Abstract: Antimicrobial and/or anti-inflammatory peptide compositions and therapeutic uses thereof are provided. The peptides and analogs or derivatives thereof may be used as an antimicrobial agent and/or as an anti-inflammatory agent. In certain embodiments, the peptides are cationic peptides. The peptides are useful for the treatment of inflammatory diseases, such as microorganism-caused infections, acne, and psoriasis. The peptides and peptide formulations may be used topically or parenterally.
Type:
Application
Filed:
August 26, 2002
Publication date:
August 7, 2003
Applicant:
MICROLOGIX BIOTECH INC.
Inventors:
Patricia J. McNicol, Sonia K. Pawlak, Evelina Rubinchik, Dale Cameron, Maria Marta Guarna
Abstract: The present invention provides an alternative method of attaching a 3′-thiophosphate mononucleotide or oligonucleotide to a solid support. The method permits chemoselective binding of a thiophosphate mono- or oligonucleotide to a solid support. The present invention is useful in production of microarrays, chips, beads or other solid matrices for gene expression profiling, single nucleotide polymorphism, and pharmacogenomics, target validation, sequencing and for any application that involves contacting a target nucleic acid sequence with a support-bound probe.
Type:
Application
Filed:
October 3, 2002
Publication date:
July 31, 2003
Applicant:
Micrologix Biotech Inc.
Inventors:
Radhakrishnan P. Iyer, Rajendra K. Pandey, Satya N. Kuchimanchi, Arlene Roland
Abstract: The present invention relates to novel phosphoramidate compounds and libraries containing such compounds, and methods for preparing such compounds. Compounds of the invention will be useful in a variety of applications, e.g. as a nucleoside or oligonucleotide therapeutic agent, or for diagnostic or analytical applications, e.g. as a capture probe in a hybridization assay.
Type:
Application
Filed:
June 28, 2002
Publication date:
July 24, 2003
Applicant:
Micrologix Biotech Inc.
Inventors:
Radhakrishnan P. Iyer, Yi Jin, Arlene Roland
Abstract: The present invention provides a new class of polyene macrolide derivatives useful for treating or preventing fungal infections. The new polyene macrolide derivatives exhibit surprisingly superior antifungal activity and water solubility compared to amphotericin B methyl ester (AME). In addition, the new polyene macrolide derivatives have improved water solubility and lower toxicity than both amphotericin B (AmB) and AME.
Type:
Grant
Filed:
December 20, 2001
Date of Patent:
May 13, 2003
Assignee:
Micrologix Biotech Inc.
Inventors:
Christopher J. Baldwin, Conway C. Chang, Binh T. Dang
Abstract: The invention comprises short, thiophosphate nucleic acids (primarily mono-, di-, and tri-nucleotides), libraries comprising them, and methods of using them as therapeutic anti-viral (particularly anti-HBV) agents.
Abstract: Compositions and methods for treating infections, especially bacterial infections, are provided. Indolicidin peptide analogues containing at least two basic amino acids are prepared. The analogues are administered as modified peptides, preferably containing photo-oxidized solubilizer.
Type:
Grant
Filed:
September 22, 2000
Date of Patent:
March 25, 2003
Assignee:
Micrologix Biotech, Inc.
Inventors:
Janet R. Fraser, Michael H. P. West, Timothy J. Krieger, Robert Taylor, Douglas Erfle
Abstract: The present invention provides a laspartomycin core peptide, a laspartomycin core peptide derivative, a antimicrobial laspartomycin derivative, a method for making laspartomycin core peptides, methods for making laspartomycin core peptide derivatives, methods for making antimicrobial laspartomycin derivatives, pharmaceutical compositions of antimicrobial laspartomycin derivatives, methods of inhibiting microbial growth and methods for treating and/or preventing microbial infections in a subject.
Type:
Grant
Filed:
January 12, 2001
Date of Patent:
January 28, 2003
Assignee:
Micrologix Biotech Inc.
Inventors:
Donald B Borders, William V Curran, Amedeo A Fantini, Noreen D Francis, Howard Jarolmen, Richard A Leese
Abstract: Compositions and methods for treating infections, especially bacterial infections, are provided. Indolicidin peptide analogues containing at least two basic amino acids are prepared. The analogues are administered as modified peptides, preferably containing photo-oxidized solubilizer.
Type:
Grant
Filed:
February 25, 1998
Date of Patent:
January 7, 2003
Assignee:
Micrologix Biotech Inc.
Inventors:
Timothy J. Krieger, Robert Taylor, Douglas Erfle, Janet R. Fraser, Michael H. P. West, Patricia J. McNichol
Abstract: Compositions and methods for treating infections, especially bacterial infections, are provided. Indolicidin peptide analogues containing at least two basic amino acids are prepared. The analogues are administered as modified peptides, preferably containing photo-oxidized solubilizer.
Type:
Grant
Filed:
August 20, 1997
Date of Patent:
January 30, 2001
Assignee:
Micrologix Biotech Inc.
Inventors:
Janet R. Fraser, Michael H. P. West, Timothy J. Krieger, Robert Taylor, Douglas Erfle