Abstract: The present invention relates to liquid-crystalline media comprising one or more polymerisable compounds, preferably of formula P Pa-(Spa)s1-(A1-Z1)n1-A2-Q-A3-(Z4-A4)n2-(Spb)s2-Pb??P and one or more compounds selected from the group of compounds of formulae I, II, and III, in which the parameters have the meaning indicated in Claim 1, and to components comprising these media for high-frequency technology, in particular phase shifters and microwave array antennas.
Abstract: The present invention is directed to a crystalline sodium salt of 5-methyl-(6S)-tetrahydrofolic acid wherein the molar ratio of 5-methyl-(6S)-tetrahydrofolic acid to sodium is from 1:0.5 to 1:1.
Type:
Application
Filed:
March 28, 2018
Publication date:
January 30, 2020
Applicant:
Merck Patent GmbH
Inventors:
Rudolf MOSER, Viola GROEHN, Fritz BLATTER, Martin SZELAGIEWICZ, Ruth BOEHNI STAMM, Markus RUETTIMANN, Giuseppe LAPADULA
Abstract: The present invention relates to the use of at least one compatible solute and/or its physiologically acceptable salt for countering age-related skin color change or for the suppression and/or reduction of protein carbonylation and/or for the suppression and/or reduction of the accumulation of carbonylated proteins in the stratum corneum. The invention is further directed to formulations comprising at least one compatible solute and/or its physiologically acceptable salt and at least one further skin pore lightening active, as well as a process for preparing such formulation.
Abstract: The present invention is directed to processes for preparing beta 3 agonists of Formula (I) and Formula (II) and their intermediates. The beta 3 agonists are useful in the treatment of certain disorders, including overactive bladder, urinary incontinence, and urinary urgency.
Type:
Application
Filed:
October 1, 2019
Publication date:
January 30, 2020
Applicant:
Merck Sharp & Dohme Corp.
Inventors:
John Y.L. CHUNG, Kevin CAMPOS, Edward CLEATOR, Robert F. DUNN, Andrew GIBSON, R. Scott HOERRNER, Stephen KEEN, Dave LIEBERMAN, Zhuqing LIU, Joseph LYNCH, Kevin M. MALONEY, Feng XU, Nobuyoshi YASUDA, Naoki YOSHIKAWA, Yong-Li ZHONG
Abstract: The present invention describes compounds comprising at least one structural element having at least three fused aromatic or heteroaromatic rings (AR) and at least one structural element having an aromatic or heteroaromatic valerolactam (AV), especially for use in electronic devices. The invention further relates to a process for preparing the compounds of the invention and to electronic devices comprising these.
Type:
Application
Filed:
November 27, 2017
Publication date:
January 30, 2020
Applicant:
Merck Patent GmbH
Inventors:
Anja Jatsch, Amir Parham, Rouven Linge, Tobias Grossmann
Abstract: The present invention relates to mixtures comprising at least one phosphorescent dopant and at least one compound of one of the formulae (1) and (2), and the use thereof in electronic devices, especially in organic electroluminescent devices.
Type:
Grant
Filed:
August 25, 2015
Date of Patent:
January 28, 2020
Assignee:
Merck Patent GmbH
Inventors:
Amir Hossain Parham, Christof Pflumm, Anja Jatsch, Thomas Eberle, Jonas Valentin Kroeber, Rouven Linge
Abstract: The present invention relates to spirocyclic quinolizine derivatives and pharmaceutically acceptable salts or prodrug thereof, compositions comprising at least one spirocyclic quinolizine derivative, and methods of using the spirocyclic quinolizine derivatives for treating or preventing HIV infection in a subject.
Type:
Grant
Filed:
December 12, 2016
Date of Patent:
January 28, 2020
Assignee:
Merck Sharp & Dohme Corp.
Inventors:
Yonglian Zhang, Sherman T. Waddell, Tao Yu, John A. McCauley, Andrew Stamford
Abstract: The present invention relates to an electro-optical switching element comprising at least one light source, and a light converting layer, and to a use of the electro-optical switching element in an optical device. The invention further relates to an optical device comprising the electro-optical switching element.
Abstract: The invention relates to a process for the production of amide bonds, in particular peptide bonds, with the aid of novel amide linking reagents containing an anion of the formula (I), to the novel reagents, and to the preparation thereof.
Type:
Grant
Filed:
November 6, 2017
Date of Patent:
January 28, 2020
Assignee:
Merck Patent GmbH
Inventors:
Nikolai Mykola Ignatyev, Walter Frank, Peter Barthen, Myroslav Vysotsky
Abstract: The present invention provides multispecific molecules, e.g., comprising more than one ISVD or Nanobody, that bind to PD1 and CTLA4. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.
Type:
Grant
Filed:
November 17, 2016
Date of Patent:
January 28, 2020
Assignee:
Merck Sharp & Dohme Corp.
