Patents Assigned to Merck
  • Pigment mixture
    Patent number: 6632275
    Abstract: The present invention relates to pigment mixtures consisting of at least two components, component A being Sio2 flakes coated with one or more metal oxides and/or metals and component B being special-effect pigments, and to their use in varnishes, paints, printing inks, masterbatches, plastics and cosmetic formulations.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: October 14, 2003
    Assignee: Merck Patent Gesellschaft mit beschränkter Haftung
    Inventors: Sabine Schoen, Reiner Vogt, Norbert Schül, Karl Osterried, Johann Munz
  • Mutant OB receptors and nucleotides encoding them
    Patent number: 6632625
    Abstract: Mutant ob receptors have been made which a) lack a functional first CK-F3 domain; b) lack a functional second CK-F3 domain or c) lack a functional intracellular domain. These receptors may be used in various assays, such as a transactivation assay to identify novel ligands.
    Type: Grant
    Filed: December 2, 1997
    Date of Patent: October 14, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Tung M. Fong, Ruey-Ruey C. Huang, Leonardus Van Der Ploeg
  • Connection coupling for plate-shaped microcomponents
    Patent number: 6632043
    Abstract: A connection coupling forms a line connection for liquid or gaseous substances to microcomponents (1) in platelet form. A coupling body (2), which is substantially U-shaped in cross section, accommodates the edge of the plate-like microcomponent (1) between an upper limb plate (3), which has the line connection (14), and a lower limb plate (5). An edge web (6) forms a transverse stop for an edge (8) of the microcomponent (1). A further stop means, for example a lug (9), forms a longitudinal stop for positioning of the microcomponents (1).
    Type: Grant
    Filed: June 21, 2001
    Date of Patent: October 14, 2003
    Assignee: Merck Patent Gesellschaftmit Beschrankter Haftung
    Inventors: Hanns Wurziger, Michael Schmelz, Norbert Schwesinger
  • Substituted pyridine compounds useful as modulators of acetylcholine receptors
    Patent number: 6632823
    Abstract: In accordance with the present invention, a novel class of substituted pyridine compounds (optionally containing ether, ester, amide, ketone or thioether substitutions) that promote the release of ligands involved in neurotransmission have been discovered. In a particular aspect compounds of the present invention are capable of modulating acetylcholine receptors. The compounds of the present invention are capable of modulating acetylcholine receptors. Invention compounds may act as agonists, partial agonists, antagonists or allosteric modulators of acetylcholine receptors.
    Type: Grant
    Filed: December 22, 1997
    Date of Patent: October 14, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Jean-Michel Vernier, Nicholas D. P. Cosford, Ian A. McDonald
  • Conductive pigments
    Patent number: 6632276
    Abstract: The invention relates to electrically conductive pigments which have, as conductive layer on a substrate, a tin oxide layer doped with phosphorus.
    Type: Grant
    Filed: November 28, 1997
    Date of Patent: October 14, 2003
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventor: Reiner Vogt
  • Dialkyne compounds
    Patent number: 6632484
    Abstract: Described are dialkyne compounds of the formula I in which n, m, R1, R2, X1, X2, X3, X4, Z1, Z2, A1, A2, Q, Y1 and Y2 are as defined herein and the use of such compounds in liquid-crystal media.
    Type: Grant
    Filed: July 19, 2001
    Date of Patent: October 14, 2003
    Assignee: Merck Patent Gesellschaft mit beschränkter Haftung
    Inventors: Volker Reiffenrath, Georg Lüssem
  • Carbocyclic potassium channel inhibitors
    Patent number: 6632836
    Abstract: The present invention relates to a class of carbocyclic compounds of Formula I that are useful as potassium channel inhibitors to treat autoimmune disorders, cardiac arrhythmias, and the like.
