Patents Assigned to Merck
  • Process for formulation of carbapenem antibiotic compositions
    Patent number: 6548492
    Abstract: A novel process for preparing a stabilized, lyophilized carbapenem, antibiotic formulation suitable for intravenous administration to patients in need thereof, wherein the active ingredient is of formula II: The process entails compounding a unstable, monosodium salt carbapenem with a sodium bicarbonate solution at a temperature range of from about 0° to about 5° C. while maintaining a pH between about 7.0 and about 8.0, filtering the resultant solution, bottling under sterile conditions, and lyophilizing to produce the formulation.
    Type: Grant
    Filed: October 27, 2000
    Date of Patent: April 15, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Anthony Al-Dehneh, William A. Hunke, Kathleen J. Illig, Anand Kanike, Hiren Patel, Scott D. Reynolds, Stelios C. Tsinontides
  • METHOD FOR PRODUCING ORTHO-ALKYLATED BENZOIC ACID DERIVATIVES
    Publication number: 20030069444
    Abstract: The invention relates to a process for the preparation of ortho-alkylated benzoic acid derivatives of the formula I 1
    Type: Application
    Filed: October 8, 2002
    Publication date: April 10, 2003
    Applicant: MERCK KGAA
    Inventors: Ekkehard Bartmann, Ingeborg Stein
  • Mono-, oligo-and polyalkylidenefluorenes and their use as charge transport materials
    Publication number: 20030067267
    Abstract: Conjugated mono-, oligo- and polyalkylidenefluorenes are suitable for use as semiconductors or charge transport materials in optical, electrooptical or electronic devices including field effect transistors, electroluminescent, photovoltaic and sensor devices.
    Type: Application
    Filed: August 19, 2002
    Publication date: April 10, 2003
    Applicant: Merck Patent GmbH
    Inventors: Martin Heeney, Steven Tierney, Mark Giles, Louise Diane Farrand, Maxim Shkunov, David Sparrowe, Iain McCulloch
  • Dual compartment mixing and dispensing device
    Patent number: 6544213
    Abstract: The present invention is directed to a dual compartment, mixing and dispensing device suitable for the containment of two separate pharmaceutical components that mixable, upon breaking of a seal that separates the compartments, to provide an instantly mixed dose of medication. The medication can be administered to a patient through an aperture located at one end of the device. The device is characterized as two compartments connected by a flexible, sealed orifice, wherein the two components are separated. Flexing of the device at the orifice breaks the seal and allows mixing of the components to prepare the dose. Thereafter, an end-portion of the device can be opened for oral administration of the dose.
    Type: Grant
    Filed: September 11, 2000
    Date of Patent: April 8, 2003
    Assignee: Merck & Co., Inc.
    Inventor: Arthur L. Lifshey
  • Method for inhibiting bone resorption
    Patent number: 6544967
    Abstract: Disclosed are methods for inhibiting bone resorption in mammals while minimizing the occurrence of or potential for adverse gastrointestinal effects. Also disclosed are pharmaceutical compositions and kits for carrying out the therapeutic methods disclosed herein.
    Type: Grant
    Filed: January 8, 2001
    Date of Patent: April 8, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Anastasia G. Daifotis, Arthur C. Santora, II, A. John Yates
  • Cyclopentyl modulators of chemokine receptor activity
    Patent number: 6545023
    Abstract: The present invention is directed to compounds of the formula I: (wherein R1, R2, R3, R4, R5, R6 and X are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.
    Type: Grant
    Filed: August 16, 2001
    Date of Patent: April 8, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Lihu Yang, Gabor Butora, William H. Parsons, Alexander Pasternak
  • Supertwist liquid-crystal displays and liquid-crystal mixtures therefor
    Patent number: 6544602
    Abstract: The invention relates to supertwist liquid-crystal displays (SLCDs) having very short response times and good steepnesses and angle dependencies, and to the novel nematic liquid-crystal mixtures used therein, which are distinguished in that they comprise at least one compound of the formula IA and at least one compound of the formula IB in which Ra, Rb, Rc, Rd, Y1, Y2, n and p have the meaning given.
    Type: Grant
    Filed: May 4, 2000
    Date of Patent: April 8, 2003
    Assignee: Merck Patent Gesellschaft mit beschränkter Haftung
    Inventors: Harald Hirschmann, Clarissa Weller, Georg Weber, Kazuo Totani, Akihiro Kojima
  • Galanin receptor (GALR2) binding assay
    Patent number: 6544753
    Abstract: A new galanin receptor, GALR2, is described. Also provided are nucleic acids encoding same and various assays to identify ligands particular to said receptor. Ligands so identified are useful for the treatment of obesity, treatment of pain, and treatment of cognitive disorders.
    Type: Grant
    Filed: June 26, 2000
    Date of Patent: April 8, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Carina Tan, Kathleen Sullivan
  • Thrombin receptor antagonists
    Patent number: 6544982
    Abstract: A thrombin receptor antagonist having the formula useful for inhibiting the aggregation of blood platelets. The compounds can be used in a method of acting upon a thrombin receptor which comprises administering a therapeutically effective but non-toxic amount of such compound to a mammal, preferably a human.
    Type: Grant
    Filed: October 27, 2000
    Date of Patent: April 8, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Harold G. Selnick, Philippe G. Nantermet, James C. Barrow, Roger M. Freidinger, Thomas Connolly
  • Liquid-crystalline medium
    Patent number: 6544603
    Abstract: The invention relates to a liquid-crystalline medium based on a mixture of polar compounds having positive dielectric anisotropy, characterized in that it comprises one or more compounds of the formula I
    Type: Grant
    Filed: December 6, 2000
    Date of Patent: April 8, 2003
    Assignee: Merck Patent GmbH
    Inventors: Kazuaki Tarumi, Brigitte Schuler, Eike Poetsch
  • Tyrosine kinase inhibitors
    Patent number: 6544988
    Abstract: The present invention relates to pyrazolo-pyrimidinyl compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.
