Abstract: The present invention relates to compounds of the formula (I) and in particular medicaments comprising at least one compound of the formula (I) for use in the treatment and/or prophylaxis of physiological and/or pathophysiological states in the triggering of which cathepsin D is involved, in particular for use in the treatment and/or prophylaxis of arthrosis, traumatic cartilage injuries, arthritis, pain, allodynia or hyperalgesia.
Type:
Application
Filed:
February 11, 2016
Publication date:
August 11, 2016
Applicant:
Merck Patent GmbH
Inventors:
Markus KLEIN, Christos TSAKLAKIDIS, Hans GUEHRING, Brigitta LEUTHNER
Abstract: Disclosed are compounds of formula I the use of compounds of formula I in liquid crystal media and in particular to flexoelectric liquid crystal devices containing the liquid crystal media.
Abstract: Compounds of the formula I in which R1 and R2 have the meanings indicated in Claim 1, are inhibitors of GCN2, and can be employed, inter alia, for the treatment of cancer.
Type:
Grant
Filed:
December 21, 2012
Date of Patent:
August 9, 2016
Assignee:
Merck Patent GmbH
Inventors:
Dieter Dorsch, Guenter Hoelzemann, Kai Schiemann, Ansgar Wegener
Abstract: The present invention relates to coordination compounds which are used in an electron-transport layer in electronic devices, to ligands, and to the use thereof for the preparation of metal complexes, to a layer, and to an electronic device which comprise the compounds according to the invention, and to a process for the preparation of the compounds according to the invention.
Type:
Grant
Filed:
December 28, 2010
Date of Patent:
August 9, 2016
Assignee:
Merck Patent GmbH
Inventors:
Arne Buesing, Holger Heil, Teresa Mujica-Fernaud, Irina Martynova
Abstract: The present invention relates to intermediate compounds for the preparation of hydrido-tricyano-borate anions, their preparation and their uses.
Type:
Grant
Filed:
February 19, 2016
Date of Patent:
August 9, 2016
Assignee:
Merck Patent GmbH
Inventors:
Nikolai (Mykola) Ignatyev, Michael Schulte, Kentaro Kawata, Tomohisa Goto, Eduard Bernhardt, Vera Bernhardt-Pitchougina, Helge Willner
Abstract: Novel benzamide derivatives of formula (I) wherein W1, W2, R1 to R10 and X have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.
Type:
Grant
Filed:
January 9, 2013
Date of Patent:
August 9, 2016
Assignee:
Merck Patent GmbH
Inventors:
Henry Yu, Thomas E. Richardson, Pandi Bharathi, Brian H. Heasley, Matthew G. Jenks, Robert J. Foglesong
Abstract: The invention relates to bimesogenic compounds of formula I wherein R11, R12, CG1, MG1, X11, X12 and Sp1 have the meaning given in claim 1, to the use of mesogenic compounds of formula I in liquid crystal media and particular to flexoelectric liquid crystal devices comprising a liquid crystal medium according to the present invention.
Type:
Application
Filed:
August 13, 2014
Publication date:
August 4, 2016
Applicant:
MERCK PATENT GMBH
Inventors:
Kevin ADLEM, Owain Llyr PARRI, Rachel TUFFIN, Patricia Eileen SAXTON, Mariam NAMUTEBI, Benjamin SNOW
Abstract: The present invention relates to interference pigments based on transparent, low-refractive-index, flake-form substrates which have a high-refractive-index coating consisting of TiO2 having a layer thickness of 20-200 nm and optionally an outer protective layer, and to the use thereof in paints, coatings, printing inks, security printing inks, plastics, button pastes, ceramic materials, glasses, for seed coloring, as dopants in the laser marking of plastics and papers, as additive for the laser welding of plastics, as additive for coloring in the foods and pharmaceuticals sectors, and in cosmetic formulations and for the preparation of pigment compositions and dry preparations.
Type:
Application
Filed:
March 31, 2016
Publication date:
August 4, 2016
Applicant:
Merck Patent GmbH
Inventors:
Christoph SCHMIDT, Tanja DELP, Sabine SCHOEN
Abstract: The invention relates to an organic electroluminescent device (OLED) containing an emitting layer which contains a compound having a small difference between the S1 and the T1 energy levels and to another compound of formula (I) or (II).
