Abstract: An apparatus and method for remotely adjusting the hydraulic horse power per square inch (HSI) of a drill bit. The apparatus and method may allow the nozzle geometry to be varied remotely without the need to pull the drill string outside the hole. This nozzle may include a body configured to be secured within the rotary drill bit, and a fluid passage within that body that leads to an orifice. The geometry of the fluid passage may be variable, and varying it may result in a change in the nozzle HSI; this may allow drilling different rock formations to be optimized in different drilling environments. Different placements of the nozzle, such as within the inner flow passage or between the inner flow passage and annular flow passage for controlling flow profile within a wellbore, a tubular string or a flow conduit, may be envisioned.

Abstract: The present invention relates to a device for high-frequency technology, or for the microwave region and millimetre wave region of the electromagnetic spectrum, characterised in that it contains a liquid-crystal medium which consists of one or more compounds, which one or more compounds, which contain 6 to 15 five-, six- or seven-membered rings, preferably 1,4-linked phenylene rings, or in that it contains a liquid-crystal medium which itself comprises a component A, which itself consists of one or more of the said compounds, which one or more compounds, which contain 6 to 15 five-, six- or seven-membered rings, preferably 1,4-linked phenylene rings. The present invention additionally relates to compounds of the formula (I), in which the parameters have the meanings given in the text, and to the corresponding, novel liquid-crystal media, to the use and preparation thereof, and to the production and use of the devices.

Abstract: A heat exchanger with a housing comprising two chambers separated by a partition plate, with each chamber comprising an inlet opening and an outlet opening for fluids. The housing and the partition plate are formed from a single metal sheet, the partition plate is formed from a middle area of the metal sheet, comprising a plurality of ribs and channels running alternately in parallel, and the housing is formed from side areas of the metal sheet which are folded along bend lines.

Abstract: The present invention relates to curable mixtures for the sealing, encapsulation, bonding or coating of opto-electronic components, such as OLEDs, solar cells, optical sensors and liquid-crystal displays, or for the alignment of liquid crystals. The mixtures comprise in total at least 50 percent by weight of vinyl ethers.

Abstract: The invention relates to novel polymers containing repeating units based on benzodithiophene or derivatives thereof, monomers and methods for their preparation, their use as semiconductors in organic electronic (OE) devices, especially in organic photovoltaic (OPV) devices, and to OE and OPV devices comprising these polymers.

Abstract: A method and apparatus is disclosed for remotely and selectively controlling fluid flow through tubular string disposed within a wellbore and further control fluid flow between the tubular string inner flow passage and the annular flow passage. The present invention further discloses a method of selectively and remotely receiving and interpreting a form of command or information at a desired apparatus within the wellbore caused by the operator on earth surface.

Abstract: A method for controlling a voltage transformer for operating a switchable load having at least one inductance and a switch, which is activated by a digital control device. When the switch is closed, a magnetizing current flows through the inductance. When the switch is open, a demagnetizing current flows through the inductance. The method comprises the steps of measuring the demagnetizing time of the inductance and, when a maximum value of the demagnetizing time of the inductance is exceeded, storing such an occurrence as a fault. The load is disconnected by the control device when a predetermined maximum frequency of faults is exceeded.

Abstract: A method for producing a plurality of LED illumination devices which each emit light having an average value of a first photometric parameter including producing a plurality of LED chips which emit light of the same color; measuring values of the first photometric parameter of the LED chips; combining the LED chips to form groups of at least two LED chips which have different values of the first photometric parameter such that differences in the average values of all the LED illumination devices are imperceptible to the human eye; and equipping a respective LED illumination device with a group of LED chips.

Abstract: The holding frame is equipped for holding at least one optical element, the holding frame consisting of an opaque material.

Abstract: Surface mounted ceramic capacitors (14) on printed circuit boards (10?) are subject to vibrations (18) caused by the piezo effect. Other electronic components are subject to magnetostriction and likewise generate vibrations. In prior art, the vibrations can propagate (20) on a printed circuit board (10). To suppress the propagation of the vibrations caused by the electronic component (14), the invention provides at least one slot (22) in the printed circuit board (10?). The slot (22) extends, for example, parallel to a side wall of the electronic component (14).

