Patents Assigned to Merck
  • Monoreactive mesogenic compounds
    Patent number: 6491990
    Abstract: The invention relates to monoreactive mesogenic compounds of formula I wherein P, Sp, X, n, Y1, Y2, r1, r2, r3, Z1 and Z2 are defined herein.
    Type: Grant
    Filed: July 3, 2000
    Date of Patent: December 10, 2002
    Assignee: Merck Patent Gesellschaft mit beschraenkter Haftung
    Inventors: Owain Llyr Parri, Ian Victor Edward Hassall, Tara Louise Cutler
  • Method for producing bead polymers
    Patent number: 6492471
    Abstract: A continuous process for the preparation of inorganic and organic bead polymers using a static micromixer is disclosed. The bead polymers obtainable by the process according to the invention have a very uniform particle size distribution, which can be set in a range of between 0.1 and 300 &mgr;m.
    Type: Grant
    Filed: November 5, 2001
    Date of Patent: December 10, 2002
    Assignee: Merck Patent Gesellschaft mit Beschraenkter Haftung
    Inventors: Friedhelm Eisenbeiss, Joachim Kinkel, Hans-Daniel-Jakob Müller
  • Compounds having cytokine inhibitory activity
    Patent number: 6492516
    Abstract: There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which exhibit utility for the treatment of cytokine mediated diseases such as arthritis.
    Type: Grant
    Filed: May 4, 2000
    Date of Patent: December 10, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Nigel J. Liverton, David A. Claremon, Cory R. Theberge
  • Composition comprising isoquercetin and ascorbic acid in a sustained release form
    Patent number: 6491948
    Abstract: The present invention relates to novel, orally administered compositions comprising two redox systems: reduced ascorbic acid in a sustained release form and oxidized isoquercetin with an increased concentration of reduced vitamin C over a prolonged time in the brain. These compositions are useful as neuroprotective agents possessing preventive properties against memory dysfunctions.
    Type: Grant
    Filed: March 15, 2000
    Date of Patent: December 10, 2002
    Assignee: Merck Patent GmbH
    Inventors: Herwig A. Buchholz, Jerzy D. Meduski
  • Cleaning compositions
    Publication number: 20020183234
    Abstract: The present invention relates to cleaning compositions which comprise the insect repellent ethyl 3-(N-butylacetamino)propionate and the use of this insect repellent in all types of cleaning compositions for repelling insects. This invention furthermore relates to a method for cleaning and for simultaneously repelling insects in which cleaning compositions comprising ethyl 3-(N-butylacetamino)propionate are used.
    Type: Application
    Filed: June 11, 2002
    Publication date: December 5, 2002
    Applicant: Merck Patent GmbH
    Inventors: Mohammad Jalalian, Maria Elisabeth Prenzel, Roland Martin, Francesc Rosell I Oller
  • Pigment mixture
    Patent number: 6488756
    Abstract: The present invention relates to pigment mixtures consisting of at least two components, component A being SiO2 flakes coated with one or more metal oxides and/or metals and component B being platelet-shaped, acicular or spherical colorants or fillers, and to their use in particular in varnishes, paints, printing inks, powder coating materials, plastics and cosmetic formulations.
    Type: Grant
    Filed: May 28, 1999
    Date of Patent: December 3, 2002
    Assignee: Merck Patent Gesellschaft
    Inventors: Sabine Schoen, Reiner Vogt, Norbert Schül, Karl Osterried, Uta Maurer
  • Coupling for microcomponents
    Patent number: 6488315
    Abstract: A coupling for microcomponents has several essentially plane-parallel plates with line connections for delivering and discharging liquid or gaseous components. The line connections are mounted on a connection block which protrudes through openings in the plates with fixing segments that engage a pressure plate retained by a clip. The line connections open out in an area of line bores in the plate.
    Type: Grant
    Filed: April 27, 2000
    Date of Patent: December 3, 2002
    Assignee: Merck Patent GmbH
    Inventors: Günter Brenner, Michael Schmelz, Hanns Wurziger, Norbert Schwesinger
  • 2-aza-bicyclo[2.2.2]octane NMDA/NR2B antigonists
    Patent number: 6489477
    Abstract: Novel 2-aza-bicyclo[2.2.2]octanes substituted in the 2-position are effective as NMDA NR2B antagonists useful for relieving pain.
