Patents Assigned to Millipore Corporation
  • Patent number: 10399039
    Abstract: The present invention provides compact spiral-wound filter elements having cassette-like performance. The invention further provides filtration systems (e.g., TFF systems) and processes (e.g., SPTFF processes) employing compact spiral-wound filter elements having cassette-like performance.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: September 3, 2019
    Assignee: EMD Millipore Corporation
    Inventor: Jonathan Steen
  • Publication number: 20190224626
    Abstract: A scaling tool for replicating filtration characteristics of a large-scale filtration device, the scaling tool comprising a housing having a fluid inlet and a fluid outlet, and a filter receiving region in fluid communication with the fluid inlet and the fluid outlet and configured to contain a membrane comprising one or more pleats, the filter receiving region being defined by a rigid wall framework configured to hold the one or more pleats of the membrane and compress the pleats in an amount effective to replicate the filtration performance of the large-scale filtration device. Also disclosed is a methodology for configuring a filter receiving region in a scaling tool.
    Type: Application
    Filed: August 23, 2017
    Publication date: July 25, 2019
    Applicant: EMD Millipore Corporation
    Inventors: Songhua Liu, Michael Lynch, Ryan Sylvia, Joseph Almasian, Salvatore Giglia, Luc Messier
  • Publication number: 20190224600
    Abstract: Treatment methods for reduction of (1?3)-?-D-glucan leachables from cellulose-containing filter materials are described.
    Type: Application
    Filed: October 23, 2017
    Publication date: July 25, 2019
    Applicant: EMD Millipore Corporation
    Inventors: Akshat Gupta, Dana Kinzlmaier, Kara Pizzelli, Elizabeth Goodrich
  • Patent number: 10350518
    Abstract: Methods of filtering a liquid feed are disclosed. In one version, the method comprises passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers without recirculation through the SPTFF system. In another version, the method of filtering a liquid feed, comprises passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: July 16, 2019
    Assignee: EMD Millipore Corporation
    Inventors: Jonathan Steen, Mikhail Kozlov, Herbert Lutz, Joseph Parrella, Elizabeth M. Goodrich, Bala Raghunath
  • Patent number: 10328393
    Abstract: A laminate is provided comprising at least one polysulfone and/or polyethersulfone porous membrane heat bonded to a polyvinylidene fluoride substrate.
    Type: Grant
    Filed: May 15, 2008
    Date of Patent: June 25, 2019
    Assignee: EMD Millipore Corporation
    Inventor: Kevin Rautio
  • Patent number: 10322376
    Abstract: A laminate is provided comprising at least one polysulfone and/or polyethersulfone porous membrane heat bonded to a polyvinylidene fluoride substrate.
    Type: Grant
    Filed: November 15, 2016
    Date of Patent: June 18, 2019
    Assignee: EMD Millipore Corporation
    Inventor: Kevin Rautio
  • Patent number: 10287314
    Abstract: The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal of certain undesirable impurities without adversely effecting the yield of the desired protein product.
    Type: Grant
    Filed: June 23, 2015
    Date of Patent: May 14, 2019
    Assignee: EMD Millipore Corporation
    Inventors: Nanying Bian, Christopher Gillespie, Matthew T. Stone, Mikhail Kozlov, Jie Chen, Martin Siwak
  • Patent number: 10272639
    Abstract: A biocontainer film enhanced with an abrasion resistant or “cut-proof” substrate. Such substrates can be combined with current biocontainer materials, via various techniques of embedding, coextrusion or laminating, to maintain the cleanliness and low extractables already validated for biotech manufacturing. The substrate of choice may be constructed from materials known to be more resistant to abrasion and sharp razor type cuts or from materials oriented in such a way to prevent puncture to occur. The new substrate must also be flexible to allow for typical folding as demonstrated by current packaging practices. The new substrate may be constructed from materials other than polymers such as metal, glass or carbon or in combination with polymers. A non-constrained pressure test is also disclosed.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: April 30, 2019
    Assignee: EMD Millipore Corporation
    Inventors: David DeCoste, Joseph Cianciolo, Michael Furbush, John Saragosa
  • Patent number: 10272429
    Abstract: In one embodiment, a removable pneumatic connector, comprises a body having a plurality of bores passing through, each bore surrounded by a sealing member on an inner surface of the body. A plurality of gas lines may be placed within a corresponding bore. A vacuum port is disposed on the inner surface of the body, and an outer seal on the inner surface of the body surrounds the sealing members and the vacuum port. A vacuum line may be placed within the vacuum port, and configured to deliver negative pressure to the vacuum port. A vacuum holding area is created in the volume between the outer seal and each of the sealing members when the inner surface of the body is placed against a substrate. When the vacuum line is activated, a vacuum is created within the vacuum holding area, creating a positive seal between the body and the substrate.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: April 30, 2019
    Assignee: EMD Millipore Corporation
    Inventors: Terry Gaige, Andrew Zayac, Paul Sydlowski, Philip Lee
  • Patent number: 10252199
    Abstract: A method for removing retroviruses from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention is disclosed. Retroviruses are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a retrovirus LRV greater than about 6, and the nanofiber(s) has a diameter from about 10 nm to about 100 nm. The filtration medium can be in the form of a fibrous electrospun polymeric nanofiber liquid filtration medium mat.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: April 9, 2019
    Assignee: EMD Millipore Corporation
    Inventors: Onur Y. Kas, Mikhail Kozlov, Wilson Moya, Sherry A. Leon, Philip Goddard, Jibin Hao, Gabriel Tkacik
  • Patent number: 10247312
    Abstract: A disposable device for the sterile transfer of fluids, such as liquids or gases, includes a body, a bore formed through at least a portion of the interior of the body, and a linearly moveable plunger contained within the bore. The body is formed from a rotating section and a stationary section. Partial rotation of the rotating section around a portion of the stationary section and the plunger drives the plunger linearly within the bore, opening and closing the device. The plunger includes at least a first and a second opening, and a fluid channel in the interior of the plunger connecting the first and second openings forming a fluid pathway to downstream components when the device is open. A termination component at one end of the plunger connects to a downstream component. A flange at one end of the body attaches to an upstream component.
