Abstract: Medical devices and methods are provided for electrical stimulation of neural tissue and controlled drug delivery to a patient. The device includes an implantable drug delivery module which comprises a plurality of reservoirs, a release system comprising at least one drug contained in each of the reservoirs, and control means for selectively releasing a pharmaceutically effective amount of drug from each reservoir; a neural electrical stimulator which comprises a signal generator connected to at least one stimulation electrode for operable engagement with a neural tissue of the patient; and at least one microcontroller for controlling operational interaction of the drug delivery module and the neural electrical stimulator. The microcontroller may control the signal generator and the control means of the drug delivery module. The device may further include a sensor operable to deliver a signal to the microcontroller, for example to indicate when to deliver electrical stimulation, drug, or both.

Abstract: Methods for operating a sensor device are provided, which may include (a) providing at a site (e.g., implanting in a patient) a device which comprises at least first and second reservoirs, a first sensor and corresponding first reference sensor located within the first reservoir, a second sensor and corresponding second reference sensor located within the second reservoir, a first reservoir cap closing an opening in the first reservoir and a second reservoir cap closing an opening in the second reservoir, and a power source, control circuitry, and electrodes for selectively disintegrating each reservoir cap; (b) disintegrating the first reservoir cap and operating the first sensor and reference sensor; and (c) using the first reference sensor to determine whether the first sensor is operating properly. If not operating properly, then the control circuitry initiates disintegration of the second reservoir cap and operation of the second sensor and reference sensor.

Abstract: A packet based high bandwidth copy protection method is described that includes the following operations. Forming a number of data packets at a source device, encrypting selected ones of the data packets based upon a set of encryption values, transmitting the encrypted data packets from the source device to a sink device coupled thereto, decrypting the encrypted data packets based in part upon the encryption values, and accessing the decrypted data packets by the sink device.

Abstract: A method, system and apparatus for synchronizing an analog video signal to an LCD monitor is described. For each of a succession of associated video frames are surveyed for a number of displayed features based upon a pseudo-random selection of regions into which the displayed video frame is divided. During successive associated video frames, a minimum number of features each is which is generated by an associated pixel clock is determined based upon a pre-selected number of scans. Subsequent to the determination of the minimum number of features, a transition region for each of plurality of horizontal resolution values is determined by scanning through a selected number of pixel clock phases. Based upon a minimum transition zone corresponding to a maximum change in the number of features for a particular pixel clock phase, an associated horizontal resolution is provided.

Abstract: A method and apparatus for displaying different presentations of program material allows various presentations of a DVD movie, for example, to be displayed on a display for a user's selection. The various presentations might involve different angles from which a user must select or different chapters from which a program should begin. The selection of a presentation is facilitated by displaying the various options on a single display such that the user can quickly choose which presentation to choose. Furthermore, audio is provided with chapter presentations to assist a user in selecting a chapter from where playback should be initiated.

Abstract: A method and apparatus of optimizing transmission (both real time and continuous) of a number of multimedia data packets between a multimedia source device and a multimedia display device is disclosed. In the described embodiment, the multimedia source device and the display device are coupled by way of a unidirectional main link arranged to carry the multimedia data packets from the multimedia source device and the multimedia display device and a bi-directional auxiliary channel arranged to transfer information between the multimedia source device and the multimedia display device. The method can be carried out by following at least the following operations. Providing a test pattern by the multimedia source device on the main link, determining a transmission quality factor of the main link based upon the test pattern, and optimizing the transmission of the multimedia data packets based upon the transmission quality factor.

Abstract: Methods are provided for making a reservoir-based sensor device. The method may include fabricating a first substrate portion which comprises an upper surface, an opposed lower surface, a plurality of through holes defining reservoirs between said upper surface and said lower surface, and a plurality of reservoir caps closing off one end of said through holes at said upper surface; fabricating a plurality of sensors on an upper surface of a second substrate portion; aligning the first and second substrate portions such that each of said plurality of sensors is in alignment with each of said plurality of reservoirs; and bonding together the lower surface of said first substrate portion and the upper surface of said second substrate portion to seal each of said sensors inside the reservoir with which it is aligned.

Abstract: A packet based high bandwidth copy protection method is described that includes the following operations. Forming a number of data packets at a source device, encrypting selected ones of the data packets based upon a set of encryption values, transmitting the encrypted data packets from the source device to a sink device coupled thereto, decrypting the encrypted data packets based in part upon the encryption values, and accessing the decrypted data packets by the sink device.

Abstract: Reservoir-based devices are provided in which an individual reservoir has at least two openings with a support structure therebetween and closed by reservoir caps covering the openings to control release or exposure of reservoir contents. In one embodiment, the device is an implantable medical device and provides for the controlled release of drug or exposure of a sensor. The device includes a substrate; at least one reservoir disposed in the substrate, the reservoir having two or more openings; reservoir contents located in the reservoir; two or more discrete reservoir caps, each reservoir cap sealingly covering at least one of the reservoir openings; and control means for selectively disintegrating or permeabilizing the reservoir caps.

Abstract: Medical devices and methods are provided for electrical stimulation of neural tissue and controlled drug delivery to a patient. The device includes an implantable drug delivery module which comprises a plurality of reservoirs, a release system comprising at least one drug contained in each of the reservoirs, and control means for selectively releasing a pharmaceutically effective amount of drug from each reservoir; a neural electrical stimulator which comprises a signal generator connected to at least one stimulation electrode for operable engagement with a neural tissue of the patient; and at least one microcontroller for controlling operational interaction of the drug delivery module and the neural electrical stimulator. The microcontroller may control the signal generator and the control means of the drug delivery module. The device may further include a sensor operable to deliver a signal to the microcontroller, for example to indicate when to deliver electrical stimulation, drug, or both.