    Type: Grant
    Filed: October 25, 2000
    Date of Patent: December 3, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Wayne Thompson, David A. Claremon, Peter M. Munson
  • Process for the synthesis of 3,5-bis(trifluoromethyl)benzoic acid
    Patent number: 6489507
    Abstract: The present invention is concerned with a novel process for the preparation of 3,5-bis(trifluoromethyl)benzoic acid (CAS 725-89-3). This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity, in particular, as substance P (neurokinin-1) receptor antagonists.
    Type: Grant
    Filed: June 8, 2000
    Date of Patent: December 3, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Raymond Cvetovich, John Leazer
  • Stabilization of pearl luster pigments
    Patent number: 6488758
    Abstract: The invention relates to a pearl luster pigment which may possess a first, inner layer, consisting of a platelet-shaped substrate, a second layer, comprising one or more metal oxides, the first and second layers forming a calcined base pigment, a third layer, comprising the corresponding uncalcined oxide, hydroxide or oxide hydrate of the oxide of the second layer, a fourth layer, comprising oxides, hydroxides and/or oxide hydrates of silicon or aluminum, a fifth layer, comprising oxides, hydroxides and/or oxide hydrates of silicon, aluminum, zirconium and/or cerium, this layer differing from the fourth layer, and a sixth layer, comprising one or more organofunctional coupling reagents. The present invention relates to also a preparation process, and the use of the pigments in paints, inks, plastics, coatings and cosmetics.
    Type: Grant
    Filed: November 6, 2001
    Date of Patent: December 3, 2002
    Assignee: Merck Patent Gesellschaft mit beschraenkter Haftung
    Inventors: Ralf Glausch, Marita Jekel
  • After coating of pearl luster pigments with hydrophobic coupling reagents
    Patent number: 6488757
    Abstract: The present invention relates to a pearl luster pigment on the basis of a platelet-shaped substrate coated with metal oxides and a top layer which is located on the metal oxide layer and can possess a multilayer structure, comprising a first layer, containing a hydroxide or oxide hydrate of the elements aluminum or silicon, a second layer, containing at least one hydroxide or oxide hydrate of the elements aluminum, silicon, cerium or zirconium, with the exception of the hydroxide or oxide hydrate which forms the first layer, and a third layer, containing at least one organic hydrophobic coupling agent. The present invention also relates to a preparation process and the use of pigments in paints, inks, plastics, coatings and cosmetics.
    Type: Grant
    Filed: November 6, 2001
    Date of Patent: December 3, 2002
    Assignee: Merck Patent Gesellschaft mit beschraenker Haftung
    Inventor: Ralf Glausch
  • Tetrahydropyran derivatives and their use as therapeutic agents
    Patent number: 6489343
    Abstract: The present invention relates to compounds of the formula (I): wherein R1 is fluorine or trifluoromethyl; R2 is fluorine or trifluoromethyl; R3 is methyl or hydroxymethyl; R4 represents a variety of substituents; and n is zero, 1 or 2; and pharmaceutically acceptable salts thereof. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migaine, emesis or postherpetic neuralgia.
    Type: Grant
    Filed: August 20, 2001
    Date of Patent: December 3, 2002
    Assignee: Merck Sharp & Dohme Ltd.
    Inventors: Jose Luis Castro Pineiro, Simon Neil Owen, Eileen Mary Seward, Christopher John Swain, Brian John Williams
  • 3-alkyl substituted pyrrolidine modulators of chemokine receptor activity
    Patent number: 6489354
    Abstract: The present invention is directed to pyrrolidine compounds of the formula I: (wherein R1, R2, R3, R4c, R4d, and R4f are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-3 and/or CCR-5.
    Type: Grant
    Filed: March 1, 2000
    Date of Patent: December 3, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Jianming Bao, Robert K. Baker, William H. Parsons, Kathleen Rupprecht
  • Process for the synthesis of carbapenem intermediates, and compounds produced
    Patent number: 6489471
    Abstract: A process of synthesizing a carbapenem compound of formula (6) is disclosed, wherein R represents H or methyl, P and P* independently represent H or protecting groups and each R1 is independently selected from: H, halo, OH, OP wherein P is a protecting group, C1-6 alkyl or C1-6 alkyl substituted with 1-3 of halo, OH, OP, NH2, NHC1-4 alkyl or N(C1-4 alkyl)2, comprising reacting a carbapenem of formula (4′) with a compound of formula (7), wherein R, R1, P and P* are as previously defined and R2 represents acetate, C(O)OR′ or P(O)(OR″)2, wherein R′ and R″ independently represent Clot alkyl, benzyl or aryl, in the presence of a catalyst to produce a compound of formula (6).
