Patents Assigned to Modern Meadow, Inc.
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Patent number: 11913166Abstract: Engineered, reinforced leather materials (engineered leathers) including a composite of a fibrous matrix that has been tanned to allow crosslinking of the fibrous matrix to the collagen formed by cultured cells (e.g., fibroblasts). These engineered leathers may be referred to as fiber-reinforced biological tissue composites. Also described herein are methods of making such fiber-reinforced biological tissue composites.Type: GrantFiled: September 21, 2016Date of Patent: February 27, 2024Assignee: MODERN MEADOW, INC.Inventors: Brendan Patrick Purcell, Gabor Forgacs
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Publication number: 20230174955Abstract: The disclosure herein provides a monomeric prolyl 4-hydroxylase. A microorganism including a monomeric prolyl 4-hydroxylase is provided. The disclosure provides a microorganism including a monomeric prolyl 4-hydroxylase; and another protein to be hydroxylated. A method for providing skincare benefits including applying the fusion protein of the present disclosure on skin is also taught.Type: ApplicationFiled: February 12, 2021Publication date: June 8, 2023Applicant: Modern Meadow, Inc.Inventors: Lixin DAI, Poonam SRIVASTAVA, Sumreet Singh JOHAR, Shashwat Mohan VAJPEYI, Mahadevan LAKSHMINARASIMHAN, James Egan WELCH
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Patent number: 11542374Abstract: The invention is directed to a composite material comprising a biofabricated material and a secondary component. The secondary component may be a porous material, such as a sheet of paper, cellulose, or fabric that has been coated or otherwise contacted with the biofabricated material. The biofabricated material comprises a uniform network of crosslinked collagen fibrils and provides strength, elasticity and an aesthetic appearance to the composite material.Type: GrantFiled: February 15, 2017Date of Patent: January 3, 2023Assignee: MODERN MEADOW, INC.Inventors: Brendan Patrick Purcell, David Thomas Williamson, Suzanne Lee, Amy Congdon
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Patent number: 11530304Abstract: A biofabricated material comprising a network of crosslinked collagen fibrils produced from recombinant collagen that contains substantially no 3-hydroxyproline residues is disclosed. This material is composed of collagen which is also a major component of natural leather and is produced by a process of fibrillation of collagen molecules into fibrils, crosslinking the fibrils and lubricating the crosslinked fibrils. Unlike natural leathers, this biofabricated material exhibits non-anisotropic (not directionally dependent) physical properties, for example, a sheet of biofabricated material can have substantially the same elasticity or tensile strength when stretched or stressed in different directions. Unlike natural leather, it has a uniform texture that facilitates uniform uptake of dyes and coatings. Aesthetically, it produces a uniform and consistent grain for ease of manufacturability.Type: GrantFiled: February 15, 2017Date of Patent: December 20, 2022Assignee: MODERN MEADOW, INC.Inventors: Brendan Patrick Purcell, David Thomas Williamson, Lixin Dai, Darryl Miles Cassingham, Stephen M. Spinella, Katherine Amy Congdon
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Patent number: 11525042Abstract: The invention is directed to a composite material comprising a biofabricated material and a secondary component. The secondary component may be a porous material, such as a sheet of paper, cellulose, or fabric that has been coated or otherwise contacted with the biofabricated material. The biofabricated material comprises a uniform network of crosslinked collagen fibrilsand provides strength, elasticity and an aesthetic appearance to the composite material.Type: GrantFiled: February 15, 2017Date of Patent: December 13, 2022Assignee: MODERN MEADOW, INC.Inventors: Brendan Patrick Purcell, David Thomas Williamson, Suzanne Lee, Amy Congdon
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Patent number: 11384135Abstract: This invention relates to genetically engineered strains of yeast and methods, for producing recombinant protein (e.g., collagen). Recombinant protein of the present invention is used to produce biofabricated leather or a material having leather-like properties containing recombinant or engineered collagen. The yeast strains are engineered to produce ascorbate and/or increased production of ? ketoglutarate.Type: GrantFiled: September 7, 2018Date of Patent: July 12, 2022Assignee: MODERN MEADOW, INC.Inventors: Lixin Dai, Poonam Srivastava
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Patent number: 11352497Abstract: The present disclosure provides layered collagen materials comprising one or more collagen/polymer matrix layers. The collagen/polymer matrix layer(s) are formed of a collagen blended with one or more polymers. The collagen blended within the polymer(s) can be dissolved within the polymer(s). The one or more collagen/polymer matrix layers can be attached to a substrate layer, for example a fabric layer.Type: GrantFiled: January 16, 2020Date of Patent: June 7, 2022Assignee: Modern Meadow, Inc.Inventors: Lorenzo Teglia, Varna Lakshmi Sharma, Dale Lee Handlin, Jr., Irina Kleiman, Hemanthram Varadaraju
