Abstract: The invention provides compositions containing a fraction isolated or derived from hops and a methylxanthine. The invention additionally provides compositions containing a fraction derived from hops and a curcuminoid. The invention also provides methods of using such compositions to reduce inflammation.
Type:
Grant
Filed:
February 27, 2004
Date of Patent:
March 29, 2011
Assignee:
Metaproteomics, LLC
Inventors:
John G. Babish, Matthew L. Tripp, Jeffrey S. Bland
Abstract: A natural formulation of compounds isolated or derived from hops which inhibit the activity of cyclooxygenase-2 (COX-2) and/or 5-lipoxygenase (5-LOX) is disclosed. The hops formulations may be administered to a mammal to treat or inhibit a pathological condition associated with the activity of COX-2 and/or 5-LOX in such a mammal.
Type:
Grant
Filed:
June 10, 2004
Date of Patent:
March 8, 2011
Assignee:
Metaproteomics, LLC
Inventors:
Matthew L. Tripp, Gary K. Darland, Mark Fuller, John G. Babish, Jeffrey S. Bland
Abstract: A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandin selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops.
Type:
Application
Filed:
April 7, 2010
Publication date:
January 27, 2011
Applicant:
Metaproteomics, LLC
Inventors:
Matthew L. Tripp, John G. Babish, Jeffrey S. Bland, Gary K. Darland, Robert Lerman, Daniel O. Lukaczer, DeAnn J. Liska, Terrence Howell
Abstract: A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops.
Type:
Grant
Filed:
January 30, 2006
Date of Patent:
October 26, 2010
Assignee:
Metaproteomics, LLC
Inventors:
Matthew L. Tripp, John G. Babish, Jeffrey S. Bland, Gary K. Darland, Robert Lerman, Daniel O. Lukaczer, DeAnn J. Liska, Terrence Howell
Abstract: The invention provides hops (Humulis lupulus) extracts or derivatives thereof for use in treating a patient prophylactically and/or therapeutically for ulcerogenic-type disorders of the stomach and/or intestines. The ulcerogenic disorders can be of the type chemically induced, environmentally-induced, infection-induced, and/or stress-induced. The invention also provides a pharmaceutical composition comprising an active amount of hops extracts or derivatives thereof, in combination with an analgesic compound and/or an anti-inflammatory compound. The invention further provides for use of hops extracts or derivatives thereof, significantly reducing and/or therapeutically treating ulcerogenic-type disorders of the stomach and/or intestines.
Type:
Grant
Filed:
February 15, 2006
Date of Patent:
October 19, 2010
Assignee:
Metaproteomics, LLC
Inventors:
John G. Babish, Matthew L. Tripp, Jeffrey S. Bland, Terrence Howell, Gary K. Darland, Robert H. Lerman, Daniel O. Lukaczer
Abstract: The invention provides hops (Humulus lupulus) extracts or derivatives thereof for use in treating a patient prophylactically and/or therapeutically for ulcerogenic-type disorders of the stomach and/or intestines. The ulcerogenic disorders can be of the type chemically induced, environmentally-induced, infection-induced, and/or stress-induced. The invention also provides a pharmaceutical composition comprising an active amount of hops extracts or derivatives thereof, in combination with an analgesic compound and/or an anti-inflammatory compound. The invention further provides for use of hops extracts or derivatives thereof, significantly reducing and/or therapeutically treating ulcerogenic-type disorders of the stomach and/or intestines.
Type:
Grant
Filed:
May 21, 2004
Date of Patent:
October 12, 2010
Assignee:
Metaproteomics, LLC
Inventors:
John Babish, Matthew Tripp, Terrence Howell, Jeffrey S. Bland, Gary Darland, Robert Lerman, Daniel O. Lukaczer
Abstract: A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops.
Type:
Grant
Filed:
April 12, 2006
Date of Patent:
September 14, 2010
Assignee:
Metaproteomics, LLC
Inventors:
Matthew L. Tripp, John G. Babish, Jeffrey S. Bland, Gary K. Darland, Robert Lerman, Daniel O. Lukaczer, DeAnn J. Liska, Terrence Howell
Abstract: A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.
Type:
Grant
Filed:
January 30, 2006
Date of Patent:
September 7, 2010
Assignee:
Metaproteomics, LLC
Inventors:
Matthew L. Tripp, John G. Babish, Jeffrey S. Bland, Gary K. Darland, Robert Lerman, Daniel O. Lukaczer, DeAnn J. Liska, Terrence Howell
Abstract: Compounds and methods for protein kinase modulation for cancer treatment are disclosed. The compounds and methods disclosed are based on xanthohumol or isoxantohumol, or tetrahydro-isoalpha acids commonly found in hops.
Type:
Grant
Filed:
June 20, 2007
Date of Patent:
June 15, 2010
Assignee:
Metaproteomics, LLC
Inventors:
Matthew L. Tripp, John G. Babish, Jeffrey S. Bland, Veera Konda, Amy Hall, Linda M. Pacioretty, Anu Desai
Abstract: A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops.
Type:
Grant
Filed:
January 30, 2006
Date of Patent:
May 25, 2010
Assignee:
Metaproteomics, LLC
Inventors:
Matthew L. Tripp, John G. Babish, Jeffrey S. Bland, Gary K. Darland, Robert Lerman, Daniel O. Lukaczer, DeAnn J. Liska, Terrence Howell
Abstract: Compositions of reduced isoalpha acids, vitamins and minerals are disclosed as well as methods of using the same for the treatment of autoimmune diseases. Additional combinations including other compounds are also contemplated. Synergistic properties and methods exploiting such synergy are also disclosed.
