Patents Assigned to Ministero Dell'Universita' e Della Ricerca Scientifica e
Tecnologica
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Publication number: 20030220466Abstract: A method of synthesizing biodegradable aliphatic polyesters from one or more aliphatic dicarboxylic acids or diesters of the said acids and one or more linear or branched aliphatic glycols, comprising a first esterification or transesterification step and a second deglycolation under vacuum step, in which the catalyst is monobutylstannoic acid both for the esterification or transesterification step and for the deglycolation under vacuum step.Type: ApplicationFiled: March 4, 2003Publication date: November 27, 2003Applicant: Ministero Dell'Universita' E Della Ricerca Scientifica E TecnologicaInventors: Fernanda Farachi, Marco Foa', Tiziana Milizia
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Patent number: 6569079Abstract: A device comprises a bag with associated actuator means which can be selectively activated to permit the expansion of the bag and its consequent filing with a body of blood which flows towards the bag, and to produce the contraction of the bag with the consequent expulsion from the bag of a body of blood which has flowed into the bag. Means are provided for selectively varying the resistance offered by the said bag to filing with the said body of blood.Type: GrantFiled: April 27, 2001Date of Patent: May 27, 2003Assignee: Ministero dell'Universita e della Ricerca Scientifica e TecnologicaInventors: Maurizio Arabia, Mauro Ercolani, Manlio Fierli, Stefano Rinaldi, Giorgio Sorcini, Maurizio Zagara
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Patent number: 6562939Abstract: A method of synthesizing biodegradable aliphatic polyesters from one or more aliphatic dicarboxylic acids or diesters of the said acids and one or more linear or branched aliphatic glycols, comprising a first esterification or transesterification step and a second deglycolation under vacuum step, in which the catalyst is monobutylstannoic acid both for the esterification or transesterification step and for the deglycolation under vacuum step.Type: GrantFiled: December 4, 2001Date of Patent: May 13, 2003Assignee: Ministero Dell ′Universita′ e Della Ricerca Scientifica e TecnologicaInventors: Fernanda Farachi, Marco Foa′, Tiziana Milizia
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Patent number: 6388025Abstract: A method for increasing the molecular weight of aliphatic polyester resins from dicarboxylic aliphatic acids having 2-22 carbon atoms, or from hydroxy-acids having 2-22 carbon atoms, in which the solid resin is brought into contact with a chain extender preferably chosen from the organic disocyaciates.Type: GrantFiled: September 13, 2000Date of Patent: May 14, 2002Assignee: Ministero Dell'Universita' e Della Ricerca Scientifica e TecnologicaInventors: Gabriele Perego, Catia Bastioli, Gian Domenico Cella, Andrea Gardano
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Patent number: 6344362Abstract: Disclosed herein are uses of a recombinant protein as a receptor for a hepatitis virus. Also disclosed are a nucleic acid coding for the receptor, a vector comprising a nucleic acid encoding the receptor, a host cell transformed or transfected with the nucleic acid, and a new recombinant protein having the biological property to act as a receptor for a hepatitis virus and a transgenic animal expressing the recombinant protein.Type: GrantFiled: March 12, 1999Date of Patent: February 5, 2002Assignee: Ministero Dell Universita'E Della Ricerca Scientifica E Tecnologica (M.U.R.S.T. )Inventors: Giorgio Fassina, Sandro De Falco, Antonio Verdoliva, Menotti Ruvo
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Patent number: 6034265Abstract: A process for synthesizing aromatic urethanes, which entails:a) reacting an organic carbonate, in an amount which is equal to or greater than a stoichiometric amount, with an aromatic amine at a temperature of 00 to 190.degree. C.; andb) recovering the aromatic urethane from the reaction mixture, wherein step a) is carried out by maintaining reaction alcohol in an amount of from 10 to 40 mol % based on a total quantity of alcohol coproduced during the reaction.Type: GrantFiled: April 22, 1998Date of Patent: March 7, 2000Assignee: Ministero dell'Universita e della Ricerca Scientifica e TecnologicaInventors: Aldo Bosetti, Emanuele Cauchi, Vittorio Carletti, Pietro Cesti
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Patent number: 5902566Abstract: A process for the production of yttrium-90, generated by radioactive decay of strontium-90, by means of a generator including a column containing strontium-90 adsorbed on a cation-exchange resin, wherein yttrium-90, the decay product of strontium-90, is obtained by the flow of an eluent through the resin column of the generator, an acetate buffer solution being used as the eluent. The process enables a solution to be obtained which is usable directly for labelling protein substrates, particularly monoclonal antibodies, with yttrium-90.Type: GrantFiled: April 10, 1996Date of Patent: May 11, 1999Assignee: Ministero Dell `Universita` E Della Ricerca Scientifica E TecnologicaInventors: Marco Chinol, Rodolfo Franceschini, Fabio Lunghi
