Patents Assigned to Merck Sharp
  • 4-(Substituted thiazolyl)-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase
    Patent number: 4377588
    Abstract: Novel 4-(substituted thiazolyl)-3-hydroxy-3-pyrroline-2,5-diones are disclosed which inhibit glycolic acid oxidase and thus are useful in the treatment and prevention of calcium oxalate renal lithiasis.
    Type: Grant
    Filed: September 11, 1979
    Date of Patent: March 22, 1983
    Assignees: Merck Sharp & Dohme (I.A.) Corp., Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., Clarence S. Rooney, Haydn W. R. Williams
  • N -(Substituted)-2-aza-2'-hydroxy-5,6-benzotricyclo[6.3.0.sup.1,8.0.sup.4,1 1 ] undecane centrally-acting analgesics
    Patent number: 4376779
    Abstract: Novel N-(substituted) derivatives of 2-aza-2'-hydroxy-5,6-benzotricyclo[6.3.0.sup.1,8.0.sup.4,11 ] undecane of the formula: ##STR1## are centrally acting analgesics effective in the relief of pain.
    Type: Grant
    Filed: January 26, 1981
    Date of Patent: March 15, 1983
    Assignee: Merck Sharp & Dohme (I.A.) Corp.
    Inventors: Patrice C. Belanger, Robert N. Young
  • Benzoxazines
    Patent number: 4349673
    Abstract: Compounds of the formula Het--O--CH.sub.2 --CHOR--CH.sub.2 -NHaralkyl where Het is a 10 membered N-containing ring are disclosed. The compounds are useful as pharmaceuticals.
    Type: Grant
    Filed: December 23, 1980
    Date of Patent: September 14, 1982
    Assignees: Merck & Co., Inc., Merck Sharp & Dohme Corp.
    Inventors: Joseph G. Atkinson, John J. Baldwin, David E. McClure
  • Quinolinyl ethanolamines
    Patent number: 4348398
    Abstract: Heterocyclic ethanolamines of the formulaHet--CHOH--CH.sub.2 --NH--aralkylwhere het is a 10 membered N heterocycle are disclosed. The compounds are useful as pharmaceuticals.
    Type: Grant
    Filed: December 23, 1980
    Date of Patent: September 7, 1982
    Assignee: Merck Sharp & Dohme (I.A.) Corp.
    Inventors: Joseph G. Atkinson, Burton K. Wasson
  • 2-(3-Substituted amino-2-hydroxypropoxy)-3-piperidino pyrazines for use in treating hypertension
    Patent number: 4343802
    Abstract: 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazine compounds optionally having substituents in the 5 and/or 6 positions, possessing .beta.-adrenergic blocking properties are described. The products are prepared by reaction of a 2-chloro (or hydroxy) pyrazine with a 5-hydroxymethyl (or sulfonyloxymethyl) oxazolidine followed by acid hydrolysis.
    Type: Grant
    Filed: July 3, 1980
    Date of Patent: August 10, 1982
    Assignee: Merck, Sharp & Dohme (I.A.) Corp.
    Inventors: Burton K. Wasson, Leonard M. Weinstock
  • (3-Aralkylamino-2-or-propoxy) heterocyclic compounds
    Patent number: 4331679
    Abstract: Compounds of the formula Het-O-CH.sub.2 -CHOR-CH.sub.2 -NH-aralkyl where Het is ##STR1## are disclosed. The compounds are useful as pharmaceuticals.
    Type: Grant
    Filed: December 23, 1980
    Date of Patent: May 25, 1982
    Assignee: Merck Sharp & Dohme (I.A.) Corp.
    Inventor: Yves Girard
  • 3-Hydroxymethyldibenzo[b,f]thiepins as prostaglandin antagonists
    Patent number: 4237160
    Abstract: Novel 3-hydroxymethyldibenzo[b,f]thiepin and derivatives are prepared and employed in the treatment and control of allergic conditions such as allergic asthma.
    Type: Grant
    Filed: November 27, 1979
    Date of Patent: December 2, 1980
    Assignee: Merck Sharp & Dohme (I.A.) Corp.
    Inventors: Pierre A. Hamel, Joshua Rokach
  • 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazine compounds and compositions
    Patent number: 4193995
    Abstract: 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazine compounds optionally having substituents in the 5 and/or 6 positions, possessing .beta.-adrenergic blocking properties are described. The products are prepared by reaction of a 2-chloro(or hydroxy)pyrazine with a 5-hydroxymethyl(or sulfonyloxymethyl)oxazolidine followed by acid hydrolysis.
    Type: Grant
    Filed: March 8, 1977
    Date of Patent: March 18, 1980
    Assignee: Merck Sharp & Dohme (I.A.) Corp.
