Patents Assigned to Merck
  • Liquid-crystalline compounds
    Publication number: 20030230737
    Abstract: The invention relates to liquid-crystalline compounds of the formula I, 1
    Type: Application
    Filed: December 21, 2001
    Publication date: December 18, 2003
    Applicant: Merck GmbH
    Inventors: Peer Kirsch, Florian Huber, Joachim Krause, Michael Heckmeier, Detlef Pauluth
  • Conjugates useful in the treatment of prostate cancer
    Publication number: 20030232760
    Abstract: Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are disclosed. Such conjugates are useful in the treatment of prostatic cancer and benign prostatic hypertrophy (BPH).
    Type: Application
    Filed: June 6, 2003
    Publication date: December 18, 2003
    Applicant: Merck & Co., Inc.
    Inventors: Victor M. Garsky, Dong-Mei Feng, Defeo-Jones Deborah
  • Liquid-crystalline medium having a high birefringence and improved UV stability
    Publication number: 20030228426
    Abstract: A liquid-crystalline medium comprises the compound of the formula (I) 1
    Type: Application
    Filed: February 5, 2003
    Publication date: December 11, 2003
    Applicant: Merck Patent GmbH
    Inventors: Michael Heckmeier, Volker Reiffenrath
  • Adenovirus carrying gag gene HIV vaccine
    Publication number: 20030228329
    Abstract: An adenoviral vector is described which carries a codon-optimized gag gene, along with a heterologous promoter and transcription terminator. This viral vaccine can effectively prevent HIV infection when administered to humans either alone or as part of a prime and boost regime also with a vaccine plasmid.
    Type: Application
    Filed: June 13, 2003
    Publication date: December 11, 2003
    Applicant: Merck & Co., Inc.
    Inventors: Ling Chen, John W. Shiver, Andrew J. Bett, Danilo R. Casimiro, Michael J. Caulfield, Michael A. Chastain, Emilio A. Emini
  • Fluorinated (dihydro)phenanthrene derivatives, and their use in liquid-crystalline media
    Publication number: 20030227000
    Abstract: The invention relates to liquid-crystalline (dihydro)phenanthrene derivatives of the formula I 1
    Type: Application
    Filed: June 7, 2002
    Publication date: December 11, 2003
    Applicant: Merck Patent GmbH
    Inventors: Matthias Bremer, Detlef Pauluth, Michael Heckmeier, Hans-Rolf Dubal, Barbara Hornung, Wolfgang Schmidt, Rainer Wingen
  • Galenic formulation containing biotin
    Patent number: 6660251
    Abstract: The invention relates to galenic formulations which contain a) one or more compounds selected from biotin, its physiologically compatible salts, biotin esters and the steroisomeric forms of these compounds; and b) one or more compounds selected from urea and urea derivatives. The above formulations are suitable for use as topically administered formulations for the cosmetic and/or medical treatment of the skin, hair and/or nails.
    Type: Grant
    Filed: July 27, 2001
    Date of Patent: December 9, 2003
    Assignee: Merck Patent GmbH
    Inventors: Joachim Bünger, Hansjürgen Driller, Wolfgang Wohlrab, Lothar Motitschke, Christoph Huschka, Reinhard Neubert
  • Thermochromic liquid crystalline medium
    Patent number: 6660345
    Abstract: The invention relates to a thermochromic liquid crystalline medium comprising a liquid crystalline host component and an active component, to a thermochromic ink comprising such a thermochromic liquid crystalline medium encapsulated in a light transmissive polymeric material, to the use of a thermochromic medium or ink in decorative applications like pigments, inks and paints, cosmetics, thermodiagnostic applications like medical thermography, thermometry, optical and electrooptical applications, and security applications and devices, to a security marking or device comprising a thermochromic liquid crystalline medium or thermochromic ink and to a document of value comprising such a security marking.
