Patents Assigned to Merck
  • Antibody peptide conjugates that have agonist activity at both the glucagon and glucagon-like peptide 1 receptors
    Patent number: 11773150
    Abstract: Described are antibody peptide conjugates (APCs) comprising an antibody conjugated to a peptide analog of glucagon, which have been modified to be resistant to cleavage and inactivation by dipeptidyl peptidase IV (DPP-IV) and to increase in vivo half-life of the peptide analog while enabling the peptide analog to have agonist activity at the glucagon (GCG) receptor and the glucagon-like peptide 1 (GLP-1) receptor and the use of such APCs for treatment of metabolic disorders such as diabetes, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and obesity.
    Type: Grant
    Filed: August 27, 2020
    Date of Patent: October 3, 2023
    Assignees: Merck Sharp & Dohme LLC, Ambrx, Inc.
    Inventors: Paul E. Carrington, Grigori Ermakov, Robert M. Garbaccio, Wolfgang Seghezzi, Elisabetta Bianchi, Federica Orvieto, Dennis Gately, Nick Knudsen, Anthony Manibusan
  • Polypeptides that bind to IL-17A, IL-17F and/or IL17-A/F and methods of treatment using same
    Patent number: 11773159
    Abstract: The present disclosure relates to amino acid sequences that are directed against (as defined herein) any of IL-17A, IL-17F and/or IL-17A/F including combinations thereof, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences.
    Type: Grant
    Filed: September 29, 2020
    Date of Patent: October 3, 2023
    Assignee: Merck Patent GmbH
    Inventors: Heidi Rommelaere, Joost Alexander Kolkman, Michael John Scott Saunders, Ann Union, Yolande Chvatchko, Amanda E. I. Proudfoot, Alain Vicari, Denis Bruniquel, Laurent Chevalet, Olivier Leger
  • Effect pigments
    Patent number: 11773270
    Abstract: The present invention relates to effect pigments which are based on flake-form substrates having a circular form factor of 1.2-2 and are coated with at least one high-refractive-index layer, and to the use thereof, inter alia in paints, coatings, printing inks, plastics and in cosmetic formulations.
    Type: Grant
    Filed: July 6, 2020
    Date of Patent: October 3, 2023
    Assignee: MERCK PATENT GMBH
    Inventors: Gerhard Pfaff, Stephanie Andes, Klaus Ambrosius, Ralf Petry, Michael Roesler, Sabine Schoen
  • Progressively-trained scale-invariant and boundary-aware deep neural network for the automatic 3D segmentation of lung lesions
    Patent number: 11776130
    Abstract: A system and method are disclosed for segmenting a set of two-dimensional CT slices corresponding to a lesion. In an embodiment, for each of at least a subset of the set of CT slices, the system inputs the CT slice into a plurality of branches of a trained segmentation block. Each branch of the segmentation block includes a convolutional neural network (CNN) with filters at a different scale, and produces a plurality of levels of output. The system generates, for each CT slice in the subset, feature maps for each level of output. The system generates a segmentation of each CT slice in the subset based on the feature maps of each level of output. The system aggregates the segmentations of each slice in the subset to generate a three-dimensional segmentation of the lesion. The system provides data representing the three-dimensional segmentation for display.
    Type: Grant
    Filed: January 18, 2022
    Date of Patent: October 3, 2023
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Antong Chen, Gregory Goldmacher, Bo Zhou
  • 2-AMINOQUINAZOLINES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
    Publication number: 20230303540
    Abstract: The present invention is directed to certain 2-aminoquinzaoline derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R3, R4, X1, and X2 are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.
    Type: Application
    Filed: September 1, 2021
    Publication date: September 28, 2023
    Applicant: Merck Sharp & Dohme LLC
    Inventors: John J. Acton, III, Ryan Chau, Peter H. Fuller, Anmol Gulati, Rebecca Elizabeth Johnson, Solomon Kattar, Mitchell H. Keylor, Derun Li, Kaila A. Margrey, Gregori J. Morriello, Xin Yan
  • COMPOUNDS FOR THE TREATMENT OF VIRAL INFECTIONS
    Publication number: 20230301991
    Abstract: The present invention encompasses ATR inhibitor for use in the treatment of coronavirus infections, including COVID-19, alone or in combination with one or more additional therapeutic agents.
    Type: Application
    Filed: October 22, 2021
    Publication date: September 28, 2023
    Applicant: MERCK PATENT GMBH
    Inventors: Ulrich BETZ, Thomas FUCHSS
  • TLR7/8 ANTAGONISTS AND USES THEREOF
    Publication number: 20230301981
    Abstract: Compounds disclosed herein and pharmaceutically acceptable compositions thereof are useful as TLR7/8 antagonists.
