Patents Assigned to Merck
  • Formulations of anti-LAG3 antibodies and co-formulations of anti-LAG3 antibodies and anti-PD-1 antibodies
    Patent number: 11845798
    Abstract: The present invention provides formulations of anti-LAG3 antibodies, and co-formulations of anti-PD-1 antibodies and anti-LAG3 antibodies, and their use in treating various disorders.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: December 19, 2023
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Preeti G. Desai, Shuai Shi, Valentyn Antochshuk, Rubi Burlage, Smita Raghava
  • Nanoparticle
    Patent number: 11845889
    Abstract: The present invention relates to a nanoparticle and a composition comprising a nanoparticle.
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: December 19, 2023
    Assignee: Merck Patent GmbH
    Inventor: Itai Lieberman
  • ANTI-RESPIRATORY SYNCYTIAL VIRUS (RSV) ANTIBODY CELL-BASED POTENCY ASSAY
    Publication number: 20230399648
    Abstract: The disclosure describes methods for measuring the potency of anti-Respiratory Syncytial Virus (RSV) antibody against respiratory syncytial virus in a cell culture system using an RSV reporter virus. The disclosure also describes respiratory syncytial viruses that carry a reporter gene, and expression vectors for producing an infectious recombinant respiratory syncytial virus (RSV) that carry a reporter gene.
    Type: Application
    Filed: November 8, 2021
    Publication date: December 14, 2023
    Applicant: MERCK SHARP & DOHME LLC
    Inventors: Dai WANG, John P. BILELLO, Kevin B. GURNEY, Ping HAN, Xi HE, Dengyun SUN, Amy Hsu TOU
  • METHOD FOR PRODUCING AN AMORPHOUSE SOLID DISPERSION AND PHARMACEUTICAL COMPOSITION FOR STABILIZING ACTIVE PHARMACEUTICAL INGREDIENTS
    Publication number: 20230398222
    Abstract: The present invention relates to a method for producing an amorphous solid dispersion of at least one active pharmaceutical ingredient in a polymer matrix. The Invention further relates to a pharmaceutical composition using polymers as an excipient and particularly to an improved pharmaceutical composition comprising polyvinyl alcohol grades with different degrees of hydrolysis, which is suitable to stabilize active pharmaceutical ingredients.
    Type: Application
    Filed: October 20, 2021
    Publication date: December 14, 2023
    Applicant: MERCK PATENT GMBH
    Inventors: Thomas KIPPING, Finn BAUER, Nicole DI GALLO, Anja-Nadine KNUETTEL, Alessandro Giuseppe ELIA
  • 7-PHENYL SUBSTITUTED 2-AMINOQUINAZOLINE INHIBITORS OF HPK1
    Publication number: 20230399341
    Abstract: Compounds of the following formula (I); or the pharmaceutically acceptable salts thereof, are inhibitors of haematopoietic progenitor kinase 1 (HPK1) useful in the treatment of diseases or disorders associated with HPK1. Also disclosed herein are uses of these compounds in the potential treatment or prevention of an HPK1-associated disease or disorder. Also disclosed herein are compositions comprising one or more of the compounds. Further disclosed herein are uses of these compositions in the potential prevention or treatment of an HPK1-associated disease or disorder.
    Type: Application
    Filed: November 4, 2021
    Publication date: December 14, 2023
    Applicant: MERCK SHARP & DOHME LLC
    Inventors: David A. Candito, Joanna L. Chen, Anthony Donofrio, Xavier Fradera, Peter H. Fuller, Shuhei Kawamura, Bing Li, Jongwon Lim, Ping Liu, Joey L. Methot, Anilkumar G. Nair, Alexander Pasternak, Brandon A. Vara, Elsie C. Yu
  • Switchable window element
    Patent number: 11841591
    Abstract: A switchable window element with a layer structure comprising a switchable layer, two polarizers and two optical retarders; wherein a first polarizer and a first optical retarder are arranged in an optical path prior to the switchable layer and a second polarizer and a second optical retarder are arranged in the optical path after the switchable layer wherein the switchable layer is a vertically aligned liquid crystal layer comprising a liquid crystalline medium and wherein the product of the thickness d of the switchable layer and the optical anisotropy ?n of the liquid crystalline medium is in the range of from 0.05 ?m to 3.0 ?m and the liquid crystalline medium has a clearing point of at least 70° C.