    Type: Grant
    Filed: September 19, 2002
    Date of Patent: December 9, 2003
    Assignee: Merck Patent Gesellschaft Mit Beschränkter Haftung
    Inventors: David Coates, David Bishop, Robert Hammond-Smith
  • Prescription management system
    Publication number: 20030225595
    Abstract: An imaging and workflow method, system, computer readable medium and user interface for processing information efficiently for the processing of medical prescription orders. The system includes support for document scanning, automated rules-based order processing, statistical reporting, document generation and document storage and retrieval. The present invention takes advantage of imaging technology to assist the user in scanning information into the system and software modules to improve the processing of orders. The present invention also includes database tables that identify to application processing logic the types and sequences of actions to be implemented for orders.
    Type: Application
    Filed: April 30, 2002
    Publication date: December 4, 2003
    Applicant: Merck-Medco Managed Care, LLC
    Inventors: Scott M. Helmus, Donna L. Rosen, Leo H. Bressman
  • Fluorinated indenes and 1,7-dihydroindacenes of negative dielectric anisotrophy
    Publication number: 20030222243
    Abstract: Fluorinated indenes and 1,7-dihydroindacenes of the general formulae (I) and (II) of negative dielectric anisotropy (&Dgr;&egr;<0) 1
    Type: Application
    Filed: April 4, 2003
    Publication date: December 4, 2003
    Applicant: Merck Patent GmbH
    Inventors: Lars Lietzau, Melanie Klasen-Memmer, Matthias Bremer
  • Electro-optical liquid-crystal display and liquid-crystal medium
    Publication number: 20030224125
    Abstract: The invention relates to an electro-optical liquid-crystal display having a realignment layer, for realigning the liquid crystals, whose field has a component parallel to the liquid-crystal layer which is crucial for the realignment, containing a liquid-crystalline medium of positive dielectric anisotropy, where the medium comprises at least one mesogenic compound and at least one compound of the formula I 1
    Type: Application
    Filed: April 18, 2001
    Publication date: December 4, 2003
    Applicant: Merck Patent GmbH
    Inventors: Michael Heckmeier, Marcus Reuter, Volker Reiffenrath
  • Liquid-crystal medium, and electro-optical display containing same
    Publication number: 20030222245
    Abstract: A nematic liquid-crystal media which comprises
    Type: Application
    Filed: April 14, 2003
    Publication date: December 4, 2003
    Applicant: Merck Patent GmbH
    Inventors: Melanie Klasen-Memmer, Matthias Bremer, Malgorzata Rillich
  • Serum-free, low-protein media for rotavirus vaccine production
    Patent number: 6656719
    Abstract: Defined serum-free, low protein media (LPKM), that supports 1) Vero cell growth for up to 20 passages, 2) Vero cell growth on microcarriers and 3) rotavirus production is provided. Maximum cell densities attained are 60-100% of that in serum-containing medium; the doubling time is equal to that for cells in serum containing medium. Rotavirus titers achieved in LPKM-1 are 50-100% of the serum-containing process. Finally, since LPKM-1 contains no animal-sourced proteins, the problems associated with the serum-containing rotavirus production process (i.e. lengthy wash steps before infection, potential introduction of adventitious agents and lot-to-lot variability) can be avoided; while maintaining nearly equivalent product titers.
    Type: Grant
    Filed: October 21, 1998
    Date of Patent: December 2, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Sandra L. Gould, David K. Robinson, Daniel J. Distefano, T. Craig Seamans
  • Multilayered interference pigments
    Patent number: 6656259
    Abstract: The invention relates to multilayered interference pigments which comprise a platelet-shaped substrate of silicon dioxide which is coated alternately with layers of light-transparent materials having refractive indices of n>1.8 and layers of light-transparent materials having refractive indices of n≦1.8, where the optical thickness of the platelet-shaped substrate and the optical thickness of the individual layers of light-transparent materials having refractive indices of n≦1.8 are the same.