    Type: Grant
    Filed: October 21, 1999
    Date of Patent: October 14, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Robert K. Baker, Jianming Bao, Jennifer Chee, Maria L. Garcia, Gregory J. Kaczorowski, Frank Kayser, Andrew Kotliar, Chou Juitsai Liu, Shouwu Miao, William H. Parsons, Kathleen M. Rupprecht, William A. Schmalhofer, Christopher F. Claiborne, David A. Claremon, Nigel Liverton, Wayne J. Thompson
  • Perfluoro-n-alkylsulfonic acid derivatives
    Publication number: 20030191335
    Abstract: Described are bis(perfluoro-n-alkane-sulfonate) compounds, methods for preparing these compounds and use of these compounds, for example as starting materials for the synthesis of chiral and phosphine ligands for transition metal catalysts.
    Type: Application
    Filed: August 9, 2001
    Publication date: October 9, 2003
    Applicant: Merck Patent GmbH
    Inventors: Andreas Wachtler, Karl-Heinz Derwenskus, Andreas Meudt
  • Combination of optical elements
    Publication number: 20030190437
    Abstract: The invention relates to a combination of optical elements comprising at least one optical retardation film and at least one broadband reflective polarizer, characterized in that the optical retardation film is comprising at least one layer of an anisotropic polymer material having an optical symmetry axis substantially parallel to the plane of the layer, said optical retardation film being obtainable by polymerization of a mixture of a polymerizable mesogenic material comprising: a) at least one reactive mosogen having at least one polymerizable functional group; b) an initiator; c) optionally a non-mesogenic compound having two or more polymerizable functional groups; and d) optionally a stabilizer, and relates to an optical retardation film used in said combination of optical elements and to a liquid crystal display comprising said combination of optical elements.
    Type: Application
    Filed: February 19, 2003
    Publication date: October 9, 2003
    Applicant: Merck Patent Gesellschaft mitbeschrankter haftung
    Inventors: Mark Verrall, Jeremy Ward, James Hanmer, David Coates
  • Method of preparing an anisotropic polymer film on a substrate with a structured surface
    Publication number: 20030189684
    Abstract: An anisotropic polymer film with improved alignmentis prepared by coating onto a substrate with a structured surface. The polymer films thereby obtained are useful in optical and electrooptical devices for decorative and security applications.
    Type: Application
    Filed: February 13, 2003
    Publication date: October 9, 2003
    Applicant: Merck Patent GmbH
    Inventors: Matthias Kuntz, John Patrick, Guy Gregory, Tony Bleasdale, Rodney Riddle, Robert Hammond-Smith, Peter Howarth, Allan Marshall
  • Liquid crystalline compound, medium and display
    Publication number: 20030190436
    Abstract: The invention relates to a liquid crystalline compound of the formula I 1
    Type: Application
    Filed: November 7, 2002
    Publication date: October 9, 2003
    Applicant: Merck Patent GmbH
    Inventors: Atsutaka Manabe, Matthias Bremer
  • Substituted triazolo-pyridazine derivative, pharmaceutical compositions made therefrom
    Patent number: 6630471
    Abstract: 7-(1,1 -Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine, and pharmaceutically acceptable salts thereof are selective ligands for GABAA receptors useful in the treatment of disorders of the central nervous system.
    Type: Grant
    Filed: February 1, 2001
    Date of Patent: October 7, 2003
    Assignee: Merck Sharp & Dohme Ltd.
    Inventors: William Robert Carling, Jose Luis Castro Pineiro, Cameron John Cowden, Antony John Davies, Andrew Madin, James Francis McCabe, Gareth Edward Pearce, Leslie Joseph Street
  • Spheronized self-emulsifying system for hydrophobic and water-sensitive agents
    Patent number: 6630150
    Abstract: A self-emulsifying system comprises i) microcrystalline cellulose and ii) an oily substance, surfactant, and water is useful for providing solid dosage forms of hydrophobic or water sensitive agents when dried or extruded and spheronized.