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: December 12, 2023
    Assignee: Merck Patent GmbH
    Inventors: Michael Junge, Andreas Beyer
  • MODIFIED BENZOFURAN-CARBOXAMIDES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS
    Publication number: 20230391758
    Abstract: The present invention relates to Compounds of Formula I: and pharmaccutically acceptable salts or prodrug thereof. The present invention also relates to compositions comprising at least one compound of Formula I, and methods of using the compounds of Formula I for treatment or prophylaxis of lysosomal storage diseases, neurodegenerative disease, cystic disease, cancer, or a diseases or disorders associated with elevated levels of glucosylceramide (GlcCer), glucosylsphingosine (GlcSph) and/or other glucosylceramide-based glycosphingolipids (GSLs).
    Type: Application
    Filed: September 15, 2021
    Publication date: December 7, 2023
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Michael J. Breslin, Mark E. Fraley, Melissa C. Ford, Kristen L.G. Jones, SR., Anthony J. Roecker, Kathy M. Schirripa, Ling Tong
  • PHARMACEUTICAL COMPOSITION AND METHOD FOR ENHANCING SOLUBILITY OF POORLY SOLUBLE ACTIVE PHARMACEUTICAL INGREDIENTS
    Publication number: 20230390204
    Abstract: The present invention relates to pharmaceutical compositions using polymers as an excipient. Particularly, the invention relates to a pharmaceutical composition comprising polyvinyl alcohol which is suitable to enhance solubility of poorly soluble active pharmaceutical ingredients in aqueous media. The present invention also relates to a method for enhancing solubility of poorly soluble active pharmaceutical ingredients.
    Type: Application
    Filed: October 27, 2021
    Publication date: December 7, 2023
    Applicant: Merck Patent GmbH
    Inventors: Thomas KIPPING, Finn BAUER, Nicole DI GALLO, Anja-Nadine KNUETTEL, Alessandro Giuseppe ELIA
  • TRANSFER MECHANISM FOR TRANSFERRING OBJECTS THROUGH A TRANSFER PORT
    Publication number: 20230390756
    Abstract: Transfer mechanism/device (40) transferring one or more objects (O) through a transfer port (R), having a supporting base (41), a shuttle (42) with a mount (43) for a holder (47) for the one or more objects (O) or with a holder (47) and a container (44) accommodating the base (41) and the shuttle (42) and accommodating the objects (O), and having at least one opening (45) at an end portion in an axial direction (X) of the container (44).
    Type: Application
    Filed: October 20, 2021
    Publication date: December 7, 2023
    Applicant: Merck Patent GmbH
    Inventor: Stephane OLIVIER
  • LIQUID-CRYSTAL MEDIUM
    Publication number: 20230392077
    Abstract: A liquid-crystal (LC) medium based on a mixture of polar compounds, its use for optical, electro-optical and electronic purposes, in particular in LC displays, especially in LC displays of the vertically aligned mode, to an LC display of the vertically aligned mode containing the LC medium, especially an energy-saving LC display and a process of manufacturing the LC display.
    Type: Application
    Filed: June 1, 2023
    Publication date: December 7, 2023
    Applicant: MERCK PATENT GMBH
    Inventors: Harald HIRSCHMANN, Sabine SCHOEN, Philipp WUCHER
  • AROMATIC ISOTHIOCYANATES
    Publication number: 20230392075
    Abstract: The present invention relates to a compound of formula T as defined in claim 1, to a liquid crystal medium comprising a compound of formula T and to high-frequency components comprising these media, especially microwave components for high-frequency devices, such as devices for shifting the phase of microwaves, tunable filters, tunable metamaterial structures, and electronic beam steering antennas, e.g. phased array antennas.
