Abstract: A multivalent FeLV-infected feline vaccine composed of (1) a small but immunologically effective amount of inactivated feline leukemia virus; (2) a small but effective amount of an inactivated virus selected from the group consisting of Feline Rhinotracheitis Virus, Feline Calici Virus and Feline Panleukopenia Virus; and (3) a pharmaceutically acceptable immunologica adjuvant. Components (1) and (2) may be inactivated by any of the known techniques. The inactivated feline leukemia virus must be from subgroup A and is the Rickard isolate of the virus designated FeLV-A.sub.R1. This combination vaccine is effective in preventing Viremia, leukemia-associated syndromes, and deaths in cats caused by Feline Leukemia Virus, Feline Rhinotracheitis Virus, Feline Calici Virus and Feline Panleukemia Virus infections.

Abstract: The present invention is a method for the detection of creatinine in an aqueous solution, particularly urine, which involves contacting the solution with a soluble cupric salt, a hydroperoxide and an oxidizable indicator which provides a detectable response in the presence of oxygen free radicals and a pseudoperoxidase. The invention is predicated on the discovery that cupric ions form a complex with creatinine which complex exhibits peroxidase like activity.

Abstract: Disclosed are a method and device for performing sequential analytical reactions involving a first dry reagent and a second dry reagent comprised of two or more components having different rates of solubilization. The invention enables one to fully solubilize the components of the second reagent before they are brought into contact with each other to thereby avoid interference with the reaction kinetics which result when one or both of the components are not fully dissolved prior to their being brought into contact. The invention is especially useful in conjunction with immunoassay formats involving latex bound antibodies and polymeric agglutinators.

Abstract: The present invention is directed to a process for the preparation of an aqueous two-component polyurethane-forming composition bya) dispersing in water a polyisocyanate which has an isocyanate content of at least 12% by weight andb) also blending with water either before, during or after dispersing the polyisocyanate, a polyhydroxyl compound whichi) has a molecular weight of 62 to 10,000,ii) contains at least two hydroxyl groups,iii) is water soluble or water dispersible,iv) does not contain urea or urethane groups andv) is selected from the group of polyesters, polylactones, polycarbonates, polyethers, polythioethers, polyacetals, polyether esters, polyester amides and polyamides,wherein the equivalent ratio of isocyanate groups to aqueous groups is 0.8:1 to 6:1.The present invention is also directed to the aqueous composition prepared by this process and to its use as a binder for fiberglass.

Abstract: Products having improved green strength, improved physical properties and improved thermal properties are prepared via the RIM process using a reaction mixture containing an isocyanate, a specific low molecular weight diol or triol, and a specified amine terminated material.

Abstract: The present invention is directed to a aqueous polyurea dispersion for the preparation of an aqueous polyurea dispersion byI) dispersing in water at an NCO:NH equivalent ratio of 0.5:1.0 to 2.0:1.0a) a polyisocyanate which has an average functionality of 1.5 to 4.0 and an isocyanate content of at least 12% by weight andb) a polyamine component containingi) 30 to 70 mole percent of a polyamine having at least two primary and/or secondary amino groups and a molecular weight of at least 1000 andii) 30 to 70 mole percent of a polyamine having at least two primary and/or secondary amino groups, a molecular weight of less than 400 and at least one anionic or potential anionic group andII) allowing the polyisocyanate and polyamine component to react to form an aqueous polyurea dispersion.The present invention is also directed to the aqueous polyurea dispersion prepared by this aqueous polyurea dispersion.

Abstract: A thermosetting composition is prepared by reacting a highly crosslinked nylon-1 which contains structural units corresponding to ##STR1## where R is an organic radical with a isocyanate-reactive compound. In carrying out the reaction the molar ratio of carbonyl groups to NCO-reactive groups is about 0.5:1 to 20:1. Desirable properties characterize the reaction product thus prepared.

Abstract: A method of determining the presence or concentration of a peroxidatively active substance, such as hemoglobin, in a test sample is disclosed. The method comprises contacting the test sample with an indicator reagent composition which interacts with the peroxidatively active substance to produce a measurable or detecable color change. The indicator reagent composition comprises a redox indicator dye, a hydroperoxide, a ferric ion and a phosphorous compound having the formula ##STR1## wherein R.sub.1 or R.sub.2 are certain substituted or an unsubstituted aromatic moieties or certain polyhydric compounds, and wherein X is O, S or NH. The assay can be performed in wet phase or the composition can be incorporated into a carrier matrix. The method provides a more accurate and trustworthy assay of a test sample for a peroxidatively active substance and is especially useful in the assay of urine for occult blood.

Abstract: Disclosed is an improved procedure for the manufacture of a diagnostic test device comprising a matrix having uniformly dispersed a tetrazolium salt and a reagent system designed to convert the tetrazolium to its colored formazan upon contacting the matrix with a fluid containing an analyte whose presence and/or concentration is being sought. The procedure involves applying the tetrazolium salt to the matrix from its solution in an organic solvent and, after drying, applying the reagent system to the matrix from its aqueous solution to which has been added hexanesulfonate as wetting agent.

Abstract: Methods for characterizing and distinguishing reticulocytes and mature red blood cells use reagent compositions which include an organic cationic dye for staining the reticulocytes in the blood sample and a buffer solution for maintaining a pH of about 6 to about 9. The dyes may be the red excitable fluorescent dye Oxazine 750, or the blue excitable fluorescent dyes Acridine Orange or derivatives of Acridine Orange.