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Patent number: 11312968Abstract: Strains of yeast genetically engineered to produce increased amounts of non-hydroxylated collagen or hydroxylated collagen are described. An all-in-one vector including the DNA necessary to produce collagen, promotors, and hydroxylating enzymes is also described. Methods for producing non-hydroxylated or hydroxylated collagen are also provided.Type: GrantFiled: June 29, 2018Date of Patent: April 26, 2022Assignee: MODERN MEADOW, INC.Inventors: Lixin Dai, Julia Borden, Jeffrey Nelson, Kristin Ruebling-Jass
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Patent number: 11286354Abstract: Described herein is a method for producing a biofabricated material from collagen or collagen-like proteins. The collagen or collagen-like proteins are isolated from animal sources or produced by recombinant DNA techniques or by chemical synthesis. The collagen or collagen-like proteins are fibrillated, crosslinked, dehydrated and lubricated thus forming the biofabricated material having a substantially uniform network of collagen fibrils.Type: GrantFiled: February 15, 2017Date of Patent: March 29, 2022Assignee: MODERN MEADOW, INC.Inventors: Brendan Patrick Purcell, David Thomas Williamson, Francoise Suzanne Marga, Susan J. Schofer, Darryl Miles Cassingham
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Patent number: 11214844Abstract: The invention herein provides biofabricated materials having zonal properties and methods of making biofabricated materials having zonal properties.Type: GrantFiled: November 13, 2018Date of Patent: January 4, 2022Assignee: Modern Meadow, Inc.Inventors: Brendan Patrick Purcell, Suzanne Lee, Lixin Dai, Katherine Amy Congdon, Stephen M. Spinella, Chi Man Ng
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Patent number: 11028146Abstract: This invention relates to genetically engineered strains of yeast and methods for producing recombinant protein (e.g., collagen). Recombinant protein of the present invention is used to produce biofabricated leather or a material having leather-like properties containing recombinant or engineered collagen. The yeast strains are engineered to produce ascorbate and/or increased production of ? ketoglutarate.Type: GrantFiled: September 7, 2018Date of Patent: June 8, 2021Assignee: MODERN MEADOW, INC.Inventors: Lixin Dai, Kristin Ruebling-Jass, David Thomas Williamson
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Patent number: 11001679Abstract: A biofabricated material containing a network of crosslinked collagen fibrils is disclosed. This material is composed of collagen which is also a major component of natural leather and is produced by a process of fibrillation of collagen molecules into fibrils, crosslinking the fibrils and lubricating the crosslinked fibrils. Unlike natural leathers, this biofabricated material exhibits non-anisotropic (not directionally dependent) physical properties, for example, a sheet of biofabricated material can have substantially the same elasticity or tensile strength when stretched or stressed in different directions. Unlike natural leather, it has a uniform texture that facilitates uniform uptake of dyes and coatings. Aesthetically, it produces a uniform and consistent grain for ease of manufacturability. It can have substantially identical grain, texture and other aesthetic properties on both sides distinct from natural leather where the grain increases from one side (e.g.Type: GrantFiled: March 19, 2019Date of Patent: May 11, 2021Assignee: Modern Meadow, Inc.Inventors: Brendan Patrick Purcell, David Thomas Williamson, Lixin Dai, Darryl Miles Cassingham, Stephen M. Spinella
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Publication number: 20200207932Abstract: The invention is directed to a method for producing a composite material comprising a biofabricated material and a secondary component. The secondary component may be a porous material, such as a sheet of paper, cellulose, or fabric that has been coated or otherwise contacted with the biofabricated material. The biofabricated material comprises a uniform network of crosslinked collagen fibrils and provides strength, elasticity and an aesthetic appearance to the composite material.Type: ApplicationFiled: November 4, 2019Publication date: July 2, 2020Applicant: Modern Meadow, Inc.Inventors: Brendan Patrick PURCELL, David Thomas WILLIAMSON, Suzanne LEE, Amy CONGDON
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Patent number: 10519285Abstract: The invention is directed to a method for producing a composite material comprising a biofabricated material and a secondary component. The secondary component may be a porous material, such as a sheet of paper, cellulose, or fabric that has been coated or otherwise contacted with the biofabricated material. The biofabricated material comprises a uniform network of crosslinked collagen fibrils and provides strength, elasticity and an aesthetic appearance to the composite material.Type: GrantFiled: February 15, 2017Date of Patent: December 31, 2019Assignee: Modern Meadow, Inc.Inventors: Brendan Patrick Purcell, David Thomas Williamson, Suzanne Lee, Amy Congdon
