Patents Assigned to Merck
  • DIELECTRIC MATERIALS BASED ON BISMALEIMIDES CONTAINING CARDO/SPIRO MOIETIES
    Publication number: 20240010796
    Abstract: The present invention relates to a new class of dielectric polymer material, which is particularly suitable for the manufacturing of electronic devices. The dielectric polymer material is formed by reacting bismaleimide compounds and shows an advantageous well-balanced profile of favorable material properties. The bismaleimide compounds have an oligomeric structure with a cardo and/or spiro moiety containing repeating unit in the middle part of the molecule and maleimide groups at each terminal end of the molecule. There is further provided a method for forming said dielectric polymer material and an electronic device comprising the same as dielectric material.
    Type: Application
    Filed: December 2, 2021
    Publication date: January 11, 2024
    Applicant: MERCK PATENT GMBH
    Inventors: Gregor LARBIG, Frank Egon MEYER, Pawel MISKIEWICZ
  • INCREASED VOLTAGE-GATED SODIUM CHANNEL ALPHA PROTEIN SUBUNIT EXPRESSION THROUGH VIRAL 2A-MEDIATED CO-EXPRESSION OF NAV BETA SUBUNITS
    Publication number: 20240012004
    Abstract: A voltage-gated sodium channel expression system is described. The system comprises providing a polycistronic RNA message that encodes a polyprotein comprising a voltage-gated sodium channel alpha protein (Nav?) subunit and one or more voltage-gated sodium channel beta protein (Nav?) subunits, each of said subunits being separated by a 2A self-cleaving peptide. During translation, the polyprotein is cleaved into individual subunit proteins which can assemble into a voltage-gated sodium channel. Host cells and lipoparticles comprising the sodium channel expression system are also provided.
    Type: Application
    Filed: November 12, 2021
    Publication date: January 11, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Richard L. Kraus, John Majercak
  • ANTI-CEACAM5 ANTIBODIES AND CONJUGATES AND USES THEREOF
    Publication number: 20240010749
    Abstract: Antibodies which bind human CEACAM5 protein, as well as isolated nucleic acids and host cells containing a sequence encoding said antibodies are disclosed. Immunoconjugates containing said antibodies linked to a growth-inhibitory agent, and pharmaceutical compositions containing antibodies or said immunoconjugates are also disclosed. A use of the antibodies, immunoconjugates, and pharmaceutical compositions disclosed herein is provided for the treatment of cancer or for diagnostic purposes.
    Type: Application
    Filed: August 13, 2021
    Publication date: January 11, 2024
    Applicant: Merck Patent GmbH
    Inventors: Jan ANDERL, Sabine RAAB-WESTPHAL, Stefan HECHT, Carl DEUTSCH, Min SHAN, Doreen KÖNNING, Willem N. SLOOT, Felix HART, Christian SCHRÖTER, Lars TOLEIKIS, Nir BERGER
  • Polysiloxane, composition comprising the same and cured film using the same
    Patent number: 11866553
    Abstract: [Problem] To provide a polysiloxanecapable of forming a cured film of a thick film with high heat resistance, a composition comprising the polysiloxane, and a method of manufacturing a cured film using the composition. [Means for Solution] To provide a polysiloxane comprising a repeating unit represented by the following formula (Ib), wherein R2 is each independently hydrogen, alkyl, aryl, alkenyl, and the like, a composition comprising the polysiloxane, and a method of manufacturing a cured film using the composition.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: January 9, 2024
    Assignee: Merck Patent GmbH
    Inventors: Naofumi Yoshida, Megumi Takahashi, Seishi Shibayama, Katsuto Taniguchi, Masanobu Hayashi, Toshiaki Nonaka
  • Polycarbosilazane, and composition comprising the same, and method for producing silicon-containing film using the same
    Patent number: 11866554
    Abstract: To provide a new silicon-containing polymer making it possible to form a cured film has features that its residual stress is small and crack resistance is high. A polycarbosilazane having particular cyclic structures.
