Patents Assigned to Miles Inc.
  • Patent number: 5349082
    Abstract: Disclosed herein is a process for recovering toluene diisocyanate (TDI) from a TDI residue solution, comprising mixing the residue solution with a polyisocyanate consisting essentially of methylenediphenyl diisocyanate (MDI) or MDI in combination with its higher ring oligomer, followed by heating the resulting mixture over a temperature range of 130.degree. to 250.degree. C. for a period of time sufficient to remove free TDI and thermally splittable TDI generated from equilibration of the TDI residue with MDI or the MDI oligomer by either a batch or continuous process.
    Type: Grant
    Filed: March 19, 1993
    Date of Patent: September 20, 1994
    Assignee: Miles Inc.
    Inventors: William E. Slack, Kenneth L. Dunlap, Larry W. Arndt, Louis Renbaum
  • Patent number: 5348745
    Abstract: The invention discloses an aqueous granulating solution containing sodium, potassium or mixed sodium potassium salt of an edible organic acid selected from the group consisting of citric, malic, tartaric and fumaric acid and optionally containing sodium or potassium bicarbonate. The granulating solution is especially useful for granulating finely divided solids including acetaminophen, ketoprofen or calcium carbonate. The resulting granulate may be used to prepare a swallow tablet or mixed with an edible organic acid and the mixture tableted to provide an effervescent tablet without resorting to controlled reaction or special handling techniques.
    Type: Grant
    Filed: May 5, 1992
    Date of Patent: September 20, 1994
    Assignee: Miles Inc.
    Inventor: Lawrence J. Daher
  • Patent number: 5348855
    Abstract: A method for detecting (i) one or more microorganisms or (ii) nucleic acid sequences from a prokaryotic source or an eukaroytic source in an unpurified nucleic acid-containing test sample comprising(a) labeling the nucleic acids in the test sample,(b) contacting, under hybridization conditions, the labeled hybridizable nucleic acid and one or more immobilized hybridizable nucleic acid probes comprising (i) one or more known microorganisms or (ii) sequences from eukaroytic or prokaryotic sources, to form hybridized labeled nucleic acids, and(d) assaying for the hybridized nucleic acids by detecting the label. The method can be used to detect genetic disorders, e.g., sickle-cell anemia.
    Type: Grant
    Filed: October 4, 1991
    Date of Patent: September 20, 1994
    Assignee: Miles Inc.
    Inventors: Nanibhushan Dattagupta, Peter M. M. Rae, Daniel U. Rabin, Edward D. Huguenel
  • Patent number: 5346981
    Abstract: This invention relates to radiopaque polyurethane compositions that are reaction products of(a) cycloaliphatic diisocyanates;(b) at least one polyester, polycarbonate, and/or polyester carbonate diol having a molecular weight of from about 1000 to about 6000;(c) an isocyanate-reactive bromine-containing aromatic chain extender; and(d) optionally, a catalyst;wherein the quantity of component (c) is such that the amount of bromine in the polyurethane composition is from 10 to 35% by weight, and wherein the components are reacted at an isocyanate index of from 0.95 to 1.2.
    Type: Grant
    Filed: January 13, 1993
    Date of Patent: September 13, 1994
    Assignee: Miles Inc.
    Inventors: Ashok M. Sarpeshkar, Peter H. Markusch
  • Patent number: 5345870
    Abstract: A "direct-to-press" diffusion transfer reversal positive lithographic printing plate and method for exposing same. The "direct-to-press" printing plate provides an ink receiving image area and at least one ink repelling mechanical gripper area. Additionally, the plate can include at least one ink repelling border area. The "direct-to-press" printing plate exposure method provides direct exposure of a diffusion transfer reversal photo-lithographic recording substrate by a laser imagesetter using a method of controlling both the imagesetter recording beam and the movement of the recording substrate by the imagesetter. The imagesetter improvements allow exposure of a recording substrate in regions which could not previously be exposed by an imagesetter, providing a positive lithographic printing plate which requires no additional stripping or exposure steps after imagesetter recording.
    Type: Grant
    Filed: February 10, 1993
    Date of Patent: September 13, 1994
    Assignee: Miles Inc.
    Inventors: Dwayne E. Bailey, Kenneth L. Langlais
  • Patent number: 5342905
    Abstract: A two step process for the preparation of an ester group-containing polyether sulfone is disclosed. In the first step a dihalogenodiphenyl sulfone is reacted with excess amount of an aromatic dihydroxy compound and in a second step the reaction product is reacted with a dicarboxylic acid derivative. The excess amount of the aromatic dihydroxy compound is that amount which is sufficient to react with said derivative to form the corresponding ester. The process of the invention is characterized by its economics and good yield and by the high purity of the product. The thus produced polyether sulfone is useful as a thermoplastic resin and as a reactant in the melt blending process for the preparation of block copolymers.