    Type: Grant
    Filed: September 6, 2001
    Date of Patent: April 8, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Mark T. Bilodeau, Mark E. Fraley, Randall W. Hungate
  • Laser-markable plastics
    Patent number: 6545065
    Abstract: The present invention relates to laser-markable plastics of which a feature is that they include, as absorber material, a mixture of pearl luster pigments and/or non-lustrous metal oxide-coated mica pigments and inorganic platelet-form substrates.
    Type: Grant
    Filed: January 4, 1999
    Date of Patent: April 8, 2003
    Assignee: Merck Patent Gesellschaft mit beschränkter Haftung
    Inventors: Hans-Jürgen Solms, Manfred Kieser
  • Combination of optical elements
    Patent number: 6544605
    Abstract: The invention relates to a combination of optical elements comprising at least one optical retardation film and at least one broadband reflective polarizer, characterized in that the optical retardation film is comprising at least one layer of an anisotropic polymer material having an optical symmetry axis substantially parallel to the plane of the layer, said optical retardation film being obtainable by polymerization of a mixture of a polymerizable mesogenic material comprising: a) at least one reactive mesogen having at least one polymerizable functional group; b) an initiator, c) optionally a non-mesogenic compound having two or more polymerizable functional groups; and d) optionally a stabilizer; and relates to an optical retardation film used in said combination of optical elements and to a liquid crystal display comprising said combination of optical elements.
    Type: Grant
    Filed: January 25, 1999
    Date of Patent: April 8, 2003
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Mark Verrall, Jeremy Ward, James Hanmer, David Coates
  • Catechols as antimicrobial agents
    Patent number: 6545015
    Abstract: Compounds, pharmaceutically acceptable salts, and compositions thereof of the general formula: wherein Ar is aryl and heteroaryl; R1, R2, R3, and R4 are hydrido, alkyl, cyano, heteroaryl, hydroxy, amino, acylamino, halo, alkoxy, aryloxy, carboxyamido, alkenyl, cycloalkyl, heterocyclyl, acyl, acyloxy, carboalkoxy, carboxy, thio, sulfinyl, sulfonyl and sulfoxy, R5, R6, R7, and R8 are hydrido and lower alkyl; and Het is a nitrogen-containing heterocyclic ring.
    Type: Grant
    Filed: August 22, 2001
    Date of Patent: April 8, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Milton L. Hammond, Aaron H. Leeman, Milana Maletic, Gina M. Santorelli, Sherman T. Waddell, John Finn, Michael Morytko, Jason Hill, Dennis Keith
  • Ophthalmic compositions for treating ocular hypertension
    Patent number: 6545036
    Abstract: This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
    Type: Grant
    Filed: January 17, 2001
    Date of Patent: April 8, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Maria L. Garcia, Gregory J. Kaczorowski, Owen B. McManus
  • Pigment preparation
    Patent number: 6544327
    Abstract: The invention relates to a non-dusting homogeneous pigment preparation which is notable in that it comprises at least 40% by weight of one or more effect pigments, from 0.5 to 60% by weight of an aldehyde resin and/or ketonic resin and from 0.1 to 10% by weight of a redispersant.
    Type: Grant
    Filed: September 14, 2000
    Date of Patent: April 8, 2003
    Assignee: Merck Patent GmbH
    Inventors: Carsten Griessmann, Wolfgang Hechler, Gerhard Herget
  • Liquid-crystalline medium
    Publication number: 20030064172
    Abstract: The invention relates to a liquid-crystalline medium based on a mixture of polar compounds having positive dielectric anisotropy, characterized in that it comprises one or more compounds of the general formula I 1
    Type: Application
    Filed: November 2, 2001
    Publication date: April 3, 2003
    Applicant: Merck Patent Gesellschaft mitbeschrankter Haftung
    Inventors: Kazuaki Tarumi, Brigitte Schuler, Eike Poetsch, Volker Reiffenrath, Yukiomi Tanaka
  • Mono-, oligo- and poly-3-(1,1-difluoroalkyl)thiophenes and their use as charge transport materials
    Publication number: 20030062509
    Abstract: Mono-, oligo- and polymers comprising one or more identical or different recurring units of formula I
    Type: Application
    Filed: July 24, 2002
    Publication date: April 3, 2003
    Applicant: Merck Patent GmbH
    Inventors: Martin Heeney, Louise Farrand, Mark Giles, Marcus Thompson, Steven Tierney, Maxim Shkunov, David Sparrowe, Iain McCulloch
  • Substituted pyridines as selective cyclooxygenase-2 inhibitors
    Publication number: 20030065011
    Abstract: The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I.
    Type: Application
    Filed: October 30, 2001
    Publication date: April 3, 2003
    Applicant: Merck Frosst Canada & Co.
    Inventors: Daniel Dube, Rejean Fortin, Richard Friesen, Zhaoyin Wang, Jacques Yves Gauthier
  • Mono-, oligo- and poly-difluorovinyl-(hetero)arylenes, their synthesis and their use as charge transport materials
    Publication number: 20030062536
    Abstract: The invention relates to new mono-, oligo- and poly-difluorovinyl(hetero)arylenes comprising one or more identical or different recurring units of formula I 1
    Type: Application
    Filed: July 24, 2002
    Publication date: April 3, 2003
    Applicant: Merck Patent GmbH
    Inventors: Martin Heeney, Louise Farrand, Mark Giles, Marcus Thompson, Steven Tierney, Maxim Shkunov, David Sparrowe, Iain McCulloch