Patents Assigned to Merial
  • Patent number: 9446117
    Abstract: The present invention provides Rotavirus antigenic polypeptides or antigens that elicit an immune response in animal or human against rotavirus, compositions comprising said rotavirus polypeptides, methods of vaccination against rotavirus, and kits for use with such methods and compositions. The invention further provide novel expression vectors for producing the vaccine antigenic polypeptides.
    Type: Grant
    Filed: February 14, 2013
    Date of Patent: September 20, 2016
    Assignee: Merial, Inc.
    Inventors: Russell F. Bey, Randy S Simonson, Kamesh Reddy Sirigireddy, Benjamin Matthew Hause
  • Patent number: 9446118
    Abstract: The present invention encompasses recombinant Newcastle Disease Virus-Herpesvirus vaccines or compositions. The invention encompasses recombinant NDV vectors encoding and expressing herpesvirus pathogen, antigens, proteins, epitopes or immunogens. Such vaccines or compositions can be used to protect animals against disease.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: September 20, 2016
    Assignee: Merial, Inc.
    Inventors: Michel Bublot, Frederic Reynard, Herve Poulet, Frederic Raymond David
  • Patent number: 9447084
    Abstract: The present invention relates to novel and inventive isoxazoline of formula (I) and salts thereof: wherein variables D1, D2, D3, D4, D5, R1, B1, B2, B3, R2, R3, R4, R5, R6, Y, Z, L, a and b are described herein are as defined in the description. The invention also relates to parasiticidal and pesticidal compositions comprising the isoxazoline compounds of formula (I), processes for their preparation and their uses to prevent or treat parasitic infections or infestations in animals and as pesticides.
    Type: Grant
    Filed: October 30, 2014
    Date of Patent: September 20, 2016
    Assignee: MERIAL, INC.
    Inventor: Charles Q Meng
  • Publication number: 20160256554
    Abstract: The present invention relates to novel stable compressed vaccine composition comprising at least one anhydrous antigenic component comprising a stabilizer susceptible to foaming when the composition is mixed with liquid diluent; and an effective amount of a sugar alcohol.
    Type: Application
    Filed: October 9, 2015
    Publication date: September 8, 2016
    Applicant: MERIAL INC.
    Inventor: Noel Yves Henri Jean Genin
  • Publication number: 20160256442
    Abstract: This invention relates to long-acting injectable formulations for combating parasites in animals, comprising at least one isoxazoline active agent, a poloxamer, and a co-solvent. This invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the long-acting injectable formulations of the invention to the animal in need thereof.
    Type: Application
    Filed: February 26, 2016
    Publication date: September 8, 2016
    Applicant: MERIAL, INC.
    Inventors: Susan Mancini Cady, Peter Cheifetz, Izabela Galeska
  • Publication number: 20160251317
    Abstract: The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one benzimidazole derivative active agent. The invention also provides for an improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mammal in need thereof.
    Type: Application
    Filed: May 6, 2016
    Publication date: September 1, 2016
    Applicant: MERIAL INC
    Inventor: Charles Q. Meng
  • Publication number: 20160220659
    Abstract: The present invention encompasses FMDV vaccines or compositions. The vaccine or composition may be a vaccine or composition containing FMDV antigens. The invention also encompasses recombinant vectors encoding and expressing FMDV antigens, epitopes or immunogens which can be used to protect animals, in particular ovines, bovines, caprines, or swines, against FMDV.
    Type: Application
    Filed: September 23, 2015
    Publication date: August 4, 2016
    Applicant: MERIAL, INC.
    Inventors: Jean-Christophe Audonnet, Zahia Hannas-Djebbara, Teshome Mebatsion, Yu-Wei Chiang, Justin Widener, Frédéric Reynard
  • Publication number: 20160220566
    Abstract: This invention relates to compositions for combating ectoparasites and endoparasites in animals, comprising at least one 1-arylpyrazole, at least one macrocyclic lactone, at least one insect growth regulator, and at least one anthelmintic compound in combination with a pharmaceutically acceptable carrier. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.
