Patents Assigned to Merck
  • Compositions and methods for inhibiting bone resorption
    Publication number: 20030078211
    Abstract: The present invention relates to oral compositions and methods for inhibiting bone resoprtion in a mammal while counteracting the occurrence of potentially adverse gastrointestinal effects. The compositions useful herein comprise the combination of a pharmaceutically effective amount of a nitrogen-containing bisphosphonate or a pharmaceutically-acceptable salt thereof and a pharmaceutically effective amount of a caspase inhibitor.
    Type: Application
    Filed: March 25, 2002
    Publication date: April 24, 2003
    Applicant: Merck & Co., Inc.
    Inventor: Alfred A. Reszka
  • Tetracyclic and pentacyclic compounds, and their use in liquid-crystalline media
    Publication number: 20030078447
    Abstract: Disclosed is a tetracyclic compound of the formula I 1
    Type: Application
    Filed: August 13, 2001
    Publication date: April 24, 2003
    Applicant: MERCK PATENTGESELLSCHAFT
    Inventors: Peer Kirsch, Joachim Krause, Georg Lussem, Dagmar Klement
  • Gamma-ketoacid tetrapeptides as inhibitors of caspase-3
    Patent number: 6552168
    Abstract: The invention encompasses the novel class of compounds represented by formula I, which are caspase-3 inhibitors. The invention also encompasses certain pharmaceutical compositions for treatment of caspase-3 mediated diseases comprising compounds of formula I.
    Type: Grant
    Filed: December 2, 1999
    Date of Patent: April 22, 2003
    Assignee: Merck Frosst Canada & Co.
    Inventors: Erich L. Grimm, Johanne Renaud, Renee Aspiotis, Christopher I. Bayly, Robert Zamboni, Shawn Black
  • Pigment preparation
    Patent number: 6551397
    Abstract: The present invention relates to a pigment preparation comprising BiOCl pigments, one or more luster pigments and spherical particles, and to the use thereof in printing inks, security printing inks, surface coatings, paints, plastics and in cosmetic formulations.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: April 22, 2003
    Assignee: Merck Patent GmbH
    Inventors: Joachim Weitzel, Wolfgang Hechler
  • Synthesis of cyclopropaneacetylene by a one-pot process
    Patent number: 6552239
    Abstract: The present invention relates to a process for the preparation of cyclopropaneacetylene by reacting a ketophosphonate with a diazo-transfer reagent in the presence of non-nucleophilic base in an aprotic solvent to generate a reaction mixture containing a ketodiazophosphonate compound and then reacting the reaction mixture with cyclopropanecarboxaldehyde in a non-nucleophilic base and a protic solvent to yield cyclopropaneacetylene.
    Type: Grant
    Filed: October 27, 2000
    Date of Patent: April 22, 2003
    Assignee: Merck & Co., Inc.
    Inventor: Karel M. J. Brands
  • Solutions for cleaning silicon semiconductors or silicon oxides
    Patent number: 6551972
    Abstract: A solution for cleaning silicon semiconductors or silicon oxides comprising H2O2, NH4OH and at least one component A selected from the group consisting of fluoro-containing compounds and other ammonium salts than NH4OH, wherein the weight ratio of H2O2 to H2O is between 1:5 and 1:50, the weight ratio of NH4OH to H2O is between 1:5 and 1:50, and the molar ratio of component A to NH4OH is between 1:10 and 1:5000 is disclosed. The solution can achieve the efficacy equivalent to that of the conventional RCA two-step cleaning solution within a shorter time by one step and effectively remove contaminants such as organics, dust and metals from the surfaces of silicon semiconductors and silicon oxides without using strong acids such as HCl and H2SO4.
    Type: Grant
    Filed: April 28, 2000
    Date of Patent: April 22, 2003
    Assignee: Merck Patent Gesellschaft
    Inventors: Tan-Fu Lei, Tien-Sheng Chao, Ming-Chi Liaw
  • Benzimidazolinyl piperidines as CGRP ligands
    Patent number: 6552043
    Abstract: The present invention relates to benzimidazolinylpiperidine derivatives useful as ligands for CGRP (Calcitonin Gene-Related Peptide) receptors, their use in therapy, pharmaceutical compositions comprising them and methods of treatment using them.