    Inventors: Burton K. Wasson, Leonard M. Weinstock
  • 2-(4-Substituted-1,2,5-thiadiazole-3-yloxy)-acetaldehydes
    Patent number: 4145550
    Abstract: Novel 2-(4-substituted-1,2,5-thiadiazol-3-yloxy) acetaldehydes are disclosed. These acetaldehydes are useful as intermediates for preparing certain .beta.-adrenergic blocking agents.
    Type: Grant
    Filed: September 21, 1977
    Date of Patent: March 20, 1979
    Assignee: Merck Sharp & Dohme (I.A.) Corp.
    Inventor: Patrice C. Belanger
  • 2-(4-Substituted-1,2,5-thiadiazole-3-yloxy)-acetaldehydes
    Patent number: 4076939
    Abstract: Novel 2-(4-substituted-1,2,5-thiadiazol-3-yloxy)acetaldehydes are disclosed. These acetaldehydes are useful as intermediates for preparing certain .beta.-adrenergic blocking agents.
    Type: Grant
    Filed: February 8, 1977
    Date of Patent: February 28, 1978
    Assignee: Merck Sharp & Dohme (I.A.) Corporation
    Inventor: Patrice C. Belanger
  • 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazines
    Patent number: 4042586
    Abstract: 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazine compounds optionally having substituents in the 5 and/or 6 positions, possessing .beta.-adrenergic blocking properties are described. The products are prepared by reaction of a 2-chloro(or hydroxy)pyrazine with a 5-hydroxy-methyl(or sulfonyloxymethyl)oxazolidine followed by acid hydrolysis.
    Type: Grant
    Filed: June 6, 1975
    Date of Patent: August 16, 1977
    Assignee: Merck Sharp & Dohme (I.A.) Corporation
    Inventors: Burton Kendall Wasson, Leonard M. Weinstock
  • 1,8-Naphthyridine compounds
    Patent number: 4031103
    Abstract: There is described 2-amino-5,7-disubstituted-naphthyridine and 5,7-disubstituted-naphthyridin-2(1H)-one derivatives with bronchodilating and hypotensive properties prepared by the reaction of 2,6-diaminopyridine with an appropriate .beta.-diketone providing the 2-amino products. The 2-oxo analogs are prepared from the 2-amino products by treatment with nitrous acid.
    Type: Grant
    Filed: December 9, 1975
    Date of Patent: June 21, 1977
    Assignee: Merck Sharp & Dohme (I.A.) Corporation
    Inventors: Hayden Windsor Richard Williams, Clarence Stanley Rooney
  • 4-(3-Amino-2-acyloxypropoxy)-1,2,5-thiadiazole compounds
    Patent number: 4011217
    Abstract: 4-[3-(Substituted amino)-2-acyloxypropoxy]-1,2,5-thiadiazole compounds, optionally substituted in the 3-position of the thiadiazole nucleus which exhibit .beta.-adrenergic blocking properties and thus are useful in the management of angina pectoris are described. The products are prepared by reaction of a 4-[3-(substituted amino)-2-hydroxypropoxy]-1,2,5-thiadiazole with the appropriate anhydride. The reaction is run under acidic conditions when the amino nitrogen is protonated.
    Type: Grant
    Filed: February 26, 1975
    Date of Patent: March 8, 1977
    Assignee: Merck Sharp & Dohme (I.A.) Corporation
    Inventor: Burton Kendall Wasson
  • Deuteration of functional group-containing hydrocarbons
    Patent number: 3966781
    Abstract: Deuterated functional group-containing hydrocarbons prepared by treating the non-labelled substrate in the liquid state with deuterium gas in the presence of a Group VII or VIII metal catalyst with heating between ambient to 300.degree. C. The labelled compounds are especially useful in reaction mechanism studies, as tracers in separation process studies, in the investigation of the physical properties of labelled compounds and in other specialized research work.
    Type: Grant
    Filed: December 10, 1973
    Date of Patent: June 29, 1976
    Assignee: Merck Sharp & Dohme (I.A.) Corporation
    Inventors: Joseph G. Atkinson, Michael O. Luke
  • 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazines
    Patent number: 3946009
    Abstract: 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazine compounds optionally having substituents in the 5 and/or 6 positions, possessing .beta.-adrenergic blocking properties are described. The products are prepared by reaction of a 2-chloro(or hydroxy)pyrazine with a 5-hydroxy-methyl(or sulfonyloxymethyl)oxazolidine followed by acid hydrolysis.
    Type: Grant
    Filed: October 19, 1973
    Date of Patent: March 23, 1976
    Assignee: Merck Sharp & Dohme (I.A.) Corporation
    Inventors: Burton Kendall Wasson, Leonard M. Weinstock