Abstract: An illumination from the class of oxynitridosilicates, doped with bivalent europium and comprising a cation M2+, said illuminant corresponding to the basic formula M(l-c)Si202N2:Dc wherein the following holds good: M=Sr(1-x)Bax mit 0.3<x<0.7.

Abstract: A method for adjusting the color point of a lighting unit including semiconductor-based lasers for generating an RGB signal. The method may include supplying at least one component of the RGB signal to a sensor via a filter; and actuating at least one of the semiconductor-based lasers by means of a signal detected by the sensor.

Abstract: The invention relates to compounds of the formulae (I) and (II) in which R1, R2, R3, R4, R5, R8, X and m have the meaning indicated in the claims, and/or physiologically acceptable salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios. The compounds of the formula (I) can be used for the inhibition of serine/threonine protein kinases and for the sensitisation of cancer cells to anticancer agents and/or ionising radiation. The invention also relates to the use of the compounds of the formula (I) in the prophylaxis, therapy or progress control of cancer, tumours, metastases or angiogenesis disorders, in combination with radiotherapy and/or an anticancer agent. The invention furthermore relates to a process for the preparation of the compounds of the formula (I).

Abstract: The present disclosure relates to methods and computational tools based, at least in part, on computer simulations that identify hot-spot amino acid residues and binding-region amino acid residues of a protein.

Abstract: A door leaf for a vehicle, in particular a rail vehicle, wherein the door leaf has a door leaf frame, a first skin mounted on a first main surface of the door leaf frame, and a second skin mounted on a second main surface opposite the first main surface. The door leaf has a heat path from the first skin to the second skin through at least two different materials, wherein the at least two different materials have a different thermal conductivity, wherein a first material of the at least two different materials has a poorer thermal conductivity than metal, in particular a poorer thermal conductivity than aluminum.

Abstract: The invention relates to biomarkers based on gene expression products and methods for determining the efficacy of anti-EGFR antibodies in the treatment of EGFR expressing cancer. The invention is further related to the prediction of sensitivity or resistance of a patient suffering from EGFR expressing cancer to the treatment of said patient with a specific anti-EGFR antibody. The invention is preferably related to the identification of respective biomarkers that allow a better prediction of the clinical outcome of the treatment with anti-EGFR antibodies in patients with KRAS wild-type tumors. In this context, the invention especially relates to anti-EFGR antibody c225/cetuximab (Erbitux®) and its use in patients suffering from colorectal Cancer (CRC).

Abstract: A pistol-shaped needleless injector includes a readily replaceable barrel (36) in the front end thereof facilitating adjustment of the dosage administered using the injector. A disposable nozzle (98) mountable on a holder (97) extending outwardly from the front discharge end of the barrel (36) provides an indication that the nozzle (98) has been used and should be discarded.

Abstract: The invention relates to a process for the preparation of salts having perfluoroalkyltricyano- or perfluoroalkylcyanofluoroborate anions, ((per)fluoro)phenyltricyano- or ((per)fluoro)phenylcyanofluoroborate anions, phenyltricyanoborate anions which are mono- or disubstituted by perfluoroalkyl groups having 1 to 4 C atoms or phenylcyanofluoroborate anions which are mono- or disubstituted by perfluoroalkyl groups having 1 to 4 C atoms, by reaction of alkali metal trifluoroperfluoroalkylborate with trialkylsilyl cyanide and a subsequent salt-exchange reaction or by direct reaction of an organic trifluoroperfluoroalkyl borate with trialkylsilyl cyanide.

Abstract: In a method for projecting an image onto a projection area (10) by at least one first (110) and second (210) beam, in order to create an improved image on the projection area, the deviation of the projection of the first and second beam on the projection area is determined, and the intensity of the first and/or second beam is varied over time according to the previously determined deviations.

Abstract: The present invention relates to the preparation and use of recombinant variants of group 5 allergens of the Poaceae (true grasses), which are characterised by reduced IgE reactivity compared with known wild-type allergens and at the same time substantially retained reactivity with T-lymphocytes.