Type:
Grant
Filed:
January 6, 2006
Date of Patent:
May 18, 2010
Assignee:
Metaproteomics, LLC
Inventors:
Matthew Tripp, Jeffrey S. Bland, Robert Lerman, Amy Hall, Veera Konda, Anu Desai
Abstract: A novel formulation is provided that serves to inhibit the inflammatory response in animals. The formulation comprises, as a first component an effective amount of a curcuminoid species and an effective amount of a second component selected from the group consisting of an alpha-acid species or a beta-acid species or derivatives thereof. The composition provides synergistic anti-inflammatory effects in response to physical or chemical injury or abnormal immune stimulation due to a biological agent or unknown etiology.
Type:
Grant
Filed:
February 2, 2007
Date of Patent:
March 23, 2010
Assignee:
Metaproteomics, LLC
Inventors:
John G. Babish, Terrence M. Howell, Linda M. Pacioretty
Abstract: The invention provides hops (Humulus lupulus) extracts or derivatives thereof for use in treating a patient prophylactically and/or therapeutically for ulcerogenic-type disorders of the stomach and/or intestines. The ulcerogenic disorders can be of the type chemically induced, environmentally-induced, infection-induced, and/or stress-induced. The invention also provides a pharmaceutical composition comprising an active amount of hops extracts or derivatives thereof, in combination with an analgesic compound and/or an anti-inflammatory compound. The invention further provides for use of hops extracts or derivatives thereof, significantly reducing and/or therapeutically treating ulcerogenic-type disorders of the stomach and/or intestines.
Type:
Grant
Filed:
February 15, 2006
Date of Patent:
February 23, 2010
Assignee:
Metaproteomics, LLC
Inventors:
John G. Babish, Matthew L. Tripp, Jeffrey S. Bland, Terrence Howell, Gary K. Darland, Robert H. Lerman, Daniel O. Lukaczer
Abstract: Compositions and methods for enhancing heavy metal detoxification are described. The compositions and methods described provide enhanced activity of key detoxification systems including that the induction of phase II detoxification enzymes, such as glutathione S-transferases (GSTs), and NADPH quinone reductase (NQO1) activity.
Type:
Application
Filed:
February 13, 2008
Publication date:
June 18, 2009
Applicant:
Metaproteomics, LLC
Inventors:
Matthew L. Tripp, Veera Konda, Amy Hall, Anu Desai, Jeffrey S. Bland
Abstract: Botanical compounds to modulate kinase activity are disclosed. The compounds and methods disclosed also inhibit expression of COX-2, inhibit synthesis o prostaglandins selectively in target cells, and inhibit inflammatory response selectively. The compositions contain at least one fraction isolated or derived from hops or Acacia.
Type:
Application
Filed:
August 9, 2006
Publication date:
October 9, 2008
Applicant:
Metaproteomics, LLC
Inventors:
Matthew L. Tripp, John G. Babish, Jeffrey S. Bland, Amy J. Hall, Veera Konda, Anu Desai
Abstract: A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.
Type:
Grant
Filed:
April 12, 2006
Date of Patent:
October 7, 2008
Assignee:
Metaproteomics, LLC
Inventors:
Matthew L. Tripp, John G. Babish, Jeffrey S. Bland, Gary K. Darland, Robert Lerman, Daniel O. Lukaczer, DeAnn J. Liska, Terrence Howell
Abstract: Compounds and methods for protein kinase modulation for cancer treatment are disclosed. The compounds and methods disclosed are based on isoalpha acids, commonly found in hops.
Type:
Application
Filed:
June 20, 2007
Publication date:
February 28, 2008
Applicant:
Metaproteomics, LLC
Inventors:
Matthew Tripp, John Babish, Jeffrey Bland, Veera Konda, Amy Hall, Linda Pacioretty, Anu Desai
Abstract: Compounds and methods for protein kinase modulation for cancer treatment are disclosed. The compounds and methods disclosed are based on xanthohumol or isoxantohumol, or tetrahydro-isoalpha acids commonly found in hops.
Type:
Application
Filed:
June 20, 2007
Publication date:
February 28, 2008
Applicant:
Metaproteomics, LLC
Inventors:
Matthew Tripp, John Babish, Jeffrey Bland, Veera Konda, Amy Hall, Linda Pacioretty, Anu Desai
Abstract: A novel formulation is provided that serves to specifically inhibit the COX-2 mediated inflammation response in animals. The formulation comprises comprising an effective amount of component I selected from the group consisting of alpha acids and beta acids and an effective amount of at least one component II selected from the group consisting of alpha acids, beta acids, essential oils, fats and waxes, with the proviso that component I and II are not the same compound. The composition provides specific inhibition of cyclooxygenase-2 with little or no effect on cyclooxygenase-1.
Abstract: Compounds and methods for protein kinase modulation for cancer treatment are disclosed. The compounds and methods disclosed are based on hexahydro-isoalpha acids, commonly found in hops.
Type:
Application
Filed:
June 20, 2007
Publication date:
February 7, 2008
Applicant:
Metaproteomics, LLC
Inventors:
Matthew Tripp, John Babish, Jeffrey Bland, Veera Konda, Amy Hall, Linda Pacioretty, Anu Desai