Patents Assigned to Metaproteomics, LLC
  • Patent number: 7914831
    Abstract: The invention provides compositions containing a fraction isolated or derived from hops and a methylxanthine. The invention additionally provides compositions containing a fraction derived from hops and a curcuminoid. The invention also provides methods of using such compositions to reduce inflammation.
    Type: Grant
    Filed: February 27, 2004
    Date of Patent: March 29, 2011
    Assignee: Metaproteomics, LLC
    Inventors: John G. Babish, Matthew L. Tripp, Jeffrey S. Bland
  • Patent number: 7901713
    Abstract: A natural formulation of compounds isolated or derived from hops which inhibit the activity of cyclooxygenase-2 (COX-2) and/or 5-lipoxygenase (5-LOX) is disclosed. The hops formulations may be administered to a mammal to treat or inhibit a pathological condition associated with the activity of COX-2 and/or 5-LOX in such a mammal.
    Type: Grant
    Filed: June 10, 2004
    Date of Patent: March 8, 2011
    Assignee: Metaproteomics, LLC
    Inventors: Matthew L. Tripp, Gary K. Darland, Mark Fuller, John G. Babish, Jeffrey S. Bland
  • Publication number: 20110021638
    Abstract: A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandin selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops.
    Type: Application
    Filed: April 7, 2010
    Publication date: January 27, 2011
    Applicant: Metaproteomics, LLC
    Inventors: Matthew L. Tripp, John G. Babish, Jeffrey S. Bland, Gary K. Darland, Robert Lerman, Daniel O. Lukaczer, DeAnn J. Liska, Terrence Howell
  • Patent number: 7820206
    Abstract: A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops.
    Type: Grant
    Filed: January 30, 2006
    Date of Patent: October 26, 2010
    Assignee: Metaproteomics, LLC
    Inventors: Matthew L. Tripp, John G. Babish, Jeffrey S. Bland, Gary K. Darland, Robert Lerman, Daniel O. Lukaczer, DeAnn J. Liska, Terrence Howell
  • Patent number: 7815944
    Abstract: The invention provides hops (Humulis lupulus) extracts or derivatives thereof for use in treating a patient prophylactically and/or therapeutically for ulcerogenic-type disorders of the stomach and/or intestines. The ulcerogenic disorders can be of the type chemically induced, environmentally-induced, infection-induced, and/or stress-induced. The invention also provides a pharmaceutical composition comprising an active amount of hops extracts or derivatives thereof, in combination with an analgesic compound and/or an anti-inflammatory compound. The invention further provides for use of hops extracts or derivatives thereof, significantly reducing and/or therapeutically treating ulcerogenic-type disorders of the stomach and/or intestines.
    Type: Grant
    Filed: February 15, 2006
    Date of Patent: October 19, 2010
    Assignee: Metaproteomics, LLC
    Inventors: John G. Babish, Matthew L. Tripp, Jeffrey S. Bland, Terrence Howell, Gary K. Darland, Robert H. Lerman, Daniel O. Lukaczer
  • Patent number: 7811610
    Abstract: The invention provides hops (Humulus lupulus) extracts or derivatives thereof for use in treating a patient prophylactically and/or therapeutically for ulcerogenic-type disorders of the stomach and/or intestines. The ulcerogenic disorders can be of the type chemically induced, environmentally-induced, infection-induced, and/or stress-induced. The invention also provides a pharmaceutical composition comprising an active amount of hops extracts or derivatives thereof, in combination with an analgesic compound and/or an anti-inflammatory compound. The invention further provides for use of hops extracts or derivatives thereof, significantly reducing and/or therapeutically treating ulcerogenic-type disorders of the stomach and/or intestines.
    Type: Grant
    Filed: May 21, 2004
    Date of Patent: October 12, 2010
    Assignee: Metaproteomics, LLC
    Inventors: John Babish, Matthew Tripp, Terrence Howell, Jeffrey S. Bland, Gary Darland, Robert Lerman, Daniel O. Lukaczer
  • Patent number: 7794757
    Abstract: A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops.