    Type: Application
    Filed: September 29, 2015
    Publication date: August 4, 2016
    Applicant: MERIAL, INC.
    Inventors: Joseph K. Rosentel, JR., Monica Tejwani, Arima Das-Nandy
  • Publication number: 20160199477
    Abstract: The present invention provides attenuated M. haemolitica strains that elicit an immune response in animal against M. haemolitica, compositions comprising said strains, methods of vaccination against M. haemolitica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping fever” or bovine respiratory disease.
    Type: Application
    Filed: January 8, 2016
    Publication date: July 14, 2016
    Applicant: Merial Inc.
    Inventors: Russell F. Bey, Paulraj Kirubakaran Lawrence, Randy R. Simonson
  • Publication number: 20160199483
    Abstract: The present invention provides vectors that contain and express in vivo or in vitro CDV polypeptides or antigens that elicit an immune response in animal against CDV, compositions comprising said vectors and/or CDV polypeptides, and methods of vaccination against CDV. The invention further provides methods for inducing an immunogenic or protective response against CDV and other canine virus, as well as methods for preventing or treating CDV and other canine virus or disease state(s) caused by CDV and other canine virus.
    Type: Application
    Filed: March 29, 2016
    Publication date: July 14, 2016
    Applicant: MERIAL, INC.
    Inventors: Jean-Christophe Audonnet, Jules Minke
  • Publication number: 20160185726
    Abstract: The present invention relates to novel anthelmintic compounds of formula (I) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X1, X2, X3, X4, X5, X6, X7 and X8 are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.
    Type: Application
    Filed: December 28, 2015
    Publication date: June 30, 2016
    Applicant: MERIAL, INC.
    Inventors: Charles Q. Meng, Alan Long, Scot Huber, Srinivas Reddy Gurrala, Douglas Edward Wilkinson, Gregory Pacofsky
  • Patent number: 9376434
    Abstract: The present invention relates to novel dihydroazole of formula (I) and salts thereof: Wherein R1, A1, A2, G, X and Y are as defined in the description, compositions thereof, processes for their preparation and their uses to prevent or treat parasitic infections or infestations in animals and as pesticides.
    Type: Grant
    Filed: March 16, 2015
    Date of Patent: June 28, 2016
    Assignee: Merial Inc.
    Inventors: Loic Patrick Le Hir de Fallois, Hyoung Ik Lee, Douglas Edward Wilkinson, Brent Christopher Beck
  • Patent number: 9370561
    Abstract: The present invention provides attenuated M. haemolitica strains that elicit an immune response in animal against M. haemolitica, compositions comprising said strains, methods of vaccination against M. haemolitica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping fever” or bovine respiratory disease.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: June 21, 2016
    Assignee: MERIAL, INC.
    Inventors: Russell F. Bey, Paulraj Kirubakaran Lawrence, Randy R. Simonson
  • Patent number: 9359305
    Abstract: The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one benzimidazole derivative active agent. The invention also provides for an improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mammal in need thereof.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: June 7, 2016
    Assignee: MERIAL, INC.
    Inventor: Charles Q Meng
  • Publication number: 20160143285
    Abstract: This invention relates to veterinary compositions for treating and/or preventing fleas or ticks infection or infestation in an animal comprising an isoxazoline active agent of Formula (II): or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: January 29, 2016
    Publication date: May 26, 2016
    Applicant: MERIAL INC.
    Inventors: Mark David Soll, Diane Larsen, Susan Mancini Cady, Peter Cheifetz, Izabela Galeska, Saijun Gong
  • Patent number: 9345759
    Abstract: The present invention encompasses BTV vaccines or compositions. The vaccine or composition may be a vaccine or composition containing BTV antigens. The invention also encompasses recombinant vectors encoding and expressing BTV antigens, epitopes or immunogens which can be used to protect animals, such as ovines, bovines, or caprines, against BTV.