    Type: Grant
    Filed: October 5, 2021
    Date of Patent: January 9, 2024
    Assignee: Merck Patent GmbH
    Inventors: Katsuchika Suzuki, Toshiya Okamura, Tetsuo Okayasu, Thorsten Vom Stein
  • Negative type photosensitive siloxane composition and methods for producing cured film and electronic device using the same
    Patent number: 11868048
    Abstract: [Object] To provide a negative type photosensitive siloxane composition capable of forming a cured film excellent in heat resistance and critical thickness for cracking [Means] The present invention provides a negative type photosensitive siloxane composition comprising: a polysiloxane containing silanol in a specific content, a particular photo base generator, and a solvent. The content of silanol is measured by FT-IR.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: January 9, 2024
    Assignee: Merck Patent GmbH
    Inventor: Masanobu Hayashi
  • Filtration head for a filter system and funnel for use in conjunction with a filtration head
    Patent number: 11865477
    Abstract: Filtration head (1) for a filter system, comprising base (2) including filter support (3) for removable filter element (4) and a fluid path from one side of filter element (4) on filter support (3), through filter element (4), and to drainage outlet (5) of base (2), and holder device (6) for removably attaching funnel (7) to base (2) to form a sample fluid reservoir on one side of filter element (4), wherein holder device (6) comprises ring-shaped element (8) configured to extend about bottom peripheral flange (7a) surrounding a lower end of funnel (7) and to selectively apply a biasing force on a radially outward protruding portion (7b) of bottom peripheral flange (7a) of funnel (7) to press funnel (7) against base (2). The filtration head allows the use of cardboard funnels without risk of liquid leakage between the funnel and the base.
    Type: Grant
    Filed: April 3, 2019
    Date of Patent: January 9, 2024
    Assignee: MERCK PATENT GMBH
    Inventors: Didier Metz, Marisa Hohnadel
  • Sterile line clip separation tool
    Patent number: 11865681
    Abstract: A system and a method are disclosed for disconnecting clips. A clip separation tool includes two arms, the arms having jaws to receive connected clips at a distal end of the arms and handle portions on a proximal end for a user to engage the tool with his hand. A pivot mechanism is coupled to the arms, where, responsive to a force applied to the handle portions, the arms rotate relative to each other around the pivot mechanism such that the distal ends of the arms pivot away from one another and the proximal ends of the arms pivot towards one another. A spring biases the arms to rotate to an equilibrium position that is attained automatically under spring loading once the proximal ends of the arms are relieved of loading. The clip separation tool disconnects connected clips as the force causes the arms to rotate around the pivot mechanism.
    Type: Grant
    Filed: July 21, 2020
    Date of Patent: January 9, 2024
    Assignee: Merck Sharp & Dohme LLC
    Inventor: Derrick Matthew Smith
  • ARGINASE 1 BINDERS FOR INHIBITING ARGINASE 1 ACTIVITY
    Publication number: 20240002533
    Abstract: Arginase 1 binders comprising human antibodies and antigen-binding fragments thereof that inhibit the activity of human Arginase 1 (hArg1) are described. These Arginase 1 binders present an alternative mechanism for inhibiting hArg1 activity and highlight the ability to utilize binders as probes in the discovery and development of peptide and small molecule inhibitors for enzymes in general.
