Patents Assigned to Merck
  • Bicyclic amino acids
    Publication number: 20010021709
    Abstract: Compounds of the formula I 1
    Type: Application
    Filed: April 26, 2001
    Publication date: September 13, 2001
    Applicant: Merck Patent Gesellschaft mit Beschrankt Patents
    Inventors: Beate Diefenbach, Simon L. Goodman, Joachim Marz, Peter Raddatz, Friedrich Rippmann, Matthias Wiesner
  • Organosilicon compounds
    Patent number: 6287650
    Abstract: R1—(A1)m—Z1—A2—(Z2—A3)n—W—SiXaYbZc  I in which R1, A1, A2, A3, Z1, R1, Z2, W, X, Y, Z, m, n, a, b and c are as defined below, can be used to produce homeotropic alignment of liquid-crystalline phases on surfaces.
    Type: Grant
    Filed: November 5, 1998
    Date of Patent: September 11, 2001
    Assignee: Merck Patent Gesellschaft mit
    Inventors: Detlef Pauluth, Matthias Bremer, Edgar Böhm, Akio Osabe, Gerhard Herget, Wolfgang Hechler
  • Nucleic acid encoding rat galanin receptor (GALR2)
    Patent number: 6287855
    Abstract: A new galanin receptor, GALR2, is described. Also provided are nucleic acids encoding same and various assays to identify ligands particular to said receptor. Ligands so identified are useful for the treatment of obesity, treatment of pain, and treatment of cognitive disorders.
    Type: Grant
    Filed: December 18, 1997
    Date of Patent: September 11, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Carina Tan, Kathleen Sullivan
  • Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
    Patent number: 6288054
    Abstract: The present invention relates to tricyclic carbapenem antibacterial agents in which the carbapenem nucleus is fused to a 6 membered carbocyclic ring. The compound is further substituted with various substituent groups including at least one cationic group. The compounds are represented by formula I: Pharmaceutical compositions and methods of use are also included.
    Type: Grant
    Filed: May 24, 1999
    Date of Patent: September 11, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Frank P. Dininno, Milton L. Hammond, Kevin D. Dykstra
  • 6-azaindole compounds as antagonists of gonadotropin releasing hormone
    Patent number: 6288078
    Abstract: There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
    Type: Grant
    Filed: March 7, 2000
    Date of Patent: September 11, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Thomas F. Walsh, Feroze Ujjainwalla
  • Liquid-crystalline medium
    Patent number: 6287648
    Abstract: The invention relates to a liquid-crystalline medium based on a mixture of polar compounds of positive dielectric anisotropy, containing at least one compound of the general formula I in which R1 and R2 are each, independently of one another, an alkyl or alkenyl radical having 1 to 12 carbon atoms which is unsubstituted, monosubstituted by CN or CF3 or at least monosubstituted by halogen, where one or more CH2 groups in these radicals may also, in each case independently of one another, be replaced by —O—, —S—, —CO—, —CO—O—, —O—CO— or —O—CO—O— in such a way that O atoms are not linked directly to one another and u is 1 or 2.
    Type: Grant
    Filed: December 22, 1999
    Date of Patent: September 11, 2001
    Assignee: Merck Patent Gesellschaft Mit
    Inventors: Kazuaki Tarumi, Peer Kirsch, Sabine Schoen, Dagmar Klement
  • Multilayer interference pigments
    Patent number: 6284032
    Abstract: Multilayer interference pigment consisting of plateletlike titanium dioxide as carrier material, coated with alternating layers of metal oxides of low and high refractive index, the difference in the refractive indices being at least 0.1, which is obtainable by solidification and hydrolysis of an aqueous solution of a thermally hydrolysable titanium compound on a continuous belt, detachment of the resulting coat, coating of the resulting titanium dioxide platelets, with or without drying in between, by a wet method with, alternately, a metal oxide hydrate of high refractive index and a metal oxide hydrate of low refractive index by hydrolysis of the corresponding, water-soluble metal compounds, separation, drying and, if desired, calcining of the material obtained.
