Patents Assigned to Merck
  • Human papilloma virus vaccine with disassembled and reassembled virus-like particles
    Patent number: 6245568
    Abstract: Human Papillomavirus vaccine formulations which contain virus-like particles (VLPs) can be made more stable and have an enhanced shelf-life, by treating the VLPs to a disassembly and reassembly process. Also provided are formulation buffers to long term stable storage of VLPs.
    Type: Grant
    Filed: March 13, 2000
    Date of Patent: June 12, 2001
    Assignee: Merck & Co., Inc.
    Inventors: David B. Volkin, Henryk Mach, Li Shi
  • Tyrosine kinase inhibitors
    Patent number: 6245759
    Abstract: The present invention relates to pyrazolo-pyrimidinyl compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.
    Type: Grant
    Filed: March 7, 2000
    Date of Patent: June 12, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Mark T. Bilodeau, Mark E. Fraley, Randall W. Hungate
  • HIV integrase inhibitors
    Patent number: 6245806
    Abstract: Novel tetracyclic aromatic ketones are natural product compounds useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. Further, the novel fungal cultures MF6388 (ATCC 74478), Sterile Fungus, and MF6591 (ATCC 74477), Ascochyta sp. are also disclosed. Further, the cultures Sterile Fungus MF6388 (ATCC 74478) and Ascochyta sp. MF6591 (ATCC 74477) are also disclosed, as well as processes for making compounds of the present invention employing the cultures.
    Type: Grant
    Filed: July 25, 2000
    Date of Patent: June 12, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Anne Dombrowski, Sheo Singh, Deborah L. Zink, Ana Teran, Fernando Pelaez, Daria Hazuda
  • Combination therapy for reducing the risks associated with cardio-and-cerebrovascular disease
    Patent number: 6245797
    Abstract: The instant invention provides a drug combination comprised of an HMG-CoA reductase inhibitor in combination with a COX-2 inhibitor, which is useful for treating, preventing, and/or reducing the risk of developing atherosclerosis and atherosclerotic disease events.
    Type: Grant
    Filed: October 20, 1998
    Date of Patent: June 12, 2001
    Assignee: Merck & Co., Inc.
    Inventor: Melvin Winokur
  • Assays for growth hormone secretagogue receptors
    Patent number: 6242199
    Abstract: An assay for the detection of growth hormone secretagogue receptors and growth hormone secretagogue related receptors is described. As these receptors are a member of the G protein coupled receptors, a subunit of the G protein must be present in order for expression to be detected. A similar assay is described where the presence of growth hormone secretagogues are detected.
    Type: Grant
    Filed: June 3, 1998
    Date of Patent: June 5, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Lee-Yuh Pai, Scott D. Feighner, Andrew D. Howard, Sheng-Shung Pong, Leonardus H. T. Van Der Ploeg
  • Method for treating attention deficit disorder
    Patent number: 6242446
    Abstract: Tachykinin receptor antagonists that are useful for treating or preventing attention deficit disorder, optionally associated with hyperactivity in a patient, are desclosed.
    Type: Grant
    Filed: May 31, 2000
    Date of Patent: June 5, 2001
    Assignee: Merck & Co., Inc.
    Inventors: David L. Glatt, Mark S. Kramer, Nadia Rupniak
  • F-18 radiolabeled neurokinin-1 receptor antagonists
    Patent number: 6241964
    Abstract: The present invention is directed to radiolabeled neurokinin-1 receptor antagonists which are useful for the labeling and diagnostic imaging of neurokinin-1 receptors in mammals.
    Type: Grant
    Filed: September 28, 1999
    Date of Patent: June 5, 2001
    Assignee: Merck & Co., Inc.
    Inventors: H. Donald Burns, Terence G. Hamill, Raymond E. Gibson
  • Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment
    Patent number: 6242493
    Abstract: Compounds of formula I: as well as pharmaceutically acceptable salts, hydrates and esters thereof, are disclosed. The compounds are useful for treating or preventing prostaglandin mediated diseases. Pharmaceutical compositions containing such compounds and methods of treatment are also included.
    Type: Grant
    Filed: March 10, 1999
    Date of Patent: June 5, 2001
    Assignee: Merck Frosst Canada & Co.
