Patents Assigned to Milestone s.r.l.
  • Publication number: 20090191533
    Abstract: A process for preserving tissues is described which comprises transferring the tissues in a container and evacuating the container.
    Type: Application
    Filed: December 9, 2008
    Publication date: July 30, 2009
    Applicant: Milestone S.r.l.
    Inventor: Giovanni Bussolati
  • Publication number: 20080318265
    Abstract: This invention relates to a quality control method for improving histoprocessing, as well as a device for measuring the thickness of an organic tissue sample suited for use in the method.
    Type: Application
    Filed: June 24, 2008
    Publication date: December 25, 2008
    Applicant: Milestone S.r.l.
    Inventor: Francesco Visinoni
  • Patent number: 7075045
    Abstract: A system and for automatic histoprocessing of organic tissue specimens using microwaves, two cavities and automatic fluid and specimen transfer between the two cavities.
    Type: Grant
    Filed: February 25, 2005
    Date of Patent: July 11, 2006
    Assignee: Milestone S.r.l.
    Inventor: Franco Visinoni
  • Patent number: 6949227
    Abstract: A devise for carrying out chemical reactions and processes in high-frequency fields, comprises a high-frequency chamber 2 for irradiating a solid, liquid or gaseous substance while under pressure with at least one radiation source and a reactor for exposing to a high-frequency field. The reactor being connectively coupled to the upper wall 4 of the high-frequency chamber 2 through a sealable connection 3. Rail elements 5 are provided around the reactor, and configured to form a pressure-resistant cage. The rail elements 5 each have a guide 11 for holding a crown-shaped holder 12. The holder 12 is fixed in its position by the guides 11 of the rail elements 5. Multiple reaction chambers can be incorporated as a batch reactor system.
    Type: Grant
    Filed: March 27, 2001
    Date of Patent: September 27, 2005
    Assignee: Milestone S.r.l.
    Inventors: Werner Lautenschläger, Bernd Ondruschka, Matthias Nüchter
  • Publication number: 20050074422
    Abstract: The present invention describes a fixative composition comprising ethanol, water, 1,2-propanediol, polyvinyl alcohol and an effective amount of at least one monomeric polyhydroxy compound. The fixative composition may be used in histopathology, cytology and immunohistochemistry.
    Type: Application
    Filed: July 16, 2003
    Publication date: April 7, 2005
    Applicant: Milestone S.r.l.
    Inventor: Francesco Visinoni
  • Patent number: 6717119
    Abstract: A magazine-type sample rotation body (7) is arranged in a high frequency chamber (5) so that it rotates away from the horizontal, the body (7) accommodating, in fixed location, reactor blocks (10) that are sealed or sealable from fluids such that fluids contained in sample vessels in the reactor blocks can be mixed before, during and after high frequency exposure because of the rotational movement of the sample rotation body.
    Type: Grant
    Filed: January 18, 2002
    Date of Patent: April 6, 2004
    Assignee: Milestone S.r.l.
    Inventors: Bernd Ondruschka, Matthias Nüchter, Werner Lautenschläger
  • Publication number: 20030194352
    Abstract: The invention relates to a device 51 for closing a plurality of digestion vessels 1 the openings of which are in each case covered by a cover 3, comprising a plurality of positioning spaces 53 for the digestion vessels, the positioning spaces 53 being able to be distributed in a circumferential row R1 and being accessible from outside, and a plurality of closing devices 73 for pressing the covers 3 against the vessels. In order to improve the capacity of the device 51 with regard to the number of digestion vessels 1 further inner positioning spaces 53 are arranged to be offset inwardly with respect to said positioning spaces 53.
    Type: Application
    Filed: February 20, 2003
    Publication date: October 16, 2003
    Applicant: MILESTONE S.R.L.
    Inventor: Werner Lautenschlager
  • Publication number: 20030127313
    Abstract: A pot-like digestion vessel (1), which is closed by a cover (3), is provided with adjustable automatic internal pressure relief by means of a pressure applying plunger (6) which is held in a screwing part (7) via a resilient pressure generating mans (8) to press against the cover (3). In another embodiment the plunger (6) holds a valve body (33) in an outlet channel (31) which extends through the cover (3).
