Abstract: The present disclosure relates to methods of releasing a target molecule from intein complexes comprising an intein-C tagged target molecule and intein-N polypeptides, by contacting the intein complexes with nitrogen containing heteroaromatic derivatives, and/or by increasing residence time of intein complexes in a medium effective to remove the target molecule. Modulating the pH further facilitates target release.
Abstract: The present application relates to a transport packaging (20) for a plurality of petri-dishes (P), comprising a shell-like main body (21) with a compartment (22) for holding the plurality of petri-dishes (P) in a parallel orientation, the compartment (22) being accessible from an opening (23) at one side of the main body (21), and a rack-like structure (24) formed in the compartment (22) for supporting the petri-dishes (P) in a fixed position during handling and configured to allow insertion/extraction of the petri-dishes (P) into/from the rack-like structure (24) in a direction.
Type:
Application
Filed:
October 20, 2021
Publication date:
December 7, 2023
Applicant:
MERCK PATENT GMBH
Inventors:
Philippe RIVAT, Mathieu ARRAULT, Francois OBLINGER, Stéphane OLIVIER, Gael WAICHE
Abstract: The present application relates to a rack (1) for holding a plurality of petri-dishes (P), comprising a plate-like main body (2) with a plurality of adjacent and spaced apart holding portions (3) each configured to receive and support, in a substantially horizontal orientation that is substantially perpendicular to a plane of the plate-like main body (2), a petri-dish (P), wherein each holding portion (3) includes positioning features (4) for positioning the petri-dish (P) in the holding portion (3).
Abstract: The present invention relates to a compound of formula T as defined in claim 1, to a liquid crystal medium comprising a compound of formula T and to high-frequency components comprising these media, especially microwave components for high-frequency devices, such as devices for shifting the phase of microwaves, tunable filters, tunable metamaterial structures, and electronic beam steering antennas, e.g. phased array antennas.
Type:
Application
Filed:
October 25, 2021
Publication date:
December 7, 2023
Applicant:
MERCK PATENT GMBH
Inventors:
Amir Hossain PARHAM, Constanze BROCKE, Carsten FRITZSCH, Dagmar KLASS
Abstract: The present application relates to a transfer device (60) for transferring a plurality of objects (O) through a transfer port (R), comprising a container (61) with an internal space (67) configured to accommodate the plurality of objects (O) to be transferred through the transfer port (R). The container (61) has at least one extraction opening (62) at an end portion of the container (61) in an axial direction (X) dimensioned such that the objects (O) can be removed from the container (61) at least individually, a door (63) configured to selectively close the at least one extraction opening (62) and seal the internal space (67) from the environment, and a piston (64) arranged in the container (61) so as to be movable in a translational motion in the axial direction (X) towards/away from the at least one extraction opening (62) to move the objects (O) accommodated in the container (61).
Abstract: The application relates to a cartridge for a plurality of petri-dishes, comprising a cylindrical cartridge housing configured to receive the plurality of petri-dishes in a stack aligned with an axial direction of the cartridge housing in an interior space of the cartridge housing such that the stack of petri-dishes can be moved in the axial direction within the interior space. An axial end portion of the cartridge housing has a first opening dimensioned so that the petri-dishes can be exposed from the cartridge housing by sliding in the axial direction. Another axial end portion of the cartridge housing has a second opening dimensioned to prevent removal of the petri-dishes through the second opening and so that a piston can be inserted into the interior space of the cartridge housing for moving the stack of petri-dishes (P) in the axial direction towards the first opening.
Abstract: The present invention relates to a compound of formula UI as defined in claim 1, to a liquid crystal medium comprising a compound of formula UI and to high-frequency components comprising these media, especially microwave components for high-frequency devices, such as devices for shifting the phase of microwaves, tunable filters, tunable metamaterial structures, and electronic beam steering antennas, e.g. phased array antennas.
Abstract: A liquid-crystal (LC) medium based on a mixture of polar compounds, its use for optical, electro-optical and electronic purposes, in particular in LC displays, especially in LC displays of the vertically aligned mode, to an LC display of the vertically aligned mode containing the LC medium, especially an energy-saving LC display and a process of manufacturing the LC display.
Type:
Application
Filed:
June 1, 2023
Publication date:
December 7, 2023
Applicant:
MERCK PATENT GMBH
Inventors:
Harald HIRSCHMANN, Sabine SCHOEN, Philipp WUCHER
Abstract: The present invention relates to pharmaceutical compositions using polymers as an excipient. Particularly, the invention relates to a pharmaceutical composition comprising polyvinyl alcohol which is suitable to enhance solubility of poorly soluble active pharmaceutical ingredients in aqueous media. The present invention also relates to a method for enhancing solubility of poorly soluble active pharmaceutical ingredients.
Type:
Application
Filed:
October 27, 2021
Publication date:
December 7, 2023
Applicant:
Merck Patent GmbH
Inventors:
Thomas KIPPING, Finn BAUER, Nicole DI GALLO, Anja-Nadine KNUETTEL, Alessandro Giuseppe ELIA
Abstract: Aromatic isothiocyanates of formula C liquid-crystalline media comprising one or more compounds of formula C, and high-frequency components comprising these media, especially microwave components for high-frequency devices, such as devices for shifting the phase of microwaves, tunable filters, tunable metamaterial structures, and electronic beam steering antennas, e.g. phased array antennas.