    Type: Grant
    Filed: March 11, 2011
    Date of Patent: May 24, 2016
    Assignee: MERIAL, INC.
    Inventors: Jean-Christophe Audonnet, Xuan Guo, Kevin Cox
  • Patent number: 9339033
    Abstract: Provided are 1-aryl-5-alkyl pyrazole compounds, of formula (I): wherein: R1 is hydrogen, cyano, halogen, R8, formyl, —C(O)R8, —C(O)OR8, —C(O)NR9R10, or —C(S)NH2; R2 is R8 or —S(O)mR11; R3 is methyl, ethyl or C1-C4 haloalkyl; R4, R5 and R7 are independently hydrogen, halogen, alkyl, haloalkyl, cyano or nitro; R6 is halogen, alkyl, haloalkyl, alkoxy, haloalkyloxy, cyano, nitro, —C(O)R12, —S(O)nR12 or SF5; Z is a nitrogen atom or C—R13; R8 is alkyl, haloalkyl, cycloalkyl or halocycloalkyl; R9 is hydrogen, alkyl, haloalkyl or alkoxy; R10 is hydrogen, alkyl, haloalkyl or alkoxy; R11 is alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl or cycloalkyl; R12 is alkyl or haloalkyl; R13 is hydrogen, halogen, cyano, nitro, alkyl, haloalkyl, alkoxy or haloalkoxy; m is 0, 1 or 2; and n is 0, 1 or 2; or a salt thereof, the method of making compounds of formula (I) and the use of these compounds against ectoparasites, endoparasites and pests.
    Type: Grant
    Filed: July 8, 2014
    Date of Patent: May 17, 2016
    Assignee: MERIAL, INC.
    Inventors: Loic Patrick Le Hir de Fallois, Hyoung Ik Lee, Philip Reid Timmons, William Glenn Cawthorne, Jr., Adalberto Perez de Leon
  • Publication number: 20160120799
    Abstract: The present invention relates to microneedle vaccine formulations, as well as methods of use thereof to provide animals, including canines, protective immunity against infection and disease caused by rabies viruses. Once placed onto the skin of the animals, the microneedle formulations dissolve quickly into the surrounding skin, where the antigens then elicit in the animals high and protective levels of rabies virus neutralizing antibodies.
    Type: Application
    Filed: November 3, 2015
    Publication date: May 5, 2016
    Applicants: GEORGIA TECH RESEARCH CORPORATION, MERIAL, INC.
    Inventors: Yu-Wei Chiang, Mark R. Prausnitz, Kristopher Daniel DeWitt, Jaya Arya
  • Publication number: 20160120973
    Abstract: This disclosure provides attenuated swine influenza strains, particularly those produced via a reverse genetics approach, compositions comprising same, and methods of production and use thereof. The attenuated strains are engineered to encode HA proteins having additional glycosylation sites, relative to the HA proteins encoded by the corresponding virulent parental viruses.
    Type: Application
    Filed: December 21, 2015
    Publication date: May 5, 2016
    Applicant: Merial Inc.
    Inventor: Benjamin M. Hause
  • Patent number: 9327137
    Abstract: The present invention provides vectors that contain and express in vivo or in vitro CDV polypeptides or antigens that elicit an immune response in animal against CDV, compositions comprising said vectors and/or CDV polypeptides, and methods of vaccination against CDV. The invention further provides methods for inducing an immunogenic or protective response against CDV and other canine virus, as well as methods for preventing or treating CDV and other canine virus or disease state(s) caused by CDV and other canine virus.
    Type: Grant
    Filed: February 25, 2011
    Date of Patent: May 3, 2016
    Assignee: MERIAL, INC.
    Inventors: Jean-Christophe Audonnet, Jules Minke