Abstract: The present invention relates to a crosslinkable polymer formulation comprising a polymer which contains a silazane repeating unit; and a specific boron Lewis acid curing catalyst, wherein the curing catalyst catalyzes the crosslinking of the polymer to obtain a crosslinked polymer composition. The crosslinked polymer composition is particularly suitable as a technical coating for industrial or household applications.
Abstract: Disclosed are liquid-crystalline media (LC media) comprising a low-molecular-weight component and a polymerisable component. The polymerisable component contains self-aligning, polymerisable meso-gens (polymerisable self-alignment additives) which effect homeotropic (vertical) alignment of the LC media at a surface or the cell walls of a liquid-crystal display (LC display). Disclosed are also LC displays having homeotropic alignment of the LC medium without alignment layers. Further disclosed are the structures for polymerisable self-alignment additives.
Type:
Grant
Filed:
November 20, 2017
Date of Patent:
January 21, 2020
Assignee:
MERCK PATENT GMBH
Inventors:
Graziano Archetti, Edward Plummer, Helmut Haensel, Rocco Fortte, Timo Uebel
Abstract: The present invention relates to organic electroluminescent devices comprising metal complexes of the formula (1), and to metal complexes for use in organic electroluminescent devices. Depending on the metal used, the metal complexes are useful as emitters, as matrix materials, as hole-blocking materials, as electron-transport materials, and in other functions in the OLED. Organic electroluminescent devices comprising the metal chelate complexes described herein result in significant improvements in the organic electroluminescent device, in particular with respect to the lifetime, the efficiency and the stability to heating, particularly in green- and blue-phosphorescent electroluminescent devices.
Abstract: A liquid-crystalline medium, preferably having a nematic phase and dielectric anisotropy of 0.5 or more, which comprises one or more compounds of formula T in which denotes and the use thereof in an electro-optical display, particularly in an active-matrix display based on the IPS or FFS effect, to displays of this type which contain a liquid-crystalline medium of this type, and to the compounds of formula T and their use for the improvement of the transmission and/or response times of a liquid-crystalline medium which contains one or more additional mesogenic compounds.
Type:
Application
Filed:
July 11, 2019
Publication date:
January 16, 2020
Applicant:
Merck Patent GmbH
Inventors:
Atsutaka MANABE, Constanze BROCKE, Sven BARAN, Sebastian HOFMEYER, Alexander HAHN
Abstract: The present invention relates to an optical medium (100) and an optical device (200) comprising an optical medium (100). The present invention further relates to a use of the optical medium (100) in an optical device (200). The invention further more relates to method for preparing the optical medium (100) and method for preparing the optical device (200).
Type:
Application
Filed:
December 18, 2017
Publication date:
January 16, 2020
Applicant:
Merck Patent GmbH
Inventors:
Christian MATUSCHEK, Arjan MEIJER, Itai LIEBERMAN, Ralf GROTTENMUELLER
Abstract: A pharmaceutical composition of 3-(1-{3-[5-(1-Methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile or a pharmaceutically acceptable salt and/or solvate thereof in combination with N-[3-[[2-[4-(4-acetylpiperazin-1-yl)-2-methoxy-anilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide.
Abstract: The present invention relates to novel phosphor mixtures and to a light-emitting device which comprises at least one of the novel phosphor mixtures. The phosphor mixtures can be used in phosphor-converted LEDs with a semiconductor that emits in the violet spectral region. The present invention furthermore relates to a lighting system which may comprise the light-emitting devices according to the invention, and to a dynamic lighting system. The present invention furthermore relates to a process for the preparation of the phosphor mixtures according to the invention and to the use thereof in light-emitting devices for use in general lighting and/or in specialty lighting.
Type:
Application
Filed:
March 5, 2018
Publication date:
January 9, 2020
Applicant:
MERCK PATENT GMBH
Inventors:
Andreas BENKER, Ralf PETRY, Ingo KOEHLER, Irene (Yu Huan) LIU, Christof HAMPEL, Aleksander ZYCH
Abstract: The present invention relates to a method, a medium and a kit for the enrichment and detection of Listeria species, especially Listeria monocytogenes. The medium is an enrichment medium comprising C12 to C16 fatty acids and/or derivatives thereof.
Type:
Application
Filed:
July 2, 2019
Publication date:
January 9, 2020
Applicant:
MERCK PATENT GMBH
Inventors:
Patrick Julian MESTER, Peter ROSSMANITH, Nadine WEYHING-ZERRER, Tobais GUNDOLF, Susanne FISTER, Anna Witte
Abstract: The present invention relates to a method of detecting a microorganism, in particular Staphylococcus aureus, in a sample, comprising the steps of a) incubating the sample with a slow off-rate modified aptamer (SOMAmer) comprising a fluorescent label, b) optionally washing the sample, c) analyzing the sample by a fluorescence-based detection method. The invention further relates to a slow off-rate modified aptamer comprising a fluorescent label, wherein the SOMAmer comprises a nucleotide sequence specific for Staphylococcus aureus, its use for detecting Staphylococcus aureus cells in a sample, and to a microarray or biosensor and a kit comprising at least one of such SOMAmers comprising a fluorescent label.
Type:
Grant
Filed:
February 20, 2015
Date of Patent:
January 7, 2020
Assignees:
Merck Patent GmbH, SOMALOGIC, Inc.