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Patent number: 10370505Abstract: The invention is directed to a composite material comprising a biofabricated material and a secondary component. The secondary component may be a porous material, such as a sheet of paper, cellulose, or fabric that has been coated or otherwise contacted with the biofabricated material. The biofabricated material comprises a uniform network of crosslinked collagen fibrils and provides strength, elasticity and an aesthetic appearance to the composite material.Type: GrantFiled: February 15, 2017Date of Patent: August 6, 2019Assignee: MODERN MEADOW, INC.Inventors: Brendan Patrick Purcell, David Thomas Williamson, Suzanne Lee, Amy Congdon
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Patent number: 10370504Abstract: Described herein is a method for producing a biofabricated material from collagen or collagen-like proteins which are recombinantly produced and which contain substantially no 3-hydroxyproline. The collagen or collagen-like proteins are isolated from animal sources, or produced by recombinant DNA techniques or by chemical synthesis. The collagen or collagen-like proteins are fibrillated, crosslinked, dehydrated and lubricated thus forming the biofabricated material having a substantially uniform network of collagen fibrils.Type: GrantFiled: February 15, 2017Date of Patent: August 6, 2019Assignee: MODERN MEADOW, INC.Inventors: Brendan Patrick Purcell, David Thomas Williamson, Francoise Suzanne Marga, Susan J. Schofer, Darryl Miles Cassingham, Stephen M. Spinella, Amy Congdon
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Publication number: 20190203000Abstract: A biofabricated material containing a network of crosslinked collagen fibrils is disclosed. This material is composed of collagen which is also a major component of natural leather and is produced by a process of fibrillation of collagen molecules into fibrils, crosslinking the fibrils and lubricating the crosslinked fibrils. Unlike natural leathers, this biofabricated material exhibits non-anisotropic (not directionally dependent) physical properties, for example, a sheet of biofabricated material can have substantially the same elasticity or tensile strength when stretched or stressed in different directions. Unlike natural leather, it has a uniform texture that facilitates uniform uptake of dyes and coatings. Aesthetically, it produces a uniform and consistent grain for ease of manufacturability. It can have substantially identical grain, texture and other aesthetic properties on both sides distinct from natural leather where the grain increases from one side (e.g.Type: ApplicationFiled: March 19, 2019Publication date: July 4, 2019Applicant: MODERN MEADOW, INC.Inventors: Brendan Patrick PURCELL, David Thomas WILLIAMSON, Lixin DAI, Darryl Miles CASSINGHAM, Stephen M. SPINELLA
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Patent number: 10301440Abstract: A biofabricated material containing a network of crosslinked collagen fibrils is disclosed. This material is composed of collagen which is also a major component of natural leather and is produced by a process of fibrillation of collagen molecules into fibrils, crosslinking the fibrils and lubricating the crosslinked fibrils. Unlike natural leathers, this biofabricated material exhibits non-anisotropic (not directionally dependent) physical properties, for example, a sheet of biofabricated material can have substantially the same elasticity or tensile strength when stretched or stressed in different directions. Unlike natural leather, it has a uniform texture that facilitates uniform uptake of dyes and coatings. Aesthetically, it produces a uniform and consistent grain for ease of manufacturability. It can have substantially identical grain, texture and other aesthetic properties on both sides distinct from natural leather where the grain increases from one side (e.g.Type: GrantFiled: February 15, 2017Date of Patent: May 28, 2019Assignee: MODERN MEADOW, INC.Inventors: Brendan Patrick Purcell, David Thomas Williamson, Lixin Dai, Darryl Miles Cassingham, Stephen M. Spinella
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Publication number: 20190144957Abstract: The invention herein provides biofabricated materials having zonal properties and methods of making biofabricated materials having zonal properties.Type: ApplicationFiled: November 13, 2018Publication date: May 16, 2019Applicant: MODERN MEADOW, INC.Inventors: Brendan Patrick PURCELL, Suzanne LEE, Lixin DAI, Katherine Amy CONGDON, Stephen M. SPINELLA, Chi Man NG
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Publication number: 20190092838Abstract: This invention relates to genetically engineered strains of yeast and methods for producing recombinant protein (e.g., collagen). Recombinant protein of the present invention is used to produce biofabricated leather or a material having leather-like properties containing recombinant or engineered collagen. The yeast strains are engineered to produce ascorbate and/or increased production of ? ketoglutarate.Type: ApplicationFiled: September 7, 2018Publication date: March 28, 2019Applicant: MODERN MEADOW, INC.Inventors: Lixin DAI, Poonam SRIVASTAVA