Patents Assigned to Merial
  • Expression of chimeric KSAC protein and method of producing soluble proteins by high pressure
    Patent number: 9315553
    Abstract: The present invention encompasses vaccines or compositions comprising the chimeric KSAC protein that possesses immunogenic and protective properties, and methods of use including administering to an animal the antigenic KSAC protein thereof to protect animals. The invention also encompasses methods for making and producing the soluble, disaggregated, refolded or active proteins from inclusion bodies produced from prokaryotes or eukaryotes.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: April 19, 2016
    Assignee: MERIAL, INC.
    Inventors: Laurent Bernard Fischer, Nicolas Pierre Yves Carboulec, Fabien Lux
  • Dissolution of hydrophobic API, including avermectins with or without other API such as pyrantel, from a complicated matrix dosage form
    Publication number: 20160097753
    Abstract: This disclosure describes the results of the studies conducted to develop a dissolution method to monitor release profiles of hydrophobic active pharmaceutical ingredients such as ivermectin with or without pyrantel pamoate from a drug product made of complex matrix that includes, but is not limited to beef, tallow, corn cob and soy protein.
    Type: Application
    Filed: October 1, 2015
    Publication date: April 7, 2016
    Applicant: MERIAL, INC.
    Inventors: Abu M. Rustum, Satish Kumar, Andrew L. McAdoo
  • Attenuated vaccines and methods of making and use thereof
    Patent number: 9289484
    Abstract: The present invention provides attenuated S. suis strains that elicit an immune response in animals against S. suis, compositions comprising said strains, methods of vaccination against S. suis, and kits for use with such methods and compositions. The invention further provides novel, mutagenically-induced mutations in S. suis genes, which are useful in the production of novel attenuated S. suis bacterial strains.
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: March 22, 2016
    Assignee: MERIAL, INC.
    Inventors: Russell F Bey, Paulraj Kirubakaran Lawrence, Randy R Simonson, Kamesh Reddy Sirigireddy, Danielle A McKeown
  • Processes for the preparation of 1-aryl-5-alkyl pyrazole compounds
    Patent number: 9273007
    Abstract: Provided are improved processes for the preparation of 1-aryl pyrazole compounds of formula (I) and (IB): which are substituted at the 5-position of the pyrazole ring with a carbon-linked functional group. The process described are efficient and scalable and do not utilize hazardous sulfenyl halide reagents.
    Type: Grant
    Filed: November 17, 2014
    Date of Patent: March 1, 2016
    Assignee: MERIAL, INC.
    Inventors: Charles Q. Meng, Loic Patrick Le Hir de Fallois, Hyoung Ik Lee, Xinxi Zhan, Jean Robert Labrosse, Michel Mulhauser
  • PARASITICIDAL COMPOSITIONS COMPRISING AN ISOXAZOLINE ACTIVE AGENT, METHODS AND USES THEREOF
    Publication number: 20160051519
    Abstract: This invention relates to topical compositions for combating ectoparasites and endoparasites in animals, comprising at least one isoxazoline active agent and a pharmaceutically acceptable carrier, optionally in combination with one or more additional active agents. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.
    Type: Application
    Filed: November 3, 2015
    Publication date: February 25, 2016
    Applicant: MERIAL, INC.
    Inventors: Mark D. Soll, Joseph K. Rosentel, JR., James Pate, Natalya Shub, Monica Tejwani-Motwani, Carol Belansky
  • Parasiticidal oral veterinary compositions comprising systemically-acting active agents, methods and uses thereof
    Patent number: 9259417
    Abstract: This invention relates to veterinary compositions for treating and/or preventing fleas or ticks infection or infestation in an animal comprising an isoxazoline active agent of Formula (II): or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: February 16, 2016
    Assignee: MERIAL, INC.
    Inventors: Mark David Soll, Diane Larsen, Susan Mancini Cady, Peter Cheifetz, Izabela Galeska
  • Anthelmintic compounds and compositions and method of using thereof
    Patent number: 9249102
    Abstract: The present invention relates to novel anthelmintic compounds of formula (I) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X1, X2, X3, X4, X5, X6, X7 and X8 are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.
    Type: Grant
    Filed: November 19, 2013
    Date of Patent: February 2, 2016
    Assignee: MERIAL, INC.
