Patents Assigned to Merck
  • METHOD FOR DETECTING BREAKAGE OF SUBSTRATE OF A SWITCHABLE OPTICAL ELEMENT AND SWITCHABLE OPTICAL DEVICE
    Publication number: 20190391419
    Abstract: A switchable optical element and method for detecting breakage of a substrate (A, B) of at least one switchable optical element (10) having a first substrate (A) and a second substrate (B), the first substrate (A) being coated with a first electrode and the second substrate (B) being coated with a second electrode, and a switchable layer (14), the switchable layer (14) being sandwiched between the first substrate (A) and second substrate (B), the first electrode and second electrode each having at least one contact, by i) measuring a change in a differential signal measured at two contacts of a substrate (A, B), ii) measuring a change in capacitance between the two substrates (A, B), iii) measuring a change in resistance of at least one of the substrates (A, B), iv) measuring a change in current applied to the switchable optical element (10).
    Type: Application
    Filed: January 24, 2018
    Publication date: December 26, 2019
    Applicant: MERCK PATENT GMBH
    Inventors: Ties DE JONG, Paul BAKKER
  • Combination of a 6-oxo-1,6-dihydro-pyridazine derivative having anti-cancer activity with an EGFR inhibitor
    Publication number: 20190388423
    Abstract: A pharmaceutical composition of 3-(1-{3-[5-(1-Methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile or a pharmaceutically acceptable salt and/or solvate thereof in combination with N-[3-[[2-[4-(4-acetylpiperazin-1-yl)-2-methoxy-anilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide.
    Type: Application
    Filed: September 6, 2019
    Publication date: December 26, 2019
    Applicant: Merck Patent GmbH
    Inventors: Friedhelm BLADT, Manja FRIESE-HAMIM
  • ORGANIC SEMICONDUCTING COMPOUNDS
    Publication number: 20190389832
    Abstract: The invention relates to novel organic semiconducting compounds containing a polycyclic unit, to methods for their preparation and educts or intermediates used therein, to compositions, polymer blends and formulations containing them, to the use of the compounds, compositions and polymer blends as organic semiconductors in, or for the preparation of, organic electronic (OE) devices, especially organic photovoltaic (OPV) devices, organic photodetectors (OPD), organic field effect transistors (OFET) and organic light emitting diodes (OLED), and to OE, OPV, OPD, OFET and OLED devices comprising these compounds, compositions or polymer blends.
    Type: Application
    Filed: July 6, 2017
    Publication date: December 26, 2019
    Applicant: Merck Patent GmbH
    Inventors: Graham MORSE, Lana NANSON, William MITCHELL, Michal KROMPIEC, Mansoor D'LAVARI, Agnieszka PRON
  • LIQUID-CRYSTALLINE MEDIUM
    Publication number: 20190390112
    Abstract: A liquid-crystalline medium and the use thereof for an active-matrix display, in particular based on the VA, PSA, PS-VA, PM-VA, SS-VA, PALC, IPS, PS-IPS, FFS or PS-FFS effect.
    Type: Application
    Filed: June 20, 2019
    Publication date: December 26, 2019
    Applicant: Merck Patent GmbH
    Inventors: Harald HIRSCHMANN, Sabine SCHOEN
  • 3-(1H-pyrazol-4-yl)pyridine allosteric modulators of the M4 muscarinic acetylcholine receptor
    Patent number: 10512638
    Abstract: The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine 5 receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: December 24, 2019
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Michael T. Rudd, David M. Tellers, Jenny Miu-Chun Wai
  • Method and filling device for filling a transport container with a fluid
    Patent number: 10513427
    Abstract: In the case of a method for filling a transportation container (12) with a fluid, the fluid in a purification circuit (1) is conveyed multiple times through the purification installation (7), and by way of a contamination-measurement installation (15) a key contamination indicator of a fluid-specimen quantity in the purification circuit (1) is determined, wherein a filling procedure of the transportation container (12) with the fluid is terminated only once the key contamination indicator undershoots a first threshold value. The fluid-specimen quantity that is provided for determining the key contamination indicator may be diverted from the purification circuit (1), be infed to the contamination-measurement installation (15), and upon determining the key contamination indicator be returned to the purification circuit (1).
