Abstract: Effect pigments based on Al2O3 flakes with high weather resistance and less photoactivity and to their use thereof in paints, industrial coatings, automotive coatings, printing inks, cosmetic formulations. The effect pigments have a ratio of the amount by weight of Al2O3 of the Al2O3 flake and the amount by weight of the metal oxide(s) of the coating layer(s) in the range of from 27:73 to 83:17 based on the total weight of the effect pigment.
Type:
Application
Filed:
December 18, 2019
Publication date:
April 23, 2020
Applicant:
Merck Patent GmbH
Inventors:
Sabine SCHOEN, Michael JUNGNITZ, Stefan SCHLUETER, Kirsten FRITSCHE, Carsten PLUEG, Stephanie ANDES, Ulrich SCHOENEFELD
Abstract: Methods of treatment of colorectal cancer can include the administration of the anti-alpha-v integrin (receptor) antibody Abituzumab. Preferably, the methods of treating colorectal cancer can include treating Stage II-IV colorectal cancer, metastatic colorectal cancer, left-sided colorectal cancer and/or left-sided metastatic colorectal cancer, involving the administration of said Abituzumab to patients in need thereof. Abituzumab is also useful for the manufacture of a medicament for treating colorectal cancer, preferably colorectal cancer as defined herein. Abituzumab is further useful for the manufacture of a medicament for treating colorectal cancer in combination with suitable targeted therapy concepts, such as growth factor or growth factor receptor targeting monoclonal antibodies, and/or chemotherapy.
Type:
Application
Filed:
October 18, 2019
Publication date:
April 23, 2020
Applicant:
Merck Patent GmbH
Inventors:
Giorgio MASSIMINI, Ilhan Celik, Josef Straub, Rolf Bruns
Abstract: An anhydrous disordered crystalline (S)-[2-chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(6-methoxy-pyridazin-3-yl)-methanol can be used in pharmaceutical compositions.
Type:
Application
Filed:
March 28, 2018
Publication date:
April 23, 2020
Applicant:
Merck Patent GmbH
Inventors:
Michael Lange, Clemens Kuehn, Thomas Fuchss, David Maillard, Marcel Breuning, Marco Poma, Edoardo Burini
Abstract: The present invention relates to the fluorene derivatives and to organic electronic devices in which these Compounds are used as matrix material in the emitting layer and/or as hole transport material and/or as electron blocker or exciton blocker material and/or as electron transport material.
Type:
Grant
Filed:
April 27, 2016
Date of Patent:
April 21, 2020
Assignee:
Merck Patent GmbH
Inventors:
Dominik Joosten, Florian Maier-Flaig, Anna Hayer, Holger Heil
Abstract: The present application relates to a device for regulating the passage of light which is characterised in that it comprises a layer comprising a liquid-crystalline mixture containing a characteristic structural element.
Type:
Grant
Filed:
November 26, 2014
Date of Patent:
April 21, 2020
Assignee:
Merck Patent GmbH
Inventors:
Michael Junge, Andreas Beyer, Ursula Patwal, Peer Kirsch, Susann Beck
Abstract: The invention relates to a method of manufacturing a liquid crystal display device wherein a liquid crystal mixture having positive dielectric anisotropy or negative dielectric anisotropy is interposed between a first substrate and a second substrate, the liquid crystal mixture comprising liquid crystal molecules, a self assembling photoalignment agent, a polymerisable compound, and wherein said LC mixture is photoaligned by irradiation with linearly polarised ultraviolet light and then cured by irradiation with ultraviolet light.
Type:
Grant
Filed:
November 18, 2016
Date of Patent:
April 21, 2020
Assignee:
MERCK PATENT GMBH
Inventors:
Kevin Adlem, Alex Davis, Rachel Tuffin, Mark Goebel, Graziano Archetti, Rocco Fortte, Karl Skjonnemand, Ian Charles Sage
Abstract: The invention relates to novel organic semiconducting compounds containing a polycyclic unit, to methods for their preparation and educts or intermediates used therein, to compositions and formulations containing them, to the use of the compounds and compositions as organic semiconductors in, or for the preparation of, organic electronic (OE) devices, especially organic photovoltaic (OPV) devices, organic photodetectors (OPD), organic field effect transistors (OFET) and organic light emitting diodes (OLED), and to OE devices comprising these compounds or compositions.
Type:
Application
Filed:
July 5, 2017
Publication date:
April 16, 2020
Applicant:
Merck Patent GmbH
Inventors:
William MITCHELL, Mansoor D'LAVARI, Changsheng WANG
Abstract: The present invention describes carbazole, dibenzofuran, dibenzothiophene and fluorene derivatives which are substituted by electron-deficient heteroaryl groups, in particular for use as triplet matrix materials in organic electroluminescent devices. The invention furthermore relates to a process for the preparation of the compounds according to the invention and to electronic devices comprising these compounds.
