Patents Assigned to Merck
  • Materials for organic electroluminescent devices
    Patent number: 12139500
    Abstract: The present invention relates to a compound of the formula (1), to the use of the compound in an electronic device, and to an electronic device comprising a compound of the formula (1). The present invention furthermore relates to a process for the preparation of a compound of the formula (1) and to a formulation comprising one or more compounds of the formula (1).
    Type: Grant
    Filed: January 14, 2020
    Date of Patent: November 12, 2024
    Assignee: Merck Patent GmbH
    Inventors: Jens Engelhart, Philipp Stoessel, Christian Ehrenreich, Christian Eickhoff, Philipp Harbach, Amir Parham
  • ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS
    Publication number: 20240368109
    Abstract: The present disclosure relates to compounds of formula I that are useful as modulators of ? 7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation.
    Type: Application
    Filed: September 19, 2022
    Publication date: November 7, 2024
    Applicant: MERCK SHARP & DOHME LLC
    Inventors: Ian M. Bell, Brendan M. Crowley, James Fells, Patrick Bazzini, Jean-Marie Contreras, Fabrice Garrido, Belinda C. Huff, Christophe Joseph, Christophe Morice, Dharam Paul, Aurelie Witzel
  • LIQUID-CRYSTALLINE MEDIUM
    Publication number: 20240368471
    Abstract: Liquid-crystalline (LC) media having positive dielectric anisotropy and liquid-crystal displays (LCDs) containing these media, especially displays addressed by an active matrix and in particular to LC displays of the TN, PS-TN, STN, TN-TFT, OCB, IPS, PS-IPS, FFS, HB-FFS, XB-FFS, PS-FFS, SA-HB-FFS, SA-XB-FFS, polymer stabilised SA-HB-FFS, polymer stabilised SA-XB-FFS, positive VA or positive PS-VA type.
    Type: Application
    Filed: June 25, 2024
    Publication date: November 7, 2024
    Applicant: Merck Patent GmbH
    Inventors: Sven Christian LAUT, Sabrina PFEIFFER, Philipp Hans FACKLER
  • Liquid crystal-based light valve
    Patent number: 12134725
    Abstract: A light valve that is operable in and electrically switchable between an optically clear and transparent state and an opaque state, wherein one or more polymerisable mesogenic compounds provided in a layer containing a liquid-crystalline medium that comprises one or more mesogenic compounds, one or more chiral compounds, one or more dichroic dyes and the one or more polymerisable mesogenic compounds are subjected to photopolymerisation. Further, a liquid-crystalline medium used in the method, a light valve obtained or respectively obtainable by carrying out the method, and the use of the light valve in mobile devices.
    Type: Grant
    Filed: June 15, 2020
    Date of Patent: November 5, 2024
    Assignee: Merck Patent GmbH
    Inventors: Christian Schoenefeld, Michael Junge, Mark Goebel, Raphael Lisicki, Kevin Kaiser
  • LIQUID CRYSTAL MEDIUM
    Publication number: 20240360362
    Abstract: Liquid crystal (LC) media having negative dielectric anisotropy, the use thereof in an electro-optical display, particularly in a display with passive matrix addressing, based on the VA, ECB, FFS or IPS effect, and displays of this type, in particular an energy saving PM-VA display with low duty driving.
    Type: Application
    Filed: April 10, 2023
    Publication date: October 31, 2024
    Applicant: MERCK PATENT GMBH
    Inventors: Akihiro KOJIMA, Fumio SHIMANO
  • TROP2 BINDERS AND CONJUGATES THEREOF
    Publication number: 20240358847
    Abstract: TROP2 binders and variants thereof are described. In a specific embodiment, the TROP2 binders that are antibodies that preferentially bind high-expressing TROP2 cells over low-expressing TROP2 cells and conjugates thereof comprising the TROP2 binders conjugated to a payload are described.
    Type: Application
    Filed: April 22, 2024
    Publication date: October 31, 2024
    Applicant: MERCK SHARP & DOHME LLC
    Inventors: Minilik Angagaw, Edward Paul Bowman, Ming-Tang Chen, Laurence Fayadat-Dilman, Malgorzata A. Gil, Marlene C. Hinton, Zhong Hua, Rebecca Elizabeth Johnson, Simon B. Lang, W. Michael Seganish, Andrew B. Waight
  • MMP13 binding immunoglobulins
    Patent number: 12129308
    Abstract: The present invention relates to immunoglobulins that specifically bind MMP13 and more in particular to polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the immunoglobulins of the present invention inhibit an activity of MMP13 and preferably are also stable.