    Type: Application
    Filed: November 22, 2021
    Publication date: January 4, 2024
    Applicant: MERCK SHARP & DOHME LLC
    Inventors: Marc Andre Bailly, Kalyan Chakravarthy, Ghassan Najib Fayad, Laurence Fayadat-Dilman, Veronica Juan, Esther Kofman, Heping Lin, Jennifer E. O'Neil, Rachel Lynn Palte, Giovanna Scapin, Hussam Hisham Shaheen, Tao Wang
  • LIQUID-CRYSTAL MEDIUM
    Publication number: 20240002728
    Abstract: A liquid-crystal (LC) material having negative dielectric anisotropy and the use thereof for optical, electro-optical and electronic purposes, such as for example in LC displays, in particular energy saving displays based on the ECB, IPS or FFS effect, where the liquid crystal medium contains one or more compounds of formula I and one or more compounds compounds of formulae IIA, IIB, IIC and IID
    Type: Application
    Filed: June 22, 2023
    Publication date: January 4, 2024
    Applicant: Merck Patent GmbH
    Inventors: Chi-Shun HUANG, Sven Christian LAUT, Hee-Kyu LEE, Minghui YANG, Harald HIRSCHMANN, Kuang-Ting CHOU, Shih-Chieh HUNG, Alexander HAHN, Philipp WUCHER
  • ARGINASE 1 BINDERS FOR INHIBITING ARGINASE 1 ACTIVITY
    Publication number: 20240002535
    Abstract: Arginase 1 binders that inhibit activity of hArg1, which comprise humanized anti-human Arginase 1 (hArg1) antibodies and antigen-binding fragments thereof obtained from mouse monoclonal antibodies comprising mouse VH and VL, are described. These Arginase 1 binders present an alternative mechanism for inhibiting hArg1 activity and highlight the ability to utilize binders as probes in the discovery and development of peptide and small molecule inhibitors for enzymes in general.
    Type: Application
    Filed: November 22, 2021
    Publication date: January 4, 2024
    Applicant: MERCK SHARP & DOHME LLC
    Inventors: Marc Andre Bailly, Kalyan Chakravarthy, Ghassan Najib Fayad, Laurence Fayadat-Dilman, Veronica Juan, Esther Kofman, Masahisa Handa, Jennifer E. O'Neil, Rachel Lynn Palte, Giovanna Scapin, Shahriar Shane Taremi
  • 3-AMINO PYRROLIDINE AND PIPERIDINE MACROCYCLIC OREXIN RECEPTOR AGONISTS
    Publication number: 20240002397
    Abstract: The present invention is directed to 3-amino pyrrolidine and piperidine macrocyclic compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.
    Type: Application
    Filed: November 18, 2021
    Publication date: January 4, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Stephane L. Bogen, Ping Chen, Dane James Clausen, Jian Liu, Michael T. Rudd, Li Xiao, Dexi Yang, Shishi Lin
  • FERROELECTRIC NEMATIC LIQUID CRYSTALLINE MEDIUM
    Publication number: 20240002727
    Abstract: The new LC media exhibit a ferroelectric nematic phase at ambient temperature. They comprise at least one or more compounds selected from each of formula IA, of formula IB and of the group of formulae IC-1/IC-2/IC-3, in which the variable groups have the meanings indicated in the text and in the claims. The mixtures are useful for electro-optics, electronics, electro-mechanic and other applications for materials with very high dielectric permittivity and other energy-saving applications.
    Type: Application
    Filed: November 30, 2021
    Publication date: January 4, 2024
    Applicant: MERCK PATENT GMBH
    Inventors: Matthias BREMER, Atsutaka MANABE, Martin KRASKA
  • COMPACT CONTAINMENT SYSTEM FOR ISOLATING, PROCESSING AND PACKAGING PHARMACEUTICAL PRODUCTS
    Publication number: 20240000663
    Abstract: A compact containment system comprises a mixing apparatus, a drying apparatus and a discharge apparatus. The mixing apparatus, which may be used to produce a slurry or solution mixture of solvent and dry powder during drug processing, comprises a dual compartment isolator for safely removing the dry powder from a dry powder container, a mixing vessel, and a negative cascading pressure controller. The drying apparatus comprises a drying unit, such as a thin film evaporator.
    Type: Application
    Filed: December 2, 2021
    Publication date: January 4, 2024
    Applicant: MERCK SHARP & DOHME LLC
    Inventors: John H. Roosa, Alan S. D'Alessandro, Frank D. Gianotti, III, Robert C. O'Connor, Luke Ryan Schenck, Timothy Stanoch, Matthew Yuhas, JR.
  • COMPOSITION
    Publication number: 20240002688
    Abstract: The present invention relates to a composition comprising at least one light emitting moiety.