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Patent number: 5801048Abstract: The present invention relates to a process for producing large amounts of 7.beta.-(4-carboxybutanamido)-cephalosporanic acid acylase ("GA") enzyme, which process consists in growing, under suitable culture conditions, a recombinant Escherichia coli K12 strain and subsequently extracting the enzyme from the resulting culture.Enzyme production is controlled by a particular expression system which can be induced by corn-steep liquor, an extremely low cost component of the culture medium.The enzyme can be used in the enzymatic preparation of 7-amino-cephalosporanic acid by starting from 7.beta.-(4-carboxybutanamido)-cephalosporanic acid.Type: GrantFiled: September 11, 1996Date of Patent: September 1, 1998Assignee: Ministero Dell `Universita` E Della Ricerca Scientifica E TecnologicaInventors: Wilhelmus Van Der Goes, Antonella Bernardi, Aldo Bosetti, Giuliana Franzosi, Pietro Cesti
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Patent number: 5698731Abstract: A process is described for the preparation of aromatic carbamates in which an organic carbonate in a stoichiometric quantity or in a quantity higher than the stoichiometric value is reacted with an aromatic amine operating in the presence of a carbamation catalyst, wherein this catalyst is selected from N,N-substituted carbamate complexes of zinc or copper.The process gives high yields and selectivity in the useful reaction product.Type: GrantFiled: June 27, 1996Date of Patent: December 16, 1997Assignee: Ministero dell `Universita` e della Ricerca Scientifica e TecnologicaInventors: Aldo Bosetti, Pietro Cesti, Fausto Calderazzo
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Patent number: 5688846Abstract: Polymeric compositions comprising a polymer and photochromic compounds belonging to the class of spiro-pyrans, having the general formula (I): ##STR1##Type: GrantFiled: May 15, 1996Date of Patent: November 18, 1997Assignee: Ministero Dell `Universita` E Della Ricerca Scientifica E TecnologicaInventors: Pietro Allegrini, Nereo Nodari, Vincenzo Malatesta, Luciana Crisci
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Patent number: 5629382Abstract: Self-extinguishing polymeric compositions comprising ammonium polyphosphate aving the general formula (I):(NH.sub.4).sub.n+2 P.sub.n O.sub.3n+1 (I)microencapsulated with condensation compounds obtained by means of the polymerization of polyaminic compositions essentially constituted by derivatives of 2,4,6-triamino-1,3,5-triazine, having the general formula (II): ##STR1## with aldehydes, preferably formaldehyde.Type: GrantFiled: September 16, 1994Date of Patent: May 13, 1997Assignee: Ministero Dell'Universita'e Della Ricerca Scientifica e TecnologicaInventors: Roberto Cipolli, Roberto Oriani, Enrico Masarati, Gilberto Nucida
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Patent number: 5612210Abstract: The present invention relates to a process for producing large amounts of 7.beta.-(4-carboxybutanamido)-cephalosporanic acid acylase ("GA") enzyme, which process consists in growing, under suitable culture conditions, a recombinant Escherichia coli K12 strain and subsequently extracting the enzyme from the resulting culture.Enzyme production is controlled by a particular expression system which can be induced by corn-steep liquor, an extremely low cost component of the culture medium.The enzyme can be used in the enzymatic preparation of 7-amino-cephalosporanic acid by starting from 7.beta.-(4-carboxybutanamido)-cephalosporanic acid.Type: GrantFiled: December 30, 1994Date of Patent: March 18, 1997Assignee: Ministero Dell'Universita' e Della Ricerca Scientifica e TecnologicaInventors: Wilhelmus Van der Goes, Antonella Bernardi, Aldo Bosetti, Pietro Cesti, Giuliana Franzosi
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Patent number: 5606011Abstract: Condensation compounds obtained by means of the polymerization of polyami compositions essentially constituted by derivatives of 2,4,6-triamino-1,3,5-triazine, having the general formula (I): ##STR1## with aldehydes, preferably formaldehyde.Type: GrantFiled: February 22, 1994Date of Patent: February 25, 1997Assignee: Ministero Dell'Universita' e Della Ricerca Scientifica e TecnologicaInventors: Roberto Cipolli, Roberto Oriani, Enrico Masarati, Gilberto Nucida