    Inventors: Yves Gareau, Marc LaBelle, Helene Juteau, Michel Gallant, Nicolas LaChance, Michel Belley
  • Preparation of betamethyl carbapenem intermediates
    Patent number: 6242596
    Abstract: A process for making a beta methyl carbapenem intermediate is disclosed. A compound of formula I: is contacted in a non-reactive solvent with methyl Meldrum's acid and a base to produce a compound of formula III: Compound III is treated in an aprotic solvent with a scavenging base, an alkali metal halide and a tri-organo silyl protecting compound for nitrogen to produce a compound of formula IV: Compound IV may be reacted with a nucleophile Nu—X in a non-reactive solvent and base, and the mixture acidified to produce a compound of formula V. Compound V may be reacted with mild acid to produce a compound of formula VI.
    Type: Grant
    Filed: May 12, 1994
    Date of Patent: June 5, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Woo-Baeg Choi, Guy R. Humphrey, Paul J. Reider, Ichiro Shinkai, Andrew S. Thompson, Ralph P. Volante
  • Method for producing powder lacquer containing gloss pigments
    Patent number: 6241382
    Abstract: A process for producing powder coating materials comprising lustre pigment comprises starting materials consisting of customary powder coating components and one or more lustre pigments. The starting materials are first introduced into the filling chamber of a first vessel which has a mixing element and is provided, if desired, with a thermostat. Subsequently, a supercritical fluid is admitted to the filling chamber, and finally the starting materials are mixed in the presence of the supercritical fluid. The mixture of the customary powder coating components, one or more lustre pigments and the supercritical fluid is transferred by a distributor into a second vessel. The distributor has a plurality of nozzles with an aperture diameter of from 0.025 cm to 2.5 cm. During transfer, the second vessel is maintained at an internal pressure of from 0 bar to 350 bar and at a temperature of from −85° C. to 200° C.
    Type: Grant
    Filed: November 19, 1999
    Date of Patent: June 5, 2001
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Manfred Kieser, Otto Stahlecker
  • Grinding aids for X-ray fluorescence analysis
    Patent number: 6242392
    Abstract: The invention relates to grinding aids for X-ray fluorescence analysis which consist of a polysaccharide binder, sugar or sugar alcohols as filler and of a lubricant. The grinding aids according to the invention are easy to use and provide very reproducible analytical data.
    Type: Grant
    Filed: August 31, 1999
    Date of Patent: June 5, 2001
    Assignee: Merck Patent Gesellschaft mit
    Inventors: Frank Hoffmann, Wolfgang Martens, Manfred Wachsmann
  • Microcapsules made of chitin or of chitin derivatives containing a hydrophobic substance, in particular a sunscreen, and process for the preparation of such microcapsules
    Patent number: 6242099
    Abstract: Microcapsules involving a wall of chitin or chitin derivatives or of polyhydroxylated polyamines or one of their salts, with the wall sheathing a hydrophobic substance, are prepared by forming a hydrophobic phase emulsion of the hydrophobic substance in an aqueous phase containing an anionic surfactant capable of causing insolubilization of chitosan or chitosan derivatives or polyhydroxylated polyamines, mixing the emulsion with a chitosan or chitosan derivative or polyhydroxylated polyamine organic salt so as to cause the coacervation of the chitosan or the chitosan derivatives or the polyhydroxylated polyamines around the droplets of the hydrophobic phase, subjecting the chitosan or chitosan derivative or the polyhydroxylated polyamine coacervate to an acetylation or crosslinking reaction and recovering the microcapsules, and are applicable to cosmetic compositions incorporating sunscreens.
    Type: Grant
    Filed: July 21, 1998
    Date of Patent: June 5, 2001
    Assignee: Merck S.A.
    Inventors: Bernard Grandmontagne, François Marchio
  • Method for inhibiting bone resorption
    Publication number: 20010002395
    Abstract: Disclosed are methods for inhibiting bone resorption in mammals while minimizing the occurrence of or potential for adverse gastrointestinal effects. Also disclosed are pharmaceutical compositions and kits for carrying out the therapeutic methods disclosed herein.
    Type: Application
    Filed: January 22, 2001
    Publication date: May 31, 2001
    Applicant: MERCK & CO., Inc.