    Type: Application
    Filed: October 18, 2021
    Publication date: January 4, 2024
    Applicant: MERCK PATENT GMBH
    Inventors: Yuki HIRAYAMA, Tadashi KISHIMOTO, Tomohisa GOTO, Hiromoto SATO, Nils GREINERT, Teruaki SUZUKI
  • NAV1.7 BINDERS
    Publication number: 20240002497
    Abstract: Antibodies and antigen-binding fragments thereof that bind the human voltage-gated sodium channel Nav1.7? protein subunit (Nav1.7 binders) are described. In particular embodiments, the Nav1.7 binders comprise a heavy-chain immunoglobulin single variable domain (ISVD or VHH).
    Type: Application
    Filed: November 18, 2021
    Publication date: January 4, 2024
    Applicants: MERCK SHARP & DOHME LLC, MERCK SHARP & DOHME RESEARCH GMBH
    Inventors: Pravien Damitha Abeywickrema, Erik Depla, Bruno Dombrecht, Daniel M. Gorman, Andrea K. Houghton, Robert A. Kastelein, Richard L. Kraus, John Majercak, Kalyan Pande, Sujata Sharma
  • ARGINASE 1 BINDERS FOR INHIBITING ARGINASE 1 ACTIVITY
    Publication number: 20240002534
    Abstract: Arginase 1 binders that inhibit the activity of human Arginase 1 (hArg1) and comprise human antibodies and antigen-binding fragments thereof comprising human VH and VL are described. These Arginase 1 binders present an alternative mechanism for inhibiting hArg1 activity and highlight the ability to utilize binders as probes in the discovery and development of peptide and small molecule inhibitors for enzymes in general.
    Type: Application
    Filed: November 22, 2021
    Publication date: January 4, 2024
    Applicant: MERCK SHARP & DOHME LLC
    Inventors: Marc Andre Bailly, Kalyan Chakravarthy, Ghassan Najib Fayad, Laurence Fayadat-Dilman, Esther Kofman, Masahisa Handa, Jennifer E. O'Neil, Rachel Lynn Palte, Giovanna Scapin, Shahriar Shane Taremi
  • APPARATUS AND METHOD FOR COLLECTING DRIED PHARMACEUTICAL PRODUCT FROM A PHARMACEUTICAL DRYING DEVICE
    Publication number: 20240003625
    Abstract: Apparatus and method for collecting a dried pharmaceutical product from a product reservoir of a pharmaceutical drying device, such as a thin film evaporator, while the product reservoir remains under continuous vacuum pressure.
    Type: Application
    Filed: December 2, 2021
    Publication date: January 4, 2024
    Applicant: MERCK SHARP & DOHME LLC
    Inventors: John H. Roosa, Frank D. Gianotti, III, Robert C. O'Connor, Luke Ryan Schenck, Matthew Yuhas, Jr.
  • 3-HETEROARYL PYRROLIDINE AND PIPERIDINE OREXIN RECEPTOR AGONISTS
    Publication number: 20240002359
    Abstract: The present invention is directed to 3-heteroaryl pyrrolidine and piperidine compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.
    Type: Application
    Filed: December 1, 2021
    Publication date: January 4, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Stephane L. Bogen, Ping Chen, Dane James Claussen, Xianhai Huang, Michael T. Rudd, Shawn P. Walsh, Lan Wei, Dexi Yang
  • Boronic acid derivatives
    Patent number: 11858951
    Abstract: ?-Amino boronic acid derivatives are useful for inhibiting the activity of immunoproteasome (LMP7) and for the treatment and/or prevention of medical conditions affected by immunoproteasome activity such as inflammatory and autoimmune diseases, neurodegenerative diseases, proliferative diseases, and cancer.
    Type: Grant
    Filed: January 31, 2022
    Date of Patent: January 2, 2024
    Assignee: Merck Patent GmbH
    Inventors: Markus Klein, Oliver Schadt, Christina Esdar