Abstract: Devices and methods are provided for transdermal diagnostic sensing, alone or in combination with transdermal drug delivery. The device includes a substrate having a plurality of discrete reservoirs, each reservoir having at least one opening; contents disposed in the reservoirs, the contents of each reservoir including a diagnostic agent or a sensor for measuring an analyte; at least one discrete reservoir cap which cover said at least one opening; control means for disintegrating or permeabilizing the reservoir cap; means for transporting an analyte from the skin to said sensors and/or for transporting said diagnostic agent to the skin following release of said diagnostic agents from said reservoir; and means for securing the device to the skin of a patient.

Abstract: A drug delivery device for implantation into a patient is provided that includes at least one device element that includes a substrate having a plurality of discrete reservoirs disposed therein, the reservoirs containing drug molecules and a degradable matrix material which controls in vivo release of the drug molecules from the reservoirs, wherein the drug delivery device is adapted to conform to a curved bone tissue surface. In one embodiment, the substrate is flexible and conforms to a bone tissue surface. In another embodiment, the device has two or more device elements attached to or integral with a flexible supporting layer.

Abstract: Disclosed is a method for generating transfer curves for adaptive contrast enhancement. Transfer curves are generated so as to enhance the bright pixels in mostly dark images and the dark pixels in mostly bright images. For a dark image, a transfer curve is generated which increases luminance in high-luminance regions of the image without substantially changing the luminance in the mid- and low-luminance regions of the image. For a bright image, a transfer curve is generated which decreases the luminance in the dark areas of the image without substantially changing the luminance in the mid- and high-luminance regions of the image. For a medium-bright image, a transfer curve is generated with increases the luminance in the high-luminance range and decreases the luminance in the low-luminance range of the histogram without substantially changing the luminance in the medium-luminance range of the image.

Abstract: An enumeration method providing the link rate and a pixel/audio clock rate is described.

Abstract: A television line doubler (interlaced to progressive scan converter) incorporating the following aspects an improved field motion detector which does not treat low frequency vertical transitions as motion; a frame motion detector having an improved ability to differentiate motion from subcarrier signal components; a sawtooth artifact detector; a sawtooth artifact detector in combination with a film pattern detector, such that the artifact detector can take the film pattern detector out of film mode earlier than it would if it only were responsive to a break in the film pattern; tandem field motion detectors; an improved field based film detector; film pattern detectors and motion detectors used therewith which operate by performing end-of-field calculations; the combination of a field motion detector and a frame motion detector such that the frame motion detector provides a motion signal used as a verification by the field motion detector; an improved NTSC film detector requiring a minimum number of NTSC film

Abstract: Method and devices are provided for extended and controlled delivery of parathyroid hormone to a patient. The method includes implanting a medical device into the patient, the medical device comprising a substrate, a plurality of reservoirs in the substrate, a release system contained in each of the reservoirs, wherein the release system comprises parathyroid hormone; and controllably releasing a pharmaceutically effective amount of the parathyroid hormone from the reservoirs. The parathyroid hormone can be released intermittently, such as once daily over an extended period (e.g., two months, ten months, or more.). The device can further include reservoirs containing a bone resorption inhibitor or other drug for release. The devices are useful in delivering PTH for the treatment and prevention of bone loss, such as associated with osteoporosis.

Abstract: Methods, formulations, and devices are provided for enhancing drug delivery from a medical device. The method is provided for increasing the rate or quantity of a drug formulation released from an implantable drug delivery device, which method comprises the step of providing a release-modifying agent within or proximate to the implantable drug delivery device, in a manner effective to inhibit gelation, aggregation, or precipitation of the drug formulation being released from the device. The drug formulation and the release-modifying agent may be stored together in at least one reservoir in the implantable drug deliver device. Alternatively, the release-modifying agent may be stored in one or more reservoirs separate from the drug formulation.

Abstract: Devices and methods are provided for transdermal administration of a pharmaceutical agent to a patient in need thereof. The device includes a substrate, a plurality of discrete reservoirs in the substrate, one or more pharmaceutical agents stored in the reservoirs, discrete reservoir caps that prevent the pharmaceutical agent from passing out from the reservoirs until desired, control means for actuating release of the one or more pharmaceutical agents from one or more of the reservoirs by disintegrating or permeabilizing the reservoir caps, means for securing the device to the skin of the patient, and means for transporting the pharmaceutical agent to the skin following release from the one or more of the reservoirs. In another embodiment, the device is adapted for diagnostic sensing instead of or in addition to drug delivery.

Abstract: Implantable drug delivery devices are provided which are adapted to be installed adjacent to at least a portion of an orthopedic prosthetic device implanted on a surgically prepared bone section of a patient. For example, the prosthetic device may be a hip joint replacement or knee joint replacement. The drug delivery device may include a body having a core formed from a non-biodegradable material formed in the shape of a sleeve and having an inner surface and an outwardly directed outer surface, wherein the outer surface has a drug formulation for release thereof into the body of the animal following implantation of the prosthetic device within the body of the animal. The outer surface may define one or more pockets for holding the drug formulation.

Abstract: Devices and methods are provided for controlled release of chemical molecules, such as drugs. One device comprises a plurality of reservoirs; a rupturable covering, such as a thin metal film, enclosing a first end of each reservoir; a release formulation in each reservoir comprising chemical molecules for release; an expanding material layer in each reservoir; and a semi-permeable membrane enclosing a second end of each reservoir distal the release formulation, the semi-permeable membrane being operable to permit selected molecules (e.g., water) from outside the reservoir to diffuse to the expanding material layer to expand the expanding material layer and displace the release formulation in an amount effective rupture the rupturable membrane and discharge the release formulation.