    Type: Grant
    Filed: August 2, 2002
    Date of Patent: December 2, 2003
    Assignee: Merck Patent Gesellschaft mit beschraenkter Haftung
    Inventors: Gerhard Pfaff, Helge Kniess, Peter Reynders
  • Method of preparing lithium complex salts for use in electrochemical cells
    Patent number: 6657072
    Abstract: The invention relates to a method of preparing lithium complex salts and their intermediaries and to the use of these in electrolytes.
    Type: Grant
    Filed: July 10, 2002
    Date of Patent: December 2, 2003
    Assignee: Merck Patent Gesellschaft mit beschränkter Haftung
    Inventors: Andrei Leonov, Armin de Meijere, Michael Schmidt
  • Orally active salts with tyrosine kinase activity
    Patent number: 6656942
    Abstract: The present invention relates to orally active salts of compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angio-genesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.
    Type: Grant
    Filed: October 17, 2001
    Date of Patent: December 2, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Mark E. Fraley, Shyam B. Karki, Yuntae Kim
  • Synthetic hepatitis C genes
    Patent number: 6653125
    Abstract: The present invention relates to polynucleotides comprising a DNA sequence encoding an HCV protein and fragments thereof that contain codons optimized for expression in a vertebrate host. Uses of the polynucleotides include eliciting an immune response specifically recognizing HCV.
    Type: Grant
    Filed: February 17, 2000
    Date of Patent: November 25, 2003
    Assignee: Merck & Co., Inc.
    Inventors: John J. Donnelly, Margaret A. Liu, John W. Shiver, Tong-Ming Fu
  • Human calcium channel compositions and methods
    Patent number: 6653097
    Abstract: Isolated DNA encoding each of human calcium channel &agr;1-, &agr;2-, &bgr;- and &ggr;-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: November 25, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Michael M. Harpold, Steven B. Ellis, Mark E. Williams, Ann F. McCue, Alison Gillespie, Daniel H. Feldman, Robert Brenner
  • Methods for encoding combinatorial libraries
    Patent number: 6653153
    Abstract: A combinatorial library comprises a plurality of ligand-bearing support units, where the ligand-bearing support units comprise (a) a solid carrier, (b) one or more ligands covalently bound to the solid carrier, and (c) one or more encoding metal salts impregnated on the support unit, where the distribution of the cations of the encoding metal salts provides a code for identifying the ligand or ligands that are attached to the support units, and the cations have been stabilized against dissolution by treatment with one or more anions that form insoluble or poorly soluble salts of the cations.
    Type: Grant
    Filed: July 3, 2001
    Date of Patent: November 25, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Yusheng Xiong, Kevin Chapman, Tiebang Wang
  • Liquid-crystalline compounds
    Publication number: 20030216554
    Abstract: The invention relates to liquid-crystalline compounds of the formula I 1
    Type: Application
    Filed: July 25, 2002
    Publication date: November 20, 2003
    Applicant: Merck Patent GmbH
    Inventors: Peer Kirsch, Michael Heckmeier, Joachim Krause, Marc Lenges, Gerald Unger
  • Method and system for real-time secure transfer of personal information between websites
    Publication number: 20030217291
    Abstract: A method of securely transferring user information between a website server and at least one external website server to authenticate a user with the at least one external website server includes receiving a request for accessing an external website server by the user and determining whether the user is not logged on to the website server. If the user is not logged on, the user is logged on to the website server by the user. A secure connection from the website server to the at least one external website server is generated and the user information is transferred from the website server to the at least one external website server by a HTTP GET protocol and/or a HTTP POST protocol.
    Type: Application
    Filed: March 18, 2003
    Publication date: November 20, 2003
    Applicants: Merck & Company, Inc., HALE AND DORR LLP
    Inventors: Susan Schramm-Apple, Sean Dippold, Melanie Kittrell, Keith Bauer, Lori Moore