Patents Assigned to Micrologix Biotech Inc.
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Publication number: 20060003951Abstract: The present invention comprises 7-deaza L-nucleosides having unexpectedly high inhibitory activity against the hepatitis B virus. The invention further comprises pharmaceutical compositions comprising such compounds as well as methods of treating mammals, particularly humans, infected with HBV and other viral infections.Type: ApplicationFiled: June 10, 2005Publication date: January 5, 2006Applicant: Micrologix Biotech Inc.Inventors: Khalid Mekouar, Robert Deziel, Samir Mounir, Radhakrishnan Iyer
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Publication number: 20050049182Abstract: Compositions and methods for making and using therapeutic formulations of antimicrobial cationic peptides are provided. The antimicrobial cationic peptide formulations may be used, for example, in the treatment of microorganism-caused infections, which infections may be systemic, such as a septicemia, or may be localized, such as in acne or an implanted or indwelling medical device.Type: ApplicationFiled: June 10, 2004Publication date: March 3, 2005Applicant: MICROLOGIX BIOTECH INC.Inventors: Timothy Krieger, Patricia McNicol
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Publication number: 20050026853Abstract: The present invention relates generally to anti-viral compounds, particularly anti-viral 7-deaza D-nucleosides and analogues, or derivatives thereof. The invention also relates to the use of such compounds to treat or prevent hepatitis B virus (HBV) infections, and to the use of such compounds to examine the biological mechanisms of HBV infection.Type: ApplicationFiled: July 25, 2003Publication date: February 3, 2005Applicant: Micrologix Biotech Inc.Inventors: Khalid Mekouar, Robert Deziel
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Patent number: 6835536Abstract: Compositions and methods for making and using therapeutic formulations of antimicrobial cationic peptides are provided. The antimicrobial cationic peptide formulations may be used, for example, in the treatment of microorganism-caused infections, which infections may be systemic, such as a septicemia, or may be localized, such as in acne or an implanted or indwelling medical device.Type: GrantFiled: August 20, 2002Date of Patent: December 28, 2004Assignee: Micrologix Biotech Inc.Inventors: Timothy J. Krieger, Patricia J. McNicol
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Publication number: 20040242467Abstract: The present invention provides a rapid and inexpensive method for extractively isolating acidic lipopeptide antibiotics in high yield and purity.Type: ApplicationFiled: March 26, 2004Publication date: December 2, 2004Applicant: MICROLOGIX BIOTECH INC.Inventors: Donald B. Borders, Noreen D. Francis, Amedeo A. Fantini
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Publication number: 20040138437Abstract: The present invention provides two new classes of polyene macrolide amide derivatives useful for treating or preventing fungal infections. The new polyene macrolide amide derivatives exhibit antifungal activity and are more water-soluble than conventional polyene antibiotics, such as amphotericin B and amphotericin B methyl ester.Type: ApplicationFiled: October 23, 2003Publication date: July 15, 2004Applicant: Micrologix Biotech Inc.Inventors: Conway C. Chang, Binh T. Dang, Christopher J. Baldwin, David J. Loury, Reyna J. Simon, Robert R. Webb
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Publication number: 20040138107Abstract: The present invention provides Dab9 derivatives of amphomycin-type lipopeptide antibiotics that display antimicrobial activity against Gram-positive bacteria, methods and intermediates for synthesizing such compounds, and methods of using the compounds in a variety of contexts, including in the treatment and prevention of infections.Type: ApplicationFiled: January 2, 2003Publication date: July 15, 2004Applicant: Micrologix Biotech Inc.Inventors: Maria Fardis, Dale R. Cameron, Vincent A. Boyd
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Patent number: 6750199Abstract: The present invention provides antimicrobial sulfonamide derivatives of lipopeptide antibiotics, pharmaceutical compositions of antimicrobial sulfonamide derivatives, methods for making antimicrobial sulfonamide derivatives, methods for inhibiting microbial growth with antimicrobial sulfonamide derivatives and methods for treating or preventing microbial infections in a subject with antimicrobial sulfonamide derivatives. Antimicrobial sulfonamide derivatives are generally an amino core antibiotic that has been further modified with a lipophilic sulfonyl group.Type: GrantFiled: July 13, 2001Date of Patent: June 15, 2004Assignee: Micrologix Biotech Inc.Inventors: William V. Curran, Richard A. Leese, Howard Jarolmen, Donald B. Borders
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Publication number: 20040106785Abstract: The invention herein provides novel viral DNA polymerase compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with viral DNA polymerase activity, and processes and intermediates useful for preparing such compounds.Type: ApplicationFiled: July 25, 2003Publication date: June 3, 2004Applicant: Micrologix Biotech Inc.Inventors: Robert Deziel, Eric Fournier, Arlene Roland
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Patent number: 6737403Abstract: The present invention provides laspartomycin core peptides, laspartomycin core peptide derivatives, antimicrobial laspartomycin derivatives, methods for making laspartomycin core peptides, methods for making laspartomycin core peptide derivatives, methods for making antimicrobial laspartomycin derivatives, pharmaceutical compositions of antimicrobial laspartomycin derivatives, methods of inhibiting microbial growth and methods for treating and/or preventing microbial infections in a subject.Type: GrantFiled: July 13, 2001Date of Patent: May 18, 2004Assignee: Micrologix Biotech Inc.Inventors: Donald B Borders, William V Curran, Amedeo A Fantini, Noreen D Francis, Howard Jarolmen, Richard A Leese
