Abstract: [Problem] To provide a semiconductor aqueous composition capable of preventing a pattern collapse and suppressing a bridge defect. [Means for Solution] A semiconductor aqueous composition comprising a single or plurality of surfactant(s) having a monovalent anion part represented by formula (I): Chain 1-X1—X2-Chain 2 (I) wherein, X1 and X2 are each independently —C(=0)- or —S(=0)2-, and Chain 1 and Chain 2 are each independently a linear or branched C1-20 alkyl, wherein one or more H in said C1-20 alkyl are replaced by F, and one or more methylenes in Chain 1 may be replaced by -0-, with the proviso that Chain 1 and Chain 2 may be bonded to form a ring structure) and a monovalent cation part other than hydrogen ion; and water.
Abstract: The present application relates to an amine compound according to formula (I), (II) or (III) which is suitable for use in electronic devices.
Abstract: The present invention relates to heteroaromatic isothiocyanates of formula N as defined in claim 1, to liquid-crystalline media comprising one or more compounds of formula N and to high-frequency components comprising these media, especially microwave components for high-frequency devices, such as devices for shifting the phase of microwaves, tunable filters, tunable metamaterial structures, and electronic beam steering antennas, e.g. phased array antennas.
Type:
Grant
Filed:
December 13, 2021
Date of Patent:
September 3, 2024
Assignee:
MERCK PATENT GMBH
Inventors:
Amir Hossain Parham, Constanze Brocke, Carsten Fritzsch, Dagmar Klass
Abstract: The disclosure herein relates to a flow path comprising half clamps 1 having an interior surface surrounding a flexible tubing 3 connection with a barb adapter 3, when assembled may be placed within a clamshell reduce or prevent deformation of the flexible tubing.
Type:
Grant
Filed:
May 17, 2021
Date of Patent:
September 3, 2024
Assignee:
Merck Patent GmbH
Inventors:
Olivier Flick, Robert Langlois, James Vigna, Christine Crequy, Thomas Coton
Abstract: Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof wherein A, E, U, X, Y, Z, R1, R2 and n are as defined herein. The compounds of Formula I act as IL4I1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for IL4I1-related diseases. Also provided herein are pharmaceutical compositions comprising the compounds of the invention, or their pharmaceutically acceptable salts, and a pharmaceutically acceptable carrier and methods of treatment with the compounds of the invention.
Type:
Application
Filed:
June 23, 2022
Publication date:
August 29, 2024
Applicant:
Merck Sharp & Dohme LLC
Inventors:
BRANDON D. CASH, GEORGE MADALIN GIAMBASU, ANDREW M. HAIDLE, BRETT A. HOPKINS, MATTHEW A. LARSEN, CHARLES A. LESBURG, PING LIU, RYAN QUIROZ, SULAGNA SANYAL, CATHERINE M. WHITE, XIN YAN, XIAO MEI ZHENG
Abstract: The present invention is directed to prodrugs of compound A: which are nucleoside reverse transcriptase translocation inhibitors (NRTTI) and are useful in the inhibition of HIV reverse transcriptase. The present invention also relates to the use of these compounds for prophylaxis of infection by HIV, treatment of infection by HIV, and prophylaxis, treatment, and delay in the onset or progression of AIDS and/or AIDS-related complexes.
Type:
Application
Filed:
January 26, 2024
Publication date:
August 29, 2024
Applicant:
Merck Sharp & Dohme LLC
Inventors:
Mark W. Embrey, Jay A. Grobler, Mark E. Layton, Izzat T. Raheem
Abstract: VHH-based NKp30 binders are provided having favorable characteristics. Moreover, pharmaceutical compositions including such a compound are produced and methods of medical treatment with such compounds and pharmaceutical compositions are developed. In a compound including a VHH antibody domain or fragment thereof, the VHH antibody domain or fragment thereof can have complementary determining regions CDR1, CDR2, and CDR3 of one of VHH1 to VHH16, or a humanized modification thereof, or a modification involving replacement, addition, and/or deletion of up to three amino acids in each complementary determining region.
Type:
Application
Filed:
June 22, 2022
Publication date:
August 29, 2024
Applicant:
Merck Patent GmbH
Inventors:
Stefan ZIELONKA, Lars Toleikis, Simon Krah, Lukas Pekar, Andreas Evers
Abstract: A solid form of [(1R)-2-(1-benzofuran-3-yl)-1-{[(1S,2R,4R)-7-oxabicyclo[2.2.1]heptan-2-yl]formamido}ethyl]boronic acid, hydrates, solvates, and/or adducts thereof can be used as LMP7 inhibitors. The solid form can be a trimeric crystalline anhydrous form characterized by two or more 2? XRPD peaks at 6.5±0.2°, 11.2±0.2°, 17.1±0.2°, 19.6±0.2°, and 21.9±0.2° degrees.
Type:
Application
Filed:
July 28, 2022
Publication date:
August 29, 2024
Applicant:
Merck Patent GmbH
Inventors:
Delia-Maria GRUIA, Markus Klein, Michael Lange
Abstract: The present application relates to compounds of formula (I) containing a group selected from amino groups, bridged amino groups and carbazole groups, to processes for preparation thereof, and to the use thereof in electronic devices, and in particular OLEDs.
Type:
Grant
Filed:
September 5, 2018
Date of Patent:
August 27, 2024
Assignee:
Merck Patent GmbH
Inventors:
Elvira Montenegro, Teresa Mujica-Fernaud, Florian Maier-Flaig, Frank Voges
Abstract: The present invention relates to a display device, in particular a backlit display device having a visible side and a back side, which appears opaque in colour and texture on viewing of the visible side without backlighting, but, with the backlighting switched on, is sufficiently transparent that the transmission of information by the light source from the back side is possible, and to the production of a display device of this type and to the use thereof.
