Abstract: The present invention relates to a solid pharmaceutical preparation of of 8-(1,3-Dimethyl-1 H-pyrazol-4-yl)-1-(Sa)-(3-fluoro-5-methoxy-pyridin-4-yl)-7-methoxy-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one, as well as a method of making same, as well as medical uses thereof.
Type:
Application
Filed:
September 15, 2021
Publication date:
October 19, 2023
Applicant:
MERCK PATENT GMBH
Inventors:
Alessandra AMBRUOSI, Riccardo MANNINI, Markus RIEHL, Axel BECKER
Abstract: Liquid-crystalline media containing one or more mesogenic compounds, one or more chiral compounds, and one or more polymerizable mesogenic compounds, wherein the media exhibit a pitch of 0.55 ?m or more and a clearing point of 80° C. or more and wherein the one or more polymerizable mesogenic compounds are contained in an amount, based on the overall contents of the media, of 5% by weight or less, are suitable as modulation materials. Such modulation materials can be used in switching layers and window elements.
Type:
Grant
Filed:
December 3, 2018
Date of Patent:
October 17, 2023
Assignee:
MERCK PATENT GMBH
Inventors:
Paul Verbunt, Ties De Jong, Michael Junge, Mila Fischer
Abstract: A connecting mechanism (1) for a cartridge-type replaceable module (2) that has at least one fluid port (2a,2b) at each of opposite sides of the module (2) in a longitudinal direction of the module (2). The connecting mechanism (1) comprises two connector elements (3) spaced apart in the longitudinal direction of the module (2) and each provided with at least one fluid connector (3b) configured to releasably inter-engage with a complementary fluid port (2a,2b) of the module (2) at the respective side thereof, wherein at least one of the connector elements (3) is movable to perform a translational movement in the longitudinal direction of the module (2).
Type:
Grant
Filed:
April 28, 2021
Date of Patent:
October 17, 2023
Assignee:
Merck Patent GmbH
Inventors:
Pascal Roitel, Germain Gaydier, Thierry Cassou, Christian Berducat
Abstract: The present invention relates to liquid-crystal (LC) media as defined in claim 1, having negative dielectric anisotropy and to the use thereof for optical, electro-optical and electronic purposes, in particular in LC displays.
Abstract: A method can treat a patient suffering from at least one of fibrosis and a fibrotic disorder. The method includes administering a therapeutically effective amount of an anti-?v integrin antibody DI17E6, or a biologically active variant or modification thereof, to the patient.
Abstract: The present invention relates to a liquid-crystal material (LC media) comprising thiophene derivatives which are stabilised by sterically hindered amines or amine derivatives (HALS, hindered amine light stabilisers), and to liquid-crystal displays (LC displays) which contain these LC materials.
Type:
Application
Filed:
April 11, 2023
Publication date:
October 12, 2023
Applicant:
MERCK PATENT GMBH
Inventors:
Atsutaka MANABE, Rocco FORTTE, Harald HIRSCHMANN
Abstract: The present invention provides a calibration device for an optical detector comprising a light emitting diode 1, and an electronic circuit 3 for driving the light emitting diode 1, wherein the electronic circuit 3 is a constant current generator configured to supply a constant driving current to the light emitting diode 1 in the range of 0.5 to 25 ?A. Furthermore, the present invention provides a setting device for setting at least one calibration point for a calibration device as described above. The setting device comprises a light detector 51 configured to output a signal representing the light emission intensity of a calibration device under examination, a controller 53 for controlling the constant driving current of the calibration device under examination, and a calibration point setting means 55 for setting at least one calibration point for the calibration device under examination.
Type:
Grant
Filed:
May 29, 2019
Date of Patent:
October 10, 2023
Assignee:
MERCK PATENT GmbH
Inventors:
Fabrice Comini, Frederick G. Bargoot, Victor Etre
Abstract: The present invention relates to an LC medium comprising and a liquid-crystalline host consisting of an LC component H) comprising one or more mesogenic or liquid-crystalline compounds and an optically active component D) and optionally a polymerizable component P) comprising one or more polymerizable compounds; and to the use of the polymerizable compounds and LC media for optical, electro-optical and electronic purposes, in particular in LC displays, especially in LC displays of the polymer sustained alignment type.