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Publication number: 20040087540Abstract: The invention provides new methods for synthesis of nucleotide-based compounds and new libraries of such compounds. Compounds of the invention are useful for a variety of therapeutic applications, including treatment of viral or bacterial infections and associated diseases and disorders.Type: ApplicationFiled: April 28, 2003Publication date: May 6, 2004Applicant: Micrologix Biotech Inc.Inventors: Wenqiang Zhou, Yi Jin, Arlene Roland, Radhakrishnan Parameswaran Iyer
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Patent number: 6716962Abstract: The present invention provides a rapid and inexpensive method for extractively isolating acidic lipopeptide antibiotics, such as those having a cyclic peptide or cyclic depsipeptide core, in high yield and purity. In particular, there is provided a method of extracting a variety of acidic lipopeptide antibiotics, directly or indirectly, into water immiscible organic solvents by using a divalent cation chelation procedure.Type: GrantFiled: September 6, 2001Date of Patent: April 6, 2004Assignee: Micrologix Biotech Inc.Inventors: Donald B Borders, Noreen D Francis, Amedeo A Fantini
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Publication number: 20040029817Abstract: The present invention provides a new class of polyene macrolide derivatives useful for treating or preventing fungal infections. The new polyene macrolide derivatives exhibit surprisingly superior antifungal activity and water solubility compared to amphotericin B methyl ester (AME). In addition, the new polyene macrolide derivatives have improved water solubility and lower toxicity than both amphotericin B (AmB) and AME.Type: ApplicationFiled: April 25, 2003Publication date: February 12, 2004Applicant: Micrologix Biotech Inc.Inventors: Christopher J. Baldwin, Conway Cheng Chang, Binh T. Dang
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Publication number: 20040009910Abstract: Compositions and methods for treating infections, especially bacterial infections, are provided. Indolicidin peptide analogues containing at least two basic amino acids are prepared. The analogues are administered as modified peptides, preferably containing photo-oxidized solubilizer.Type: ApplicationFiled: January 24, 2003Publication date: January 15, 2004Applicant: MICROLOGIX BIOTECH INC.Inventors: Janet R. Fraser, Michael H. P. West, Timothy J. Krieger, Robert Taylor, Douglas Erfle
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Publication number: 20030232750Abstract: Compositions and methods for treating infections, especially bacterial infections, are provided. Indolicidin peptide analogues containing at least two basic amino acids are prepared. The analogues are administered as modified peptides, preferably containing photo-oxidized solubilizer.Type: ApplicationFiled: October 18, 2002Publication date: December 18, 2003Applicant: Micrologix Biotech Inc.Inventors: Timothy J. Krieger, Robert Taylor, Douglas Erfle, Janet R. Fraser, Michael H.P. West, Patricia J. MicNicol
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Patent number: 6664241Abstract: The present invention provides two new classes of polyene macrolide amide derivatives useful for treating or preventing fungal infections. The new polyene macrolide amide derivatives exhibit antifungal activity and are more water-soluble than conventional polyene antibiotics, such as amphotericin B and amphotericin B methyl ester.Type: GrantFiled: May 29, 2001Date of Patent: December 16, 2003Assignee: Micrologix Biotech Inc.Inventors: Conway C. Chang, Binh T. Dang, Christopher J. Baldwin, David J. Loury, Reyna J. Simon, Robert R. Webb
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Publication number: 20030219854Abstract: Compositions and methods for making and using modified anti-infective peptides are provided. For example, synthetically and/or recombinantly produced analogues or derivatives of naturally occurring anti-infective peptides may be efficiently modified using the compositions and methods provided herein to generate similar or identical post-translational modifications found in wild-type anti-infective peptides. The modified anti-infective peptides (e.g., antimicrobial cationic peptides) and analogues or derivatives thereof may be used, for example, in the treatment of microorganism-caused infections.Type: ApplicationFiled: March 21, 2003Publication date: November 27, 2003Applicant: MICROLOGIX BIOTECH INC.Inventors: Maria Marta Guarna, Yuchen Chen, Robert Cory, Jacqui Brinkman, Jennifer Cabralda, Luba Metlitskaia, Dinar Suleman
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Patent number: 6620796Abstract: The invention provides new methods for synthesis of nucleotide-based compounds and new libraries of such compounds. Compounds of the invention are useful for a variety of therapeutic applications, including treatment of viral or bacterial infections and associated diseases and disorders.Type: GrantFiled: November 8, 2000Date of Patent: September 16, 2003Assignee: Micrologix Biotech Inc.Inventors: Wenqiang Zhou, Yi Jin, Arlene Roland, Radhakrishnan Iyer
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Publication number: 20030171281Abstract: Compositions and methods for making and using therapeutic formulations of antimicrobial cationic peptides are provided. The antimicrobial cationic peptide formulations may be used, for example, in the treatment of microorganism-caused infections, which infections may be systemic, such as a septicemia, or may be localized, such as in acne or an implanted or indwelling medical device.Type: ApplicationFiled: August 20, 2002Publication date: September 11, 2003Applicant: MICROLOGIX BIOTECH INC.Inventors: Timothy J. Krieger, Patricia J. McNicol, Janet R. Fraser
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Publication number: 20030153744Abstract: The present invention comprises 7-deaza L-nucleosides having unexpectedly high inhibitory activity against the hepatitis B virus. The invention further comprises pharmaceutical compositions comprising such compounds as well as methods of treating mammals, particularly humans, infected with HBV and other viral infections.Type: ApplicationFiled: December 20, 2002Publication date: August 14, 2003Applicant: Micrologix Biotech Inc.Inventors: Khalid Mekouar, Robert Deziel, Samir Mounir, Radhakrishnan P. Iyer