    Type: Application
    Filed: June 1, 2021
    Publication date: September 28, 2023
    Applicant: Merck Patent GmbH
    Inventors: Lukas Shinji Okitsu, Julie DeMartino, Thomas Spangenberg
  • Fluorine compounds
    Patent number: 11767396
    Abstract: The present invention relates to fluorine compounds (I), (II) and (III), to processes for the preparation thereof, and to the use thereof.
    Type: Grant
    Filed: June 24, 2021
    Date of Patent: September 26, 2023
    Assignee: Merck Patent GmbH
    Inventors: Reiner Friedrich, Fabian Koch
  • N3-substituted iminopyrimidinones as antimalarial agents
    Patent number: 11766435
    Abstract: The present invention provides methods of treating malaria comprising administration of an N3-substituted iminopyrimidinone of Formula (I) or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein the variables R1, R2, R3, R4, R5, A, B, L, m, and n are as defined herein. The invention also provides uses of the compounds of Formula (I), as defined herein, for inhibiting plasmepsin V activity, for treating a Plasmodium infection, and for treating malaria. Also provided are methods of treatment further comprising administration of one or more additional anti-malarial compounds.
    Type: Grant
    Filed: February 13, 2017
    Date of Patent: September 26, 2023
    Assignees: Merck Sharp & Dohme LLC, The Walter and Eliza Hall Institute of Medical Research
    Inventors: Tanweer A. Khan, Jared N. Cumming, David B. Olsen, Justin A. Boddey, Alan F. Cowman, Brad E. Sleebs
  • Process for making beta 3 agonists and intermediates
    Patent number: 11767292
    Abstract: The present invention is directed to a process for preparing a compound of formula I-11 through multiple-step reactions:
    Type: Grant
    Filed: September 17, 2021
    Date of Patent: September 26, 2023
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: John Y. L. Chung, Kevin Campos, Edward Cleator, Robert F. Dunn, Andrew Gibson, R. Scott Hoerrner, Stephen Keen, Dave Lieberman, Zhuqing Liu, Joseph Lynch, Kevin M. Maloney, Feng Xu, Nobuyoshi Yasuda, Naoki Yoshikawa, Yong-Li Zhong
  • Esters containing aromatic groups as solvents for organic electronic formulations
    Patent number: 11770971
    Abstract: The present invention relates to formulations for the preparation of organic electronic devices (OLEDs) which comprise (A) at least one specific ester solvent containing an aromatic group and (B) at least one organic functional material selected from organic conductors, organic semiconductors, organic fluorescent compounds, organic phosphorescent compounds, organic light-absorbent compounds, organic light-sensitive compounds, organic photosensitisation agents and other organic photoactive compounds, selected from organometallic complexes of transition metals, rare earth metals, lanthanides and actinides.
    Type: Grant
    Filed: October 11, 2021
    Date of Patent: September 26, 2023
    Assignee: Merck Patent GmbH
    Inventors: Gaëlle Béalle, Christoph Leonhard, Hsin-Rong Tseng, Irina Martynova, Aurélie Ludemann, Edgar Kluge, Anja Jatsch, Manuel Hamburger, Li Wei Tan, Pawel Miskiewicz, Philip Edward May, Daniel Walker
  • Spin-on compositions comprising an inorganic oxide component and an alkynyloxy substituted spin-on carbon component useful as hard masks and filling materials with improved shelf life
    Patent number: 11767398
    Abstract: The present invention relates to a composition comprising; components a) b) and d); wherein, component a) is a metal compound having the structure (I), component b) is a spin on high carbon polymer, having a polymer backbone comprising mono-cyclic aromatic hydrocarbon, fused-ring ring hydrocarbon moieties, or mixtures of these, having a wt. % of carbon from about 81 wt. % to about 94 wt. %, which is soluble to at least about 5 wt. % in a spin casting solvent, and wherein at least one, of said mono-cyclic aromatic hydrocarbon or said fused-ring ring hydrocarbon moieties, present in said spin on high carbon polymer, is functionalized with at least one alkynyloxy moiety of structure (VIII), and component d) is a spin casting solvent.
    Type: Grant
    Filed: February 20, 2020
    Date of Patent: September 26, 2023
    Assignee: Merck Patent GmbH
    Inventors: M. Dalil Rahman, Takashi Sekito
  • Materials for organic electroluminescent devices
    Patent number: 11767299
    Abstract: The present invention relates to compounds of the formula (1) which are suitable for use in electronic devices, in particular organic electroluminescent devices, and to electronic devices which comprise these compounds.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: September 26, 2023
    Assignee: Merck Patent GmbH
    Inventors: Ilona Stengel, Kathy Vinokurov, Frank Voges, Aurélie Ludemann
  • LIQUID CRYSTAL MEDIUM
    Publication number: 20230295511
    Abstract: The present invention relates to a liquid crystal (LC) medium comprising a compound of formula I and one or more compounds selected from the group of compounds of the formulae IIA, IIB, IIC and IID, as defined in claim 1, and to the use thereof for optical, electro-optical and electronic purposes, in particular in LC displays, especially in IPS, FFS, VA or PS-VA displays.