    Type: Grant
    Filed: May 30, 2001
    Date of Patent: April 22, 2003
    Assignees: Merck Sharpe & Dohme Ltd., Merck & Co, Inc.
    Inventors: Arthur A. Patchett, Raymond George Hill, Lihu Yang
  • Continuous method for separating substances according to molecular size
    Patent number: 6551512
    Abstract: Continuous separation methods, in partricular using SMB methods, are disclosed, in which the analytes are separated by size exclusion chromatography (gel permeation chromatography).
    Type: Grant
    Filed: June 13, 2001
    Date of Patent: April 22, 2003
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Lothar Britsch, Michael Schulte, Jochen Strube
  • Process for the preparation of conjugates useful in the treatment of prostate cancer
    Patent number: 6552166
    Abstract: The present invention is directed to the improved synthesis of compounds of formula I: which may be useful in the treatment of prostate cancer. Such compounds are synthesized in the presence of a carboxyl activating agent, an additive and a base for the preparation of a PSA conjugate which comprises an anthracycline antibiotic and an oligopeptide.
    Type: Grant
    Filed: October 18, 2000
    Date of Patent: April 22, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Joseph E. Lynch, Michael A. Robbins, Yao-Jun Shi, David R. Lieberman
  • Cyclohexane derivatives and liquid-crystalline medium
    Patent number: 6551666
    Abstract: The invention relates to cyclohexane derivatives of the formula I in which n, m, p, R1, X1, X2, Z1, Z2, Z3, A1 A2 and Y are as defined above.
    Type: Grant
    Filed: June 28, 2001
    Date of Patent: April 22, 2003
    Assignee: Merck Patent Gesellschaft Mit
    Inventors: Peer Kirsch, Joachim Krause, Michael Heckmeier
  • Pigment flakes
    Patent number: 6552102
    Abstract: Described are chiral liquid crystalline polymer materials and polymerizable compounds used for preparing them. The polymer materials can serve as a carrier material or are coated onto a carrier material. Also described are methods of making such materials and using them to make pigment flakes used in paints, printing inks, spray paints, cosmetic products, colored plastics, optical elements and security applications.
    Type: Grant
    Filed: July 3, 2001
    Date of Patent: April 22, 2003
    Assignee: Merck Patent Gesellschaft mit beschränkter Haftung
    Inventors: Eike Poetsch, Gerhard Pfaff, Matthias Kuntz, Stephan Derow, David Coates
  • Liquid-crystalline medium
    Publication number: 20030071244
    Abstract: Liquid-crystalline mediums based on a mixture of polar compounds of negative dielectric anisotropy, comprising one or more compounds of the general formula I, 1
    Type: Application
    Filed: July 30, 2002
    Publication date: April 17, 2003
    Applicant: MERCK PATENT GESELLSCHAFT
    Inventors: Melanie Klasen-Memmer, Malgorzata Rillich, Volker Reiffenrath
  • Triazolo-pyridine derivatives as ligands for GABA receptors
    Publication number: 20030073717
    Abstract: A class of substituted or 6,7-ring fused 1,2,3-triazolo[4,5-b]pyridine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the 3-position and a substituted alkoxy moiety at the 5-position, are selective ligands for GABAA receptors, in particular having high affinity for the &agr;2 and/or &agr;3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.
    Type: Application
    Filed: November 8, 2002
    Publication date: April 17, 2003
    Applicant: Merck & Co., Inc.
    Inventors: Howard Barff Broughton, Jose Luis Castro Pineiro, Ian James Collins, Leslie Joseph Street
  • Use of additives in electrolyte for electrochemical cells
    Patent number: 6548212
    Abstract: The invention relates to the use of salt-based compounds as additives in electrolytes for improving the properties of electrochemical cells.