    Type: Grant
    Filed: June 4, 2018
    Date of Patent: October 29, 2024
    Assignees: MERCK PATENT GMBH, ABLYNX NV
    Inventors: Francis Descamps, Gerald Beste, Guy Hermans, Hans Guehring, Lars Toleikis, Christoph Ladel
  • SYRINGES AND INJECTORS WITH CAPACITIVE SENSING LOCKS AND METHODS OF MAKING AND USING SAME
    Publication number: 20240350738
    Abstract: An injecting device comprises a reservoir for containing a medicament, a needle in communication with the reservoir and configured to deliver the medicament to a patient's body, a capacitance sensor disposed adjacent to the needle, and a plunger rod assembly comprising a housing and a piston, the housing and piston being configured to transition between a locked condition in which the piston and the housing are coupled to move together, and an unlocked condition in which the piston is capable of translating relative to the housing.
    Type: Application
    Filed: September 7, 2022
    Publication date: October 24, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: John B. Cline, Jeffrey C. Givand, Guangli Hu, Edward Yeung
  • METHOD FOR REDUCING ENDOTOXIN LEVELS IN NUCLEIC ACID PURIFICATION
    Publication number: 20240352441
    Abstract: The present invention relates to a method for reducing endotoxin levels or removing endotoxins from nucleic acids. For this a non-ionic detergent selected from the group of alkylglycosides and secondary alcohol alkoxylates or mixtures thereof is added prior or during anion exchange chromatographic purification of the nucleic acids using a membrane or monolith-based sorbent.
    Type: Application
    Filed: August 3, 2022
    Publication date: October 24, 2024
    Applicant: MERCK PATENT GMBH
    Inventors: Anja HEINEN-KREUZIG, Andre KIESEWETTER, Andreas STEIN, Akshat GUPTA
  • METHOD FOR PRODUCING SILICA PARTICLES, SILICA PARTICLES PRODUCED BY SUCH METHOD, COMPOSITIONS AND USES OF SUCH SILICA PARTICLES
    Publication number: 20240351889
    Abstract: The present application relates to a method for producing silica particles, and to the silica particles produced by such method. The present application further relates to compositions comprising the silica particles produced by such method as well as to uses of such silica particles and compositions comprising such silica particles.
    Type: Application
    Filed: August 10, 2022
    Publication date: October 24, 2024
    Applicant: MERCK PATENT GMBH
    Inventors: Eric JACQUINOT, Leo HANUS, Geary GRAHAM
  • Anti-PD-1 antibodies
    Patent number: 12122834
    Abstract: The present invention relates to anti-PD-1 antibodies and antigen-binding fragments, and use of these antibodies and antigen-binding fragments in the treatment of cancer or infectious disease.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: October 22, 2024
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Laurence Fayadat-Dilman, Veronica Juan, Shireen Khan, Shaopeng Huang, Hua Ying
  • Negative resist formulation for producing undercut pattern profiles
    Patent number: 12124166
    Abstract: A negative-acting, photoresist composition, imageable by 365 nm radiation that is developable in aqueous base. Apart from solvent, this composition comprises: a) an aqueous base soluble phenolic film-forming polymeric binder resin having ring bonded hydroxyl groups; b) a photoacid generator c) a crosslinking agent which comprises an etherified melamine; d) a dye as described herein; e) a quencher system consisting essentially of an amine quencher, or a mixture of such amine quenchers, as described. This invention also pertains to processes of using this composition as a photoresist.
    Type: Grant
    Filed: April 23, 2018
    Date of Patent: October 22, 2024
    Assignee: Merck Patent GmbH
    Inventors: Anupama Mukherjee, Medhat A. Toukhy
  • Stable salt of 5,10-methylene-(6R)-tetrahydrofolic acid
    Patent number: 12122783
    Abstract: The present invention is directed towards the hemisulfate salt of 5,10-methylene-(6R)-tetrahydrofolic acid, preferably in substantially crystalline form, as well as pharmaceutical compositions and uses thereof in therapy, preferably chemotherapy.
    Type: Grant
    Filed: October 8, 2021
    Date of Patent: October 22, 2024
    Assignee: MERCK & CIE
    Inventors: Rudolf Moser, Viola Groehn, Thomas Egger, Thomas Ammann
  • METHOD FOR ANALYZING TRACE LEVELS OF SEMI-VOLATILE NITROSAMINES IN SOLID SAMPLES
    Publication number: 20240345038
    Abstract: This invention describes a novel method encompassing preparing a nitrosamine sample. adding in relevant chemicals that reduces or eliminates in situ nitrosamine formation, utilizing full evaporation static headspace gas chromatograph coupled with nitrogen phosphorous detector (FE-SHSGC-NPD), and analysis of rapid results in the gaseous phase for sensitive detection of semi-volatile nitrosamines, including ND.MA.