    Inventors: Charles Q. Meng, Alan Long, Srinivas Reddy Gurrala, Douglas Edward Wilkinson
  • RECOMBINANT GALLID HERPESVIRUS 3 (MDV SEROTYPE 2) VECTORS EXPRESSING ANTIGENS OF AVIAN PATHOGENS AND USES THEREOF
    Publication number: 20160015801
    Abstract: The present invention provides recombinant Gallid herpesvirus 3 (MDV-2) vectors that contain and express antigens of avian pathogens, recombinant Gallid herpesvirus 3 (MDV-2) vectors that contain a mutated gC gene, compositions comprising the recombinant Gallid herpesvirus 3 (MDV-2) vectors, polyvalent vaccines comprising the recombinant Gallid herpesvirus 3 (MDV-2) vectors and one or more wild type viruses or recombinant vectors. The present invention further provides methods of vaccination against a variety of avian pathogens and method of producing the recombinant Gallid herpesvirus 3 (MDV-2) vectors.
    Type: Application
    Filed: April 9, 2015
    Publication date: January 21, 2016
    Applicant: MERIAL, INC.
    Inventors: Michel Bublot, Teshome Mebatsion, Joyce Pritchard, Perry Linz
  • Inactivated Vaccine for Porcine Epidemic Diarrhea Virus (PEDV)
    Publication number: 20160008457
    Abstract: The present invention encompasses porcine epidemic diarrhea virus (PEDV) vaccines or compositions. The vaccine or composition may be a vaccine or composition containing inactivated PEDV. The invention also encompasses epitopes or immunogens which can be used to protect porcine animals against PEDV.
    Type: Application
    Filed: July 13, 2015
    Publication date: January 14, 2016
    Applicant: MERIAL, INC.
    Inventors: Srivishnupriya Anbalagan, Emily Collin, Benjamin Matthew Hause
  • Parasiticidal oral veterinary compositions comprising systemically-acting active agents, methods and uses thereof
    Patent number: 9233100
    Abstract: This invention relates to oral veterinary compositions for combating ectoparasites and endoparasites in animals, comprising at least one systemically-acting active agent in combination with a pharmaceutically acceptable carrier. This invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: January 12, 2016
    Assignee: MERIAL, INC.
    Inventors: Mark David Soll, Diane Larsen, Susan Mancini Cady, Peter Cheifetz, Izabela Galeska, Saijun Gong
  • Hyperbaric Device and Methods for Producing Inactivated Vaccines and for Refolding/Solubilizing Recombinant Proteins
    Publication number: 20160000896
    Abstract: The invention relates to hyperbaric devices for inactivating microorganisms and viruses while retaining their immunogenicity and for making and producing the soluble, disaggregated, refolded or active immunogenic or therapeutic proteins from inclusion bodies produced from prokaryotes or eukaryotes. The invention encompasses hyperbaric methods for inactivating pathogenic organisms, and methods for producing vaccine compositions using the inactivated pathogens. The hyperbarically inactivated microorganisms are safer and more immunogenic than chemically inactivated microorganisms. Similarly, the solubilized proteins have superior properties compared to more heavily aggregated proteins, including reduced non-specific immune reactions.
    Type: Application
    Filed: September 11, 2015
    Publication date: January 7, 2016
    Applicant: MERIAL INC.
    Inventors: Nicolas Pierre Yves Carboulec, Rene Labatut, Lionel Gerentes
  • Leishmania vaccine using sand fly salivary immunogen
    Patent number: 9228002
    Abstract: The present invention provides vectors that contain and express in vivo or in vitro sand fly Lu. longipalpis salivary antigens that elicit an immune response in animal or human against Leishmania, vaccine compositions comprising said vectors and/or Lu. longipalpis salivary polypeptides, methods of vaccination against Leishmania, and kits for use with such methods and compositions.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: January 5, 2016
    Assignees: MERIAL, INC., The United States of America As Represented by The Secretary of the Department of Health and Human Services
    Inventors: Laurent Fischer, Shaden Kamhawi, Jesus Valenzuela, Jose Ribeiro
  • Her2 DNA Vaccine as Adjunct Treatment for Cancers in Companion Animals
    Publication number: 20150374808
    Abstract: The application discloses therapeutic vaccines based upon the “pING” DNA plasmid vector expressing the gene encoding the rat Her2 protein. Vaccines according to the instant disclosure are used as an adjunct treatment for surgery, radiation and/or chemotherapy for dogs and cats with cancers that over express the Her2 antigen, and prolong the post-surgical disease free interval and/or survival time. Also included are therapeutically effective methods of immunization using said vaccines.
    Type: Application
    Filed: April 29, 2015
    Publication date: December 31, 2015
    Applicant: MERIAL INC.
    Inventor: Laurent Bernard Fischer
  • PARASITICIDAL COMPOSITIONS COMPRISING INDOLE DERIVATIVES, METHODS AND USES THEREOF
    Publication number: 20150366198
    Abstract: The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one indole derivative active agent. The invention also provides for an improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mammal in need thereof.
