Patents Assigned to Merck
  • Polynucleotide encoding estrogen receptor
    Patent number: 6562592
    Abstract: This invention relates to a novel estrogen receptor and to the polynucleotide sequences encoding this receptor. This invention also relates to methods for identifying ligands which bind to this receptor, to the ligands so identified, and to pharmaceutical compositions comprising such ligands. This invention also relates to pharmaceutical compositions useful for treating or preventing estrogen receptor mediated diseases or conditions, such as abnormal bone resorption, cardiovascular diseases, cancer, or central nervous system disorders.
    Type: Grant
    Filed: April 26, 2000
    Date of Patent: May 13, 2003
    Assignee: Merck & Co., Inc.
    Inventor: Hilary Wilkinson
  • Inhibitors of prenyl-protein transferase
    Patent number: 6562823
    Abstract: The present invention is directed to peptidomimetic piperazine-containing macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
    Type: Grant
    Filed: June 28, 2001
    Date of Patent: May 13, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Christopher J. Dinsmore, Jeffrey M. Bergman, Samuel L. Graham, Diem N. Nguyen, Gerald E. Stokker, Theresa M. Williams, C. Blair Zartman
  • Matrix liquid crystal display
    Patent number: 6562419
    Abstract: The invention relates to a matrix liquid crystal display containing integrated non-linear elements and a liquid crystal mixture which has a particularly high resistivity.
    Type: Grant
    Filed: December 21, 1999
    Date of Patent: May 13, 2003
    Assignee: MERCK Patent Gesellschaft mit beschrankter Haftung
    Inventors: Georg Weber, Ludwig Pohl, Reinhard Hittich, Herbert Plach, Bernhard Scheuble, Takamasa Oyama, Bernhard Rieger, Hans Adolf Kurmeier, Ekkehard Bartmann
  • Mono-, oligo- and polymers of benzo[b]thiophene and 2,2'-bisbenzo[b]thiophene and their use as charge transport materials
    Publication number: 20030085381
    Abstract: Conjugated mono-, oligo- and polymers of benzo[b]thiophene and bisbenzo[b]thiophene are useful as semiconductors or charge transport materials in optical, electrooptical or electronic devices including field effect transistors, electroluminescent, photovoltaic and sensor devices.
    Type: Application
    Filed: September 27, 2002
    Publication date: May 8, 2003
    Applicant: Merck Patent GmbH
    Inventors: Christopher Worrall, Martin Heeney, Steven Tierney, Louise Diane Farrand, Mark Giles, Marcus Thompson, Maxim Shkunov, David Sparrowe, Iain McCulloch
  • Polymerizable liquid crystal material
    Publication number: 20030085377
    Abstract: The invention relates to a polymerizable liquid crystal material containing at least one polymerizable surface-active compound, its use for the preparation of anisotropic polymer films, and the use of the liquid crystal material and the polymer films in optical and electrooptical devices, and for decorative and security applications.
    Type: Application
    Filed: May 1, 2002
    Publication date: May 8, 2003
    Applicant: MERCK PAPTENTGESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Christopher J. Dunn, Simon Greenfield, Richard Harding, Ian Victor Edward Hassall, Alison Linda May, Julian Frederick Samuel Vaughan-Spickers
  • Preparation and isolation of indolocarbazole glycosides
    Patent number: 6559299
    Abstract: The present invention relates to a novel process to make indolocarbazole glycosides in high purity which inhibit the growth of tumor cells and are therefore useful in the treatment of cancer in mammals, and the like.
    Type: Grant
    Filed: March 21, 2002
    Date of Patent: May 6, 2003
    Assignees: Merck & Co., Inc., Banyu Pharmaceutical Co., Ltd.
    Inventors: Steven Weissman, David Tschaen, Asayuki Kamatani, Shouichi Hiraga, Masashi Kawasaki, Takehiko Iida
  • Nitromethyl ketone compounds having aldose reduction inhibiting properties and methods for their use
    Patent number: 6559185
    Abstract: The present invention relates to the compounds of formula: in which R1, R2, R3, E, A, X, Z, p and n are as defined herein. These compounds are aldose reductase inhibitors.