    Inventors: Anastasia G. Daifotis, A. John Yates, Arthur C. Santora
  • Modular artificial hip joint
    Patent number: 6238436
    Abstract: A modular artificial hip joint includes a head part and at least one shaft part. The shaft part, which can be driven into the bone and forms the distal region, is connected to the distal end of the head part by insertion, preferably by means of an insert cone. A first screw or tie rod, guided through an axial bore in the head part, can be screwed into the threaded bore in the shaft part. In order to guide a second screw for separating the conical insert connection between the individual components of the artificial joint, the bore in the head part is threaded and has a diameter which is greater than the diameter of the threaded bore in the shank part.
    Type: Grant
    Filed: August 6, 1997
    Date of Patent: May 29, 2001
    Assignee: Biomet, Merck Deutschland GmbH
    Inventors: Günter Lob, Hans-Joachim Fischer, Gerd Steür, Curt Kranz
  • Interference pigments having a blue mass tone
    Patent number: 6238471
    Abstract: Multilayer interference pigment having a blue mass tone, comprised of a platelet-shaped carrier material and a coating which is formed from (i) a first layer of a colorless, transparent metal oxide of high refractive index, (ii) a second layer of colorless, transparent metal oxide of low refractive index and (iii) a third, outer layer of cobalt aluminate, cobalt-containing glass, tungsten bronzes or cobalt oxide, it also being possible for the first and third layer to be swapped around.
    Type: Grant
    Filed: February 1, 1999
    Date of Patent: May 29, 2001
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Reiner Vogt, Hans-Dieter Brückner
  • Process for synthesizing biaryl inhibitors of farnesyl-protein transferase
    Patent number: 6239280
    Abstract: The present invention is directed to a process for synthesizing 1,5 disubstituted imidazoles with biaryl components of the formula (I): which are usefull as Farnesyl-Protein Transferase inhibitors.
    Type: Grant
    Filed: June 30, 1999
    Date of Patent: May 29, 2001
    Assignee: Merck & Co., Inc.
    Inventors: David Askin, Jennifer A. Cowen, Peter E. Maligres, J. Christopher McWilliams, Marjorie S. Waters
  • 3-phenyl-4-(4(methylsulfonyl)phenyl)-2-(5H)-furanone as a cox-2 inhibitor
    Patent number: 6239173
    Abstract: The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: May 29, 2001
    Assignee: Merck Frosst Canada Inc./Merck Frosst Canada & Co.
    Inventors: Zhaoyin Wang, Michel Therien
  • Metal oxide coated titanium dioxide lamellas
    Patent number: 6238472
    Abstract: Colored pearl luster pigment consisting of a core of platelet shaped titanium dioxide and one or more layers of other metal oxides or metal oxide hydrates obtainable by solidifying an aqueous solution of a thermally hydrolyzable titanium compound on a continuous belt, detaching the resulting layer, coating the resulting titanium dioxide platelets, with or without drying in between, with one or more other metal oxides or metal oxide hydrates, for example Fe2O3, Fe3O4, FeOOH or Cr2O3, by a wet method, separating, drying and, if desired, calcining the material obtained.
    Type: Grant
    Filed: March 9, 1999
    Date of Patent: May 29, 2001
    Assignee: Merck Patent GmbH
    Inventors: Stephanie Andes, Gerd Bauer, Günter Brenner, Dieter Brückner, Michael Schmelz, Andrea Heyland, Matthias Kuntz, Karl Osterried, Gerhard Pfaff
  • Thrombin inhibitors
    Patent number: 6239132
    Abstract: Compounds of the invention, useful as thrombin inhibitors and having therapeutic value in for example, preventing coronary artery disease, have the following structure: or a pharmaceutically acceptable salt thereof, wherein A is
    Type: Grant
    Filed: April 18, 2000
    Date of Patent: May 29, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Craig Coburn, Joseph P. Vacca
  • Process for the synthesis of carbapenem intermediated and compounds produced
    Patent number: 6235898
    Abstract: A process of synthesizing a carbapenem compound of formula 6: is disclosed using a compound of formula 4′: The intermediate compounds that are described herein are also included in the present invention.
    Type: Grant
    Filed: February 23, 2000
    Date of Patent: May 22, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Mark S. Jensen, Chunhua Yang, Nobuyoshi Yasuda