Abstract: The present invention provides genetic markers on human chromosome 6 that are associated with a beneficial response to a treatment that targets Clostridium difficile (C. difficile) toxin B (TcdB), e.g. a TcdB antibody. These TcdB treatment response markers are useful, inter alia, to identify patients who are most likely to benefit from treatment that targets TcdB in methods of treating patients having a disease susceptible to treatment with a TcdB antibody, and in methods for selecting the most appropriate therapy for such patients. The invention also provides antibodies, drug products, and kits useful with the TcdB Treatment response markers of the invention.
Type:
Grant
Filed:
December 7, 2017
Date of Patent:
August 27, 2024
Assignees:
Merck Sharp & Dohme LLC, Beijing Genomics Institute at Shenzhen
Inventors:
Peter M. Shaw, Devan V. Mehrotra, Rebecca L. Blanchard, Judong Shen, Robin Mogg, Mary Beth Dorr, Junhua Li, Xun Xu
Abstract: The disclosed technology relates to a continuous impregnating process of active pharmaceutical ingredients (API) onto porous carriers, a continuous impregnation process for making impregnated porous carrier particles and pharmaceutical dosage forms comprising impregnated porous carrier particles, impregnated porous carrier particles and pharmaceutical dosage forms comprising impregnated porous carrier particles prepared by the continuous impregnation process.
Type:
Application
Filed:
June 13, 2022
Publication date:
August 22, 2024
Applicants:
MERCK PATENT GMBH, RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
Inventors:
Fernando J. MUZZIO, Benjamin J. GLASSER, Thamer A. OMAR, Andrés D. ROMÁN-OSPINO, Gudrun BIRK
Abstract: Reactive mesogens (RMs) derived from tolane, mixtures and formulations comprising them, polymers obtained from such RMs and RM mixtures, and the use of the RMs, RM mixtures and polymers in optical or electrooptical components or devices.
Type:
Application
Filed:
May 4, 2022
Publication date:
August 22, 2024
Applicant:
Merck Patent GmbH
Inventors:
Kevin Adlem, Owain Llyr Parri, Alex Davis, Stephen Mulcahy, Philipp Wucher, Beate Schneider
Abstract: The present application concerns compounds for use in electronic devices, processes for preparing the compounds, and electronic devices comprising the compounds.
Type:
Grant
Filed:
December 17, 2019
Date of Patent:
August 20, 2024
Assignee:
Merck KGaA
Inventors:
Elvira Montenegro, Teresa Mujica-Fernaud, Florian Maier-Flaig, Frank Voges
Abstract: The present invention describes amines with dibenzofuran, dibenzothiophene and fluorene groups, especially for use as triplet matrix materials in organic electroluminescent devices. The invention further relates to a process for preparing the compounds of the invention and to electronic devices comprising these.
Type:
Grant
Filed:
December 29, 2021
Date of Patent:
August 20, 2024
Assignee:
MERCK PATENT GMBH
Inventors:
Amir Hossain Parham, Thomas Eberle, Anja Jatsch, Tobias Grossmann, Jonas Valentin Kroeber, Elvira Montenegro, Caroline Wern
Abstract: Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: Formula (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.
Type:
Grant
Filed:
November 1, 2019
Date of Patent:
August 20, 2024
Assignee:
Merck Sharp & Dohme LLC
Inventors:
Yongxin Han, David Jonathan Bennett, Indu Bharathan, Liangqin Guo, Brett A. Hopkins, Xianhai Huang, Derun Li, Min Lu, Alexander Pasternak, David L. Sloman, Hongjun Zhang, Hua Zhou
Abstract: The invention relates to polymers having at least one repeating unit of the following formula (I): wherein Ar1, Ar2, Ar3 and Ar4, R and X, and a, b, c, d, e and f can have the meanings defined in claim 1, to processes for the preparation thereof and to the use thereof in electronic or optoelectronic devices, in particular in organic electroluminescent devices, so-called OLEDs (OLED?Organic Light Emitting Diodes). The present invention also relates to electronic or optoelectronic devices, in particular organic electroluminescent devices, which contain said polymers.
Abstract: Embodiments of the present invention avoid the processing problems associated with using conventional computer systems for identifying and characterizing all of the substructures (e.g., metabolites) of large complex molecules by using a defined minimum cleavable unit (MCU) and an MCU graph for a chosen molecule, as well as a “cut vertex” in the MCU graph for the chosen molecule. The system splits the MCU graph of the chosen molecule at the specified cut vertex to produce two separate MCU graph components (i.e., a first MCU subgraph and a second MCU subgraph) of the chosen molecule, and generates and traverses a first line graph component and a second line graph component, respectively, for the two MCU subgraph components with a graph traversing algorithm to generate and store in memory a first database of substructures and molecular weights for the first component, and a second database of substructures and molecular weights for the second line graph component.
Type:
Grant
Filed:
June 11, 2019
Date of Patent:
August 20, 2024
Assignee:
Merck Sharp & Dohme LLC
Inventors:
Arthur Fridman, Ansuman Bagchi, Xiang Yu, Mark Cancilla
Abstract: [Problem] To obtain a substrate cleaning solution capable of cleaning a substrate and removing particles. [Means for Solution] The present invention is a substrate cleaning solution comprising an insoluble or hardly soluble solute (A), a soluble solute (B), and a solvent (C).