    Type: Grant
    Filed: April 12, 2006
    Date of Patent: September 14, 2010
    Assignee: Metaproteomics, LLC
    Inventors: Matthew L. Tripp, John G. Babish, Jeffrey S. Bland, Gary K. Darland, Robert Lerman, Daniel O. Lukaczer, DeAnn J. Liska, Terrence Howell
  • Patent number: 7790205
    Abstract: A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.
    Type: Grant
    Filed: January 30, 2006
    Date of Patent: September 7, 2010
    Assignee: Metaproteomics, LLC
    Inventors: Matthew L. Tripp, John G. Babish, Jeffrey S. Bland, Gary K. Darland, Robert Lerman, Daniel O. Lukaczer, DeAnn J. Liska, Terrence Howell
  • Patent number: 7736677
    Abstract: Compounds and methods for protein kinase modulation for cancer treatment are disclosed. The compounds and methods disclosed are based on xanthohumol or isoxantohumol, or tetrahydro-isoalpha acids commonly found in hops.
    Type: Grant
    Filed: June 20, 2007
    Date of Patent: June 15, 2010
    Assignee: Metaproteomics, LLC
    Inventors: Matthew L. Tripp, John G. Babish, Jeffrey S. Bland, Veera Konda, Amy Hall, Linda M. Pacioretty, Anu Desai
  • Patent number: 7722903
    Abstract: A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops.
    Type: Grant
    Filed: January 30, 2006
    Date of Patent: May 25, 2010
    Assignee: Metaproteomics, LLC
    Inventors: Matthew L. Tripp, John G. Babish, Jeffrey S. Bland, Gary K. Darland, Robert Lerman, Daniel O. Lukaczer, DeAnn J. Liska, Terrence Howell
  • Patent number: 7718198
    Abstract: Compositions of reduced isoalpha acids, vitamins and minerals are disclosed as well as methods of using the same for the treatment of autoimmune diseases. Additional combinations including other compounds are also contemplated. Synergistic properties and methods exploiting such synergy are also disclosed.
    Type: Grant
    Filed: January 6, 2006
    Date of Patent: May 18, 2010
    Assignee: Metaproteomics, LLC
    Inventors: Matthew Tripp, Jeffrey S. Bland, Robert Lerman, Amy Hall, Veera Konda, Anu Desai
  • Patent number: 7682636
    Abstract: A novel formulation is provided that serves to inhibit the inflammatory response in animals. The formulation comprises, as a first component an effective amount of a curcuminoid species and an effective amount of a second component selected from the group consisting of an alpha-acid species or a beta-acid species or derivatives thereof. The composition provides synergistic anti-inflammatory effects in response to physical or chemical injury or abnormal immune stimulation due to a biological agent or unknown etiology.
    Type: Grant
    Filed: February 2, 2007
    Date of Patent: March 23, 2010
    Assignee: Metaproteomics, LLC
    Inventors: John G. Babish, Terrence M. Howell, Linda M. Pacioretty
  • Patent number: 7666449
    Abstract: The invention provides hops (Humulus lupulus) extracts or derivatives thereof for use in treating a patient prophylactically and/or therapeutically for ulcerogenic-type disorders of the stomach and/or intestines. The ulcerogenic disorders can be of the type chemically induced, environmentally-induced, infection-induced, and/or stress-induced. The invention also provides a pharmaceutical composition comprising an active amount of hops extracts or derivatives thereof, in combination with an analgesic compound and/or an anti-inflammatory compound. The invention further provides for use of hops extracts or derivatives thereof, significantly reducing and/or therapeutically treating ulcerogenic-type disorders of the stomach and/or intestines.
