Patents Assigned to Metanomics GmbH
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Publication number: 20110272353Abstract: The present invention relates to a process for extracting constituents from organic material, comprising the step of extracting with a monophasic mixture of 50% by volume to 90% by volume of methanol and 50 to 10% by volume of water and optionally 0% by volume to 40% by volume of a further solvent or solvent mixture.Type: ApplicationFiled: July 18, 2011Publication date: November 10, 2011Applicant: Metanomics GmbH and Co. KGaAInventors: Michael Manfred Herold, Martin Dostler, Ralf Looser, Tilmann B. Walk, Achim Fegert, Martin Kluttig, Britta Lehmann, Silke Heidemann, Annette Hennig, Joachim Kopka
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Publication number: 20110271402Abstract: The present invention relates to a process for the increase in yield in a plant organism by reducing gene expression. The invention furthermore relates to nucleic acid molecules, polypeptides, nucleic acid constructs, vectors, antisense molecules, antibodies, host cells, plant tissue, propagation material, harvested material and plants.Type: ApplicationFiled: June 7, 2011Publication date: November 3, 2011Applicant: Metanomics GmbHInventors: Piotr Puzio, Agnes Chardonnens
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Patent number: 8030539Abstract: The invention relates to a method for the stable expression of nucleic acids in transgenic plants, controlled by a parsley-ubiquitin promoter (PCUbi4-2). Said promoter, isolated from parsley (petroselinum crispum) exhibits in almost all transgenic plants an intensely constitutive expression in almost all vegetable tissue, including the seed. It also contains, among others, a potentially heat-shock inducible element (HSE). The invention also relates to nucleic acid constructs, vectors and transgenic plants and to the use of the latter for producing foodstuffs, animal feed, seeds, pharmaceuticals or fine chemicals.Type: GrantFiled: May 30, 2003Date of Patent: October 4, 2011Assignee: Metanomics GmbH & Co. KGaAInventors: Gunnar Plesch, Marcus Ebneth
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Patent number: 7981294Abstract: The present invention relates to a process for extracting constituents from organic material, comprising the step of extracting with a monophasic mixture of 50% by volume to 90% by volume of methanol and 50 to 10% by volume of water and optionally 0% by volume to 40% by volume of a further solvent or solvent mixture.Type: GrantFiled: October 1, 2008Date of Patent: July 19, 2011Assignee: Metanomics GmbH and Co. KGaAInventors: Michael Manfred Herold, Martin Dostler, Ralf Looser, Tilmann B. Walk, Achim Fegert, Martin Kluttig, Britta Lehmann, Silke Heidemann, Annette Hennig, Joachim Kopka
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Patent number: 7982095Abstract: The present invention relates to a process for the increase in yield in a plant organisms by reducing gene expression. The invention furthermore relates to nucleic acid molecules, polypeptides, nucleic acid constructs, vectors, antisense molecules, antibodies, host cells, plant tissue, propagation material, harvested material and plants.Type: GrantFiled: November 26, 2005Date of Patent: July 19, 2011Assignee: Metanomics GmbHInventors: Piotr Puzio, Agnes Chardonnens
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Patent number: 7951565Abstract: The present invention relates to a process for the production of methionine in an organism such as a microorganism, a non-human animal or plant. The invention furthermore relates to nucleic acid molecules, polypeptides, nucleic acid constructs, vectors, antisense molecules, antibodies, host cells, plant tissue, propagation material, harvested material, plants, microorganisms as well as agricultural compositions and to their use.Type: GrantFiled: March 30, 2005Date of Patent: May 31, 2011Assignee: Metanomics GmbHInventors: Marcus Ebneth, Piotr Puzio, Astrid Blau, Tilmann B. Walk, Volker Haake, Klaus Däschner, Gunnar Plesch
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Patent number: 7873481Abstract: A method for analyzing a test sample is disclosed, the test sample comprising at least one compound. A test sample comprising at least one compound is provided. Next, the at least one compound in the test sample is determined, thereby generating raw results. The generated raw results are analyzed, wherein the analysis of the test sample is accompanied by an analysis of at least one reference sample. The test sample and the reference sample are analyzed in an identical sequence in each step of the method. A system for carrying out the method is also disclosed.Type: GrantFiled: July 25, 2006Date of Patent: January 18, 2011Assignee: Metanomics GmbHInventors: Tilmann B. Walk, Ralf Looser, Bianca Bethan, Michael Manfred Herold, Beate Kamlage, Oliver Schmitz, Jan C. Wiemer, Alexandre Prokoudine, Bennard Van Ravenzwaay, Werner Mellert, Georgia Coelho Palermo Cunha, Thomas Ehrhardt, Gerhard Krennrich