    Type: Grant
    Filed: January 11, 2001
    Date of Patent: September 4, 2001
    Assignee: Merck Patent GmbH
    Inventors: Stephanie Andes, Gerd Bauer, Günter Brenner, Dieter Brückner, Michael Schmelz, Andrea Heyland, Matthias Kuntz, Karl Osterried, Gerhard Pfaff
  • Inhibitors of prenyl-protein transferase
    Patent number: 6284755
    Abstract: The present invention is directed to azepan-2-one compounds which inhibit prenyl-protein transferase, particularly farnesyl-protein transferase (Ftase), and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
    Type: Grant
    Filed: December 7, 1999
    Date of Patent: September 4, 2001
    Assignee: Merck & Co., Inc.
    Inventors: S. Jane deSolms, Samuel L. Graham, Anthony W. Shaw, Terrence M. Ciccarone, Gerald E. Stokker
  • Phenylcyclohexanes and a liquid-crystalline medium
    Patent number: 6284154
    Abstract: Novel phenylcyclohexanes of the formula I in which n is 0 to 7, Q1 and Q2 are H, or one of these radicals is alternatively CH3, r is 0, 1, 2, 3, 4 or 5, A is trans-1,4-cyclohexylene, 1,4-phenylene, 3-fluoro-1,4-phenylene or a single bond, X is F, Cl, —CF3, —CN, —OCF3 or —OCHF2, and Y and Z are each, independently of one another, H or F, with the proviso that, in the case where A is a single bond, Q1═Q2═H and simultaneously X═CN, Y and/or Z are F.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 4, 2001
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Andreas Wächtler, Reinhard Hittich, Eike Poetsch, Herbert Plach, David Coates, Bernhard Rieger, Joachim Krause
  • Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
    Patent number: 6284753
    Abstract: The present invention relates to tricyclic carbapenem antibacterial agents wherein X is CH2, CHRa, CHRb, C═CHRa, C═CHRb, O, S, SO, SO2, CO, COO<OCO, NRa, NRb; and Z is trans-ethenediyl or ethynediyl. The compound is further substituted with various substituent groups including at least one cationic group. The compounds are represented by formula I: Pharmaceutical compositions and methods of use are also included.
    Type: Grant
    Filed: May 24, 1999
    Date of Patent: September 4, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Frank P. Dininno, Kevin D. Dykstra
  • Substituted 1H-pyridinyl-2-ones as GABAA alpha 2/3 ligands
    Publication number: 20010018438
    Abstract: Compounds according to Formula (I) or a salt thereof are selective ligands for GABAA receptors useful for treatment of disorders of the central nervous system: 1
    Type: Application
    Filed: January 4, 2001
    Publication date: August 30, 2001
    Applicant: MERCK SHARP & DOHME LIMITED
    Inventors: Ian James Collins, Stephen Robert Fletcher, Timothy Harrison, Paul David Leeson, Christopher Richard Moyes, Alan John Nadin, Michael Rowley, Timothy Jason Sparey, Martin Richard Teall
  • Method for inhibiting bone resorption
    Publication number: 20010018431
    Abstract: Disclosed are methods for inhibiting bone resorption in mammals while minimizing the occurrence of or potential for adverse gastrointestinal effects. Also disclosed are pharmaceutical compositions and kits for carrying out the therapeutic methods disclosed herein.
    Type: Application
    Filed: March 20, 2001
    Publication date: August 30, 2001
    Applicant: MERCK & CO., Inc.
    Inventors: Anastasia G. Daifotis, Arthur C. Santora, A. John Yates
  • Methods for inhibiting bone resorption
    Publication number: 20010018433
    Abstract: The present invention relates to methods for inhibiting bone resorption in a mammal comprising administering to a mammal in need thereof a therapeutically effective amount of an EP4 receptor subtype antagonist.
    Type: Application
    Filed: March 26, 2001
    Publication date: August 30, 2001
    Applicant: Merck & Co., Inc.