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: December 24, 2019
    Assignee: Merck Patent GmbH
    Inventors: Guenter Hauke, Leticia Garcia Diez, Volker Hilarius
  • Inhibitors of the renal outer medullary potassium channel
    Patent number: 10513518
    Abstract: The present invention provides compounds of Formula I (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: December 24, 2019
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Reynalda K. deJesus, Qinghong Fu, Jinlong Jiang, Haifeng Tang
  • Liquid-crystalline media having homeotropic alignment
    Patent number: 10513657
    Abstract: The present invention relates to liquid-crystalline media (LC media) having negative or positive dielectric anisotropy, comprising a low-molecular-weight component and a polymerizable component. The polymerizable component comprises self-aligning, polymerizable mesogens (polymerizable self-alignment additives) which effect homeotropic (vertical) alignment of the LC media at a surface or the cell walls of a liquid-crystal display (LC display). The invention therefore also encompasses LC displays having homeotropic alignment of the LC medium without alignment layers. The invention discloses novel structures for self-alignment additives which have a certain position of the functional groups.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: December 24, 2019
    Assignee: Merck Patent GmbH
    Inventors: Graziano Archetti, Izumi Saito, Rocco Fortte, Thorsten Kodek
  • ARYL SULFONAMIDES AS BLT1 ANTAGONISTS
    Publication number: 20190382363
    Abstract: Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are antagonists of leukotriene B4 receptor 1 (BLT1) and may be useful in the treatment, prevention and suppression of diseases mediated by the leukotriene B4 receptor 1 (BLT1). The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, insulin resistance, hyperglycemia, dyslipidemia, lipid disorders, obesity, hypertension, Non-alcoholic fatty liver disease/nonalcoholic steatohepatitis, metabolic syndrome, atherosclerosis, and cancer.
    Type: Application
    Filed: November 28, 2016
    Publication date: December 19, 2019
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Yongxin Han, Jongwon Lim, Satyanarayana Tummanapalli, Phieng Siliphaivanh, Kerrie Spencer
  • METAL COMPLEXES
    Publication number: 20190386228
    Abstract: The present invention relates to binuclear metal complexes and electronic devices, in particular organic electroluminescent devices containing said metal complexes.
    Type: Application
    Filed: October 9, 2017
    Publication date: December 19, 2019
    Applicant: Merck Patent GmbH
    Inventors: Philipp Stoessel, Nils Koenen, Christian Ehrenreich
  • METHOD OF MICROWAVE VACUUM DRYING SPHERICAL-SHAPED PELLETS OF BIOLOGICAL MATERIALS
    Publication number: 20190383556
    Abstract: Methods for preparing dried pellets of biological materials are described. The pellets can have a substantially spherical shape and are prepared by freezing droplets of a liquid composition of a desired biological material on a solid surface followed by microwave vacuum drying the frozen droplets. These methods are useful for preparing dried pellets having a high concentration of a desired biological material, in particular a therapeutic protein or vaccine, and which have a faster reconstitution time than lyophilized powder cakes prepared in vials.
    Type: Application
    Filed: August 30, 2019
    Publication date: December 19, 2019
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Akhilesh Bhambhani, Robert K. Evans, Jessica Sinacola, Rebecca Lizzano
  • SEMICONDUCTOR NANOSIZED MATERIAL
    Publication number: 20190382656
    Abstract: The present invention relates to a method for synthesizing a semiconductor material.