    Type: Grant
    Filed: October 15, 2001
    Date of Patent: October 7, 2003
    Assignee: Merck Sharp & Dohme Limited
    Inventors: Steven William Booth, Ashley Clarke, John Michael Newton
  • Substituted succinic acid metallo-&bgr;-lactamase inhibitors and their use in treating bacterial infections
    Patent number: 6630510
    Abstract: This invention relates to novel substituted succinic acid metallo-&bgr;-lactamase inhibitors which are useful potentiators of &bgr;-lactam antibiotics. Accordingly, the present invention provides a method of treating bacterial infections in animals or humans which comprises administering, together with a b-lactam antibiotic, a therapeutically effective amount of a compound of formula I: including pharmaceutically acceptable salts, prodrugs, anhydrides, and solvates thereof.
    Type: Grant
    Filed: October 26, 2000
    Date of Patent: October 7, 2003
    Assignee: Merck & Co., Inc.
    Inventors: James M. Balkovec, Mark L. Greenlee, Steven H. Olson, Gregory P. Rouen
  • Colored and coated plateletlike pigments
    Patent number: 6630018
    Abstract: The invention relates to a platelet-shaped pigment having high luster and high covering power or high transparency, consisting of a transparent, inorganic, platelet-shaped matrix which can contain an additional constituent, characterized in that the additional constituent is a soluble or insoluble colorant and in that the matrix is coated at least on one side with one or more thin, transparent or semi-transparent reflective layers of metal oxides or metals to achieve the luster.
    Type: Grant
    Filed: April 15, 1994
    Date of Patent: October 7, 2003
    Assignee: Merck Patent Gesellschaft mit beschränkter Haftung
    Inventors: Gerd Bauer, Karl Osterried, Christoph Schmidt, Reiner Vogt, Helge-Bettina Kniess, Michael Uhlig, Norbert Schül, Günther Brenner
  • Pentafluorosulfuranylbenzene derivatives
    Patent number: 6630210
    Abstract: The invention relates to pentafluorosulfuranylbenzene derivatives of the formula I in which R1, A1, A2, Z1, L1, L2, L3 and n are as defined herein and to the use thereof in liquid-crystalline media.
    Type: Grant
    Filed: June 27, 2001
    Date of Patent: October 7, 2003
    Assignee: Merck GmbH
    Inventors: Peer Kirsch, Joachim Krause, Michael Heckmeier
  • Gene therapy for obesity
    Patent number: 6630346
    Abstract: Gene therapy can treat obesity in mammals. An obesity regulating gene is delivered to a mammal. Preferably, the gene encodes leptin or a leptin receptor. The protein which is delivered and expressed in vivo is more effective than protein which is injected into the animal.
    Type: Grant
    Filed: April 1, 1999
    Date of Patent: October 7, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Manal Morsy, MingCheng Gu, Jing Zhang Zhao, C. Thomas Caskey, Stephan Kochanek
  • Liquid-crystalline medium
    Publication number: 20030186002
    Abstract: Liquid-crystalline media comprising at least one compound of the formula I 1
    Type: Application
    Filed: November 8, 2002
    Publication date: October 2, 2003
    Applicant: Merck Patent GmbH
    Inventors: Michael Heckmeier, Martin Engel, Brigitte Schuler, Volker Reiffernrath
  • Salt mixtures for storing thermal energy in the form of heat of phase transformation
    Patent number: 6627106
    Abstract: Thermal energy in the form of heat of phase transformation can be stored in a ternary salt mixture of the formula: ANO3+LiNO3+Mg(NO3)2.6H2O.
    Type: Grant
    Filed: September 19, 2000
    Date of Patent: September 30, 2003
    Assignee: Merck Patent GmbH
    Inventors: Natascha Lotz, Mark Neuschütz
  • Birefringent film and its use
    Publication number: 20030178609
    Abstract: A birefringent film comprising at least one birefringent layer of liquid crystal material forming multi domains with a splayed structure may be coated onto a reflective substrate, e.g., with an aluminium surface. The birefringent film is particularly suited for decorative, security, authentification or identification applications.
    Type: Application
    Filed: February 5, 2003
    Publication date: September 25, 2003
    Applicant: Merck Patent GmbH
    Inventors: Robert Hammond-Smith, John Patrick, Donald Gordon Graham