Patents Assigned to Merck
  • Fluorine compounds
    Patent number: 11767396
    Abstract: The present invention relates to fluorine compounds (I), (II) and (III), to processes for the preparation thereof, and to the use thereof.
    Type: Grant
    Filed: June 24, 2021
    Date of Patent: September 26, 2023
    Assignee: Merck Patent GmbH
    Inventors: Reiner Friedrich, Fabian Koch
  • N3-substituted iminopyrimidinones as antimalarial agents
    Patent number: 11766435
    Abstract: The present invention provides methods of treating malaria comprising administration of an N3-substituted iminopyrimidinone of Formula (I) or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein the variables R1, R2, R3, R4, R5, A, B, L, m, and n are as defined herein. The invention also provides uses of the compounds of Formula (I), as defined herein, for inhibiting plasmepsin V activity, for treating a Plasmodium infection, and for treating malaria. Also provided are methods of treatment further comprising administration of one or more additional anti-malarial compounds.
    Type: Grant
    Filed: February 13, 2017
    Date of Patent: September 26, 2023
    Assignees: Merck Sharp & Dohme LLC, The Walter and Eliza Hall Institute of Medical Research
    Inventors: Tanweer A. Khan, Jared N. Cumming, David B. Olsen, Justin A. Boddey, Alan F. Cowman, Brad E. Sleebs
  • Esters containing aromatic groups as solvents for organic electronic formulations
    Patent number: 11770971
    Abstract: The present invention relates to formulations for the preparation of organic electronic devices (OLEDs) which comprise (A) at least one specific ester solvent containing an aromatic group and (B) at least one organic functional material selected from organic conductors, organic semiconductors, organic fluorescent compounds, organic phosphorescent compounds, organic light-absorbent compounds, organic light-sensitive compounds, organic photosensitisation agents and other organic photoactive compounds, selected from organometallic complexes of transition metals, rare earth metals, lanthanides and actinides.
    Type: Grant
    Filed: October 11, 2021
    Date of Patent: September 26, 2023
    Assignee: Merck Patent GmbH
    Inventors: Gaëlle Béalle, Christoph Leonhard, Hsin-Rong Tseng, Irina Martynova, Aurélie Ludemann, Edgar Kluge, Anja Jatsch, Manuel Hamburger, Li Wei Tan, Pawel Miskiewicz, Philip Edward May, Daniel Walker
  • Spin-on compositions comprising an inorganic oxide component and an alkynyloxy substituted spin-on carbon component useful as hard masks and filling materials with improved shelf life
    Patent number: 11767398
    Abstract: The present invention relates to a composition comprising; components a) b) and d); wherein, component a) is a metal compound having the structure (I), component b) is a spin on high carbon polymer, having a polymer backbone comprising mono-cyclic aromatic hydrocarbon, fused-ring ring hydrocarbon moieties, or mixtures of these, having a wt. % of carbon from about 81 wt. % to about 94 wt. %, which is soluble to at least about 5 wt. % in a spin casting solvent, and wherein at least one, of said mono-cyclic aromatic hydrocarbon or said fused-ring ring hydrocarbon moieties, present in said spin on high carbon polymer, is functionalized with at least one alkynyloxy moiety of structure (VIII), and component d) is a spin casting solvent.
    Type: Grant
    Filed: February 20, 2020
    Date of Patent: September 26, 2023
    Assignee: Merck Patent GmbH
    Inventors: M. Dalil Rahman, Takashi Sekito
  • Materials for organic electroluminescent devices
    Patent number: 11767299
    Abstract: The present invention relates to compounds of the formula (1) which are suitable for use in electronic devices, in particular organic electroluminescent devices, and to electronic devices which comprise these compounds.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: September 26, 2023
    Assignee: Merck Patent GmbH
    Inventors: Ilona Stengel, Kathy Vinokurov, Frank Voges, Aurélie Ludemann
  • LIQUID CRYSTAL MEDIUM
    Publication number: 20230295510
    Abstract: The present invention relates to a liquid crystal (LC) medium comprising a compound of formula I and one or more compounds of formula II as defined in claim 1, and to the use thereof for optical, electro-optical and electronic purposes, in particular in LC displays, especially in IPS, FFS, VA or PS-VA displays.