    Type: Application
    Filed: December 12, 2002
    Publication date: July 10, 2003
    Applicant: MILESTONE S.r.l.
    Inventor: Werner Lautenschlager
  • Publication number: 20030127311
    Abstract: A device 5 for closing pot-like digestion vessel 1 whose opening is covered by a cover 3, has a pressure-applying plunger 6, a screwing part 7 arranged co-axially with the pressure applying plunger 6 and a resilient pressure-generating means 8 arranged between the pressure-applying plunger 6 and the screwing part. The screwing part and the pressure-applying plunger 6 fit round one another in a socketed arrangement.
    Type: Application
    Filed: March 15, 2002
    Publication date: July 10, 2003
    Applicant: MILESTONE S.R.L.
    Inventor: Werner Lautenschlager
  • Patent number: 6455317
    Abstract: A system and method for controlling a microwave heated chemical process is disclosed. Time varying concentrations of some chemical substances within fumes in the microwave oven are monitored to detect concentration variations for which responses are known. Responses to the detected variations are initiated to control the chemical process without terminating the process. Examples of responses include varying microwave radiation energy, initiating safety systems, increased venting of the microwave oven, and so forth.
    Type: Grant
    Filed: March 6, 2000
    Date of Patent: September 24, 2002
    Assignee: Milestone s.r.L.
    Inventor: Werner Lautenschlager
  • Patent number: 6242723
    Abstract: Disclosed is an apparatus for use within a microwave radiation field which enables the operator to perform successively a plurality of chemical or physical processes while the apparatus remains in the microwave cavity. The apparatus according to the invention can be used to perform a total microwave solvent extraction including the steps of drying, extraction, filtration, and concentration. Other examples of processes, which are carried out with this apparatus are digestions, hydrolyses, separations, agitations, and precipitations. The apparatus is constructed from a container having an inside vessel. The container and the inside vessel have a substantially closed volume there between. The container and the inside vessel are in fluid communication through a glass fiber filter disposed at approximately the bottom of the inside vessel.
    Type: Grant
    Filed: July 29, 1999
    Date of Patent: June 5, 2001
    Assignee: Milestone s.r.l.
    Inventor: Werner Lautenschlager
  • Patent number: 6054695
    Abstract: Disclosed is an apparatus for condensing vapors for use inside a microwave cavity. The cooling in the apparatus is provided by gas flow ventilation with air being the most convenient gas for use as a coolant. The apparatus has two ports, one port for connecting with a sample vessel and a second port for connecting with a pressure control device. The pressure control device has valves for operating a vacuum line and a feeding line. The disclosed apparatus enables a plurality of chemical digestion reactions, reflux reactions and dehydrations to be carried out simultaneously or sequentially within a microwave radiation field.
    Type: Grant
    Filed: July 30, 1998
    Date of Patent: April 25, 2000
    Assignee: Milestone S.r.l.
    Inventor: Werner Lautenschlager
  • Patent number: 6042874
    Abstract: This invention relates to the processing of organic tissues to prepare them for further investigation such as by light microscopy, electron microscopy, microwave staining, immunostaining, decalcification, hybridisation etc.The present invention discloses a process for processing organic tissue, which comprises the steps of fixing an organic sample to be processed, dehydrating and clearing the sample and subsequently infiltrating and embedding the sample in a supporting medium to prepare it for further examination wherein the steps of dehydrating and clearing are carried out simultaneously by applying a mixture of a dehydration agent and an essentially lipophilic agent simultaneously to the sample.
    Type: Grant
    Filed: November 23, 1998
    Date of Patent: March 28, 2000
    Assignee: Milestone S.r.l.
    Inventors: Francesco Visinoni, Werner Lautenschlager
  • Patent number: 6033912
    Abstract: A system and method for controlling a microwave heated chemical process is disclosed. Time varying concentrations of some chemical substances within fumes in the microwave oven are monitored to detect concentration variations for which responses are known. Responses to the detected variations are initiated to control the chemical process without terminating the process. Examples of responses include varying microwave radiation energy, initiating safety systems, increased venting of the microwave oven, and so forth.
    Type: Grant
    Filed: November 13, 1997
    Date of Patent: March 7, 2000
    Assignee: Milestone S.r.l.
    Inventor: Werner Lautenschlager