted with an extractant to generate an extract solution, which comprises contacting the solution with a cyclodextrin to neutralize the extractant. preferred extractants are cationic or other kinds of surfactants. The cyclodextrin is preferably used in solution. Preferred intracellular components are ATP which can, after neutralization of the extractant, be assayed by a firefly luciferase assay; and DNA or RNA which can, after neutralization of the surfactant, be amplified or further processed in other ways.
    Type: Grant
    Filed: November 23, 1994
    Date of Patent: September 24, 1996
    Assignee: Merck Patent GmbH
    Inventor: Arne Lundin
  • Patent number: RE36849
    Abstract: Anisotropic compounds of the formula (1) specified in claim 1 are suitable, owing to their low .DELTA..epsilon./.epsilon..perp. values for liquid crystal displays which have high information densities of for examples up to 10.sup.6 image dots and accordingly need to be highly multiplexible; compared with known compounds they offer improved application properties and are relatively simple to synthesize.
    Type: Grant
    Filed: April 1, 1993
    Date of Patent: September 5, 2000
    Assignee: Merck Patent GmbH
    Inventors: Hans P. Schad, Stephen M. Kelly, Eike Poetsch, Reinhard Hittich, Georg Weber