    Type: Application
    Filed: June 30, 2021
    Publication date: September 21, 2023
    Applicant: MERCK PATENT GMBH
    Inventor: Sven Christian LAUT
  • STEERABLE ANTENNA AND METHOD FOR HEATING AND/OR TEMPERING OF A STEERABLE ANTENNA
    Publication number: 20230295509
    Abstract: A steerable antenna having a plurality of radiating elements and a plurality of modifier elements configured for shifting phase and/or adjusting amplitude of a signal to be emitted by the radiating elements is disclosed. Each of the radiating elements is coupled to one of the modifier elements, wherein the modifier elements each comprise a liquid crystalline medium and wherein the modifier elements are configured such that the adjustment of the phase and/or amplitude is dependent on a state of the liquid crystalline medium. The steerable antenna further comprises a signal generator connected to the modifier elements and configured for generating a signal suited for dielectric heating of the liquid crystalline media of the modifier elements. Further aspects relate to a method for heating and/or controlling the temperature of the liquid crystalline medium of such a steerable antenna.
    Type: Application
    Filed: June 7, 2021
    Publication date: September 21, 2023
    Applicant: MERCK PATENT GMBH
    Inventors: Michael WITTEK, Carsten FRITZSCH, Dagmar KLASS
  • LIQUID CRYSTAL MEDIUM
    Publication number: 20230295511
    Abstract: The present invention relates to a liquid crystal (LC) medium comprising a compound of formula I and one or more compounds selected from the group of compounds of the formulae IIA, IIB, IIC and IID, as defined in claim 1, and to the use thereof for optical, electro-optical and electronic purposes, in particular in LC displays, especially in IPS, FFS, VA or PS-VA displays.
    Type: Application
    Filed: June 30, 2021
    Publication date: September 21, 2023
    Applicant: MERCK PATENT GMBH
    Inventors: Sven Christian LAUT, Fisher (Shuo) YU
  • CRYSTALLINE FORMS OF 4-[(7-CHLORO-2-METHOXYBENZO[B][1,5]NAPHTHYRIDIN-10-YL)AMINO]-2,6-BIS(PYRROLIDIN-1-YLMETHYL)PHENOL AND SALTS THEREOF
    Publication number: 20230295156
    Abstract: Novel crystalline forms of 4-1(7-chloro-2-methoxybenzo[bll 1,5]naphthyridin-10-yl)aminol-2,6-bis(pyrrolidin-l-%Ilmethyl)phenol and salts thereof are useful, in particular for pharmaceutical formulations. Processes can be used for manufacturing the crystalline forms, and the crystalline forms can be used in methods of treatment.
    Type: Application
    Filed: April 14, 2021
    Publication date: September 21, 2023
    Applicant: Merck Patent GmbH
    Inventors: Axel BECKER, Delia-Maria Gruia
  • ELECTRONIC SWITCHING DEVICE
    Publication number: 20230301173
    Abstract: An electronic switching device, in particular tunnel junctions, containing an organic molecular layer for use in memory, sensors, field-effect transistors or Josephson junctions. More particularly, related to the field of random access non-volatile memristive memories (RRAM). Another aspect is a compound of formula I for use in a molecular layer. Also, the use of the molecular layer and processes for the production and operation of an electronic switching element and components based thereon.
    Type: Application
    Filed: March 15, 2023
    Publication date: September 21, 2023
    Applicant: Merck Patent GmbH
    Inventors: Peer KIRSCH, Henning SEIM, Frank VOGES, Holger HEIL
  • Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates
    Patent number: 11759523
    Abstract: The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Streptococcus pneumoniae serotypes.
    Type: Grant
    Filed: June 24, 2022
    Date of Patent: September 19, 2023
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Richard J. Porambo, Chitrananda Abeygunawardana, Luwy Kavuka Musey, Michael J. Kosinski, Yadong Adam Cui
  • Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates
    Patent number: 11759510
    Abstract: The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Streptococcus pneumoniae serotypes.
    Type: Grant
    Filed: June 24, 2022
    Date of Patent: September 19, 2023
    Assignee: Merck, Sharp & Dohme LLC
    Inventors: Richard J. Porambo, Chitrananda Abeygunawardana, Luwy Kavuka Musey, Michael J. Kosinski, Yadong Adam Cui
  • Liquid-crystalline medium for use in a switching element
    Patent number: 11760931
    Abstract: The present invention relates to liquid-crystalline media comprising one or more mesogenic compounds of formula I as set forth hereinafter, wherein the one or more compounds of formula I are contained in the medium in an amount, based on the overall contents of the medium, of at least 15% by weight. The present invention further relates to a switching layer, a switching element and a window element containing the liquid-crystalline medium.
