Patents Assigned to Millipore Corporation
  • Patent number: 11410752
    Abstract: A system, software application and method that allows a customer to protect their proprietary database of compounds and substances while utilizing a retrosynthesis software application is disclosed. The customer's proprietary database is encrypted prior to being provided to the retrosynthesis system. This encrypted is performed using a hash and optionally a salt. The retrosynthesis algorithm then creates synthons as is traditionally done. However, after their creation, the synthons are hashed so that they may be compared to the entries in the customer's proprietary database. In this way, the actual contents of the customer's database are never made available to the retrosynthesis system or software application.
    Type: Grant
    Filed: July 30, 2019
    Date of Patent: August 9, 2022
    Assignees: EMD Millipore Corporation, Sigma-Aldrich Co., LLC
    Inventors: Sarah Trice, Tim Knehans, Maciej Wojcikowski
  • Patent number: 11358102
    Abstract: The embodiments described herein relate to agarose ultrafiltration membrane composites and methods for making and using the same.
    Type: Grant
    Filed: July 1, 2020
    Date of Patent: June 14, 2022
    Assignee: EMD Millipore Corporation
    Inventors: Jad Jaber, Wilson Moya, Mikhail Kozlov
  • Publication number: 20220170073
    Abstract: The present disclosure is directed to methods and/or uses of oligonucleotide conjugates for assays and flow cytometry detections and related systems and/or kits. Certain methods are directed to a method for detecting one or more biological targets of a sample in a detection assay, comprising: providing a molecular probe, comprising a binding moiety and an oligonucleotide sequence, to a sample comprising one or more biological targets; binding the one or more biological targets with the binding moiety; providing a detectable component to the sample, wherein the detectable component comprises a signal generating moiety conjugated to an oligonucleotide sequence complementary to the oligonucleotide sequence of the molecular probe; hydridizing the oligonucleotide sequence of the target-bound molecular probe to the detectable component; and detecting a signal generated from the hydridized detectable component. Various other embodiments, applications etc. are disclosed herein.
    Type: Application
    Filed: July 7, 2021
    Publication date: June 2, 2022
    Applicants: The University of Chicago, EMD Millipore Corporation
    Inventors: David A. Schwartz, Jimmy Williams, Xinfang Zhao, Chunfang Zhao, William B. Busa, Stephen J. Kron, Amy Catherine Flor
  • Patent number: 11305271
    Abstract: Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of biomolecules, such as monoclonal antibodies (mAbs).
    Type: Grant
    Filed: August 15, 2017
    Date of Patent: April 19, 2022
    Assignee: EMD Millipore Corporation
    Inventors: David Yavorsky, John Amara, Joaquin Umana, William Cataldo, Mikhail Kozlov, Matthew Stone
  • Patent number: 11278827
    Abstract: Methods of filtering a liquid feed are disclosed. In one version, the method comprises passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers without recirculation through the SPTFF system. In another version, the method of filtering a liquid feed, comprises passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: March 22, 2022
    Assignee: EMD Millipore Corporation
    Inventors: Jonathan Steen, Mikhail Kozlov, Herbert Lutz, Joseph Parrella, Elizabeth M. Goodrich, Bala Raghunath
  • Patent number: 11236125
    Abstract: The present invention refers to new species of an ion exchange adsorber which is suitable for the separation of host cell proteins (HCPs), antibody fragments and low molecular weight substances from solutions containing antibodies. The invention especially refers to a process for purifying biological samples by separating biomolecules of interest and impurities, comprising steps of contacting a sample with said chromatography media consisting of fibers, said fibers having imparted thereon functionality enabling ion exchange chromatography and/or hydrophobic interaction.
    Type: Grant
    Filed: September 5, 2019
    Date of Patent: February 1, 2022
    Assignee: EMD Millipore Corporation
    Inventors: Matthew T. Stone, John P. Amara
  • Patent number: 11192070
    Abstract: A method of integrity testing a porous material is disclosed, providing a porous material suitable for filtration to be tested, said porous material having a first surface and a second surface; wetting said porous material with a wetting liquid; providing a gas stream comprising at least first and second gases humidified with said wetting liquid below the saturation vapor pressure of said wetting liquid and wherein said humidified gas stream has a humidity of 50-99%; introducing said gas stream to said first surface of said porous material; causing said first and second gases to flow through said porous material; measuring the concentration of at least one of said first and second gases in the permeate stream exiting said second surface of said porous material; and comparing the measured concentration to a predetermined concentration.