    Type: Grant
    Filed: January 29, 1993
    Date of Patent: August 30, 1994
    Assignee: Miles Inc.
    Inventors: Robert J. Kumpf, Aaron D. Meltzer, Harald Pielartzik
  • Patent number: 5342855
    Abstract: This invention relates to a process for the preparation of stable dispersions of hydroxyl-containing polyhydrazodicarbonamides in a hydroxyl-containing compound. The dispersions are prepared by the reaction of organic isocyanates, isocyanate-reactive compounds having a molecular weight in the range from 400 to 10,000, relatively low molecular weight isocyanate-reactive compounds, and hydrazines or hydrazides. This invention further relates to the dispersions prepared by said process, the use of the dispersions to prepare polyurethane foams having exceptional hardness, and the foams prepared thereby.
    Type: Grant
    Filed: January 23, 1990
    Date of Patent: August 30, 1994
    Assignee: Miles Inc.
    Inventors: Michael A. Lucarelli, Richard E. Keegan, Mark A. Koshute, Hans-Albrecht Freitag, Geza Avar
  • Patent number: 5332763
    Abstract: The present invention relates to an improved process for preparing foams comprising reacting polyisocyanates with an in situ produced stable low solids dispersion of polyureas and/or polyhydrazodicarbonamides in a hydroxyl-group-containing material as a dispersing agent by reacting:(a) organic polyisocyanates with(b) a member selected from the group consisting of (i) polyamines containing primary and/or secondary amino groups, (ii) hydrazines, (iii) hydrazides, or (iv) mixtures thereof, in(c) said hydroxyl-group-containing material.
    Type: Grant
    Filed: July 10, 1992
    Date of Patent: July 26, 1994
    Assignee: Miles Inc.
    Inventor: Mark A. Koshute
  • Patent number: 5330976
    Abstract: Nikkomycin compounds have been found to be orally or parenterally effective as anti-fungals in animals. They may be used alone or, preferably, in combination with azole antimycotics for a synergistic anti-fungal effect.
    Type: Grant
    Filed: February 11, 1993
    Date of Patent: July 19, 1994
    Assignee: Miles Inc.
    Inventors: Richard F. Hector, Klaus Schaller, Heinrich F. Moeschler, Manfred Plempel
  • Patent number: 5328830
    Abstract: An assay for detecting molecules and compounds which specifically bind to sites which regulate cellular potassium channels, for use, inter alia, as a method for identifying drugs with activity specific for modulating K.sup.+ channels.
    Type: Grant
    Filed: September 8, 1992
    Date of Patent: July 12, 1994
    Assignee: Miles Inc.
    Inventors: Ronald A. Janis, Frederick J. Hoffman, Jr.
  • Patent number: 5328977
    Abstract: An improvement in the process of preparing nylon-1 by the polymerization of isocyanates is disclosed. Accordingly, the improvement comprising using in the process a catalyst conforming to(X).sub.n Me(OR).sub.mwhere Me is titanium or zirconium, X is chlorine or bromine atom, R is an aliphatic radical having 1 to 20 carbon atoms and where the sum of m=n is 4 with the proviso that where Me is titanium n is 1 or 2, and where Me is zirconium n is 1-4.
    Type: Grant
    Filed: November 12, 1993
    Date of Patent: July 12, 1994
    Assignee: Miles Inc.
    Inventors: Aaron D. Meltzer, Gary W. Munko, Harald Pielartzik
  • Patent number: 5328850
    Abstract: The present test device provides a merocyanine protein error indicator compound. Merocyanine compounds are a new class of protein error indicators, providing an analytical tool useful in the detection of protein in a sample.
    Type: Grant
    Filed: December 14, 1992
    Date of Patent: July 12, 1994
    Assignee: Miles Inc.
    Inventor: Paul F. Corey
  • Patent number: 5326829
    Abstract: Disclosed herein is a method of preparing an activated polyether polyol by reacting an aminoalcohol with a polyether terminated with a leaving group.
    Type: Grant
    Filed: October 7, 1992
    Date of Patent: July 5, 1994
    Assignee: Miles Inc.
    Inventors: William E. Slack, Rick L. Adkins
  • Patent number: 5325580
    Abstract: A process is disclosed for the production of metal sheets enamelled with two layers, wherein the sheet is coated, before shaping, with a polymer suspension. The sheet is then dried and shaped, and optionally is coated with an enamel frit. The sheet is then fired at a temperature of 560 to 850 degrees C. The binder in the polymer suspension is preferably a material which burns completely at melting and stoving temperature.
    Type: Grant
    Filed: February 5, 1993
    Date of Patent: July 5, 1994
    Assignees: Bayer Aktiengesellschaft, Miles Inc.