    Type: Application
    Filed: June 30, 2021
    Publication date: September 21, 2023
    Applicant: MERCK PATENT GMBH
    Inventors: Sven Christian LAUT, Fisher (Shuo) YU
  • ELECTRONIC SWITCHING DEVICE
    Publication number: 20230301173
    Abstract: An electronic switching device, in particular tunnel junctions, containing an organic molecular layer for use in memory, sensors, field-effect transistors or Josephson junctions. More particularly, related to the field of random access non-volatile memristive memories (RRAM). Another aspect is a compound of formula I for use in a molecular layer. Also, the use of the molecular layer and processes for the production and operation of an electronic switching element and components based thereon.
    Type: Application
    Filed: March 15, 2023
    Publication date: September 21, 2023
    Applicant: Merck Patent GmbH
    Inventors: Peer KIRSCH, Henning SEIM, Frank VOGES, Holger HEIL
  • LIQUID CRYSTAL MEDIUM
    Publication number: 20230295510
    Abstract: The present invention relates to a liquid crystal (LC) medium comprising a compound of formula I and one or more compounds of formula II as defined in claim 1, and to the use thereof for optical, electro-optical and electronic purposes, in particular in LC displays, especially in IPS, FFS, VA or PS-VA displays.
    Type: Application
    Filed: June 30, 2021
    Publication date: September 21, 2023
    Applicant: MERCK PATENT GMBH
    Inventor: Sven Christian LAUT
  • STEERABLE ANTENNA AND METHOD FOR HEATING AND/OR TEMPERING OF A STEERABLE ANTENNA
    Publication number: 20230295509
    Abstract: A steerable antenna having a plurality of radiating elements and a plurality of modifier elements configured for shifting phase and/or adjusting amplitude of a signal to be emitted by the radiating elements is disclosed. Each of the radiating elements is coupled to one of the modifier elements, wherein the modifier elements each comprise a liquid crystalline medium and wherein the modifier elements are configured such that the adjustment of the phase and/or amplitude is dependent on a state of the liquid crystalline medium. The steerable antenna further comprises a signal generator connected to the modifier elements and configured for generating a signal suited for dielectric heating of the liquid crystalline media of the modifier elements. Further aspects relate to a method for heating and/or controlling the temperature of the liquid crystalline medium of such a steerable antenna.
    Type: Application
    Filed: June 7, 2021
    Publication date: September 21, 2023
    Applicant: MERCK PATENT GMBH
    Inventors: Michael WITTEK, Carsten FRITZSCH, Dagmar KLASS
  • CRYSTALLINE FORMS OF 4-[(7-CHLORO-2-METHOXYBENZO[B][1,5]NAPHTHYRIDIN-10-YL)AMINO]-2,6-BIS(PYRROLIDIN-1-YLMETHYL)PHENOL AND SALTS THEREOF
    Publication number: 20230295156
    Abstract: Novel crystalline forms of 4-1(7-chloro-2-methoxybenzo[bll 1,5]naphthyridin-10-yl)aminol-2,6-bis(pyrrolidin-l-%Ilmethyl)phenol and salts thereof are useful, in particular for pharmaceutical formulations. Processes can be used for manufacturing the crystalline forms, and the crystalline forms can be used in methods of treatment.
    Type: Application
    Filed: April 14, 2021
    Publication date: September 21, 2023
    Applicant: Merck Patent GmbH
    Inventors: Axel BECKER, Delia-Maria Gruia
  • Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates
    Patent number: 11759511
    Abstract: The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Streptococcus pneumoniae serotypes.
    Type: Grant
    Filed: June 24, 2022
    Date of Patent: September 19, 2023
    Assignee: MERCK SHARP & DOHME LLC
    Inventors: Richard J. Porambo, Chitrananda Abeygunawardana, Luwy Kavuka Musey, Michael J. Kosinski, Yadong Adam Cui
  • Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates
    Patent number: 11759523
    Abstract: The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Streptococcus pneumoniae serotypes.
    Type: Grant
    Filed: June 24, 2022
    Date of Patent: September 19, 2023
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Richard J. Porambo, Chitrananda Abeygunawardana, Luwy Kavuka Musey, Michael J. Kosinski, Yadong Adam Cui