    Type: Application
    Filed: October 25, 2021
    Publication date: December 7, 2023
    Applicant: MERCK PATENT GMBH
    Inventors: Amir Hossain PARHAM, Constanze BROCKE, Carsten FRITZSCH, Dagmar KLASS
  • TRANSPORT PACKAGING FOR A PLURALITY OF PETRI-DISHES AND BLISTER PACKAGING WITH A PLURALITY OF PETRI-DISHES
    Publication number: 20230392103
    Abstract: The present application relates to a transport packaging (20) for a plurality of petri-dishes (P), comprising a shell-like main body (21) with a compartment (22) for holding the plurality of petri-dishes (P) in a parallel orientation, the compartment (22) being accessible from an opening (23) at one side of the main body (21), and a rack-like structure (24) formed in the compartment (22) for supporting the petri-dishes (P) in a fixed position during handling and configured to allow insertion/extraction of the petri-dishes (P) into/from the rack-like structure (24) in a direction.
    Type: Application
    Filed: October 20, 2021
    Publication date: December 7, 2023
    Applicant: MERCK PATENT GMBH
    Inventors: Philippe RIVAT, Mathieu ARRAULT, Francois OBLINGER, Stéphane OLIVIER, Gael WAICHE
  • CARTRIDGE, TRANSFER DEVICE, METHOD FOR SAMPLING AIR, AND PRODUCTION ISOLATOR SYSTEM
    Publication number: 20230393033
    Abstract: The application relates to a cartridge for a plurality of petri-dishes, comprising a cylindrical cartridge housing configured to receive the plurality of petri-dishes in a stack aligned with an axial direction of the cartridge housing in an interior space of the cartridge housing such that the stack of petri-dishes can be moved in the axial direction within the interior space. An axial end portion of the cartridge housing has a first opening dimensioned so that the petri-dishes can be exposed from the cartridge housing by sliding in the axial direction. Another axial end portion of the cartridge housing has a second opening dimensioned to prevent removal of the petri-dishes through the second opening and so that a piston can be inserted into the interior space of the cartridge housing for moving the stack of petri-dishes (P) in the axial direction towards the first opening.
    Type: Application
    Filed: October 20, 2021
    Publication date: December 7, 2023
    Applicant: MERCK PATENT GMBH
    Inventors: Stéphane OLIVIER, Vincent SCHAAL
  • METHODS FOR TARGET RELEASE FROM INTEIN COMPLEXES
    Publication number: 20230391821
    Abstract: The present disclosure relates to methods of releasing a target molecule from intein complexes comprising an intein-C tagged target molecule and intein-N polypeptides, by contacting the intein complexes with nitrogen containing heteroaromatic derivatives, and/or by increasing residence time of intein complexes in a medium effective to remove the target molecule. Modulating the pH further facilitates target release.
    Type: Application
    Filed: September 27, 2021
    Publication date: December 7, 2023
    Applicant: MERCK PATENT GMBH
    Inventors: Oliver RAMMO, Vanessa KOHL
  • AROMATIC ISOTHIOCYANATES
    Publication number: 20230392076
    Abstract: The present invention relates to a compound of formula UI as defined in claim 1, to a liquid crystal medium comprising a compound of formula UI and to high-frequency components comprising these media, especially microwave components for high-frequency devices, such as devices for shifting the phase of microwaves, tunable filters, tunable metamaterial structures, and electronic beam steering antennas, e.g. phased array antennas.