    Type: Grant
    Filed: April 29, 2020
    Date of Patent: December 7, 2021
    Assignee: EMD Millipore Corporation
    Inventors: Salvatore Giglia, David Nhiem
  • Patent number: 11179677
    Abstract: A sealing case for a filtration cassette that reliably prevents leaks after assembly and installation into a filtration system. The sealing case fits on the filtration cassette and provides a fluid-tight seal between the sealing case and around at least one port in the filtration cassette when installed in a filtration system. The sealing case may comprise two halves that mate together, and each half may be identical. The internal surface of the sealing case is flat or substantially flat.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: November 23, 2021
    Assignee: EMD Millipore Corporation
    Inventor: Brian Hillier
  • Patent number: 11154821
    Abstract: A composite liquid filtration platform including a composite filtration medium featuring an electrospun polymeric nanofiber layer collected on a porous membrane. When in use, the porous membrane acts as a prefilter used upstream from the polymeric nanofiber layer to remove particles from a liquid stream flowing through the composite filtration structure. The nanofiber layer, positioned downstream from the porous membrane, is used as the retentive layer for critical filtration to provide biosafety assurance, and is responsible for capturing microorganisms like bacteria, mycoplasma or viruses. The composite liquid filtration platform provided herein exhibits permeability advantages over conventional porous membranes or nanofiber mats spun on coarse non-wovens.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: October 26, 2021
    Assignee: EMD Millipore Corporation
    Inventors: Onur Y. Kas, Mikhail Kozlov, Gabriel Tkacik, David Nhiem, Philip Goddard, Sherry A. Leon
  • Patent number: 11155403
    Abstract: A needle protector, having a flexible material, a pocket defining an internal volume, a wrapping strap having a plurality of holes, and a main body disposed between the pocket and the wrapping strap; at least one rigid body or cylinder for placement within the internal volume; and; a pin for placement within one of the plurality of holes, wherein the pin is capable of releasabiy locking the pocket and the main body when the wrapping strap is wrapped around the pocket and the main body.
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: October 26, 2021
    Assignee: EMD Millipore Corporation
    Inventors: John Gugliotti, Michael Gugliotti
  • Patent number: 11110684
    Abstract: A multilayered film for biocontainers, an abrasion-resistant substrate attached to the interior or the exterior side of the film wherein the substrate is one of a polymeric woven fibrous material or a polymeric non-woven fibrous material, a woven fibrous material or a non-woven fibrous material having metal fibers, a woven fibrous material or a non-woven fibrous material having glass fibers, or a woven fibrous material or a non-woven fibrous material having carbon fibers; a polymer backing to attach the substrate to the film, including one of polyolefins, polyurethanes and nylons; an outer protective layer disposed on the outside of the substrate to encapsulate the substrate; and a gas impermeable layer that includes ethylene vinyl alcohol disposed intermediate to the substrate and the outer protective layer.