    Type: Grant
    Filed: March 28, 2016
    Date of Patent: April 2, 2019
    Assignee: EMD Millipore Corporation
    Inventors: Jeff Hartnett, Alf Lofving, Lars Hultquist, Jan Davidsson, Lennart Myhrberg
  • Patent number: 10233211
    Abstract: The present invention relates to a selectively soluble polymer capable of binding to a desired molecules in an unclarified mixture containing various biological materials and the methods of using such a polymer to purify a molecule from such a mixture. The polymer is soluble in the mixture under a certain set of process conditions such as pH or temperature and/or salt concentration and is rendered insoluble and precipitates out of solution upon a change in the process conditions. The polymer is capable of binding to the desired molecule (protein, polypeptide, etc) and remains capable of binding to that molecule even after the polymer is precipitated out of solution. The precipitate can then be filtered out from the remainder of the stream and the desired biomolecule is recovered such as by elution and further processed.
    Type: Grant
    Filed: July 31, 2013
    Date of Patent: March 19, 2019
    Assignee: EMD Millipore Corporation
    Inventors: Wilson Moya, Jad Jaber
  • Patent number: 10207225
    Abstract: The present invention provides, in various embodiments, hybrid single-pass tangential flow filtration assemblies, disposable single-pass tangential flow filtration assemblies, scalable single-pass tangential flow filtration assemblies and adaptable modular single-pass tangential flow filtration assemblies. In other embodiments, the invention relates to processes for recovering proteins from the surface of a filtration membrane in a single-pass tangential flow filtration assembly and for cleaning a tangential flow filtration assembly. In additional embodiments, the invention provides methods of increasing the processing capacity of a single-pass tangential flow filtration assembly.
    Type: Grant
    Filed: June 11, 2015
    Date of Patent: February 19, 2019
    Assignee: EMD Millipore Corporation
    Inventors: Herbert Lutz, Joseph Parrella, Bala Raghunath
  • Patent number: 10195605
    Abstract: The method comprises the step of forming pipes (12) by clamping a bag between shells (13, 14) and by injecting an inflating agent via an inflating connector. The circuit comprises a bag (126) and a press (10) comprising two shells (13, 14) clamping said bag in a state in which pipes (12) are formed between the films (25, 26) of the bag.
    Type: Grant
    Filed: May 23, 2016
    Date of Patent: February 5, 2019
    Assignee: EMD Millipore Corporation
    Inventors: Rene Reinbigler, Jean-Louis Weissenbach
  • Patent number: 10195544
    Abstract: Redundant filtration system that includes at least one barrier filter as a process filter, the barrier filter having both hydrophilic and hydrophobic paths, allowing both fluid and gas permeability. The need for vents is eliminated, as is an intermediate drain filter. The device also can be dried in series. The filtration system includes a network of conduits and receptacles, the network receiving liquid raw and/or starting material at one end, conducting it through the process stream defined thereby, and producing the desired liquid product at another end. The network is provided with one or more inputs for introducing liquid raw material into the fluid process stream, and one or more output ports for discharging fluid out of the fluid process stream. The network is preferably an essentially closed network, and also, preferably sterile and/or aseptic.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: February 5, 2019
    Assignee: EMD Millipore Corporation
    Inventors: Jeremy Perreault, Sean Foley, Kevin Rautio
  • Patent number: 10195550
    Abstract: A method of filtering a liquid feed is described, comprising passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers. A method of filtering a liquid feed is also described comprising passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods of the invention can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: February 5, 2019
    Assignee: EMD Millipore Corporation
    Inventors: Jonathan Steen, Mikhail Kozlov, Herbert Lutz, Joseph Parrella, Elizabeth M. Goodrich, Bala Raghunath
  • Patent number: 10190085
    Abstract: A micro-incubator manifold for improved microfluidic configurations and systems and methods of manufacture and operation for a manifold and automated microfluidic systems are disclosed. Various embodiments relate to assays, systems, and/or devices for culturing cells or other biologic material in controlled environments and are applicable to related fields generally using microfluidic systems. Particular embodiments involve configurations that can be used with various standard automated handling systems, with active or passive loading and perfusion of medium and to provide high-throughput multi-assay automated systems for culturing, viewing, and analyzing cell growth, invasion, movement, chemotaxis or other properties. More specifically, specific embodiments relate to heat control systems for microfluidic culture plates and other automated systems for culture plates.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: January 29, 2019
    Assignee: EMD Millipore Corporation
    Inventors: Philip J. Lee, Terry Gaige, Wei Hsuan (Jessie) Ho
  • Patent number: D853226
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: July 9, 2019
    Assignee: EMD Millipore Corporation
    Inventors: Joseph Geringer, Stephen G. Hunt, Mikhail Kozlov, Joseph Almasian, Gregory Straeffer
  • Patent number: D853831
    Type: Grant
    Filed: March 20, 2018
    Date of Patent: July 16, 2019
    Assignee: EMD Millipore Corporation
    Inventors: Joseph Geringer, Stephen G. Hunt, Mikhail Kozlov, Joseph Almasian, Gregory Straeffer
  • Patent number: D857839
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: August 27, 2019
    Assignee: EMD Millipore Corporation
    Inventors: Matthew Natale, Brian Hillier