    Type: Application
    Filed: February 7, 2018
    Publication date: December 19, 2019
    Applicant: MERCK PATENT GMBH
    Inventors: David MOCATTA, Amir HOLTZMAN, Nina LIDICH, Yael NISENHOLZ
  • Tricyclic compounds as inhibitors of mutant IDH enzymes
    Patent number: 10508108
    Abstract: The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes (I); wherein A is —C(R1)? or —N?; and X is selected from the group consisting of: (II-i), and (II-ii). The present invention is also directed to uses of the tricyclic compounds described herein in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: December 17, 2019
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Christian Fischer, Stephane L. Bogen, Matthew L. Childers, Francesc Xavier Fradera Llinas, J. Michael Ellis, Sara Esposite, Dawn M. Hoffman, Chunhui Huang, Solomon D. Kattar, Alexander J. Kim, John W. Lampe, Michelle R. Machacek, Daniel R. McMasters, Dann L. Parker, Jr., Michael H. Reutershan, Nunzio Sciammetta, Pengcheng P. Shao, David L. Sloman, Wanying Sun, Feroze Ujjainwalla, Zhicai Wu, Yang Yu, Craig R. Gibeau
  • Photosensitive composition and color converting film
    Patent number: 10509319
    Abstract: The present invention relates to a photosensitive composition comprising at least one nanosized fluorescent material and polysiloxane, to a color conversion film, and to a use of the color conversion film in an optical device. The invention further relates to an optical device comprising the color conversion film and a method for preparing the color conversion film and the optical device.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: December 17, 2019
    Assignees: Merck Patent GmbH, AZ Electronic Materials (Luxembourg) S.a.r.l.
    Inventors: Masayoshi Suzuki, Tadashi Kishimoto, Yuki Hirayama, Stephan Dertinger, Toshiaki Nonaka, Daishi Yokoyama
  • Process for printing multicoloured printed images
    Patent number: 10508208
    Abstract: The present invention relates to a process for printing multicoloured printed images in which exclusively interference pigments are used for the coloured pigmentation of the printing inks, to printed products produced using a process of this type, to the use thereof, and to suitable interference pigments.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: December 17, 2019
    Assignee: Merck Patent GmbH
    Inventors: Peter Clauter, Cairon Platzer, Kirsten Fritsche, Marc-Dieter Weingart, Lorenz Boegli, Christoph Schmidt
  • Materials for organic electroluminescent devices
    Patent number: 10510960
    Abstract: The present invention relates to compounds of the formula (1) which are suitable for use in electronic devices, in particular organic electroluminescent devices, and to electronic devices which comprise these compounds.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: December 17, 2019
    Assignee: Merck Patent GmbH
    Inventors: Teresa Mujica-Fernaud, Elvira Montenegro, Jochen Pfister
  • Liposomal Formulations for Allosteric AKT Inhibitors
    Publication number: 20190374468
    Abstract: Disclosed herein is a lipid nanoparticle (LNP) composition comprising (a) an Akt inhibitor; (b) DSPC; (c) cholesterol; and (d) PEG-DMG. Also disclosed herein is a method for preparing the lipid composition using a scalable tangential flow micro-mixing technology.
    Type: Application
    Filed: August 22, 2019
    Publication date: December 12, 2019
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Michael Hughes Smith, Marian Gindy
  • COMPOSITION COMPRISING A NANOSIZED LIGHT EMITTING MATERIAL
    Publication number: 20190375957
    Abstract: The present invention relates to a composition comprising a nanosized light emitting material, and method for preparing of said composition. The present invention further relates to a light luminescent medium, a light emitting device, the present invention further more relates to method for preparing of a composition and to method for preparing of a light emitting medium.
    Type: Application
    Filed: November 27, 2017
    Publication date: December 12, 2019
    Applicant: MERCK PATENT GMBH
    Inventors: Masaki HASEGAWA, Noriyuki MATSUDA
  • Substituted Heterocyclic Compounds as Inhibitors of PRDM9
    Publication number: 20190374526
    Abstract: The present invention relates to Substituted Heterocyclic Compounds of Formula (I): R1—R2—R3—R4?? (I) and pharmaceutically acceptable salts or prodrug thereof, wherein R1, R2, R3, and R4 are as defined herein. The present invention also relates to compositions comprising at least one Substituted Heterocyclic Compound, and methods of using the Substituted Heterocyclic Compounds for inhibiting PRDM9 activity in a subject or for treating or preventing a disease mediated by PRDM9 activity.
    Type: Application
    Filed: June 6, 2019
    Publication date: December 12, 2019
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Christian Fischer, Solomon D. Kattar, John M. Sanders
  • Autoinjector pen
    Patent number: D870270
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: December 17, 2019
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Greg Burkett, Shu Kuen Chang, Angie Kim, Jin Ko, Scott Mackie, Philip G. Green, Sharad Gupta, Angela M. Amend Kwasnik, Christin L. O'Neill, Robert Stianchi, Witold Swiatek