    Type: Grant
    Filed: March 5, 2001
    Date of Patent: December 3, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Guy R. Humphrey, Ross A. Miller, Nobuyoshi Yasuda
  • Method of treating migraines and pharmaceutical compositions
    Publication number: 20020177617
    Abstract: A combination of a 5HT1B/1D agonist and a COX-2 selective inhibitor is useful in the treatment and or prevention of migraine.
    Type: Application
    Filed: March 26, 2002
    Publication date: November 28, 2002
    Applicant: Merck & Co., Inc.
    Inventors: Kremena Simitchieva, Scott A. Reines, Errol McKinney, Eric J. Sandquist, Deepak K. Khannna, Richard Hargreaves
  • Phosphonic acid biaryl derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B)
    Patent number: 6486141
    Abstract: The invention encompasses the novel class of compounds represented by formula I which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related conditions.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: November 26, 2002
    Assignee: Merck Frosst Canada & Co.
    Inventors: Cheuk Kun Lau, Christopher Bayly, Jacques Yves Gauthier, Yves Leblanc, Chun Sing Li, Patrick Roy, Michel Therien, Zhaoyin Wang
  • Phenylindole derivatives as 5-HT2A receptor ligands
    Patent number: 6486153
    Abstract: A class of tryptamine analogues bearing an optionally substituted phenyl nucleus at the 2-position are selective antagonists of the human 5-HT2A receptor and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of adverse neurological conditions, including psychotic disorders such as schizophrenia.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: November 26, 2002
    Assignee: Merck Sharp & Dohme Ltd.
    Inventors: Jose Luis Castro Pineiro, Steven Michael Hutchins, Stephen John Lewis, Michael Rowley, Adrian Leonard Smith, Graeme Irvine Stevenson
  • Use of inhibitors of cyclooxygenase in the treatment of neurodegenerative diseases
    Patent number: 6486194
    Abstract: The present invention provides a method of treating a neurodegenerative disease and in particular Alzheimers disease which comprises administering to a human in need thereof a therapeutically effective amount of a non-steroid COX-II inhibitor.
    Type: Grant
    Filed: February 28, 2001
    Date of Patent: November 26, 2002
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Yves Ducharme, Jacques Yves Gauthier, Petpiboon Prasit, Yves Leblanc, Zhaoyin Wang, Serge Leger, Michel Therien
  • Thermodynamically stable crystal form of 4?-deoxy-4?-epi-methylamino avermectin B1a/B1b benzoic acid salt and processes for its preparation
    Patent number: 6486195
    Abstract: The most thermodynamically stable crystalline form of the benzoic acid salt of 4″-deoxy-4″-epi-methylamino avermectin B1a/B1b as the hemihydrate is obtained by crystallization from organic solvents containing a controlled amount of water.
    Type: Grant
    Filed: January 20, 1995
    Date of Patent: November 26, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Raymond Cvetovich, James A. McCauley, Richard Demchak, Richard J. Varsolona
  • Human metabotropic glutamate receptors, nucleic acids encoding same and uses thereof
    Patent number: 6485919
    Abstract: In accordance with the present invention, there are provided nucleic acids encoding human metabotropic glutamate receptor subtypes and the proteins encoded thereby. In a particular embodiment, the invention nucleic acids encode mGluR1, mGluR2, mGluR3 and mGluR5 subtypes of human metabotropic glutamate receptors. In addition to being useful for the production of metabotropic glutamate receptor subtypes, these nucleic acids are also useful as probes, thus enabling those skilled in the art, without undue experimentation, to identify and isolate related human receptor subunits. In addition to disclosing novel metabotropic glutamate receptor subtypes, the present invention also comprises methods for using such receptor subtypes to identify and characterize compounds which affect the function of such receptors, e.g., agonists, antagonists, and modulators of glutamate receptor function.
    Type: Grant
    Filed: December 13, 1999
    Date of Patent: November 26, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Lorrie Daggett, Steven B. Ellis, Chen Liaw, Aaron Pontsler, Edwin C. Johnson, Stephen D. Hess