    Type: Application
    Filed: June 19, 2015
    Publication date: December 24, 2015
    Applicant: MERIAL, INC.
    Inventors: Charles Meng, Loïc Le Hir de Fallois
  • Antibiotic-free plasmids
    Patent number: 9217153
    Abstract: The present invention provides a method of maintaining a gram negative bacterium plasmid without the use of antibiotic selection pressure. Further, the invention relates to the drugless plasmids produced including drugless plasmids containing a heterologous gene. The invention also provides formulations and/or compositions comprising the drugless plasmids comprising a heterologous gene, formulations and/or compositions comprising a protein or an immunogen expressed using the drugless plasmids, and methods of administering such formulations and/or compositions to a host. The invention relates to gram negative bacteria containing the drugless plasmids.
    Type: Grant
    Filed: May 24, 2010
    Date of Patent: December 22, 2015
    Assignee: MERIAL, INC.
    Inventors: Jean Christophe Francis Audonnet, Edmond Jolivet
  • Adjuvanted rabies vaccine with improved viscosity profile
    Patent number: 9216213
    Abstract: The present invention relates to adjuvanted recombinant anti-rabies vaccines and the oral administration of such vaccines to raccoons and other wildlife. Advantageously, the anti-rabies vaccine may comprise a recombinant vaccinia virus containing a rabies glycoprotein gene. The invention encompasses methods of vaccinating raccoons and other wildlife by administration of an anti-rabies vaccines which may comprise a recombinant vaccinia virus containing a rabies glycoprotein gene, in combination with an adjuvant which increases both vaccine viscosity and efficacy. The invention provides effective oral recombinant vaccines used in oral rabies vaccination (ORV) programs for wildlife, effective at protecting raccoons, gray foxes, coyotes, and other animals.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: December 22, 2015
    Assignees: MERIAL, INC., The United States of America As Represented By The Secretary of Agriculture
    Inventors: Joanne L. Maki, Tricia Lynn Fry, Jerome Cornelius Hurley, Lowell Allen Miller
  • Attenuated swine influenza vaccines and methods of making and use thereof
    Patent number: 9216211
    Abstract: This disclosure provides attenuated swine influenza strains, particularly those produced via a reverse genetics approach, compositions comprising same, and methods of production and use thereof. The attenuated strains are engineered to encode HA proteins having additional glycosylation sites, relative to the HA proteins encoded by the corresponding virulent parental viruses. Advantageously, the attenuated influenza strains may be administered.
    Type: Grant
    Filed: July 11, 2013
    Date of Patent: December 22, 2015
    Assignee: MERIAL, INC.
    Inventor: Benjamin M Hause
  • Recombinant Spike Protein Subunit Based Vaccine for Porcine Epidemic Diarrhea Virus (PEDV)
    Publication number: 20150328307
    Abstract: The present invention encompasses porcine epidemic diarrhea virus (PEDV) vaccines or compositions. The vaccine or composition may be a vaccine or composition containing PEDV antigens. The invention also encompasses recombinant vectors encoding and expressing PEDV antigens, epitopes or immunogens which can be used to protect porcine animals against PEDV.
    Type: Application
    Filed: May 19, 2015
    Publication date: November 19, 2015
    Applicant: MERIAL, INC.
    Inventors: Paulraj Lawrence, Russell Bey
  • Method and Device for Conditional in ovo Injection
    Publication number: 20150327521
    Abstract: The present invention provides in ovo injection devices, including a novel vaccine/substance conservation valve (VCV), a needle depth adjuster (NDA), and methods for selectively delivering vaccines and other substances to eggs in the context of poultry hatcheries. The valve of the present invention allows for the conditional dispensing of vaccines and other substances dependent upon the presence or absence of an egg. When an egg is present, the valve becomes activated, allowing vaccines or other substances to be injected. When an egg is absent, the valve is not activated, thus vaccines and other valuable substances are conserved. The NDA allows embryonated eggs to be more safely injected by reducing the depth of needle penetration, particularly in smaller eggs.
    Type: Application
    Filed: May 19, 2015
    Publication date: November 19, 2015
    Applicant: MERIAL, INC.
    Inventors: Christopher Davis Leslie, Chien Dinh Nguyen, Erich Bevensee
  • Parasiticidal compositions comprising an isoxazoline active agent, methods and uses thereof
    Patent number: 9180121
    Abstract: This invention relates to topical compositions for combating ectoparasites and endoparasites in animals, comprising at least one isoxazoline active agent and a pharmaceutically acceptable carrier, optionally in combination with one or more additional active agents. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: November 10, 2015
    Assignee: MERIAL, INC.
    Inventors: Mark D. Soll, James Pate, Natalya Shub