    Type: Application
    Filed: July 11, 2022
    Publication date: October 17, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Rebecca Evans, Xinxin Han, Daniel E. Lee, Christine L. Radich, Jinjian Zheng
  • METHODS FOR MAKING POLYSACCHARIDE-PROTEIN CONJUGATES
    Publication number: 20240342263
    Abstract: The present invention provides methods for making polysaccharide-protein conjugates in which polysaccharides, typically from bacteria, are conjugated to a carrier protein by reductive amination under conditions which improve conjugation reaction consistency, increase consumption of protein during conjugation reaction, generate conjugates of higher molecular weight, and/or reduce the levels of free cyanide in the conjugate reaction product. The polysaccharide-protein conjugates obtained using these methods are useful for inclusion in multivalent vaccines.
    Type: Application
    Filed: June 28, 2024
    Publication date: October 17, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Jitin Bajaj, Michael Albert Winters, Emily Wen, Jian He
  • Smart consumables/identifier label and antenna for smart consumables/identifier label
    Patent number: 12118420
    Abstract: Described herein is a label 1 for marking containers or equipment by adhering the label to a surface thereof. The label 1 includes a support material base 11, at least one RFID microelectronic device 5c included in the support material base 11, and a plurality of antennas 5a,5b for different frequency ranges connected with the at least one RFID microelectronic device 5c and included in the support material base 11. The plurality of antennas 5a, 5b include a first antenna 5a for the frequency range of 860 to 960 MHz and having a theoretical read range peak of more than 4 m when provided on a glass surface, and the label has a dimension of 40 mm*20 mm or less.
    Type: Grant
    Filed: November 18, 2020
    Date of Patent: October 15, 2024
    Assignee: MERCK PATENT GMBH
    Inventors: Christian-Hubertus Kuechenthal, Roja Azees, Dan Kvelstad, Sven Erfurth
  • Liquid crystal medium
    Patent number: 12116521
    Abstract: The present invention relates to a liquid crystal (LC) medium comprising a compound of formula I and one or more compounds of formula II as defined in claim 1, and to the use thereof for optical, electro-optical and electronic purposes, in particular in LC displays, especially in IPS, FFS, VA or PS-VA displays.
    Type: Grant
    Filed: June 30, 2021
    Date of Patent: October 15, 2024
    Assignee: MERCK PATENT GMBH
    Inventor: Sven Christian Laut
  • SOLID-PHASE GLYCAN REMODELING OF GLYCOPROTEINS
    Publication number: 20240336946
    Abstract: A solid-phase glycan remodeling (SPGR) system for the glycoengineering of glycoproteins to provide glycoprotein compositions comprising particular predominant glycoforms is described.
    Type: Application
    Filed: April 11, 2022
    Publication date: October 10, 2024
    Applicant: MERCK SHARP & DOHME LLC
    Inventors: YEN-PANG HSU, BENJAMIN F. MANN, SHUWEN SUN, DEEPTAK VERMA
  • NOVEL TREATMENT REGIMEN FOR THE TREATMENT OF AUTOIMMUNE DISORDERS
    Publication number: 20240335529
    Abstract: A novel treatment regimen is provided for the treatment of autoimmune disorders. Said novel treatment regimen provides for an efficacious treatment of autoimmune disorders with an advantageous safety profile and/or a high quality of life for the patient. Said novel treatment regimen provides for an advantageous benefit-risk ratio for patients endangered by the risk of infections.
    Type: Application
    Filed: June 20, 2024
    Publication date: October 10, 2024
    Applicant: Merck Patent GmbH
    Inventors: Ursula Boschert, Urs Wiedemann
  • STREPTOCOCCUS PNEUMONIAE SEROTYPE-SPECIFIC DETECTION ASSAY, REAGENTS AND KITS
    Publication number: 20240337656
    Abstract: S. pneumoniae is a major cause of community-acquired pneumonia (CAP) in young children, older adults, and those with conditions or medications that compromise their immunity. Since the introduction of pneumococcal vaccines, the disease burden of vaccine serotypes (STs) on invasive pneumococcal disease has reduced; however, the effect on the burden of CAP is less well known, potentially due to a lack of testing for pneumococcal STs.
    Type: Application
    Filed: April 3, 2024
    Publication date: October 10, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Zhifeng Chen, Kara S. Cox, Katrina M. Nolan, Gowrisankar Rajam, Jeanette F. E. Roman, Mary Lillian Shank-Retzlaff, Thorsten Verch, Kalpit A. Vora