    Type: Application
    Filed: October 25, 2021
    Publication date: December 7, 2023
    Applicant: MERCK PATENT GMBH
    Inventors: Constanze BROCKE, Dagmar KLASS, Carsten FRITSCH
  • TRANSFER DEVICE FOR TRANFERRING A PLURALITY OF OBJECTS THROUGH A TRANSFER PORT
    Publication number: 20230393031
    Abstract: The present application relates to a transfer device (60) for transferring a plurality of objects (O) through a transfer port (R), comprising a container (61) with an internal space (67) configured to accommodate the plurality of objects (O) to be transferred through the transfer port (R). The container (61) has at least one extraction opening (62) at an end portion of the container (61) in an axial direction (X) dimensioned such that the objects (O) can be removed from the container (61) at least individually, a door (63) configured to selectively close the at least one extraction opening (62) and seal the internal space (67) from the environment, and a piston (64) arranged in the container (61) so as to be movable in a translational motion in the axial direction (X) towards/away from the at least one extraction opening (62) to move the objects (O) accommodated in the container (61).
    Type: Application
    Filed: October 20, 2021
    Publication date: December 7, 2023
    Applicant: MERCK PATENT GMBH
    Inventors: Stéphane OLIVIER, Vincent SCHAAL
  • MACROCYCLIC UREA OREXIN RECEPTOR AGONISTS
    Publication number: 20230391795
    Abstract: The present invention is directed to macrocyclic urea compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.
    Type: Application
    Filed: October 28, 2021
    Publication date: December 7, 2023
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Kira A. Armacost, Maria Irina Chiriac, Danielle M. Hurzy, Jeffrey C. Kern, Jian Liu, Peter J. Manley, Vanessa L. Rada, Michael T. Rudd, Craig A. Stump, Zhe Wu, Dong Xiao
  • COMPOSITION
    Publication number: 20230392033
    Abstract: The present invention relates to a composition comprising at least one light emitting moiety.
    Type: Application
    Filed: October 11, 2021
    Publication date: December 7, 2023
    Applicant: Merck Patent GmbH
    Inventors: Tadashi KISHIMOTO, Yuki HIRAYAMA, Julian BURSCHKA, Teruaki SUZUKI, Nils GREINERT, Denis GLOZMAN, Ehud SHAVIV, Yaron AVIV, Elizaveta KOSSOY
  • RACK FOR HOLDING A PLURALITY OF PETRI-DISHES AND TRANSPORT PACKAGING WITH THE RACK
    Publication number: 20230390780
    Abstract: The present application relates to a rack (1) for holding a plurality of petri-dishes (P), comprising a plate-like main body (2) with a plurality of adjacent and spaced apart holding portions (3) each configured to receive and support, in a substantially horizontal orientation that is substantially perpendicular to a plane of the plate-like main body (2), a petri-dish (P), wherein each holding portion (3) includes positioning features (4) for positioning the petri-dish (P) in the holding portion (3).
    Type: Application
    Filed: October 20, 2021
    Publication date: December 7, 2023
    Applicant: Merck Patent GmbH
    Inventor: Stephane OLIVIER
  • Dielectric copolymer materials
    Patent number: 11834598
    Abstract: The present invention relates to a polymerizable mixture which can be used to form a dielectric material for the preparation of passivation layers in electronic devices. The polymerizable mixture comprises a first monomer and a second monomer which may react to form a copolymer providing excellent film forming capability, excellent thermal properties and excellent mechanical properties. There is further provided a method for forming said copolymers and an electronic device containing said copolymers as dielectric material. Beyond that, the present invention relates to a manufacturing method for preparing a packaged microelectronic structure and to a microelectronic device comprising said packaged microelectronic structure formed by said manufacturing method.
    Type: Grant
    Filed: October 15, 2019
    Date of Patent: December 5, 2023
    Assignee: Merck Patent GmbH
    Inventors: Gregor Larbig, Pawel Miskiewicz, Frank Meyer, Joerg Pahnke, Karsten Koppe