    Type: Grant
    Filed: December 3, 2018
    Date of Patent: September 19, 2023
    Assignee: Merck Patent GmbH
    Inventors: Michael Junge, Andreas Beyer, Mila Fischer, Ewa Ptak
  • Materials for organic electroluminescent devices
    Patent number: 11760734
    Abstract: The present invention relates to fluorene derivatives and to electronic devices in which these compounds are used as matrix material in the emitting layer and/or as hole-transport material and/or as electron-blocking or exciton-blocking material and/or as electron-transport material.
    Type: Grant
    Filed: April 5, 2021
    Date of Patent: September 19, 2023
    Assignee: MERCK PATENT GMBH
    Inventors: Adam W. Franz, Rémi Manouk Anémian
  • Composition comprising block copolymer, and method for producing siliceous film using the same
    Patent number: 11760842
    Abstract: To provide a siliceous film manufacturing composition that can fill a narrow and a high aspect ratio trench and can produce a thick siliceous film. [Means for Solution] The present invention provides a siliceous film manufacturing composition that comprises, (a) a block copolymer having a linear and/or cyclic polysilane backbone block with or more silicon atoms and a polycarbosilane backbone block with or more silicon atoms, and (b) a solvent.
    Type: Grant
    Filed: April 6, 2020
    Date of Patent: September 19, 2023
    Assignee: MERCK PATENT GMBH
    Inventors: Takashi Fujiwara, Atsuhiko Sato
  • Device for the regulation of light transmission
    Patent number: 11762241
    Abstract: Devices for the regulation of light transmission and in particular switchable windows, including window elements containing a switchable optical cell having a homeotropically aligned liquid crystal layer with a pretilt angle in the range of 77° to 88°.
    Type: Grant
    Filed: December 15, 2020
    Date of Patent: September 19, 2023
    Assignee: MERCK PATENT GMBH
    Inventors: Michael Junge, Rainer Neeff
  • Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates
    Patent number: 11759511
    Abstract: The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Streptococcus pneumoniae serotypes.
    Type: Grant
    Filed: June 24, 2022
    Date of Patent: September 19, 2023
    Assignee: MERCK SHARP & DOHME LLC
    Inventors: Richard J. Porambo, Chitrananda Abeygunawardana, Luwy Kavuka Musey, Michael J. Kosinski, Yadong Adam Cui
  • Polymerizable compounds
    Patent number: 11760935
    Abstract: Polymerizable compounds, processes and intermediates for their preparation, compositions containing them, polymers made from the compounds or compositions, and uses of the polymerizable compounds, compositions and polymers.
    Type: Grant
    Filed: March 29, 2021
    Date of Patent: September 19, 2023
    Assignee: MERCK PATENT GMBH
    Inventors: Thorsten Kodek, Oliver Heppert, Timo Uebel, Rocco Fortte, Leo Weegels
  • PLASMA KALLIKREIN INHIBITORS
    Publication number: 20230286958
    Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing one or more disease states that could benefit from inhibition of plasma kallikrein, including hereditary angioedema, uveitis, posterior uveitis, wet age related macular edema, diabetic macular edema, diabetic retinopathy and retinal vein occlusion. The compounds are selective inhibitors of plasma kallikrein.
    Type: Application
    Filed: June 10, 2021
    Publication date: September 14, 2023
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Salman Jabri, Anthony Ken Ogawa, Christopher J. Sinz, Jacqueline D. Hicks, Alan C. Cheng, Ying-Duo Gao, Song Yang, Jianming Bao, Donna A. A. W. Hayes, Simon B. Lang, Brandon M. Taoka, Maoqun Tian, Galen Paul Shearn-Nance, Rongze Kuang, Matthew J. Lombardo, Zhicai Wu, Zhiqiang Zhao
  • RACK FOR HOLDING A PLURALITY OF PETRI-DISHES AND TRANSPORT PACKAGING WITH THE RACK
    Publication number: 20230285978
    Abstract: The present application relates to a rack (1) for holding a plurality of petri-dishes (P), comprising a main body (2) with a plurality of adjacent and spaced apart holding portions (3) each configured to receive and support, in a substantially parallel orientation that is substantially perpendicular to a longitudinal direction (X) of the rack (1), a petri-dish (P), wherein each holding portion (3) includes positioning features (4) for positioning the petri-dish (P) in the holding portion (3) and allowing insertion of the petri-dish (P) from a lateral side in a direction substantially perpendicular to the longitudinal direction (X). The holding portions (3) and positioning features (4) respectively comprise a pair of separation elements (11) spaced apart from each other to define therebetween a slot (12) configured to receive the petri-dish (P).
    Type: Application
    Filed: October 20, 2021
    Publication date: September 14, 2023
    Applicant: Merck Patent GmbH
    Inventor: Stephane OLIVIER