    Inventors: Shun-Ichi Harada, Mohamed Machwate, Gideon A. Rodan, Marc Labelle, Kathleen Metters, Robert N. Young
  • 4-(1-piperazinyl) benzoic acid derivatives, process for preparing them and their therapeutic applications
    Patent number: 6281215
    Abstract: New 4-(1-piperazinyl)benzoic acid derivatives of the formula (I) are described. Also described is methods for making these compounds and their use as therapeutic agents. In particular, the compounds find use in the treatment of diabetes.
    Type: Grant
    Filed: October 20, 1999
    Date of Patent: August 28, 2001
    Assignee: Merck Patent GmbH
    Inventors: Gérard Moinet, Gérard Botton, Liliane Doare, Micheline Kergoat, Didier Messangeau
  • Synthesis of methylthiophenyl hydroxyketones
    Patent number: 6281391
    Abstract: This invention encompasses a novel process for synthesizing compounds represented by formula A: These compounds are intermediates useful in the preparation of certain agents that are selective COX-2 inhibitors.
    Type: Grant
    Filed: October 27, 1999
    Date of Patent: August 28, 2001
    Assignees: Merck & Co., Inc., Merck Frosst Canada & Co.
    Inventors: Richard D. Tillyer, Ian W. Davies, Robert D. Larsen, Xin Wang, Paul O'Shea, Anthony On-Ping King, Dalian Zhao, Cheng Y. Chen, Edward J. J. Grabowski
  • Multilayer pearl luster pigment based on an opaque substrate
    Patent number: 6280520
    Abstract: Multilayer pearl luster pigment based on an absorbing platelet-shaped substrate which is coated with alternating layers of a material of low refractive index and a material of high refractive index, or with a metal, the difference in the refractive indices being at least 0.1.
    Type: Grant
    Filed: April 19, 1999
    Date of Patent: August 28, 2001
    Assignee: Merck Patent GmbH
    Inventors: Stephanie Andes, Dieter Brückner, Gerald Fuchs-Pohl, Matthias Kuntz, Gerhard Pfaff, Reiner Vogt
  • Peptide-coated implants and methods for producing same
    Patent number: 6280760
    Abstract: The invention describes the possibility of the biofunctionalization of biomaterials, in particular implants, by their made-to-measure coating with synthesized cell- or tissue-selective RGD peptides which in vitro stimulate the adhesion of mainly those cell species which in each case are intended to accomplish the tissue integration of the appropriate biomaterial.
    Type: Grant
    Filed: November 22, 1999
    Date of Patent: August 28, 2001
    Assignee: Merck Patent Gesellschaft mit beschraenkter Haftung
    Inventors: Jorg Meyer, Alfred Jonczyk, Berthold Nies, Horst Kessler, Dirk Finsinger, Martin Kantlehner
  • Rat ob-receptors and nucleotides encoding them
    Patent number: 6281346
    Abstract: The rat ob receptor gene has been isolated and cloned. Two different alleles have been identified: the wild-type, and the fa-allele which differs from the wild type by only one base pair. The base pair change, however introduces an MspI restriction site into the DNA sequence, and also results in an amino acid change. Also part of the invention are the receptors, vectors containing the nucleic acid encoding the receptors, host cells transformed with this gene, and assays which use the gene or protein and identify new ligands.
    Type: Grant
    Filed: February 20, 1997
    Date of Patent: August 28, 2001
    Assignee: Merck & Co., Inc.
    Inventors: John W. Hess, C. Thomas Caskey, Qingyun Liu, Michael Sean Phillips
  • Formulations of recombinant papillomavirus vaccines
    Patent number: 6280740
    Abstract: Vaccine formulations comprising recombinant early (E) and late (L) proteins of papillomavirus and oxidized mannan as well as methods of making and using the formulations are provided.
    Type: Grant
    Filed: January 14, 2000
    Date of Patent: August 28, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Sunil K. Gupta, George E. Mark, III
  • Phenylcyclohexanes and a liquid-crystalline medium
    Publication number: 20010015422
    Abstract: Novel phenylcyclohexanes of the formula I 1
    Type: Application
    Filed: February 8, 2001
    Publication date: August 23, 2001
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Andreas Wachtler, Reinhard Hittich, Eike Poetsch, Herbert Plach, David Coates, Bernhard Rieger, Joachim Krause