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Patent number: 5576391Abstract: Ammonium polyphosphate having the general formula (I):(NH.sub.4).sub.n+2 P.sub.n O.sub.3n+1 (I)microencapsulated with condensation compounds obtained by means of the polymerization of polyaminic compositions essentially constituted by derivatives of 2,4,6-triamino-1,3,5-triazine, having the general formula (II): ##STR1## with aldehydes, preferably formaldehyde.Type: GrantFiled: June 2, 1995Date of Patent: November 19, 1996Assignee: Ministero Dell'Universita' E Della Ricerca Scientifica E TecnologicaInventors: Roberto Cipolli, Roberto Oriani, Enrico Masarati, Gilberto Nucida
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Patent number: 5551987Abstract: Process for the biological treatment of mud and oily residues obtained from he processing or extraction of crude oil. This process can be applied to mud alone, its mixtures and to suitable combinations of mud and oily emulsions.Type: GrantFiled: October 21, 1994Date of Patent: September 3, 1996Assignee: Ministero Dell `Universita` E Della Ricerca Scientifica E TecnologicaInventors: Ezio D'Addario, Eugenio Fascetti, Alberto Patricelli, Giulio Prosperi, Andrea Robertiello
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Patent number: 5550140Abstract: A description follows of oxa(thia)diazol- and triazol-ones(thiones), with a iticide and insecticide activity, having the general formula ##STR1## wherein: Y=0, S; Z=0, S, NCH.sub.3, one of the two substituents P and Q is an ortho-substituted phenyl and the other a substituted benzyl.Type: GrantFiled: February 21, 1995Date of Patent: August 27, 1996Assignee: Ministero Dell `Universita` e Della Ricerca Scientifica e TecnologicaInventors: Franco Bettarini, Luigi Capuzzi, Piero La Porta, Sergio Massimini, Vincenzo Caprioli
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Patent number: 5516686Abstract: The Antibiotic Complex AB-023 and its components: Antibiotic AB-023a and ibiotic AB-023b are disclosed, which are obtained by the controlled aerobic culture of Streptomyces sp. NCIMB 40212 in an aqueous nutrient culture substrate. Antibiotics AB-023 display a biological activity against pathogen fungi which attack agricultural crops and man.Type: GrantFiled: October 31, 1994Date of Patent: May 14, 1996Assignee: Ministero Dell `Universita` E Della Ricerca Scientifica E TecnologicaInventors: Rossella Bortolo, Dante Cidaria, Giorgio Cassani, Adriana Vallesi, Gianfranco Gugliemetti, Giorgio Borgonovi, Silvia Spera, Giorgio Pirali, Giovanni Confalonieri
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Patent number: 5472926Abstract: The process for preparing supported metal catalysts comprises the step of spending, in a solution of a metal compound, a carrier suitable for interacting with said compound, causing a polymer to interact with said carrier and submitting the resulting solid product to thermal treatment.Type: GrantFiled: April 21, 1993Date of Patent: December 5, 1995Assignee: Ministero dell `Universita` e della Ricerca Scientifica e TecnologicaInventors: Giuseppe Gubitosa, Maurizio Giampietri, Giuliano Vecchiato
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Patent number: 5464836Abstract: A description follows of benzophenones having an antifungal activity and responding to the general formula (I): ##STR1## wherein: R.sub.1 and R.sub.2, the same or different, represent C.sub.1 -C.sub.6 alkyl groups, C.sub.7 -C.sub.10 arylalkyl groups; or R.sub.1 and R.sub.2, considered jointly with N, represent a C.sub.3 -C.sub.8 heterocyclic group or a C.sub.2 -C.sub.7 heterocyclic group containing a second hetero-atom selected from O and S, said heterocyclic groups being optionally subsituted with one or more C.sub.1 -C.sub.4 alkyl groups;R.sub.3 and R.sub.4, the same or different, represent H atoms, C.sub.1 -C.sub.3 alkyl groups;K represents an oxygen atom or methylene;A represents a benzene group, optionally sustituted with one or more halogen atoms, C.sub.1 -C.sub.4 alkyl or haloalkyl groups, C.sub.1 -C.sub.4 alkoxylics, C.sub.1 -C.sub.4 haloalkoxylics;Y represents a C.sub.6 -C.sub.10 aryl group; said group may be optionally substituted with one or more halogen atomos, C.sub.1 -C.sub.Type: GrantFiled: October 5, 1993Date of Patent: November 7, 1995Assignee: Ministero dell'Universita` e della Ricerca Scientifica e TecnologicaInventors: Giovanni Camaggi, Lucio Filippini, Marilena Gusmeroli, Raul Riva, Carlo Garavaglia, Luigi Mirenna
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Patent number: 5464802Abstract: A process for preparing a supported metal catalyst based on Pd and Cu for e selective hydrogenation of polyunsaturated hydrocarbons comprises, in cascade, the steps of impregnating a porous support with a solution of a palladium and potassium salt, submitting the resulting solid product to a hydrogen flowing stream, impregnating the resulting solid material with a copper salt solution, submitting the resulting solid product to a flowing hydrogen stream, and drying the resulting solid product.Type: GrantFiled: April 23, 1993Date of Patent: November 7, 1995Assignee: Ministero Dell'Universita' E Della Ricerca Scientifica E TecnologicaInventors: Giuseppe Gubitosa, Alberto Cremona