Abstract: The present invention relates to a device and processes for producing liquid media for cell cultures, whereby the liquid media are produced automatically by dissolving ingredients in water. The present invention also relates to a device for producing media used in cell cultures or a substance produced by cell cultures using a bioreactor process.
Type:
Application
Filed:
July 5, 2021
Publication date:
October 5, 2023
Applicant:
Merck Patent GmbH
Inventors:
Jochen Bastian SIECK, Christian SCHULTHEISS
Abstract: The present application relates to biotechnological fluid treating, such as biopharmaceutical liquids in order to obtain products such as monoclonal antibodies, vaccines or recombinant proteins, and particularly to a system for treating a biotechnical fluid, having a bioprocess machine and at least one bioprocess machine helper, configured to connect to each other and each comprising a controller, in turn comprising a machine-to-machine communication tool configured for connecting to a network.
Type:
Application
Filed:
August 19, 2021
Publication date:
October 5, 2023
Applicant:
MERCK PATENT GMBH
Inventors:
Rene REINBIGLER, Denis DUBRET, Steve MILLER
Abstract: The present invention relates to immunoglobulins that specifically bind Aggrecan and more in particular to polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the immunoglobulins of the present invention inhibit the activity of Aggrecan.
Type:
Application
Filed:
December 23, 2022
Publication date:
October 5, 2023
Applicants:
Ablynx N.V., Merck Patent GmbH
Inventors:
Soren Steffensen, Gerald Beste, Guy Hermans, Hans Gühring, Christoph Ladel, Lars Toleikis
Abstract: The present invention relates to an optical component comprising a liquid crystal (LC) medium, operable in the infrared region of the electromagnetic spectrum. The invention further relates to the use of said LC medium in the infrared (IR) region and to devices comprising said optical component. The present invention further relates to an LC medium comprising one or more compounds of the formulae I, II, and III in which the occurring groups and parameters have the meanings defined in claim 1, and preferably one or more compounds of the formula RO in which the occurring groups and parameters have the meanings defined in claim 2.
Type:
Application
Filed:
July 6, 2021
Publication date:
October 5, 2023
Applicant:
Merck Patent GmbH
Inventors:
Izumi SAITO, Owain Llyr PARRI, Andreas TAUGERBECK, Carsten FRITZSCH, Dagmar KLASS
Abstract: The present invention relates to a composition comprising a bipolar host and an electron-transporting host, especially for use as matrix material in electronic devices, especially organic electroluminescent devices, and especially in an organic light-emitting diode (OLED). The invention further relates to electronic devices comprising said composition.
Type:
Grant
Filed:
April 10, 2018
Date of Patent:
October 3, 2023
Assignee:
Merck Patent GmbH
Inventors:
Amir Parham, Jonas Kroeber, Christian Eickhoff, Tobias Grossmann, Aurélie Ludemann, Dominik Joosten
Abstract: The present disclosure relates to amino acid sequences that are directed against (as defined herein) any of IL-17A, IL-17F and/or IL-17A/F including combinations thereof, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences.
Type:
Grant
Filed:
September 29, 2020
Date of Patent:
October 3, 2023
Assignee:
Merck Patent GmbH
Inventors:
Heidi Rommelaere, Joost Alexander Kolkman, Michael John Scott Saunders, Ann Union, Yolande Chvatchko, Amanda E. I. Proudfoot, Alain Vicari, Denis Bruniquel, Laurent Chevalet, Olivier Leger
Abstract: The present invention relates to effect pigments which are based on flake-form substrates having a circular form factor of 1.2-2 and are coated with at least one high-refractive-index layer, and to the use thereof, inter alia in paints, coatings, printing inks, plastics and in cosmetic formulations.
Type:
Grant
Filed:
July 6, 2020
Date of Patent:
October 3, 2023
Assignee:
MERCK PATENT GMBH
Inventors:
Gerhard Pfaff, Stephanie Andes, Klaus Ambrosius, Ralf Petry, Michael Roesler, Sabine Schoen
Abstract: The present invention encompasses ATR inhibitor for use in the treatment of coronavirus infections, including COVID-19, alone or in combination with one or more additional therapeutic agents.