Type:
Application
Filed:
August 13, 2014
Publication date:
August 4, 2016
Applicant:
Merck Patent GmbH
Inventors:
Amir Hossain Parham, Philipp Stoessel, Christof Pflumm, Anja Jatsch, Joachim Kaiser
Abstract: The present invention relates to semiconducting pigments based on flake-form substrates which have a doped tin dioxide layer on the surface and to the use of the pigments in paints, coatings, printing inks, plastics, security applications, floorcoverings, films, formulations, ceramic materials, glasses, paper, for laser marking, in thermal protection, in dry preparations, in pigment preparations and in particular as varistor pigment.
Abstract: Compounds selected from the group according to claim 1 are inhibitors of tyrosine kinases, in particular of Met kinase, and can be employed, inter alia, for the treatment of tumors.
Type:
Grant
Filed:
January 22, 2015
Date of Patent:
August 2, 2016
Assignee:
MERCK PATENT GMBH
Inventors:
Oliver Schadt, Dieter Dorsch, Frank Stieber, Andree Blaukat
Abstract: The present invention relates to the use of aromatic boronic acid or borinic acid derivatives in organic electronic devices, in particular electroluminescent devices.
Type:
Grant
Filed:
January 14, 2014
Date of Patent:
August 2, 2016
Assignee:
Merck Patent GmbH
Inventors:
Philipp Stoessel, Esther Breuning, Arne Buesing, Amir Hossain Parham, Holger Heil, Horst Vestweber
Abstract: The invention relates to a polymer film comprising a polymerised liquid crystal (LC) material with improved adhesion to a substrate, to methods for preparing such a polymer film, to a polymerisable LC material used for the preparation of such a polymer film, and to the use of the polymer film and said polymerisable LC material for optical, electrooptical, decorative or security uses and devices.
Abstract: The present invention relates to a novel process for the preparation of printable, low-viscosity oxide media, and to the use thereof in the production of solar cells.
Type:
Application
Filed:
December 18, 2013
Publication date:
July 28, 2016
Applicant:
MERCK PATENT GMBH
Inventors:
Ingo KOEHLER, Oliver DOLL, Sebastian BARTH
Abstract: A filter device (1) for filtering complex fluid samples, comprising a first filter funnel (2) having an inlet (2a) an outlet (2b) and a first internal space (2c) and a second filter funnel (3) having an inlet (3a), an outlet (3b) and a second internal space (3c). The first and second filter funnels (2,3) are sequentially arranged with a first filter medium (4) located therebetween such that the volume of sample fluid placed in the first internal space (2c) can pass through the first filter medium (4) and be collected in the second internal space (3c). An intermediate connector (12) provided downstream of the first filter medium (4) and upstream of the internal space (3c) has a port (13) and/or a vent for communicating the internal second space (3c) with an external gas source/atmosphere and/or a vacuum source via a valve arrangement (14).
Abstract: Disclosed are a liquid crystal (LC) medium containing a polymerisable compound, a process for its preparation, its use for optical, electro-optical and electronic purposes, in particular in LC displays, especially in an LC display of the polymer sustained alignment (PSA) type, and to an LC display, especially a PSA display.
Abstract: The present invention relates to quinoline compounds, and pharmaceutically acceptable compositions thereof, useful as antagonists of P2X7, and for the treatment of P2X7-related disorders.
Type:
Grant
Filed:
June 4, 2015
Date of Patent:
July 26, 2016
Assignee:
Merck Patent GmbH
Inventors:
Srinivasa R. Karra, Yufang Xiao, Jeyaprakashnarayanan Seenisamy, Jayashankaran Jayadevan
Abstract: The present invention relates dry granulated cell culture media which do not comprise peptones or tryptones, especially to dry granulated cell culture media formulations that support the growth of mammalian, and/or insect and/or plant cells. The present invention further relates to the production of these dry granulated cell culture media and their use.
Type:
Grant
Filed:
November 18, 2011
Date of Patent:
July 26, 2016
Assignee:
MERCK PATENT GMBH
Inventors:
Michael Howard Rayner-Brandes, Xiaojian (David) Zhao
Abstract: The invention relates to a method for producing alkali metal salts having monofluoro-tricyanoborate anions from alkali metal tetrafluoroborates.
Type:
Grant
Filed:
June 6, 2014
Date of Patent:
July 26, 2016
Assignee:
Merck Patent GmbH
Inventors:
Nikolai (Mykola) Ignatyev, Jan Arke Peter Spenger, Johannes Landmann, Maik Finze
Abstract: A method of producing mixtures of interference pigments having special effects comprises mixing at least one large particle size interference pigment with at least one normal size interference pigment of predetermined colors and in proportions desired to obtain a unique effect.