    Inventors: Hermann Gruber, Eberhard Arning, Hans Hoffmann, Alain Viquesnel, Paul Zybell, Dieter Margotte, Keith Foster
  • Patent number: 5326707
    Abstract: A composition, test device and method of determining the presence or concentration of proteins, such as albumin, in a liquid test sample, such as urine. The test device includes a test pad with a carrier matrix incorporating a indicator reagent composition capable of interacting with proteins to produce a detectable response. The indicator reagent composition includes an indicator dye that is capable of interacting with albumin and undergoing a detectable color transition; a buffer; a hydrophobic polymeric compound having the general structural formula: ##STR1## wherein A is ##STR2## and PO is an oxypropylene unit, EO is an oxyethylene unit, y is a number in the range of 0 to about 20, z is a number in the range of 0 to about 20, the sum y+z is a number in the range of about 2 to about 20, and R.sub.2 and R.sub.3 are selected, independently, from the group consisting of hydrogen, an alkyl group, an aralkyl group, and an aryl group;R.sub.
    Type: Grant
    Filed: November 29, 1991
    Date of Patent: July 5, 1994
    Assignee: Miles Inc.
    Inventors: Gunter Franke, Michael Salvati, Ronald G. Sommer
  • Patent number: 5326872
    Abstract: This invention relates to a process for preparing asymmetric isoindoline pigments of the formula ##STR1## in which R.sup.1 is an electron-withdrawing group, R.sup.2 and R.sup.3 are independently hydrogen, alkyl, or aryl, and R.sup.4 R.sup.5 R.sup.6 and R.sup.7 are independently hydrogen, halogen, alkyl, alkoxy, or aryloxy. The process employs an initial reaction of a 1,2-dicyanobenzene with an alcohol in an organic medium in the presence of a base. The resultant imino-isoindoline intermediate composition reacts without isolation with a cyanomethylene compound NC--CH.sub.2 -R.sup.1 to form a partly condensed product that is then condensed, optionally without isolation, in the presence of water with barbituric acid or a derivative thereof to form the asymmetric isoindoline pigment.
    Type: Grant
    Filed: March 6, 1992
    Date of Patent: July 5, 1994
    Assignees: Miles Inc., Bayer Aktiengesellschaft
    Inventors: Barbara J. Wagner, Bernd Kaletta
  • Patent number: 5326697
    Abstract: A composition, test device and method of determining the presence or concentration of ketone bodies, and specifically D-.beta.-hydroxybutyrate, in a test sample are disclosed. The test device includes a test pad comprising a suitable carrier matrix incorporating an indicator reagent composition capable of interacting with D-.beta.-hydroxybutyrate to produce a detectable or measurable response. In addition, a new and improved indicator reagent composition, comprising a) an indicator dye that is responsive to thiols, such as a substituted isobenzothiazolone, Ellman's reagent or a derivative of Ellman's reagent: b) D-.beta.-hydroxybutyrate dehydrogenase; c) lipoamide dehydrogenase; d) D,L-lipoamide; and e) nicotinamide adenine dinucleotide, is incorporated into the carrier matrix to provide an accurate and sensitive assay of a test sample for D-.beta.-hydroxybutyrate (DHBA) in particular, and for ketone bodies in general.
    Type: Grant
    Filed: September 8, 1992
    Date of Patent: July 5, 1994
    Assignee: Miles Inc.
    Inventor: Thomas A. Magers
  • Patent number: 5324773
    Abstract: Products made using the RIM process where the reaction mixture contains an acidic release agent have improved green strength when the reaction mixture also contains a peralkylated polyalkylene polyamine.
    Type: Grant
    Filed: December 1, 1993
    Date of Patent: June 28, 1994
    Assignee: Miles Inc.
    Inventors: Robson Mafoti, David D. Steppan, Michael F. Hurley, Albert Magnotta
  • Patent number: 5324446
    Abstract: Disclosed herein are compositions comprising an effective combination of an amine terminated polyether and a urea compound, and melamine/polyol blends containing the same.
    Type: Grant
    Filed: September 13, 1991
    Date of Patent: June 28, 1994
    Assignee: Miles Inc.
    Inventor: Edmund J. Madaj
  • Patent number: 5324903
    Abstract: An arm switch assembly, for an electrical instrument having a casing and electrical contacts, comprises an elongated insulating body member with a conductive member moved into engagement with and disengagement from the electrical contacts in response to operation of a camming mechanism. The camming mechanism is slidably mounted to the casing and has a cam surface movable between first and second positions. The insulating body member includes first and second ends, and a lateral arm connected to the first end permits the insulating body member to pivot relative to the casing. A cam follower is connected to and extends laterally from the second end of the insulating body member. The cam follower engages the cam surface in the first position and disengages the cam surface in the second position. The conductive member is mounted on the second end of the insulating body member and is positioned adjacent to the electrical contacts.
    Type: Grant
    Filed: December 24, 1992
    Date of Patent: June 28, 1994
    Assignee: Miles Inc.
    Inventor: Joseph L. Moulton