    Type: Grant
    Filed: February 15, 2006
    Date of Patent: February 23, 2010
    Assignee: Metaproteomics, LLC
    Inventors: John G. Babish, Matthew L. Tripp, Jeffrey S. Bland, Terrence Howell, Gary K. Darland, Robert H. Lerman, Daniel O. Lukaczer
  • Publication number: 20090155382
    Abstract: Compositions and methods for enhancing heavy metal detoxification are described. The compositions and methods described provide enhanced activity of key detoxification systems including that the induction of phase II detoxification enzymes, such as glutathione S-transferases (GSTs), and NADPH quinone reductase (NQO1) activity.
    Type: Application
    Filed: February 13, 2008
    Publication date: June 18, 2009
    Applicant: Metaproteomics, LLC
    Inventors: Matthew L. Tripp, Veera Konda, Amy Hall, Anu Desai, Jeffrey S. Bland
  • Publication number: 20080248131
    Abstract: Botanical compounds to modulate kinase activity are disclosed. The compounds and methods disclosed also inhibit expression of COX-2, inhibit synthesis o prostaglandins selectively in target cells, and inhibit inflammatory response selectively. The compositions contain at least one fraction isolated or derived from hops or Acacia.
    Type: Application
    Filed: August 9, 2006
    Publication date: October 9, 2008
    Applicant: Metaproteomics, LLC
    Inventors: Matthew L. Tripp, John G. Babish, Jeffrey S. Bland, Amy J. Hall, Veera Konda, Anu Desai
  • Patent number: 7431948
    Abstract: A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.
    Type: Grant
    Filed: April 12, 2006
    Date of Patent: October 7, 2008
    Assignee: Metaproteomics, LLC
    Inventors: Matthew L. Tripp, John G. Babish, Jeffrey S. Bland, Gary K. Darland, Robert Lerman, Daniel O. Lukaczer, DeAnn J. Liska, Terrence Howell
  • Publication number: 20080051466
    Abstract: Compounds and methods for protein kinase modulation for cancer treatment are disclosed. The compounds and methods disclosed are based on isoalpha acids, commonly found in hops.
    Type: Application
    Filed: June 20, 2007
    Publication date: February 28, 2008
    Applicant: Metaproteomics, LLC
    Inventors: Matthew Tripp, John Babish, Jeffrey Bland, Veera Konda, Amy Hall, Linda Pacioretty, Anu Desai
  • Publication number: 20080051465
    Abstract: Compounds and methods for protein kinase modulation for cancer treatment are disclosed. The compounds and methods disclosed are based on xanthohumol or isoxantohumol, or tetrahydro-isoalpha acids commonly found in hops.
    Type: Application
    Filed: June 20, 2007
    Publication date: February 28, 2008
    Applicant: Metaproteomics, LLC
    Inventors: Matthew Tripp, John Babish, Jeffrey Bland, Veera Konda, Amy Hall, Linda Pacioretty, Anu Desai
  • Patent number: 7332185
    Abstract: A novel formulation is provided that serves to specifically inhibit the COX-2 mediated inflammation response in animals. The formulation comprises comprising an effective amount of component I selected from the group consisting of alpha acids and beta acids and an effective amount of at least one component II selected from the group consisting of alpha acids, beta acids, essential oils, fats and waxes, with the proviso that component I and II are not the same compound. The composition provides specific inhibition of cyclooxygenase-2 with little or no effect on cyclooxygenase-1.
    Type: Grant
    Filed: October 24, 2002
    Date of Patent: February 19, 2008
    Assignee: Metaproteomics, LLC
    Inventors: John G. Babish, M. Terrence Howell
  • Publication number: 20080033056
    Abstract: Compounds and methods for protein kinase modulation for cancer treatment are disclosed. The compounds and methods disclosed are based on xanthohumol or isoxantohumol, commonly found in hops.
    Type: Application
    Filed: June 20, 2007
    Publication date: February 7, 2008
    Applicant: Metaproteomics, LLC
    Inventors: Matthew Tripp, John Babish, Jeffrey Bland, Veera Konda, Amy Hall, Linda Pacioretty, Anu Desai