    Type: Grant
    Filed: November 12, 1999
    Date of Patent: May 6, 2003
    Assignee: Merck Patent GmbH
    Inventors: Claude Lardy, Jaques Barbanton, Herve Dumas, Francois Collonges, Philippe Durbin
  • Bicyclic amino acids
    Patent number: 6559144
    Abstract: Compounds of the formula I in which X, Y, Z, R1, R2, R3, R4, R5, R7, R8, R11, m and n have the meanings stated in claim 1, and their physiologically acceptable salts can be used as integrin inhibitors, in particular for the prophylaxis and treatment of circulatory disorders, for thrombosis, myocardial infarct, coronary heart disease, arteriosclerosis, osteoporosis, for pathological processes maintained or propagated by angiogenesis, and in tumour therapy.
    Type: Grant
    Filed: April 26, 2001
    Date of Patent: May 6, 2003
    Assignee: Merck Patent Gesellschaft Mit
    Inventors: Beate Diefenbach, Simon L. Goodman, Joachim März, Peter Raddatz, Friedrich Rippmann, Matthias Wiesner
  • Phenylsulphonyl derivatives as 5-HT receptor ligands
    Patent number: 6559166
    Abstract: A class of phenylsulphonyl derivatives wherein the sulphonyl moiety is also attached to an N-arylalkyl-substituted azetidine, pyrrolidine or piperidine ring are selective antagonists of the human 5-HT2A receptor and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of adverse conditions of the central nervous system, including schizophrenia and depression.
    Type: Grant
    Filed: September 27, 2001
    Date of Patent: May 6, 2003
    Assignee: Merck Sharp & Dohme Ltd.
    Inventors: Peter Blurton, Frank Burkamp, Susan Koon-Fung Cheng, Stephen Robert Fletcher, Angus Murray MacLeod, Daniel Spinks, Monique Bodil Van Niel
  • N-arylsulfonyl aryl aza-bicyclic derivatives as potent cell adhesion inhibitors
    Patent number: 6559174
    Abstract: Compounds of Formula I are antagonists of VLA-4 and/or alpha4/beta7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of AIDS-related dementia, allergic conjunctivitis, allergic rhinitis, Alzheimer's disease, asthma, atherosclerosis, autologous bone marrow transplantation, certain types of toxic and immune-based nephritis, contact dermal hypersensitivity, inflammatory bowel disease including ulcerative colitis and Crohn's disease, inflammatory lung diseases, inflammatory sequelae of viral infections, meningitis, multiple sclerosis, multiple myeloma, myocarditis, organ transplantation, psoriasis, pulmonary fibrosis, restenosis, retinitis, rheumatoid arthritis, septic arthritis, stroke, tumor metastasis, uveititis, and type I diabetes.
    Type: Grant
    Filed: March 13, 2002
    Date of Patent: May 6, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Linus S. Lin, Shrenik K. Shah, Linda L. Chang, William K. Hagmann, Richard A. Mumford
  • Method of adsorbing metals and organic compounds from vaporous streams
    Patent number: 6558642
    Abstract: A method and adsorption powder useful for the removal of mercury and other metals, as well as furans, dioxins and other organic compounds from high temperature and high moisture gaseous streams. The method utilizes an adsorption powder characterized as containing a carbon-based powder and an effective amount of cupric chloride suitable to remove metals and organic compounds. The powder may contain calcium hydroxide, sulfur, potassium permanganate, potassium iodide, and combinations thereof.
    Type: Grant
    Filed: March 29, 2001
    Date of Patent: May 6, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Youssef El-Shoubary, Rudy Maes
  • Cycloalkanone derivatives
    Publication number: 20030080321
    Abstract: The invention relates to compounds of formula I 1
    Type: Application
    Filed: April 5, 2002
    Publication date: May 1, 2003
    Applicant: MERCK KGAA
    Inventors: Louise Diane Farrand, Christopher Peter Worrall, Owain Llyr Parri, Ian Victor Edward Hassal, Julian Frederick Samuel Vaughan-Spickers
  • Reactive thienothiophenes
    Publication number: 20030080322
    Abstract: The invention relates to reactive thienothiophenes, their use as semiconductors or charge transport materials, in optical, electrooptical or electronic devices like for example organic field effect transistors (FET or OFET) for thin film transistor liquid crystal displays and integrated circuit devices such as RFID tags, electroluminescent devices in flat panel displays, and in photovoltaic and sensor devices, and to a field effect transistor, light emitting device or ID tag comprising the reactive thienothiophenes.