Inventors:
Juha Punnonen, Edward Bowman, Maribel Beaumont, Marie-Ange Buyse, Carlo Boutton, Bruno Dombrecht, Bjorn Victor, David Vlerick, Robert A. Kastelein
Abstract: The invention relates to novel organic semiconducting oligomers or polymers containing alkylated dithieno[2,3-d:2?,3?-d?]-s-indaceno[1,2-b:5,6-b?]dithiophene units, methods for their preparation and educts or intermediates used therein, polymers, blends, mixtures and formulations containing them, the use of the oligomers, polymers, blends, mixtures and formulations as semiconductor in organic electronic (OE) devices, especially in organic photovoltaic (OPV) devices or organic photodetectors (OPD), and to OE, OPV and OPD devices comprising these oligomers, polymers, blends, mixtures or formulations.
Type:
Grant
Filed:
September 6, 2013
Date of Patent:
January 28, 2020
Assignee:
MERCK PATENT GMBH
Inventors:
William Mitchell, Changsheng Wang, Mansoor D'Lavari, David Sparrowe
Abstract: The instant invention provides compounds of formula (I) which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases such as inflammation, asthma, COPD and cancer.
Type:
Grant
Filed:
March 24, 2017
Date of Patent:
January 28, 2020
Assignee:
Merck Sharp & Dohme Corp.
Inventors:
Abdelghani Abe Achab, Matthew P. Christopher, Francesc Xavier Fradera Llinas, Jason D. Katz, Joey L. Methot, Hua Zhou, Shimin Xu, Jianmin Fu, Ning Fu, Yabin Li, Xichao Wang
Abstract: The present invention relates to metallo-?-lactamase inhibitor compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein Z, RA, X1, X2 and R1 are as defined herein. The present invention also relates to compositions which comprise a metallo-?-lactamase inhibitor compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, optionally in combination with a beta lactam antibiotic and/or a beta-lactamase inhibitor. The invention further relates to methods for treating a bacterial infection comprising administering to a patient a therapeutically effective amount of a compound of the invention, in combination with a therapeutically effective amount of one or more ?-lactam antibiotics and optionally in combination with one or more beta-lactamase inhibitor compounds. The compounds of the invention are useful in the methods described herein for overcoming antibiotic resistance.
Type:
Grant
Filed:
January 10, 2019
Date of Patent:
January 28, 2020
Assignee:
Merck Sharp & Dohme Corp.
Inventors:
Frank Bennett, Jinlong Jiang, Alexander Pasternak, Shuzhi Dong, Xin Gu, Jack D. Scott, Haiqun Tang, Zhiqiang Zhao, Yuhua Huang, Dexi Yang, Katherine Young, Li Xiao, Zhibo Zhang, Jianmin Fu
Abstract: This disclosure relates to a method for estimating a particle size distribution (PSD) and a morphology for a set of particles. A computer system receives a plurality of chord length distributions (CLDs) of different types for a set of particles. The computer system then estimates a morphology for the set of particles based on the plurality of received CLDs. The computer system also identifies a plurality of descriptors of the plurality of CLDs for the set of particles based on the plurality of received CLDs. The computer system then estimates metrics for the PSD for the set of particles based on the plurality of identified CLD descriptors. Based on the estimated PSD metrics for the set of particles, the computer system generates an estimate of the PSD for the set of particles. Finally, the computer system outputs the estimated morphology and the estimated PSD for the set of particles.
Abstract: The present invention relates to a drug delivery device comprising a drug container having at least one bellow. The at least one bellow has a first surface and an opposing second surface. The first surface is comprised of a first Belleville spring and the opposing second surface is comprised of a second Belleville spring, wherein the second Belleville spring has a higher spring rate than the first Belleville spring.
Type:
Grant
Filed:
June 1, 2015
Date of Patent:
January 28, 2020
Assignee:
Merck Sharp & Dohme Corp.
Inventors:
Peter A. Basile, Steven Carl Persak, Mikhail Gotliboym
Abstract: The present invention describes diazadibenzofuran or diazadibenzothiophene derivatives having carbazole structures, especially for use in electronic devices. The invention further relates to a process for preparing the compounds of the invention and to electronic devices comprising these.
Type:
Application
Filed:
September 27, 2017
Publication date:
January 23, 2020
Applicant:
Merck Patent GmbH
Inventors:
Amir Parham, Thomas Eberle, Anja Jatsch, Tobias Grossmann, Jonas Kroeber
Abstract: The present invention describes diazadibenzofuran or diazadibenzothiophene derivatives substituted by carbazole, fluorene, phenanthrene, benzofuran and/or benzothiophene groups, especially for use in electronic devices. The invention further relates to a process for preparing the compounds of the invention and to electronic devices comprising these.
Type:
Application
Filed:
September 28, 2017
Publication date:
January 23, 2020
Applicant:
Merck Patent GmbH
Inventors:
Amir Parham, Thomas Eberle, Anja Jatsch, Tobias Grossmann, Jonas Kroeber
Abstract: The invention relates to a polymerisable LC medium with flat optical dispersion, a polymer film with flat optical dispersion obtainable from such a medium, and the use of the polymerisable LC medium and polymer film in optical, electro optical, electronic, semiconducting or luminescent components or devices.
Type:
Application
Filed:
November 28, 2017
Publication date:
January 23, 2020
Applicant:
Merck Patent GmbH
Inventors:
Eduardo BELTRAN GRACIA, Iain GARDINER, Rebecca PROCTOR, Stephen MULCAHY