Type:
Grant
Filed:
April 1, 2015
Date of Patent:
April 14, 2020
Assignee:
Merck Patent GmbH
Inventors:
Amir Hossain Parham, Anja Jatsch, Thomas Eberle, Tobias Grossmann, Jonas Valentin Kroeber, Lars Dobelmann-Mara
Abstract: The present invention relates to compounds according to formula (1) and formula (2), said compounds being suitable for use in electronic devices, in particular organic electroluminescent devices.
Type:
Grant
Filed:
June 12, 2013
Date of Patent:
April 14, 2020
Assignee:
Merck Patent GmbH
Inventors:
Amir Hossain Parham, Christof Pflumm, Anja Jatsch, Thomas Eberle, Jonas Valentin Kroeber
Abstract: The present invention relates to cell culture media comprising inorganic ester derivatives of tyrosine and/or cysteine. The poor solubility of tyrosine and the often non-sufficient stability of cysteine in cell culture media is overcome by substituting them with an inorganic ester derivative, e.g. with a phosphorylated derivative.
Type:
Grant
Filed:
April 13, 2018
Date of Patent:
April 14, 2020
Assignee:
Merck Patent GmbH
Inventors:
Joerg Von Hagen, Marcel Andre Breuning, Christian Jasper
Abstract: Disclosed herein is an auto injector assembly comprising an auto injector for dose injection of medicament and a protective casing covering the auto injector, the auto injector having a recap prevention cap with one or more recap prevention springs and a housing partly protruding through the recap prevention cap. The housing is for accommodation of a syringe with a needle, a plunger rod, a plunger rod, a syringe driver, and a plunger rod driver.
Abstract: The present invention relates to a liquid-crystalline medium based on a mixture of polar compounds having negative dielectric anisotropy (??), which is distinguished by the fact that it has a value for the ratio ?1/?n2 in the range 6-45 with a clearing point of >60° C. and a ?? of ??2.3. Media of this type are particularly suitable for electro-optical displays having active-matrix addressing based on the ECB, PA LCD, FFS or IPS effect.
Abstract: The present invention is a charge complexing chemical composition that protects metal during polymer removal. The polymer coatings include crosslinked systems by chemical-amplification and photoacid generated (PAG) means as in epoxies. The system includes a solvent, a charge complexing additive, and an acid that creates a protective complex for sensitive metals during the dissolving and rinsing practice needed for processing microelectronic parts. The composition can be utilized with a method for removing partial and fully cured crosslinked coatings that originate from chemical amplification or PAG-epoxy photoimageable coatings.
Abstract: The present invention relates to a formulation comprising at least one organofunctional material which can be employed for the production of functional layers of electronic devices, and at least one aromatic compound. The present invention furthermore relates to electronic devices which are obtainable from these formulations.
Type:
Grant
Filed:
August 4, 2015
Date of Patent:
April 7, 2020
Assignee:
Merck Patent GmbH
Inventors:
Philipp Stoessel, Irina Martynova, Aurélie Ludemann, Edgar Kluge, Nils Koenen
Abstract: A liquid-crystalline medium containing one or more compounds of formula IA, and the use thereof in an active-matrix display, in particular in a VA, IPS, U-IPS, FFS, UB-FFS, SA-VA, SA-FFS, PS-VA, PS-OCB, PS-IPS, PS-FFS, PS-UB-FFS, PS-posi-VA, PS-TN, polymer stabilised SA-VA or polymer stabilised SA-FFS display.
Type:
Application
Filed:
September 26, 2019
Publication date:
April 2, 2020
Applicant:
Merck Patent GmbH
Inventors:
Martin ENGEL, Sebastian HOFMEYER, Christoph MARTEN, Lars LIETZAU
Abstract: A method and an apparatus suitable for a continuous chromatography process which only needs three separation columns, and a two-step process containing two chromatographic steps, in which the first chromatographic step (capture) is performed alternating and sequentially on two separation columns, the second chromatographic step (polishing) is performed, also sequentially, on the third column.
Abstract: The present invention relates to mesogenic media and to electro-optical displays comprising these media as light modulation media. In particular, the electro-optical displays according to the present invention are displays, which are operated at a temperature, at which the mesogenic modulation media are in an optically isotropic phase, preferably in a blue phase.
Type:
Grant
Filed:
July 12, 2016
Date of Patent:
March 31, 2020
Assignee:
MERCK PATENT GMBH
Inventors:
Michael Wittek, Mathias Bremer, Edward Plummer, Mila Fischer, Harald Lannert, Volker Meyer