    Type: Grant
    Filed: May 5, 2020
    Date of Patent: September 7, 2021
    Assignee: EMD Millipore Corporation
    Inventors: David DeCoste, Joseph Cianciolo, Michael Furbush, John Saragosa
  • Patent number: 11110373
    Abstract: The invention concerns an installation for treating biological liquid by chromatography, extending in a longitudinal direction and comprising a supply valve (20b), a supply pump (30) downstream of the valve, instrument members downstream of the pump among which are at least one distribution valve (81a-c, 82a-c, 83a-c) and at least one device (78a-c, 85a-c, 86a-c) for measuring a physico-chemical parameter of the liquid, at least one chromatography column (99a-c) downstream of the instrument members and of the pipes connecting the valve, the pump, the instrument members and the column, instrument members being associated with the chromatography column and each mounted on at least one dedicated control and actuation platform (80a-c), which extends in a vertical direction relative to the generally longitudinal direction of extension of said installation, and which are disposed substantially above each other on said dedicated control and actuation platform.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: September 7, 2021
    Assignee: EMD Millipore Corporation
    Inventors: Sebastien Cirou, Christine Abouayad El Idrissi
  • Patent number: 11104491
    Abstract: A container and a container engaging member. The container engaging member may include a sample holder or reservoir, a filtration element and collar. In the assembled condition, the sample holder or reservoir is upstream of the filtration element, the container is downstream of the filtration element, and the sample holder or reservoir is attached to the container. The container engagement member is engageable and disengageable from the bottle or container in a quick attach, quick release manner, such as with only a 90 degree, ΒΌ turn. A tactile and/or audible indication that the engagement is complete is provided.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: August 31, 2021
    Assignee: EMD Millipore Corporation
    Inventors: Chris Scott, Kurt Greenizen, Paul Sydlowski, Jay Doyle
  • Patent number: 11092272
    Abstract: A clamp device for a barb member having a barbed region for disposing within an end of a flexible tube having an outer surface. The clamp device includes a flexible member including a body having a plurality of finger members compressible between a first resting position and a second clamping position; at least one of the flexible finger members having a radially inwardly extending tooth; the body having a through bore and an outer surface comprising threads; the flexible member being slidable over the barbed region and the outer surface of the flexible tube; a compression member having a body having a through bore and an inner surface including threads; the compression member being slidable over the flexible member; wherein upon threadingly engaging the compression member with the flexible member, the compression member compresses the finger member against the barb member.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: August 17, 2021
    Assignee: EMD Millipore Corporation
    Inventor: Martin Morrissey
  • Patent number: 11084851
    Abstract: The present invention relates to chromatography ligands having improved caustic stability, e.g., ligands based on immunoglobulin-binding proteins such as, Staphylococcal protein A, as well as methods of making and using such ligands.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: August 10, 2021
    Assignee: EMD MILLIPORE CORPORATION
    Inventors: Nanying Bian, Neil Soice, Shari Spector, Kara Levine
  • Patent number: 11079896
    Abstract: Instrumenting or modeling a bio-manufacturing process is disclosed. A data store holds information regarding one or more bio-manufacturing processes. For each process, the data store information includes workflow steps and per step indications of required equipment, services and consumables according to best practice and/or experts. A videographic user interface enables user interactive input regarding a subject bio-manufacturing process from the data store. The user-interface presents a model representation of deployment of the subject bio-manufacturing process. The user interactively navigates and makes selections in the displayed model representation. The user selections include certain bio-manufacturing products, equipment and services from an image database. The images from the image database enable the views of the model representation to appear true to life demonstrating equipment/product layout and physical equipment/computer connections used in the subject bio-manufacturing process.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: August 3, 2021
    Assignee: EMD MILLIPORE CORPORATION
    Inventors: Laurelle Sciola, Paul John Ricketts, Susan Colt
  • Patent number: 11040310
    Abstract: The present invention provides, in various embodiments, hybrid single-pass tangential flow filtration assemblies, disposable single-pass tangential flow filtration assemblies, scalable single-pass tangential flow filtration assemblies and adaptable modular single-pass tangential flow filtration assemblies. In other embodiments, the invention relates to processes for recovering proteins from the surface of a filtration membrane in a single-pass tangential flow filtration assembly and for cleaning a tangential flow filtration assembly. In additional embodiments, the invention provides methods of increasing the processing capacity of a single-pass tangential flow filtration assembly.
    Type: Grant
    Filed: December 3, 2018
    Date of Patent: June 22, 2021
    Assignee: EMD Millipore Corporation
    Inventors: Herbert Lutz, Joseph Parrella, Bala Raghunath
  • Patent number: 11033839
    Abstract: A method of filtering a liquid feed is described, comprising passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers. A method of filtering a liquid feed is also described comprising passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods of the invention can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.
    Type: Grant
    Filed: December 3, 2018
    Date of Patent: June 15, 2021
    Assignee: EMD Millipore Corporation
    Inventors: Jonathan Steen, Mikhail Kozlov, Herbert Lutz, Joseph Parrella, Elizabeth M. Goodrich, Bala Raghunath
  • Patent number: D928947
    Type: Grant
    Filed: September 10, 2018
    Date of Patent: August 24, 2021
    Assignee: EMD Millipore Corporation
    Inventor: John Gugliotti
  • Patent number: D946167
    Type: Grant
    Filed: October 16, 2020
    Date of Patent: March 15, 2022
    Assignee: EMD Millipore Corporation
    Inventors: Paul Sydlowski, John Doyle