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Publication number: 20100236321Abstract: The present invention relates to a method for diagnosing a predisposition for diabetes comprising determining at least one metabolite in a test sample of a subject suspected to have a predisposition for diabetes and comparing said at least one metabolite to a reference, whereby a predisposition for diabetes is to be diagnosed. Moreover, the present invention encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising said data collection. Furthermore, the present invention also relates to a system comprising means for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium. Further encompassed by the present invention are diagnostic means comprising at least one metabolite and the use of said at least one metabolite for the manufacture of diagnostic means for diagnosing a predisposition for diabetes.Type: ApplicationFiled: March 21, 2007Publication date: September 23, 2010Applicant: Metanomics GmbHInventors: Bianca Bethan, Kristina Busch, Jan Wiemer, Martijn Gipmans, Edgar Leibold, Jochen Spranger, Thomas Bobbert, Andreas Friedrich Hermann Pfeiffer
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Publication number: 20100163720Abstract: The present invention relates to a method for diagnosing diabetes or a predisposition thereof comprising determining at least one metabolite in a test sample of a subject suspected to suffer from diabetes or to have a predisposition therefor and comparing said at least one metabolite to a reference, whereby diabetes or a predisposition therefor is to be diagnosed. Moreover, the present invention encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising said data collection. Furthermore, the present invention also relates to a system comprising means for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium. Further encompassed by the present invention are diagnostic means comprising at least one metabolite and the use of said at least one metabolite for the manufacture of diagnostic means for diagnosing diabetes.Type: ApplicationFiled: March 21, 2007Publication date: July 1, 2010Applicant: Metanomics GmbHInventors: Bianca Bethan, Kristina Busch, Jan Wiemer, Martijn Gipmans, Edgar Leibold, Jochen Spranger, Thomas Bobbert, Andreas Friedrich Hermann Pfeiffer
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Publication number: 20100100982Abstract: A method for preparing a nonhuman organism with faster growth and/or increased yield in comparison with a reference organism, which method comprises increasing the activity of L450 in said organism or in one or parts thereof in comparison with a reference organism.Type: ApplicationFiled: July 31, 2009Publication date: April 22, 2010Applicant: Metanomics GmbHInventors: Gunnar Plesch, Agnes Chardonnens, Oliver Schmitz, Piotr Puzio, Marcus Ebneth, Xi-Qing Wang
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Publication number: 20100071091Abstract: This invention relates generally to nucleic acid sequences encoding proteins that are associated with abiotic stress responses and abiotic stress tolerance in plants. This invention further relates to transformed plant cells with altered metabolic activity compared to a corresponding non-transformed, wild-type plant cell, wherein the metabolic activity is altered by transformation with a Stress-Related Protein (SRP) coding nucleic acid and results in increased tolerance and/or resistance to an environmental stress as compared to a corresponding non-transformed, wild-type plant cell.Type: ApplicationFiled: August 12, 2006Publication date: March 18, 2010Applicants: BASF PLANT SCIENCE GMBH, METANOMICS GMBHInventors: Agnes Chardonnens, Piotr Puzio, Bryan D. McKersie
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Publication number: 20100050296Abstract: A method for preparing a nonhuman organism with faster growth and/or increased yield in comparison with a reference organism, with method comprises increasing the activity of SEQ ID NO: 2, 107, 125, 129 or 137 in said organism or in one or parts thereof in comparison with a reference organism.Type: ApplicationFiled: July 21, 2005Publication date: February 25, 2010Applicant: Metanomics GmbHInventors: Piotr Puzio, Agnes Chardonnens
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Publication number: 20100031380Abstract: A process for identifying whether plant is resistant to chilling comprises cultivating the plant at a reduced temperature for a time period selected from short term and medium term; harvesting a tissue sample of the plant; measuring concentration of at least one metabolite in the tissue sample of the plant; comparing the measured concentration with the concentration of the same metabolite in a tissue sample harvested from a reference plant or a plant of the same species after cultivation at a reference temperature; and optionally, repeating the process of foregoing steps but cultivating the plant at a reduced temperature for a time period selected from short term and medium term and not previously used; wherein resistance to chilling is indicated by one or more of the effects on metabolites listed in Table 2 or Table 4.Type: ApplicationFiled: February 6, 2008Publication date: February 4, 2010Applicant: METANOMICS GMBHInventors: Beate Kamlage, Oliver Bläsing, Yves Gibon, Mark Stitt