Inventors:
Anne Baumstummler, Frederic Marc-Kreucher, David Lehmann, Urs Ochsner, Nebojsa Janjic
Abstract: Compounds of formula (1) that have functional substituents in a specific spatial arrangement, and electronic devices that include a compound of formula (1), and to the preparation of compounds of formula (1).
Type:
Grant
Filed:
September 16, 2014
Date of Patent:
January 7, 2020
Assignee:
Merck Patent GmbH
Inventors:
Amir Hossain Parham, Irina Martynova, Anja Jatsch, Thomas Eberle, Jonas Valentin Kroeber, Christof Pflumm
Abstract: Compounds of the formula Ia or of the formula Ib in which X, Y, R1 and R2 have the meanings indicated in claim 1, are inhibitors of pyruvate dehydrogenase kinase (PDHK), and can be employed, inter alia, for the treatment of diseases such as cancer.
Abstract: The present invention relates to novel compounds, particularly to compounds comprising a photoactive unit, said novel compounds being particularly suitable for compositions and ophthalmic devices as well as to compositions and ophthalmic devices comprising such compounds.
Type:
Application
Filed:
February 14, 2018
Publication date:
January 2, 2020
Applicant:
Merck Patent GmbH
Inventors:
Lars DOBELMANN-MARA, Stefan RIEDMUELLER, Martin SCHRAUB
Abstract: The present invention relates to novel compounds, particularly to compounds comprising a photoactive unit, said novel compounds being particularly suitable for compositions and ophthalmic devices as well as to compositions and ophthalmic devices comprising such compounds.
Type:
Application
Filed:
February 14, 2018
Publication date:
January 2, 2020
Applicant:
Merck Patent GmbH
Inventors:
Lars DOBELMANN-MARA, Stefan RIEDMUELLER, Martin SCHRAUB
Abstract: The present invention relates to compounds of the formula (1) which are suitable for use in electronic devices, in particular organic electroluminescent devices, and to electronic devices which comprise these compounds.
Type:
Application
Filed:
September 12, 2019
Publication date:
January 2, 2020
Applicant:
Merck Patent GmbH
Inventors:
Elvira Montenegro, Amir Hossain Parham, Philipp Stoessel, Teresa Mujica-Fernaud, Frank Voges, Arne Buesing
Abstract: The invention relates to the prophylaxis and/or treatment of fibrosis and/or fibrotic diseases by means of antibodies. Above all, the invention relates to the administration of an anti-alpha-v integrin (receptor) antibody to patients suffering from fibrosis and/or fibrotic diseases, including but not limited to systemic sclerosis (SSc). More specifically, the instant invention relates to the treatment of fibrotic diseases of the skin, lung, heart, liver and/or kidney by means of said antibody. Even more specifically, the instant invention relates to the administration of a recombinant, de-immunized monoclonal antibody targeting ?v-integrins patients suffering from systemic sclerosis, including, but not limited to systemic sclerosis of the skin, lung, heart and/or kidney by means of the anti-alpha-v integrin antibody DI17E6 and structural mutants or modifications thereof.
Abstract: The present invention relates to a process to produce compounds of the formula (1) which are suitable for use in electronic devices, as well as to intermediate compounds of formula (Int-1) and compounds of formula (1-1) and (1-2) obtained via the process. These compounds are particularly suitable for use organic electroluminescent devices. The present invention also relate to electronic devices, which comprise these compounds.
Type:
Application
Filed:
September 6, 2019
Publication date:
January 2, 2020
Applicant:
Merck Patent GmbH
Inventors:
Frank Voges, Teresa MUJICA-FERNAUD, Elvira MONTENEGRO
Abstract: The invention relates to a liquid-crystalline medium which comprises at least one compound of the formula I, in which R1 and R1* each, independently of one another, denote an alkyl or alkoxy radical having 1 to 15 C atoms, where, in addition, one or more CH2 groups in these radicals may each be replaced, independently of one another, by in such a way that O atoms are not linked directly to one another, and in which, in addition, one or more H atoms may be replaced by halogen, A1 denotes L1 denotes F, Cl, CF3, OCF3 or CHF2, and to the use thereof for electro-optical purposes, in particular for shutter glasses, 3D applications, in TN, PS-TN, STN, TN-TFT, OCB, IPS, PS-IPS, FFS, PS-FFS and PS-VA-IPS displays.
Type:
Grant
Filed:
April 8, 2016
Date of Patent:
December 31, 2019
Assignee:
MERCK PATENT GMBH
Inventors:
Helmut Haensel, Andreas Pohle, Brigitte Schuler, Christian Jasper
Abstract: The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal, of protein, fragments without adversely affecting the yield of the desired protein product.
Type:
Grant
Filed:
April 4, 2014
Date of Patent:
December 31, 2019
Assignee:
Merck Patent GmbH
Inventors:
Mikhail Kozlov, Matthew T. Stone, Romas Skudas, Kevin Galipeau
Abstract: The present invention relates to a spectrophotometer comprising a light source; and a light sensor for measuring the light emitted by the light source and passing through or reflected a sample; and being characterized by an offset generator for applying an offset value to an output of the light sensor. The invention further relates to a method for performing a related spectrophotometric measurement.