Abstract: A method for the presumptive detection of Candida in vaginal fluid, thereby providing an aid to the diagnosis of Candida vaginosis. A sample of vaginal fluid is combined with a test composition comprising an indicator system that provides a chromogenic response in the presence of D-arabinitol; the detection of an elevated level of D-arabinitol indicating the presumptive presence of Candida. The test composition preferably comprises the enzyme D-arabinitol dehydrogenase, NAD, an electron transfer agent, and a chromogenic indicator.

Abstract: The present invention is directed to a process for the preparation of an aqueous polyurea dispersion containing blocked isocyanate groups and unreacted isocyanate-reactive groups by(I) dispersing in watera) a polyisocyanateb) a monofunctional blocking agent which is more reactive with isocyanate groups than water andc) an amine componentII) reacting the polyisocyanate with components b) and c) to form an aqueous polyurea dispersion.

Abstract: Disclosed herein is a process for the preparation of a reaction injection molded elastomer comprising injecting a reaction mixture into a closed mold via a RIM machine, with the ratio of components being such that the isocyanate index is from about 70 to about 130, said reaction mixture comprising (a) an organic di- and/or polyisocyanate, (b) an amine terminated chain extender, and (c) a compound which is derived from the reaction of a polyfunctional acetoacetic acid ester and an aliphatic amine having amino groups of different reactivity.

Abstract: Highly purified antihemophilic factor is produced by a process comprising a PEG precipitation step, a gel filtration step and a virus inactivation step. Al(OH).sub.3 adsorption and PEG precipitation carried out at room temperature allow processing to proceed directly to a gel filtration step.

Abstract: Method and apparatus for collecting and storing umbilical blood in a system that allows for the closed aliquoting of small blood volumes for autologous transfusion in neonates. The method involves locating a venous access site on an umbilical cord of the placenta of a neonate. A vacuum pressure is applied to a blood collection bag to facilitate removal of an amount of blood from the umbilical cord. The blood may then be stored in the collection bag and used for subsequent autologous neonate blood transfusion.

Abstract: A composition, method and test device for determining the divalent cation concentration or estimating the specific gravity of a test sample are disclosed. The method utilizes a test device comprising a test pad, wherein the test pad includes a carrier matrix incorporating a reagent composition capable of interacting with divalent cations present in the test sample to produce a detectable and measurable response that correlates to the divalent cation concentration or to the specific gravity of the test sample. The reagent composition, comprising a metal-sensitive triphenylmethane dye; a buffer; an optional chelating agent; and suitable carrier, is incorporated into a carrier matrix to provide a test pad of a device useful in a divalent cation assay or a specific gravity assay of a test sample.

Abstract: Novel liquid, room temperature polyisocyanate having isocyanate group contents of from 6 to 31% by weight, are prepared by reacting:a) a methylene-bis(phenyl isocyanate) containing1) from 65 to 90% by weight of the 4,4'-isomer,2) from 10 to 35% by weigh of the 2,4'-isomer, and3) no more than 2% by weight of the 2,2'-isomer, with the percents of components a)1), a)2), and a)3) totalling 100%, andb) a mixture of:1) one or more organic compounds having molecular weights of from 400 to 6000 and containing from 2 to 8 isocyanate reactive groups, and2) one or more organic diols having molecular weights of from 60 to 200, excluding tripropylene glycol, the weight ratio of component b)1) to b)2) being from 150:1 to 5:1.When used in a RIM process, molded products are obtained which have improved tear strength, improved flexural modulus, improved impact resistance, and improved tensile strength.

Abstract: Methods for characterizing and distinguishing reticulocytes and mature red blood cells use reagent compositions which include organic cationic dyes for staining the reticulocytes in the blood sample and buffer solutions for maintaining a pH of about 6 to about 9. The dyes may be the blue absorption dyes Oxazine 750 or New Methylene Blue.

Abstract: The present invention is a lancing device with an automatic cocking feature. The automatically cocking lancing device utilizes a firing burton loaded with a firing button spring and a drive spring connecting the firing button to a plunger. As the user presses the firing burton and compresses the firing burton spring, the user also moves the plunger until the plunger engages a latching mechanism. The latching mechanism holds the plunger in a latched position, and, as the user continues pressing the firing button, the user compresses the drive spring connected to the plunger. Before firing, the drive spring is compressed enough such that the biasing force of the drive spring is sufficient to cause the plunger to strike and drive a lancet into the user's finger. At that point, the pressing of the firing button causes the lancing device to fife. The plunger unlatches and drives the lancet into the user's finger under the biasing force of the drive spring.

Abstract: The present invention relates to organic polyisocyanates which have a content of unblocked and blocked isocyanate groups (calculated as NCO) of 5 to 20 wt.%, preferably 7 to 15 wt.%, wherein at least 95%, preferably 100%, of the isocyanate groups are present in blocked form and wherein the blocking agent containsA) 30 to 70 equivalent-% of diisopropylamine,B) 30 to 70 equivalent-% of at least one other blocking agent selected from CH-acidic esters and 1,2,4-triazole andC) 0 to 20 equivalent-% of blocking agents other than those set forth in A) and B),wherein the percentages of A), B) and C) add up to 100.The present invention also relates to a process for the production of these organic polyisocyanates and their use as crosslinking agents for organic polyhydroxyl compounds in polyurethane coating compositions.