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Publication number: 20090300794Abstract: The present invention relates to the manipulation of the nitrogen metabolism in photosynthetic active organisms, preferably in plants. In particular, the present invention relates to a process for the enhanced nitrogen assimilation, accumulation and/or utilization and/or for the increased total nitrogen content in a photosynthetic active organism.Type: ApplicationFiled: May 23, 2007Publication date: December 3, 2009Applicant: Metanomics GmbHInventors: Gunnar Plesch, Piotr Puzio, Astrid Blau, Ralf Looser, Birgit Wendel, Beate Kamlage, Oliver Schmitz
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Publication number: 20090263826Abstract: The present invention relates to a method for diagnosing hemolytic anemia or a predis-position thereof. It also relates to a method of determining whether a compound is capable of inducing hemolytic anemia in a subject and to a method of identifying a drug for treating hemolytic anemia. Furthermore, the present invention relates to a data collection comprising characteristic values of metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing hemolytic anemia. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing hemolytic anemia in a subject.Type: ApplicationFiled: June 4, 2007Publication date: October 22, 2009Applicant: Metanomics GmbHInventors: Tilmann B. Walk, Ralf Looser, Michael Manfred Herold, Jan C. Wiemer, Alexandre Prokoudine, Edgar Leibold, Bennard van Ravenzwaay, Werner Mellert, Georgia Coelho Palermo Cunha, Eric Fabian, Volker Strauss
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Patent number: 7606667Abstract: The invention relates to a method and device for analyzing a sample containing a number of substances. The method comprises the following steps: recording one or more mass spectra (mass spectra data D) of the sample (P); deconvoluting the mass spectra in a first evaluating device (A), which assigns the chromatographic peaks (a) and their associated deconvoluted mass spectra of one substance at a time based on the correspondence with a reference spectrum of the substance, and/or determining the intensity of the obtained peaks of the ions of the mass spectra in an evaluating device (B), which assigns the chromatographic peaks (b) of the ions and their associated mass spectra based on the correspondence of selective ions and their retention time ranges of the peaks (b) with the reference values of the substance predetermined for a substance, and verifying the assignments in a validating device (V).Type: GrantFiled: February 1, 2006Date of Patent: October 20, 2009Assignee: Metanomics GmbHInventors: Michael Manfred Herold, Martin Kluttig, Nicole Christiansen, Joachim Kopka, Jörn Quedenau
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Patent number: 7589256Abstract: A method for preparing a nonhuman organism with faster growth and/or increased yield in comparison with a reference organism, which method comprises increasing the activity of L450 in said organism or in one or parts thereof in comparison with a reference organism.Type: GrantFiled: February 13, 2004Date of Patent: September 15, 2009Assignee: Metanomics GmbHInventors: Gunnar Plesch, Agnes Chardonnens, Oliver Schmitz, Piotr Puzio, Marcus Ebneth, Xi-Qing Wang
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Publication number: 20090032462Abstract: The present invention relates to a process for extracting constituents from organic material, comprising the step of extracting with a monophasic mixture of 50% by volume to 90% by volume of methanol and 50 to 10% by volume of water and optionally 0% by volume to 40% by volume of a further solvent or solvent mixture.Type: ApplicationFiled: October 1, 2008Publication date: February 5, 2009Applicant: Metanomics GmbH and Co. KGaAInventors: Michael Manfred Herold, Martin Dostler, Ralf Looser, Tilmann B. Walk, Achim Fegert, Martin Kluttig, Britta Lehmann, Silke Heidemann, Annette Hennig, Joachim Kopka
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Publication number: 20080318790Abstract: The present invention relates to a process for the production of methionine in an organism such as a microorganism, a non-human animal or plant. The invention furthermore relates to nucleic acid molecules, polypeptides, nucleic acid constructs, vectors, antisense molecules, antibodies, host cells, plant tissue, propagation material, harvested material, plants, microorganisms as well as agricultural compositions and to their use.Type: ApplicationFiled: March 30, 2005Publication date: December 25, 2008Applicant: Metanomics GmbHInventors: Marcus Ebneth, Piotr Puzio, Astrid Blau, Tilmann B. Walk, Volker Haake, Klaus Däschner, Gunnar Plesch
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Patent number: 7431841Abstract: The invention relates to a method for the extraction of components made from organic material, comprising the step of extraction with a single-phase mixture of 50 to 90 vol. % methanol and 50 to 10 vol. % water and optionally 0 to 40 vol. % of a further solvent or solvent mixture.Type: GrantFiled: November 11, 2002Date of Patent: October 7, 2008Assignee: Metanomics GmbH & Co. KGaAInventors: Michael Manfred Herold, Martin Dostler, Ralf Looser, Tilmann B. Walk, Achim Fegert, Martin Kluttig, Britta Lehmann, Silke Heidemann, Annette Hennig, Joachim Kopka