Abstract: The present invention relates to a polymerizable mixture which can be used to form a dielectric material for the preparation of passivation layers in electronic devices. The polymerizable mixture comprises a first monomer and a second monomer which may react to form a copolymer providing excellent film forming capability, excellent thermal properties and excellent mechanical properties. There is further provided a method for forming said copolymers and an electronic device containing said copolymers as dielectric material. Beyond that, the present invention relates to a manufacturing method for preparing a packaged microelectronic structure and to a microelectronic device comprising said packaged microelectronic structure formed by said manufacturing method.
Type:
Grant
Filed:
October 15, 2019
Date of Patent:
December 5, 2023
Assignee:
Merck Patent GmbH
Inventors:
Gregor Larbig, Pawel Miskiewicz, Frank Meyer, Joerg Pahnke, Karsten Koppe
Abstract: A liquid-crystal (LC) medium which is based on a mixture of polar compounds and is substantially dielectrically neutral, its use for optical, electro-optical and electronic purposes, in particular as optical retarder or optical compensator in LC displays, an optical retarder or optical compensator containing the LC medium, an optical, electrooptical or electronic device containing the optical retarder or optical compensator, and a process of manufacturing the optical retarder or optical compensator.
Type:
Application
Filed:
May 23, 2023
Publication date:
November 30, 2023
Applicant:
Merck Patent GmbH
Inventors:
Sven Christian LAUT, Tzu-Huan TSENG, Kuang-Ting CHOU, Chi-Shun HUANG
Abstract: The present invention relates to the use of poloxamers as cell culture media additives. The poloxamers are suitable for foam reduction as well as for shear protection.
Type:
Application
Filed:
October 20, 2021
Publication date:
November 30, 2023
Applicant:
MERCK PATENT GMBH
Inventors:
Alice ANTONELLO, Melanie FEIGENSPAN, Almut RAPP, Christian SCHULTHEISS, Jochen Bastian SIECK
Abstract: The present application relates to triarylamine compounds of a defined formula. The present application further relates to processes for preparing the compounds, to the use of the compounds in electronic devices, and to electronic devices comprising the compounds.
Type:
Grant
Filed:
November 20, 2018
Date of Patent:
November 28, 2023
Assignee:
MERCK PATENT GMBH
Inventors:
Christian Wirges, Teresa Mujica-Fernaud, Elvira Montenegro, Frank Voges, Florian Maier-Flaig, Thomas Eberle
Abstract: The present invention relates to surface-modified silica particles comprising an alkoxy organosilane and to compositions comprising such particles as well as to uses of such surface-modified silica particles and compositions comprising such particles.
Abstract: The present invention relates to a method for producing purified water comprising a step of passing water through a mixed bed ion exchanger comprising beads having a diameter of less than 0.5 mm, as well as to a module comprising an ultrafiltration means and a mixed bed ion exchanger as defined above and a water treatment system for producing ultrapure water comprising ultrafiltration means and a mixed bed ion exchanger as defined above, wherein the ultrafiltration means is located upstream of said mixed bed ion exchanger.
Abstract: The present invention relates to interference pigments based on platelet-shaped substrates which are coated with at least four high refractive layers and to the use thereof, inter alia in paints, coatings, printings inks, plastics and in particular in cosmetic formulations. The interference pigments show a moderate chroma and can be used as effect pigments, as filler pigments and as protection agent against near infrared radiation, VIS and high energy light.
Type:
Grant
Filed:
March 14, 2018
Date of Patent:
November 21, 2023
Assignee:
Merck Patent GmbH
Inventors:
Michael Termer, Jutta Zur Lage, Anett Moschner, Lilia Heider
Abstract: A polymerisable LC material comprising at least one di- or multireactive mesogenic compound and at least one compound of formula CO-1, wherein R1, R2, L1, L2, L3, and n have the meanings as given in claim 1. Furthermore, a method for preparation of the LC material, a polymer film with improved thermal durability obtainable from the corresponding polymerisable LC material, a method of preparation of such polymer film, and the use of such polymer film and said polymerisable LC material for optical, electro-optical, decorative or security devices.
Abstract: Describe herein is a composition comprising: an acrylic polymer comprising repeat units selected from ones having structure (1), (2), (3), (4), (5), (6), and (7) wherein these repeat units are present in said acrylic polymer in the mole % ranges as described herein; a Novolak resin having a dissolution rate in 0.26 N aqueous TMAH of at least 50 ?/sec; a diazonaphthoquinone (DNQ) photoactive compound (PAC); and an organic spin casting solvent, and a process of using said composition as a positive photoresist developable in aqueous base.
Type:
Grant
Filed:
November 12, 2020
Date of Patent:
November 21, 2023
Assignee:
Merck Patent GmbH
Inventors:
Weihong Liu, Ping-Hung Lu, Chunwei Chen, Medhat A. Toukhy