    Type: Grant
    Filed: March 13, 2000
    Date of Patent: April 15, 2003
    Assignee: Merck Patent GmbH
    Inventors: Udo Heider, Michael Schmidt, Anja Amann, Marlies Niemann, Andreas Kühner
  • 1-(3-heteroarylpropyl- or -prop-2-enyl)-4-benzylpiperidines used as NMDA receptor antagonists
    Patent number: 6548516
    Abstract: Piperidine derivatives of the formula I and their physiologically acceptable salts in which X, Y, Z, R1, R2, R3 and R4 are as defined in claim 1 can be as excitatory amino acid antagonists for combating neurodegenerative disorders including cerebrovascular diseases, epilepsy, schizophrenia, Alzheimer's disease, Parkinson's disease and Huntington's disease, cerebral ischaemias, infarcts and psychosis.
    Type: Grant
    Filed: September 14, 2000
    Date of Patent: April 15, 2003
    Assignee: Merck Patent GmbH
    Inventors: Helmut Prücher, Joachim Leibrock, Andrew Barber, Gerd Bartoszyk
  • Method of isolating plasmid DNA
    Patent number: 6548253
    Abstract: The invention relates to a method of isolating plasmid DNA from microorganism cultures with the aid of solid-phase bodies. The solid-phase bodies can be silica gels, silicates, or glass-like materials and the solid-phase bodies can have magnetic properties. The solid-phase bodies are used for isolating the microorganisms and for isolating the plasmid DNA.
    Type: Grant
    Filed: June 8, 2001
    Date of Patent: April 15, 2003
    Assignee: Merck Patent GmbH
    Inventors: Karl Holschuh, Uwe Michelsen
  • Pigment preparation
    Patent number: 6547870
    Abstract: The invention relates to a non-dusting, homogeneous pigment preparation, comprising ≧40% by weight of one or more effect pigments, 0.5-60% by weight of a polyalkylene glycol and/or one or more polyalkylene glycol derivatives, 0-10% by weight of a redispersing auxiliary, 0-40% by weight of water or an organic solvent or solvent mixture, 0-40% by weight of at least one further hydroxyl-rich resin, and to its use as a precursor for printing inks.
    Type: Grant
    Filed: December 13, 2000
    Date of Patent: April 15, 2003
    Assignee: Merck Patent Gesellschaft mit beschränkter Haftung
    Inventors: Carsten Griessmann, Gerhard Herget
  • Process for producing a powder coating material; a powder coating material; and the use of effect pigments
    Patent number: 6547869
    Abstract: Described is a process for preparing a powder coating material, in which a mixture comprising binders, pigments and also, where appropriate, fillers, additives and cross linkers is extruded and then ground. The pigment fraction of this mixture at least in part comprises surface-modified effect pigment that has been coated with a low molecular mass polyethylene or polypropylene. Also, described is a powder coating material prepared by this process and the use of effect pigments coated with low molecular mass polyethylene or polypropylene to prepare powder coating materials.
    Type: Grant
    Filed: July 19, 2001
    Date of Patent: April 15, 2003
    Assignee: Merck Patent GmbH
    Inventor: Tobias Witt
  • Method for treating ocular hypertension
    Patent number: 6548535
    Abstract: This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions related to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of a mammalian species, particularly humans.
    Type: Grant
    Filed: January 17, 2001
    Date of Patent: April 15, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Maria L. Garcia, Gregory J. Kaczorowski, Owen B. McManus
  • Process for formulation of carbapenem antibiotic compositions
    Patent number: 6548492
    Abstract: A novel process for preparing a stabilized, lyophilized carbapenem, antibiotic formulation suitable for intravenous administration to patients in need thereof, wherein the active ingredient is of formula II: The process entails compounding a unstable, monosodium salt carbapenem with a sodium bicarbonate solution at a temperature range of from about 0° to about 5° C. while maintaining a pH between about 7.0 and about 8.0, filtering the resultant solution, bottling under sterile conditions, and lyophilizing to produce the formulation.
    Type: Grant
    Filed: October 27, 2000
    Date of Patent: April 15, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Anthony Al-Dehneh, William A. Hunke, Kathleen J. Illig, Anand Kanike, Hiren Patel, Scott D. Reynolds, Stelios C. Tsinontides