    Type: Application
    Filed: July 9, 2002
    Publication date: May 1, 2003
    Applicant: Merck Patent GmbH
    Inventors: Louise Farrand, Marcus Thompson, Mark Giles, Mark Goulding, Martin Heeney, Steven Tierney, Maxim Shkunov, David Sparrowe, Iain McCulloch
  • Highly light-scattering pigment mixture
    Publication number: 20030082123
    Abstract: Highly light-scattering pigment mixture featuring
    Type: Application
    Filed: November 13, 2002
    Publication date: May 1, 2003
    Applicant: Merck Patent GmbH
    Inventors: Ralf Anselmann, Martin Knapp, Uta Hillgartner
  • Polynucleotide encoding eimeria tenella cGMP dependent protein kinase
    Patent number: 6555358
    Abstract: Protozoal cyclic GMP dependent protein kinases have been isolated and cloned. These enzymes may be used in screening assays to identify potential antiprotozoal agents.
    Type: Grant
    Filed: March 8, 2000
    Date of Patent: April 29, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Anne Gurnett, Paul A. Liberator, Robert Donald, Dennis Schmatz, Georgianna Harris, Sandra J. Rattray
  • Phase transfer catalyzed glycosidation of an indolocarbazole
    Patent number: 6555677
    Abstract: The present invention relates to a novel glycosidation process to make intermediates useful in the preparation of indolopyrrolocarbazole derivatives which inhibit the growth of tumor cells and are therefore useful in the treatment of cancer in mammals, and the like.
    Type: Grant
    Filed: October 22, 2001
    Date of Patent: April 29, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Daniel E. Petrillo, Steven A. Weissman, Shouichi Hiraga, Nobuya Satake, Kai Rossen
  • Human theta subunit of the GABAa receptor
    Patent number: 6555341
    Abstract: This invention concerns the cloning of a novel cDNA sequence encoding a particular subunit of the human GABAA receptor. In addition, the invention relates to a stable cell line capable of expressing said cDNA and to the use of the cell line in a screening technique for the design and development of subtype-specific medicaments.
    Type: Grant
    Filed: October 25, 1999
    Date of Patent: April 29, 2003
    Assignee: Merck Sharp & Dohme Ltd.
    Inventors: Timothy Peter Bonnert, Paul John Whiting
  • Azabicyclic amine derivatives and their use as therapeutic agents
    Patent number: 6555552
    Abstract: The present invention relates compounds of the formula (I): wherein X represents hydrogen or a C1-4alkyl group optionally substituted by a hydroxy group; Y represents hydrogen, C1-6alkyl or C3-7cycloalkyl; Z is —CR9R10CH2— or —CH2CR9R10—; R represents hydrogen, fluorine, hydroxy, C1-6alkyl or C1-6alkoxy; and R1, R2, R3, R4, R5 and R6 are as defined herein. The compounds are of particular use in the treatment of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.
    Type: Grant
    Filed: April 1, 2002
    Date of Patent: April 29, 2003
    Assignee: Merck Sharp & Dohme Ltd.
    Inventors: Janusz Jozef Kulagowski, Piotr Antoni Raubo, Christopher George Thomson
  • TN and STN liquid-crystal displays
    Patent number: 6555186
    Abstract: The invention relates to TN and STN liquid-crystal displays and to the novel nematic liquid-crystal mixtures used therein, characterized in that they comprise one or more compounds of the formula I in which R1, R2, A, u, L1 and L2 are as defined herein.
    Type: Grant
    Filed: June 19, 2001
    Date of Patent: April 29, 2003
    Assignee: Merck Patent GmbH
    Inventors: Harald Hirschmann, Martina Weidner, Sven Schupfer, Peer Kirsch
  • 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2
    Patent number: RE38103
    Abstract: The Compound of Formula I and pharmaceutically acceptable sales thereof in the treatment of cyclooxygenase-2 mediated diseases are disclosed.
    Type: Grant
    Filed: April 6, 2001
    Date of Patent: April 29, 2003
    Assignee: Merck Frosst Canada & Co.
    Inventors: Daniel Guay, Chun-Sing Li